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Cheap flights from Panama City to San Diego from $300

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Diego departing on 3/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:45 am - 5:51 pm
PTY
-
SAN
35h 06m
3 stops
Multiple Airlines Logo
9:18 pm - 5:20 am
SAN
-
PTY
6h 02mnonstop
$567Multiple Airlines
Tue, Feb 24 - Wed, Mar 11
Copa Airlines Logo
1:15 pm - 5:13 pm
PTY
-
SAN
6h 58mnonstop
Copa Airlines Logo
9:18 pm - 5:20 am
SAN
-
PTY
6h 02mnonstop
$590Copa Airlines
Fri, Feb 27 - Sun, Mar 8
Multiple Airlines Logo
5:30 am - 8:45 pm
PTY
-
SAN
17h 15m
2 stops
Multiple Airlines Logo
10:02 pm - 1:55 am
SAN
-
PTY
25h 53m
2 stops
$595Multiple Airlines
Fri, Apr 3 - Tue, Apr 7
Multiple Airlines Logo
5:50 pm - 12:08 am
PTY
-
SAN
33h 18m
3 stops
Multiple Airlines Logo
9:18 pm - 5:20 am
SAN
-
PTY
6h 02mnonstop
$622Multiple Airlines
Fri, Feb 27 - Sun, Mar 8
Multiple Airlines Logo
12:03 pm - 5:51 pm
PTY
-
SAN
32h 48m
2 stops
Multiple Airlines Logo
9:18 pm - 5:20 am
SAN
-
PTY
6h 02mnonstop
$623Multiple Airlines
Tue, Feb 24 - Wed, Mar 11
United Airlines Logo
3:41 pm - 4:38 pm
PTY
-
SAN
26h 57m
1 stop
United Airlines Logo
6:15 am - 2:14 pm
SAN
-
PTY
29h 59m
1 stop
$649United Airlines
Fri, Mar 27 - Sat, Apr 4
Copa Airlines Logo
1:15 pm - 5:13 pm
PTY
-
SAN
6h 58mnonstop
Copa Airlines Logo
8:17 pm - 5:20 am
SAN
-
PTY
6h 03mnonstop
$655Copa Airlines
Fri, Feb 6 - Sun, Feb 8
Multiple Airlines Logo
3:50 pm - 8:45 pm
PTY
-
SAN
30h 55m
2 stops
Multiple Airlines Logo
10:25 am - 1:55 am
SAN
-
PTY
13h 30m
2 stops
$668Multiple Airlines
Thu, Apr 2 - Wed, Apr 15
United Airlines Logo
8:55 am - 8:18 pm
PTY
-
SAN
14h 23m
1 stop
United Airlines Logo
6:55 pm - 4:07 pm
SAN
-
PTY
19h 12m
2 stops
$671United Airlines
Thu, Mar 5 - Fri, Mar 27
Copa Airlines Logo
7:55 am - 8:05 pm
PTY
-
SAN
14h 10m
1 stop
Copa Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$675Copa Airlines
Fri, Apr 3 - Tue, Apr 7

Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
Feb 27
PTY1:15 pmPanama City Tocumen Intl
6h 58m
SAN5:13 pmSan Diego
Mar 8
SAN9:18 pmSan Diego
6h 02m
PTY5:20 amPanama City Tocumen Intl
$590
Copa Airlines
Feb 6
PTY1:15 pmPanama City Tocumen Intl
6h 58m
SAN5:13 pmSan Diego
Feb 8
SAN8:17 pmSan Diego
6h 03m
PTY5:20 amPanama City Tocumen Intl
$655
Copa Airlines
Apr 3
PTY7:55 amPanama City Tocumen Intl
14h 10m
1 stop
SAN8:05 pmSan Diego
Apr 7
SAN6:15 amSan Diego
10h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$675

Avianca flights from Panama City to San Diego

Our best Avianca deals on Panama City to San Diego flight tickets
Avianca
Feb 5
PTY7:50 pmPanama City Tocumen Intl
27h 04m
3 stops
SAN7:54 pmSan Diego
Feb 15
SAN6:10 pmSan Diego
13h 20m
2 stops
PTY10:30 amPanama City Tocumen Intl
$768
Avianca
Feb 5
PTY7:50 pmPanama City Tocumen Intl
27h 04m
3 stops
SAN7:54 pmSan Diego
Feb 9
SAN8:37 pmSan Diego
19h 18m
2 stops
PTY6:55 pmPanama City Tocumen Intl
$778
Avianca
Feb 5
PTY7:50 pmPanama City Tocumen Intl
27h 04m
3 stops
SAN7:54 pmSan Diego
Feb 10
SAN11:08 amSan Diego
20h 22m
2 stops
PTY10:30 amPanama City Tocumen Intl
$792

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 2/24

9:45 am-5:51 pm

3 stops35h 06m

San Diego

Wed 3/11

9:18 pm-5:20 am

Nonstop6h 02m

$567

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 2/27

1:15 pm-5:13 pm

Nonstop6h 58m

San Diego

Sun 3/8

9:18 pm-5:20 am

Nonstop6h 02m

$590

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 4/3

5:30 am-8:45 pm

2 stops17h 15m

San Diego

Tue 4/7

10:02 pm-1:55 am

2 stops25h 53m

$595

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 2/27

5:50 pm-12:08 am

3 stops33h 18m

San Diego

Sun 3/8

9:18 pm-5:20 am

Nonstop6h 02m

$622

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 2/24

12:03 pm-5:51 pm

2 stops32h 48m

San Diego

Wed 3/11

9:18 pm-5:20 am

Nonstop6h 02m

$623

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 3/27

3:41 pm-4:38 pm

1 stop26h 57m

San Diego

Sat 4/4

6:15 am-2:14 pm

1 stop29h 59m

$649

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 2/6

1:15 pm-5:13 pm

Nonstop6h 58m

San Diego

Sun 2/8

8:17 pm-5:20 am

Nonstop6h 03m

$655

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 4/2

3:50 pm-8:45 pm

2 stops30h 55m

San Diego

Wed 4/15

10:25 am-1:55 am

2 stops13h 30m

$668

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 3/5

8:55 am-8:18 pm

1 stop14h 23m

San Diego

Fri 3/27

6:55 pm-4:07 pm

2 stops19h 12m

$671

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 4/3

7:55 am-8:05 pm

1 stop14h 10m

San Diego

Tue 4/7

6:15 am-6:37 pm

1 stop10h 22m

$675

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama City during the month November is also very affordable. Most momondo users find prices during this month for around $428.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $235. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $417. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City Tocumen Intl to San Diego flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Diego flights?

No. A direct flight is the cheapest option for a flight between Panama City to San Diego.

How have Panama City to San Diego flight prices changed over time?

As of January 2026, prices for Panama City to San Diego flights are approximately 26% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Fastest flight time

6h 51m

Direct flights

Mon, Tue, Thu and Sat

Airports in San Diego

1 airport
The fastest flight from Panama City to San Diego takes 6h 51m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Thursday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport in San Diego. From Panama City there are direct flights to San Diego (SAN).
Search flight deals

  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 51m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
9,157 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 5 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $224 round-trip, up to an average price of $460. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Diego

    $361 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $609, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 9,157 user reviews) flies into San Diego from Panama City 5 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
Borrego Springs
San Ysidro
La Mesa
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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