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Cheap flights from Panama City to San Diego from $424

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Diego departing on 11/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:45 pm - 6:27 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 42mnonstop
Copa Airlines Logo
10:00 pm - 7:06 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$558Copa Airlines
Mon, Oct 26 - Sun, Nov 8
Copa Airlines Logo
1:45 pm - 6:27 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 42mnonstop
Copa Airlines Logo
10:00 pm - 7:06 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$558Copa Airlines
Fri, Oct 30 - Sat, Nov 7
Copa Airlines Logo
1:45 pm - 5:15 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 30mnonstop
Copa Airlines Logo
10:00 pm - 7:06 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$558Copa Airlines
Sat, Nov 21 - Sun, Nov 29
Copa Airlines Logo
1:45 pm - 5:15 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 30mnonstop
Copa Airlines Logo
10:00 pm - 7:06 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$558Copa Airlines
Fri, Nov 13 - Wed, Nov 18
United Airlines Logo
3:30 pm - 12:18 pmPTY  Panama City Tocumen Intl-SAN San Diego
22h 48m2 stops Houston George Bush Intcntl San Francisco
United Airlines Logo
8:00 am - 6:37 pmSAN  San Diego-PTY Panama City Tocumen Intl
8h 37m1 stop Houston George Bush Intcntl
$564United Airlines
Tue, Sep 29 - Tue, Oct 6
United Airlines Logo
3:30 pm - 8:43 amPTY  Panama City Tocumen Intl-SAN San Diego
19h 13m2 stops Houston George Bush Intcntl San Francisco
United Airlines Logo
3:04 pm - 2:14 pmSAN  San Diego-PTY Panama City Tocumen Intl
21h 10m1 stop Houston George Bush Intcntl
$564United Airlines
Sun, Sep 13 - Fri, Sep 18
United Airlines Logo
3:30 pm - 11:35 amPTY  Panama City Tocumen Intl-SAN San Diego
22h 05m2 stops Houston George Bush Intcntl Los Angeles
United Airlines Logo
4:11 pm - 2:14 pmSAN  San Diego-PTY Panama City Tocumen Intl
20h 03m2 stops Denver Intl Houston George Bush Intcntl
$564United Airlines
Tue, Sep 29 - Tue, Oct 6
American Airlines Logo
1:16 pm - 10:25 amPTY  Panama City Tocumen Intl-SAN San Diego
23h 09m2 stops Miami Dallas/Fort Worth
American Airlines Logo
10:30 pm - 12:16 pmSAN  San Diego-PTY Panama City Tocumen Intl
11h 46m1 stop Miami
$566American Airlines
Mon, Sep 14 - Sun, Sep 20
American Airlines Logo
2:02 pm - 9:39 amPTY  Panama City Tocumen Intl-SAN San Diego
21h 37m2 stops Miami Dallas/Fort Worth
American Airlines Logo
4:31 pm - 2:13 pmSAN  San Diego-PTY Panama City Tocumen Intl
18h 42m2 stops Dallas/Fort Worth Miami
$577American Airlines
Fri, Oct 30 - Sat, Nov 7
American Airlines Logo
2:02 pm - 11:56 amPTY  Panama City Tocumen Intl-SAN San Diego
23h 54m1 stop Miami
American Airlines Logo
4:31 pm - 2:13 pmSAN  San Diego-PTY Panama City Tocumen Intl
18h 42m2 stops Dallas/Fort Worth Miami
$589American Airlines
Mon, Oct 26 - Sun, Nov 8

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United Airlines flights from Panama City to San Diego

Our best United Airlines deals on Panama City to San Diego flight tickets
United Airlines
Sep 13
PTY3:30 pmPanama City Tocumen Intl
31h 54m
1 stop
SAN9:24 pmSan Diego
Sep 18
SAN3:04 pmSan Diego
25h 33m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$564
United Airlines
Oct 27
PTY7:55 amPanama City Tocumen Intl
9h 59m
1 stop
SAN3:54 pmSan Diego
Oct 30
SAN5:00 pmSan Diego
18h 45m
1 stop
PTY1:45 pmPanama City Tocumen Intl
$573
United Airlines
Oct 27
PTY3:41 pmPanama City Tocumen Intl
27h 36m
2 stops
SAN5:17 pmSan Diego
Oct 30
SAN6:30 pmSan Diego
22h 08m
2 stops
PTY6:38 pmPanama City Tocumen Intl
$577

Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
Oct 30
PTY1:45 pmPanama City Tocumen Intl
6h 42m
SAN6:27 pmSan Diego
Nov 7
SAN10:00 pmSan Diego
6h 06m
PTY7:06 amPanama City Tocumen Intl
$558
Copa Airlines
Sep 6
PTY1:54 pmPanama City Tocumen Intl
6h 35m
SAN6:29 pmSan Diego
Sep 13
SAN10:00 pmSan Diego
6h 17m
PTY6:17 amPanama City Tocumen Intl
$601
Copa Airlines
Aug 31
PTY2:01 pmPanama City Tocumen Intl
6h 29m
SAN6:30 pmSan Diego
Sep 7
SAN10:00 pmSan Diego
6h 17m
PTY6:17 amPanama City Tocumen Intl
$655

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Mon 10/26

1:45 pm-6:27 pm

Nonstop6h 42m

San Diego

Sun 11/8

10:00 pm-7:06 am

Nonstop6h 06m

$558

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Fri 10/30

1:45 pm-6:27 pm

Nonstop6h 42m

San Diego

Sat 11/7

10:00 pm-7:06 am

Nonstop6h 06m

$558
Quickest round-trip

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sat 11/21

1:45 pm-5:15 pm

Nonstop6h 30m

San Diego

Sun 11/29

10:00 pm-7:06 am

Nonstop6h 06m

$558

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Fri 11/13

1:45 pm-5:15 pm

Nonstop6h 30m

San Diego

Wed 11/18

10:00 pm-7:06 am

Nonstop6h 06m

$558

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Tue 9/29

3:30 pm-12:18 pm

2 stops22h 48m

San Diego

Tue 10/6

8:00 am-6:37 pm

1 stop8h 37m

$564

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sun 9/13

3:30 pm-8:43 am

2 stops19h 13m

San Diego

Fri 9/18

3:04 pm-2:14 pm

1 stop21h 10m

$564

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Tue 9/29

3:30 pm-11:35 am

2 stops22h 05m

San Diego

Tue 10/6

4:11 pm-2:14 pm

2 stops20h 03m

$564

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Mon 9/14

1:16 pm-10:25 am

2 stops23h 09m

San Diego

Sun 9/20

10:30 pm-12:16 pm

1 stop11h 46m

$566

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Fri 10/30

2:02 pm-9:39 am

2 stops21h 37m

San Diego

Sat 11/7

4:31 pm-2:13 pm

2 stops18h 42m

$577

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Mon 10/26

2:02 pm-11:56 am

1 stop23h 54m

San Diego

Sun 11/8

4:31 pm-2:13 pm

2 stops18h 42m

$589

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of November, then departing from Panama City during the month October is also very affordable. Most momondo users find prices during this month for around $480.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $334. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $516. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City to San Diego flights?

There is only 1 cabin class available to choose from on Panama City to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Diego flights?

You could potentially save up to 22% on your flight if you consider stops on a Panama City to San Diego flight.

How have Panama City to San Diego flight prices changed over time?

As of August 2026, prices for Panama City to San Diego flights are approximately 39% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Best Price Found

$424

Fastest flight time

6h 29m

Direct flights

Mon, Tue, Thu and Sat

Airports in San Diego

1 airport
The best one-way flight to San Diego from Panama City in the past 72 hours is $424. The best round-trip flight deal from Panama City to San Diego found on momondo in the last 72 hours is $558.
The fastest flight from Panama City to San Diego takes 6h 29m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Thursday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport in San Diego. From Panama City there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from Panama City to San Diego

  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 29m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $297Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $339Free CancellationRating
7.4
10,107 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 4 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $297 round-trip, up to an average price of $707. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Diego

    $339 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $722, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 10,106 user reviews) flies into San Diego from Panama City 4 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
National City
Julian
La Mesa
Poway
San Ysidro
Imperial Beach
Santee
Borrego Springs
Lemon Grove
Alpine

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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