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Cheap flights from Panama City to San Diego from $358

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:45 pm - 5:15 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 30mnonstop
Copa Airlines Logo
10:30 pm - 7:36 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$620Copa Airlines
Sat, Nov 14 - Sun, Nov 22
Copa Airlines Logo
1:45 pm - 5:15 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 30mnonstop
Copa Airlines Logo
10:30 pm - 7:36 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$624Copa Airlines
Sun, Nov 8 - Sun, Nov 22
Copa Airlines Logo
1:45 pm - 5:15 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 30mnonstop
Copa Airlines Logo
10:30 pm - 7:36 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$635Copa Airlines
Fri, Nov 6 - Sun, Nov 22
Copa Airlines Logo
1:45 pm - 5:15 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 30mnonstop
Copa Airlines Logo
10:30 pm - 7:36 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$655Copa Airlines
Mon, Nov 9 - Mon, Nov 23
Multiple Airlines Logo
7:55 am - 6:38 pmPTY  Panama City Tocumen Intl-SAN San Diego
37h 43m2 stops Los Angeles Los Angeles San Francisco
Multiple Airlines Logo
10:30 pm - 7:36 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$656Multiple Airlines
Wed, Nov 11 - Sun, Nov 22
Multiple Airlines Logo
6:31 pm - 6:38 pmPTY  Panama City Tocumen Intl-SAN San Diego
27h 07m1 stop San Francisco
Multiple Airlines Logo
10:30 pm - 7:36 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$665Multiple Airlines
Sun, Nov 8 - Sun, Nov 22
United Airlines Logo
8:55 am - 6:02 pmPTY  Panama City Tocumen Intl-SAN San Diego
12h 07m1 stop Houston George Bush Intcntl
United Airlines Logo
5:18 pm - 5:12 pmSAN  San Diego-PTY Panama City Tocumen Intl
20h 54m1 stop Houston George Bush Intcntl
$669United Airlines
Sun, Dec 20 - Wed, Dec 30
United Airlines Logo
8:55 am - 10:29 pmPTY  Panama City Tocumen Intl-SAN San Diego
16h 34m2 stops Houston George Bush Intcntl San Francisco
United Airlines Logo
5:18 pm - 2:45 pmSAN  San Diego-PTY Panama City Tocumen Intl
18h 27m1 stop Houston George Bush Intcntl
$669United Airlines
Sun, Dec 20 - Wed, Dec 30
United Airlines Logo
4:41 pm - 11:35 amPTY  Panama City Tocumen Intl-SAN San Diego
21h 54m2 stops Houston George Bush Intcntl Los Angeles Los Angeles
United Airlines Logo
7:10 pm - 7:38 pmSAN  San Diego-PTY Panama City Tocumen Intl
21h 28m2 stops Denver Intl Houston George Bush Intcntl
$669United Airlines
Sun, Dec 20 - Wed, Dec 30
Multiple Airlines Logo
9:00 am - 12:40 pmPTY  Panama City Tocumen Intl-SAN San Diego
30h 40m1 stop Calgary
Multiple Airlines Logo
10:30 pm - 7:36 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$675Multiple Airlines
Sun, Nov 1 - Wed, Nov 11

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American Airlines flights from Panama City to San Diego

Our best American Airlines deals on Panama City to San Diego flight tickets
American Airlines
Feb 18
PTY2:39 pmPanama City Tocumen Intl
22h 26m
2 stops
SAN10:05 amSan Diego
Feb 23
SAN10:05 pmSan Diego
12h 16m
2 stops
PTY1:21 pmPanama City Tocumen Intl
$723
American Airlines
Oct 27
PTY2:02 pmPanama City Tocumen Intl
11h 01m
1 stop
SAN11:03 pmSan Diego
Nov 3
SAN10:40 pmSan Diego
12h 33m
1 stop
PTY2:13 pmPanama City Tocumen Intl
$747
American Airlines
Oct 21
PTY2:02 pmPanama City Tocumen Intl
10h 41m
1 stop
SAN10:43 pmSan Diego
Nov 4
SAN2:18 pmSan Diego
20h 55m
2 stops
PTY2:13 pmPanama City Tocumen Intl
$757

Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
Nov 14
PTY1:45 pmPanama City Tocumen Intl
6h 30m
SAN5:15 pmSan Diego
Nov 22
SAN10:30 pmSan Diego
6h 06m
PTY7:36 amPanama City Tocumen Intl
$620
Copa Airlines
Nov 8
PTY1:45 pmPanama City Tocumen Intl
6h 30m
SAN5:15 pmSan Diego
Nov 22
SAN10:30 pmSan Diego
6h 06m
PTY7:36 amPanama City Tocumen Intl
$624
Copa Airlines
Nov 6
PTY1:45 pmPanama City Tocumen Intl
6h 30m
SAN5:15 pmSan Diego
Nov 22
SAN10:30 pmSan Diego
6h 06m
PTY7:36 amPanama City Tocumen Intl
$635

momondo Fare Finder

 
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

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Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sat 11/14

1:45 pm-5:15 pm

Nonstop6h 30m

San Diego

Sun 11/22

10:30 pm-7:36 am

Nonstop6h 06m

$620

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sun 11/8

1:45 pm-5:15 pm

Nonstop6h 30m

San Diego

Sun 11/22

10:30 pm-7:36 am

Nonstop6h 06m

$624

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Fri 11/6

1:45 pm-5:15 pm

Nonstop6h 30m

San Diego

Sun 11/22

10:30 pm-7:36 am

Nonstop6h 06m

$635

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Mon 11/9

1:45 pm-5:15 pm

Nonstop6h 30m

San Diego

Mon 11/23

10:30 pm-7:36 am

Nonstop6h 06m

$655

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Wed 11/11

7:55 am-6:38 pm

2 stops37h 43m

San Diego

Sun 11/22

10:30 pm-7:36 am

Nonstop6h 06m

$656

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sun 11/8

6:31 pm-6:38 pm

1 stop27h 07m

San Diego

Sun 11/22

10:30 pm-7:36 am

Nonstop6h 06m

$665

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sun 12/20

8:55 am-6:02 pm

1 stop12h 07m

San Diego

Wed 12/30

5:18 pm-5:12 pm

1 stop20h 54m

$669

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sun 12/20

8:55 am-10:29 pm

2 stops16h 34m

San Diego

Wed 12/30

5:18 pm-2:45 pm

1 stop18h 27m

$669

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sun 12/20

4:41 pm-11:35 am

2 stops21h 54m

San Diego

Wed 12/30

7:10 pm-7:38 pm

2 stops21h 28m

$669

Panama CitySan Diego

PTY Panama City Tocumen Intl - SAN San Diego

PTYSAN

Panama City Tocumen Intl

Sun 11/1

9:00 am-12:40 pm

1 stop30h 40m

San Diego

Wed 11/11

10:30 pm-7:36 am

Nonstop6h 06m

$675

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and San Diego?

Prices are currently low for flights on this route.

Typical prices usually range from $679 to $735.
The lowest price recently found on this route was $620.

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of November, then departing from Panama City during the month December is also very affordable. Most momondo users find prices during this month for around $568.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Saturday. Travelers who choose to depart for San Diego on a Saturday will often find tickets for as low as $365. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $516. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City to San Diego flights?

There is only 1 cabin class available to choose from on Panama City to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Diego flights?

You could potentially save up to 22% on your flight if you consider stops on a Panama City to San Diego flight.

How have Panama City to San Diego flight prices changed over time?

As of September 2026, prices for Panama City to San Diego flights are approximately 37% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Best Price Found

$358

Fastest flight time

6h 30m

Direct flights

Mon, Tue, Thu, Sat and Sun

Airports in San Diego

1 airport
The best one-way flight to San Diego from Panama City in the past 72 hours is $358. The best round-trip flight deal from Panama City to San Diego found on momondo in the last 72 hours is $620.
The fastest flight from Panama City to San Diego takes 6h 30m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Thursday, Saturday and Sunday. The only airline offering direct flights is Copa Airlines.
There is 1 airport in San Diego. From Panama City there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from Panama City to San Diego

  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 30m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $339Free CancellationRating
7.4
10,208 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $460Free CancellationRating
7.6
1,542 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 4 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $460 round-trip, up to an average price of $714. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Diego

    $339 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $755, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 10,208 user reviews) flies into San Diego from Panama City 4 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
El Cajon
Coronado
National City
La Mesa
Julian
Poway
San Ysidro
Imperial Beach
Santee
Alpine
Lemon Grove
Borrego Springs

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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