Cheap flights from Panama City to San Diego from $285

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Diego departing on 9/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Copa Airlines Logo
1:15 pm - 5:57 pmPTY-SAN
6h 42mnonstop
Copa Airlines Logo
9:07 pm - 5:20 amSAN-PTY
6h 13mnonstop
$406Copa Airlines
Find Deal
Mon, Oct 20 - Fri, Oct 31
United Airlines Logo
10:00 am - 9:45 pmPTY-SAN
13h 45m1 stop
United Airlines Logo
7:50 pm - 6:49 pmSAN-PTY
20h 59m1 stop
$412United Airlines
Find Deal
Tue, Oct 21 - Sat, Nov 1
United Airlines Logo
3:30 pm - 9:12 amPTY-SAN
19h 42m2 stops
United Airlines Logo
8:00 am - 6:37 pmSAN-PTY
8h 37m1 stop
$430United Airlines
Find Deal
Wed, Oct 1 - Wed, Oct 8
American Airlines Logo
3:15 pm - 10:56 amPTY-SAN
21h 41m2 stops
American Airlines Logo
2:55 pm - 1:36 pmSAN-PTY
19h 41m2 stops
$432American Airlines
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Fri, Oct 31 - Tue, Nov 18
United Airlines Logo
3:35 pm - 12:15 amPTY-SAN
10h 40m1 stop
United Airlines Logo
8:00 am - 6:37 pmSAN-PTY
8h 37m1 stop
$439United Airlines
Find Deal
Thu, Oct 9 - Sun, Oct 12
Copa Airlines Logo
1:15 pm - 5:50 pmPTY-SAN
6h 35mnonstop
Copa Airlines Logo
9:08 pm - 5:25 amSAN-PTY
6h 17mnonstop
$441Copa Airlines
Find Deal
Sun, Sep 21 - Wed, Sep 24
United Airlines Logo
3:30 pm - 10:27 amPTY-SAN
20h 57m2 stops
United Airlines Logo
4:44 pm - 2:14 pmSAN-PTY
19h 30m1 stop
$443United Airlines
Find Deal
Thu, Oct 9 - Sun, Oct 12
Delta Logo
2:10 pm - 11:24 pmPTY-SAN
11h 14m1 stop
Delta Logo
10:30 pm - 12:55 pmSAN-PTY
12h 25m1 stop
$447Delta
Find Deal
Thu, Sep 25 - Sun, Sep 28
United Airlines Logo
10:00 am - 11:41 pmPTY-SAN
15h 41m2 stops
United Airlines Logo
7:50 pm - 1:45 pmSAN-PTY
15h 55m2 stops
$450United Airlines
Find Deal
Thu, Oct 23 - Tue, Oct 28
American Airlines Logo
3:15 pm - 11:30 amPTY-SAN
22h 15m1 stop
American Airlines Logo
10:45 pm - 2:03 pmSAN-PTY
13h 18m1 stop
$515American Airlines
Find Deal
Sat, Oct 18 - Wed, Oct 29

United Airlines flights from Panama City to San Diego

Our best United Airlines deals on Panama City to San Diego flight tickets
United Airlines
Oct 21
PTY10:00 amPanama City Tocumen Intl
13h 45m
1 stop
SAN9:45 pmSan Diego
Nov 1
SAN7:50 pmSan Diego
20h 59m
1 stop
PTY6:49 pmPanama City Tocumen Intl
United Airlines
Oct 1
PTY3:30 pmPanama City Tocumen Intl
19h 42m
2 stops
SAN9:12 amSan Diego
Oct 8
SAN8:00 amSan Diego
8h 37m
1 stop
PTY6:37 pmPanama City Tocumen Intl
United Airlines
Oct 9
PTY3:35 pmPanama City Tocumen Intl
10h 40m
1 stop
SAN12:15 amSan Diego
Oct 12
SAN8:00 amSan Diego
8h 37m
1 stop
PTY6:37 pmPanama City Tocumen Intl

Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
Oct 20
PTY1:15 pmPanama City Tocumen Intl
6h 42m
SAN5:57 pmSan Diego
Oct 31
SAN9:07 pmSan Diego
6h 13m
PTY5:20 amPanama City Tocumen Intl
Copa Airlines
Sep 21
PTY1:15 pmPanama City Tocumen Intl
6h 35m
SAN5:50 pmSan Diego
Sep 24
SAN9:08 pmSan Diego
6h 17m
PTY5:25 amPanama City Tocumen Intl
Copa Airlines
Dec 14
PTY1:15 pmPanama City Tocumen Intl
6h 52m
SAN5:07 pmSan Diego
Jan 2
SAN8:16 pmSan Diego
6h 04m
PTY5:20 amPanama City Tocumen Intl

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 10/20

1:15 pm-5:57 pm

Nonstop6h 42m

San Diego

Fri 10/31

9:07 pm-5:20 am

Nonstop6h 13m

$406

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 10/21

10:00 am-9:45 pm

1 stop13h 45m

San Diego

Sat 11/1

7:50 pm-6:49 pm

1 stop20h 59m

$412

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/1

3:30 pm-9:12 am

2 stops19h 42m

San Diego

Wed 10/8

8:00 am-6:37 pm

1 stop8h 37m

$430

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/31

3:15 pm-10:56 am

2 stops21h 41m

San Diego

Tue 11/18

2:55 pm-1:36 pm

2 stops19h 41m

$432

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/9

3:35 pm-12:15 am

1 stop10h 40m

San Diego

Sun 10/12

8:00 am-6:37 pm

1 stop8h 37m

$439

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 9/21

1:15 pm-5:50 pm

Nonstop6h 35m

San Diego

Wed 9/24

9:08 pm-5:25 am

Nonstop6h 17m

$441

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/9

3:30 pm-10:27 am

2 stops20h 57m

San Diego

Sun 10/12

4:44 pm-2:14 pm

1 stop19h 30m

$443

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 9/25

2:10 pm-11:24 pm

1 stop11h 14m

San Diego

Sun 9/28

10:30 pm-12:55 pm

1 stop12h 25m

$447

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/23

10:00 am-11:41 pm

2 stops15h 41m

San Diego

Tue 10/28

7:50 pm-1:45 pm

2 stops15h 55m

$450

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 10/18

3:15 pm-11:30 am

1 stop22h 15m

San Diego

Wed 10/29

10:45 pm-2:03 pm

1 stop13h 18m

$515

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama City during the month July is also very affordable. Most momondo users find prices during this month for around $429.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $235. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $668. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $344. Flights in the evening are often more expensive with an average ticket price of $1,009.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City Tocumen Intl to San Diego flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Diego flights?

No. A direct flight is the cheapest option for a flight between Panama City to San Diego.

How have Panama City to San Diego flight prices changed over time?

As of August 2025, prices for Panama City to San Diego flights are approximately 62% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Fastest flight time

6h 29m

Direct flights

Mon, Tue, Thu and Sat

Airports in San Diego

1 airport
The fastest flight from Panama City to San Diego takes 6h 29m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Thursday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport near San Diego: San Diego (SAN)
  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 35m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.5
1,512 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 1 flight/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $224 round-trip, up to an average price of $443. Our users have rated Copa Airlines at 7.5/10.

  • United Airlines Flights From Panama City to San Diego

    $361 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $600, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 8,930 user reviews) flies into San Diego from Panama City 3 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Imperial Beach
Poway
San Ysidro
Borrego Springs
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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1 adult
Tue 8/26
Tue 9/2

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