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Cheap flights from Panama City to San Diego from $253

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Diego departing on 3/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:30 am - 8:34 pm
PTY
-
SAN
17h 04m
2 stops
Multiple Airlines Logo
9:54 pm - 1:55 am
SAN
-
PTY
26h 01m
2 stops
$565Multiple Airlines
Wed, May 27 - Sat, May 30
Multiple Airlines Logo
5:30 am - 8:45 pm
PTY
-
SAN
17h 15m
2 stops
Multiple Airlines Logo
10:25 am - 2:55 pm
SAN
-
PTY
26h 30m
3 stops
$570Multiple Airlines
Wed, Apr 8 - Wed, Apr 29
Copa Airlines Logo
1:39 pm - 6:30 pm
PTY
-
SAN
6h 51mnonstop
Copa Airlines Logo
10:00 pm - 6:07 am
SAN
-
PTY
6h 07mnonstop
$575Copa Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
3:50 pm - 8:34 pm
PTY
-
SAN
30h 44m
2 stops
Multiple Airlines Logo
9:54 pm - 1:55 am
SAN
-
PTY
26h 01m
2 stops
$595Multiple Airlines
Sat, May 16 - Sat, May 23
Multiple Airlines Logo
5:30 am - 8:34 pm
PTY
-
SAN
17h 04m
2 stops
Multiple Airlines Logo
8:00 am - 2:55 pm
SAN
-
PTY
28h 55m
3 stops
$598Multiple Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
3:50 pm - 8:34 pm
PTY
-
SAN
30h 44m
2 stops
Multiple Airlines Logo
10:45 pm - 2:55 pm
SAN
-
PTY
38h 10m
3 stops
$611Multiple Airlines
Sat, May 16 - Sat, May 23
American Airlines Logo
1:10 pm - 10:34 pm
PTY
-
SAN
11h 24m
1 stop
American Airlines Logo
2:05 pm - 12:10 pm
SAN
-
PTY
20h 05m
2 stops
$632American Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
5:30 am - 8:45 pm
PTY
-
SAN
17h 15m
2 stops
Multiple Airlines Logo
5:58 pm - 10:30 am
SAN
-
PTY
14h 32m
2 stops
$651Multiple Airlines
Wed, Apr 8 - Wed, Apr 29
Multiple Airlines Logo
12:03 pm - 11:46 am
PTY
-
SAN
25h 43m
1 stop
Multiple Airlines Logo
12:15 pm - 8:50 am
SAN
-
PTY
18h 35m
2 stops
$668Multiple Airlines
Tue, Mar 17 - Tue, Mar 24
United Airlines Logo
7:55 am - 8:46 pm
PTY
-
SAN
14h 51m
2 stops
United Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$671United Airlines
Wed, May 27 - Sun, May 31

Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
May 27
PTY1:39 pmPanama City Tocumen Intl
6h 51m
SAN6:30 pmSan Diego
May 31
SAN10:00 pmSan Diego
6h 07m
PTY6:07 amPanama City Tocumen Intl
$575
Copa Airlines
Apr 8
PTY1:33 pmPanama City Tocumen Intl
6h 57m
SAN6:30 pmSan Diego
Apr 29
SAN4:21 pmSan Diego
11h 14m
1 stop
PTY5:35 amPanama City Tocumen Intl
$751
Copa Airlines
May 27
PTY12:38 pmPanama City Tocumen Intl
11h 58m
1 stop
SAN10:36 pmSan Diego
May 31
SAN10:00 pmSan Diego
6h 07m
PTY6:07 amPanama City Tocumen Intl
$757

American Airlines flights from Panama City to San Diego

Our best American Airlines deals on Panama City to San Diego flight tickets
American Airlines
May 27
PTY1:10 pmPanama City Tocumen Intl
11h 24m
1 stop
SAN10:34 pmSan Diego
May 31
SAN2:05 pmSan Diego
20h 05m
2 stops
PTY12:10 pmPanama City Tocumen Intl
$632
American Airlines
May 27
PTY1:10 pmPanama City Tocumen Intl
22h 06m
2 stops
SAN9:16 amSan Diego
May 31
SAN3:10 pmSan Diego
19h 00m
2 stops
PTY12:10 pmPanama City Tocumen Intl
$698
American Airlines
May 27
PTY1:10 pmPanama City Tocumen Intl
22h 08m
2 stops
SAN9:18 amSan Diego
May 31
SAN3:10 pmSan Diego
19h 00m
2 stops
PTY12:10 pmPanama City Tocumen Intl
$707

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 5/27

5:30 am-8:34 pm

2 stops17h 04m

San Diego

Sat 5/30

9:54 pm-1:55 am

2 stops26h 01m

$565

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 4/8

5:30 am-8:45 pm

2 stops17h 15m

San Diego

Wed 4/29

10:25 am-2:55 pm

3 stops26h 30m

$570

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 5/27

1:39 pm-6:30 pm

Nonstop6h 51m

San Diego

Sun 5/31

10:00 pm-6:07 am

Nonstop6h 07m

$575

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 5/16

3:50 pm-8:34 pm

2 stops30h 44m

San Diego

Sat 5/23

9:54 pm-1:55 am

2 stops26h 01m

$595

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 5/27

5:30 am-8:34 pm

2 stops17h 04m

San Diego

Sun 5/31

8:00 am-2:55 pm

3 stops28h 55m

$598

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 5/16

3:50 pm-8:34 pm

2 stops30h 44m

San Diego

Sat 5/23

10:45 pm-2:55 pm

3 stops38h 10m

$611

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 5/27

1:10 pm-10:34 pm

1 stop11h 24m

San Diego

Sun 5/31

2:05 pm-12:10 pm

2 stops20h 05m

$632

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 4/8

5:30 am-8:45 pm

2 stops17h 15m

San Diego

Wed 4/29

5:58 pm-10:30 am

2 stops14h 32m

$651

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 3/17

12:03 pm-11:46 am

1 stop25h 43m

San Diego

Tue 3/24

12:15 pm-8:50 am

2 stops18h 35m

$668

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 5/27

7:55 am-8:46 pm

2 stops14h 51m

San Diego

Sun 5/31

6:15 am-6:37 pm

1 stop10h 22m

$671

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama City during the month November is also very affordable. Most momondo users find prices during this month for around $428.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $235. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $443. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City Tocumen Intl to San Diego flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Diego flights?

You could potentially save up to 37% on your flight if you consider stops on a Panama City to San Diego flight.

How have Panama City to San Diego flight prices changed over time?

As of February 2026, prices for Panama City to San Diego flights are approximately 10% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Fastest flight time

6h 29m

Direct flights

Mon, Tue, Thu and Sat

Airports in San Diego

1 airport
The fastest flight from Panama City to San Diego takes 6h 29m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Thursday and Saturday. There are no airlines offering direct flights.
There is 1 airport in San Diego. From Panama City there are direct flights to San Diego (SAN).
Search flight deals

  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 29m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.5
1,559 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
9,231 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 4 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $224 round-trip, up to an average price of $460. Our users have rated Copa Airlines at 7.5/10.

  • United Airlines Flights From Panama City to San Diego

    $361 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $620, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 9,231 user reviews) flies into San Diego from Panama City 4 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
San Ysidro
Borrego Springs
La Mesa
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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