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Cheap flights from Panama City to San Diego from $245

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Diego departing on 12/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Copa Airlines Logo
1:45 pm - 5:37 pmPTY-SAN
6h 52mnonstop
Copa Airlines Logo
8:16 pm - 5:20 amSAN-PTY
6h 04mnonstop
$429Copa Airlines
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Tue, Dec 16 - Mon, Jan 5
United Airlines Logo
3:35 pm - 12:13 amPTY-SAN
11h 38m1 stop
United Airlines Logo
5:45 pm - 2:45 pmSAN-PTY
18h 00m2 stops
$434United Airlines
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Thu, Nov 27 - Sat, Dec 6
American Airlines Logo
2:43 pm - 11:53 pmPTY-SAN
12h 10m1 stop
American Airlines Logo
10:15 pm - 1:47 pmSAN-PTY
12h 32m1 stop
$443American Airlines
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Tue, Nov 25 - Tue, Dec 2
American Airlines Logo
2:43 pm - 8:47 amPTY-SAN
21h 04m2 stops
American Airlines Logo
10:15 pm - 1:47 pmSAN-PTY
12h 32m1 stop
$448American Airlines
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Tue, Nov 25 - Tue, Dec 2
United Airlines Logo
4:41 pm - 3:04 pmPTY-SAN
25h 23m2 stops
United Airlines Logo
4:11 pm - 2:45 pmSAN-PTY
19h 34m2 stops
$450United Airlines
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Tue, Dec 9 - Mon, Dec 15
American Airlines Logo
4:50 pm - 12:27 pmPTY-SAN
22h 37m1 stop
American Airlines Logo
10:25 pm - 1:27 pmSAN-PTY
12h 02m1 stop
$453American Airlines
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Fri, Jan 16 - Mon, Jan 19
American Airlines Logo
2:27 pm - 9:04 amPTY-SAN
21h 37m2 stops
American Airlines Logo
4:00 pm - 1:27 pmSAN-PTY
18h 27m2 stops
$458American Airlines
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Fri, Jan 16 - Mon, Jan 19
United Airlines Logo
11:35 am - 11:42 pmPTY-SAN
15h 07m2 stops
United Airlines Logo
11:12 am - 2:45 pmSAN-PTY
24h 33m2 stops
$461United Airlines
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Fri, Dec 12 - Sat, Jan 3
American Airlines Logo
4:43 pm - 8:47 amPTY-SAN
19h 04m2 stops
American Airlines Logo
10:45 pm - 3:42 pmSAN-PTY
13h 57m2 stops
$501American Airlines
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Sat, Dec 6 - Fri, Dec 12
Copa Airlines Logo
1:45 pm - 5:41 pmPTY-SAN
6h 56mnonstop
Copa Airlines Logo
8:17 pm - 5:20 amSAN-PTY
6h 03mnonstop
$536Copa Airlines
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Wed, Jan 21 - Wed, Feb 25

Copa Airlines flights from Panama City to San Diego

Our best Copa Airlines deals on Panama City to San Diego flight tickets
Copa Airlines
Dec 16
PTY1:45 pmPanama City Tocumen Intl
6h 52m
SAN5:37 pmSan Diego
Jan 5
SAN8:16 pmSan Diego
6h 04m
PTY5:20 amPanama City Tocumen Intl
$429
Find similar
Copa Airlines
Nov 5
PTY1:15 pmPanama City Tocumen Intl
6h 48m
SAN5:03 pmSan Diego
Nov 10
SAN8:10 pmSan Diego
6h 10m
PTY5:20 amPanama City Tocumen Intl
$461
Find similar
Copa Airlines
Nov 3
PTY1:15 pmPanama City Tocumen Intl
6h 48m
SAN5:03 pmSan Diego
Nov 9
SAN8:10 pmSan Diego
6h 10m
PTY5:20 amPanama City Tocumen Intl
$521
Find similar

United Airlines flights from Panama City to San Diego

Our best United Airlines deals on Panama City to San Diego flight tickets
United Airlines
Nov 27
PTY3:35 pmPanama City Tocumen Intl
11h 38m
1 stop
SAN12:13 amSan Diego
Dec 6
SAN5:45 pmSan Diego
18h 00m
2 stops
PTY2:45 pmPanama City Tocumen Intl
$434
Find similar
United Airlines
Dec 9
PTY4:41 pmPanama City Tocumen Intl
25h 23m
2 stops
SAN3:04 pmSan Diego
Dec 15
SAN4:11 pmSan Diego
19h 34m
2 stops
PTY2:45 pmPanama City Tocumen Intl
$450
Find similar
United Airlines
Dec 12
PTY11:35 amPanama City Tocumen Intl
15h 07m
2 stops
SAN11:42 pmSan Diego
Jan 3
SAN11:12 amSan Diego
24h 33m
2 stops
PTY2:45 pmPanama City Tocumen Intl
$461
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/16

