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Cheap flights from Panama City to San Diego from $354

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Diego departing on 8/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:48 pm - 6:30 pm
PTY
-
SAN
6h 42mnonstop
Copa Airlines Logo
10:00 pm - 6:13 am
SAN
-
PTY
6h 13mnonstop
$601Copa Airlines
Fri, Oct 23 - Wed, Oct 28
Delta Logo
2:21 pm - 11:03 pm
PTY
-
SAN
10h 42m
1 stop
Delta Logo
9:40 pm - 12:56 pm
SAN
-
PTY
13h 16m
1 stop
$607Delta
Fri, Oct 23 - Wed, Oct 28
United Airlines Logo
8:55 am - 10:42 pm
PTY
-
SAN
16h 47m
2 stops
United Airlines Logo
5:00 pm - 2:45 pm
SAN
-
PTY
18h 45m
2 stops
$620United Airlines
Fri, Nov 6 - Sun, Nov 8
American Airlines Logo
3:35 pm - 11:25 am
PTY
-
SAN
21h 50m
1 stop
American Airlines Logo
4:28 pm - 2:00 pm
SAN
-
PTY
19h 32m
2 stops
$636American Airlines
Fri, Oct 23 - Wed, Oct 28
American Airlines Logo
1:39 pm - 11:57 am
PTY
-
SAN
24h 18m
2 stops
American Airlines Logo
12:47 pm - 12:39 pm
SAN
-
PTY
21h 52m
2 stops
$687American Airlines
Wed, Aug 12 - Wed, Sep 2
United Airlines Logo
8:55 am - 5:50 pm
PTY
-
SAN
11h 55m
1 stop
United Airlines Logo
8:00 am - 7:38 pm
SAN
-
PTY
8h 38m
1 stop
$699United Airlines
Fri, Nov 6 - Sun, Nov 8
American Airlines Logo
1:39 pm - 8:58 am
PTY
-
SAN
21h 19m
2 stops
American Airlines Logo
12:32 pm - 12:39 pm
SAN
-
PTY
22h 07m
1 stop
$704American Airlines
Wed, Aug 12 - Wed, Sep 2
Copa Airlines Logo
2:01 pm - 6:30 pm
PTY
-
SAN
6h 29mnonstop
Copa Airlines Logo
10:00 pm - 6:17 am
SAN
-
PTY
6h 17mnonstop
$736Copa Airlines
Wed, Aug 12 - Wed, Sep 2
United Airlines Logo
3:30 pm - 9:25 pm
PTY
-
SAN
31h 55m
1 stop
United Airlines Logo
8:00 am - 6:37 pm
SAN
-
PTY
8h 37m
1 stop
$741United Airlines
Wed, Aug 12 - Wed, Sep 2
United Airlines Logo
8:55 am - 5:50 pm
PTY
-
SAN
11h 55m
1 stop
United Airlines Logo
8:00 am - 7:38 pm
SAN
-
PTY
8h 38m
1 stop
$773United Airlines
Fri, Nov 6 - Sun, Nov 8

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American Airlines flights from Panama City to San Diego

Our best American Airlines deals on Panama City to San Diego flight tickets
American Airlines
Oct 23
PTY3:35 pmPanama City Tocumen Intl
21h 50m
1 stop
SAN11:25 amSan Diego
Oct 28
SAN4:28 pmSan Diego
19h 32m
2 stops
PTY2:00 pmPanama City Tocumen Intl
$636
American Airlines
Aug 12
PTY1:39 pmPanama City Tocumen Intl
24h 18m
2 stops
SAN11:57 amSan Diego
Sep 2
SAN12:47 pmSan Diego
21h 52m
2 stops
PTY12:39 pmPanama City Tocumen Intl
$687
American Airlines
Aug 12
PTY1:39 pmPanama City Tocumen Intl
21h 19m
2 stops
SAN8:58 amSan Diego
Sep 2
SAN12:32 pmSan Diego
22h 07m
1 stop
PTY12:39 pmPanama City Tocumen Intl
$704

Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
Oct 23
PTY1:48 pmPanama City Tocumen Intl
6h 42m
SAN6:30 pmSan Diego
Oct 28
SAN10:00 pmSan Diego
6h 13m
PTY6:13 amPanama City Tocumen Intl
$601
Copa Airlines
Aug 12
PTY2:01 pmPanama City Tocumen Intl
6h 29m
SAN6:30 pmSan Diego
Sep 2
SAN10:00 pmSan Diego
6h 17m
PTY6:17 amPanama City Tocumen Intl
$736
Copa Airlines
Jul 22
PTY2:01 pmPanama City Tocumen Intl
6h 29m
SAN6:30 pmSan Diego
Jul 26
SAN10:00 pmSan Diego
6h 22m
PTY6:22 amPanama City Tocumen Intl
$787

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/23

1:48 pm-6:30 pm

Nonstop6h 42m

San Diego

Wed 10/28

10:00 pm-6:13 am

Nonstop6h 13m

$601

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/23

2:21 pm-11:03 pm

1 stop10h 42m

San Diego

Wed 10/28

9:40 pm-12:56 pm

1 stop13h 16m

$607

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 11/6

8:55 am-10:42 pm

2 stops16h 47m

San Diego

Sun 11/8

5:00 pm-2:45 pm

2 stops18h 45m

$620

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/23

3:35 pm-11:25 am

1 stop21h 50m

San Diego

Wed 10/28

4:28 pm-2:00 pm

2 stops19h 32m

$636

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 8/12

1:39 pm-11:57 am

2 stops24h 18m

San Diego

Wed 9/2

12:47 pm-12:39 pm

2 stops21h 52m

$687

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 11/6

8:55 am-5:50 pm

1 stop11h 55m

San Diego

Sun 11/8

8:00 am-7:38 pm

1 stop8h 38m

$699

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 8/12

1:39 pm-8:58 am

2 stops21h 19m

San Diego

Wed 9/2

12:32 pm-12:39 pm

1 stop22h 07m

$704
Quickest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 8/12

2:01 pm-6:30 pm

Nonstop6h 29m

San Diego

Wed 9/2

10:00 pm-6:17 am

Nonstop6h 17m

$736

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 8/12

3:30 pm-9:25 pm

1 stop31h 55m

San Diego

Wed 9/2

8:00 am-6:37 pm

1 stop8h 37m

$741

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 11/6

8:55 am-5:50 pm

1 stop11h 55m

San Diego

Sun 11/8

8:00 am-7:38 pm

1 stop8h 38m

$773

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama City during the month November is also very affordable. Most momondo users find prices during this month for around $431.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $334. If your travel schedule is flexible, try to avoid departing on a Wednesday because tickets tend to average around $631. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City to San Diego flights?

There are 2 cabin classes available to choose from on Panama City to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Diego flights?

You could potentially save up to 33% on your flight if you consider stops on a Panama City to San Diego flight.

How have Panama City to San Diego flight prices changed over time?

As of June 2026, prices for Panama City to San Diego flights are approximately 61% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Fastest flight time

6h 29m

Direct flights

Mon, Tue, Thu, Fri and Sat

Airports in San Diego

1 airport
The fastest flight from Panama City to San Diego takes 6h 29m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Thursday, Friday and Saturday. There are no airlines offering direct flights.
There is 1 airport in San Diego. From Panama City there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from Panama City to San Diego

  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 29m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.5
1,569 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
9,813 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 4 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $224 round-trip, up to an average price of $642. Our users have rated Copa Airlines at 7.5/10.

  • United Airlines Flights From Panama City to San Diego

    $361 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $722, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 9,813 user reviews) flies into San Diego from Panama City 4 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
Julian
National City
Poway
La Mesa
San Ysidro
Borrego Springs
Imperial Beach
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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