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Cheap flights from Panama City to San Diego from $283

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Diego departing on 10/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Copa Airlines Logo
1:15 pm - 5:03 pmPTY-SAN
6h 48mnonstop
Copa Airlines Logo
8:10 pm - 5:20 amSAN-PTY
6h 10mnonstop
$461Copa Airlines
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Wed, Nov 5 - Mon, Nov 10
Delta Logo
3:21 pm - 11:14 pmPTY-SAN
10h 53m1 stop
Delta Logo
10:30 pm - 2:12 pmSAN-PTY
12h 42m1 stop
$466Delta
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Wed, Nov 5 - Mon, Nov 10
United Airlines Logo
3:41 pm - 6:24 pmPTY-SAN
28h 43m1 stop
United Airlines Logo
5:55 pm - 6:49 pmSAN-PTY
21h 54m1 stop
$488United Airlines
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Fri, Oct 31 - Fri, Nov 7
American Airlines Logo
2:49 pm - 9:55 amPTY-SAN
22h 06m2 stops
American Airlines Logo
2:55 pm - 1:49 pmSAN-PTY
19h 54m2 stops
$489American Airlines
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Wed, Nov 5 - Mon, Nov 10
Copa Airlines Logo
1:15 pm - 5:57 pmPTY-SAN
6h 42mnonstop
Copa Airlines Logo
8:10 pm - 5:20 amSAN-PTY
6h 10mnonstop
$503Copa Airlines
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Fri, Oct 31 - Fri, Nov 7
United Airlines Logo
3:41 pm - 11:46 amPTY-SAN
22h 05m2 stops
United Airlines Logo
5:55 pm - 2:45 pmSAN-PTY
41h 50m3 stops
$595United Airlines
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Sat, Nov 1 - Sat, Nov 8
United Airlines Logo
3:41 pm - 10:41 amPTY-SAN
21h 00m2 stops
United Airlines Logo
6:47 pm - 7:38 pmSAN-PTY
21h 51m2 stops
$621United Airlines
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Fri, Oct 31 - Fri, Nov 7
American Airlines Logo
1:45 pm - 9:58 pmPTY-SAN
10h 13m1 stop
American Airlines Logo
10:45 pm - 2:03 pmSAN-PTY
13h 18m1 stop
$659American Airlines
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Wed, Oct 1 - Sun, Oct 5
Multiple Airlines Logo
2:55 am - 11:50 pmPTY-SAN
22h 55m3 stops
Multiple Airlines Logo
8:10 pm - 5:20 amSAN-PTY
6h 10mnonstop
$662Multiple Airlines
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Thu, Oct 30 - Fri, Nov 7
Multiple Airlines Logo
2:55 am - 8:07 pmPTY-SAN
19h 12m2 stops
Multiple Airlines Logo
8:10 pm - 5:20 amSAN-PTY
6h 10mnonstop
$692Multiple Airlines
Find Deal
Thu, Oct 30 - Fri, Nov 7

American Airlines flights from Panama City to San Diego

Our best American Airlines deals on Panama City to San Diego flight tickets
American Airlines
Nov 5
PTY2:49 pmPanama City Tocumen Intl
22h 06m
2 stops
SAN9:55 amSan Diego
Nov 10
SAN2:55 pmSan Diego
19h 54m
2 stops
PTY1:49 pmPanama City Tocumen Intl
$489
Find similar
American Airlines
Oct 1
PTY1:45 pmPanama City Tocumen Intl
10h 13m
1 stop
SAN9:58 pmSan Diego
Oct 5
SAN10:45 pmSan Diego
13h 18m
1 stop
PTY2:03 pmPanama City Tocumen Intl
$659
Find similar
American Airlines
Oct 1
PTY1:45 pmPanama City Tocumen Intl
10h 13m
1 stop
SAN9:58 pmSan Diego
Oct 5
SAN9:19 pmSan Diego
14h 44m
2 stops
PTY2:03 pmPanama City Tocumen Intl
$664
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Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
Nov 5
PTY1:15 pmPanama City Tocumen Intl
6h 48m
SAN5:03 pmSan Diego
Nov 10
SAN8:10 pmSan Diego
6h 10m
PTY5:20 amPanama City Tocumen Intl
$461
Find similar
Copa Airlines
Oct 31
PTY1:15 pmPanama City Tocumen Intl
6h 42m
SAN5:57 pmSan Diego
Nov 7
SAN8:10 pmSan Diego
6h 10m
PTY5:20 amPanama City Tocumen Intl
$503
Find similar
Copa Airlines
Oct 1
PTY1:15 pmPanama City Tocumen Intl
6h 42m
SAN5:57 pmSan Diego
Oct 5
SAN9:12 pmSan Diego
6h 13m
PTY5:25 amPanama City Tocumen Intl
$632
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

1:15 pm-5:03 pm

Nonstop6h 48m

San Diego

Mon 11/10

8:10 pm-5:20 am

Nonstop6h 10m

$461

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

3:21 pm-11:14 pm

1 stop10h 53m

San Diego

Mon 11/10

10:30 pm-2:12 pm

1 stop12h 42m

$466

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/31

3:41 pm-6:24 pm

1 stop28h 43m

San Diego

Fri 11/7

5:55 pm-6:49 pm

1 stop21h 54m

$488

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

2:49 pm-9:55 am

2 stops22h 06m

San Diego

Mon 11/10

2:55 pm-1:49 pm

2 stops19h 54m

$489

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/31

1:15 pm-5:57 pm

Nonstop6h 42m

San Diego

Fri 11/7

8:10 pm-5:20 am

Nonstop6h 10m

$503

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 11/1

3:41 pm-11:46 am

2 stops22h 05m

San Diego

Sat 11/8

5:55 pm-2:45 pm

3 stops41h 50m

$595

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/31

3:41 pm-10:41 am

2 stops21h 00m

San Diego

Fri 11/7

6:47 pm-7:38 pm

2 stops21h 51m

$621

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/1

1:45 pm-9:58 pm

1 stop10h 13m

San Diego

Sun 10/5

10:45 pm-2:03 pm

1 stop13h 18m

$659

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/30

2:55 am-11:50 pm

3 stops22h 55m

San Diego

Fri 11/7

8:10 pm-5:20 am

Nonstop6h 10m

$662

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/30

2:55 am-8:07 pm

2 stops19h 12m

San Diego

Fri 11/7

8:10 pm-5:20 am

Nonstop6h 10m

$692

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama City during the month July is also very affordable. Most momondo users find prices during this month for around $429.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $235. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $668. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $297. Flights in the evening are often more expensive with an average ticket price of $1,009.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City Tocumen Intl to San Diego flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Panama City to San Diego flight prices changed over time?

As of September 2025, prices for Panama City to San Diego flights are approximately 16% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Best Price Found

$435

Fastest flight time

6h 35m

Direct flights

Mon, Tue, Wed, Thu and Sat

Airports in San Diego

1 airport
The best one-way flight to San Diego from Panama City in the past 72 hours is $435. The best round-trip flight deal from Panama City to San Diego found on momondo in the last 72 hours is $224.
The fastest flight from Panama City to San Diego takes 6h 35m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Wednesday, Thursday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport near San Diego: San Diego (SAN)
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  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 42m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.6
1,533 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 2 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $224 round-trip, up to an average price of $443. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Diego

    $361 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $600, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 8,926 user reviews) flies into San Diego from Panama City 4 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Poway
Imperial Beach
San Ysidro
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your San Diego trip

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