1:45 pm-5:37 pm

Nonstop6h 52m

San Diego

Mon 1/5

8:16 pm-5:20 am

Nonstop6h 04m

$429

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 11/27

3:35 pm-12:13 am

1 stop11h 38m

San Diego

Sat 12/6

5:45 pm-2:45 pm

2 stops18h 00m

$434

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 11/25

2:43 pm-11:53 pm

1 stop12h 10m

San Diego

Tue 12/2

10:15 pm-1:47 pm

1 stop12h 32m

$443

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 11/25

2:43 pm-8:47 am

2 stops21h 04m

San Diego

Tue 12/2

10:15 pm-1:47 pm

1 stop12h 32m

$448

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/9

4:41 pm-3:04 pm

2 stops25h 23m

San Diego

Mon 12/15

4:11 pm-2:45 pm

2 stops19h 34m

$450

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 1/16

4:50 pm-12:27 pm

1 stop22h 37m

San Diego

Mon 1/19

10:25 pm-1:27 pm

1 stop12h 02m

$453

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 1/16

2:27 pm-9:04 am

2 stops21h 37m

San Diego

Mon 1/19

4:00 pm-1:27 pm

2 stops18h 27m

$458

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 12/12

11:35 am-11:42 pm

2 stops15h 07m

San Diego

Sat 1/3

11:12 am-2:45 pm

2 stops24h 33m

$461

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 12/6

4:43 pm-8:47 am

2 stops19h 04m

San Diego

Fri 12/12

10:45 pm-3:42 pm

2 stops13h 57m

$501

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 1/21

1:45 pm-5:41 pm

Nonstop6h 56m

San Diego

Wed 2/25

8:17 pm-5:20 am

Nonstop6h 03m

$536

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama City to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama City during the month July is also very affordable. Most momondo users find prices during this month for around $430.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama City to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $235. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $668. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $319. Flights in the evening are often more expensive with an average ticket price of $1,009.

What is the cheapest Panama City Tocumen Intl to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama City Tocumen Intl - San Diego flight prices

What cabin class options are available on Panama City Tocumen Intl to San Diego flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Diego flights?

No. A direct flight is the cheapest option for a flight between Panama City to San Diego.

How have Panama City to San Diego flight prices changed over time?

As of October 2025, prices for Panama City to San Diego flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Diego (PTY to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Diego

Best Price Found

$501

Fastest flight time

6h 48m

Direct flights

Mon, Tue, Wed, Thu and Sat

Airports in San Diego

1 airport
The best one-way flight to San Diego from Panama City in the past 72 hours is $501. The best round-trip flight deal from Panama City to San Diego found on momondo in the last 72 hours is $460.
The fastest flight from Panama City to San Diego takes 6h 48m
Direct flights go from Panama City to San Diego on Monday, Tuesday, Wednesday, Thursday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport near San Diego: San Diego (SAN)
Search flight deals

  • How far is Panama City Tocumen Intl to San Diego by plane?

    San Diego is 2903.4 mi away from Panama City Tocumen Intl. 6h 52m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Diego Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Diego?

  • What is the most popular airline from Panama City to San Diego?

Best airlines flying from Panama City to San Diego

Compare and see reviews for airlines that fly from Panama City to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.6
1,560 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
8,996 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Diego

    Copa Airlines is one of the most popular airlines flying from Panama City to San Diego, operating 3 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Diego starts from $224 round-trip, up to an average price of $460. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Diego

    $361 is the best United Airlines flight deal from Panama City to San Diego found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $609, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 8,996 user reviews) flies into San Diego from Panama City 3 times in an average week so prices can vary.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
La Mesa
Imperial Beach
Poway
Borrego Springs
San Ysidro
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Diego?

Finding the right flight to San Diego from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Panama City to San Diego with flexible booking policies on momondo?

All flight searches from Panama City to San Diego on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Diego?

momondo helps you find the best flight between Panama City and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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