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Cheap flights from Panama City to San Francisco from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Francisco departing on 3/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
3:50 pm - 11:20 pm
PTY
-
SFO
10h 30m
1 stop
Avianca Logo
11:10 pm - 6:55 pm
SFO
-
PTY
16h 45m
1 stop
$500Avianca
Tue, Feb 17 - Sun, Feb 22
Avianca Logo
9:45 am - 11:20 pm
PTY
-
SFO
16h 35m
2 stops
Avianca Logo
11:10 pm - 4:55 pm
SFO
-
PTY
14h 45m
2 stops
$501Avianca
Tue, Feb 17 - Sun, Feb 22
Avianca Logo
9:45 am - 11:20 pm
PTY
-
SFO
16h 35m
2 stops
Avianca Logo
1:20 pm - 2:00 pm
SFO
-
PTY
21h 40m
2 stops
$503Avianca
Tue, Feb 24 - Sat, Feb 28
Avianca Logo
9:45 am - 10:50 pm
PTY
-
SFO
15h 05m
2 stops
Avianca Logo
2:15 pm - 1:55 am
SFO
-
PTY
9h 40m
1 stop
$507Avianca
Fri, Mar 20 - Tue, Mar 31
Avianca Logo
7:50 pm - 12:00 pm
PTY
-
SFO
19h 10m
1 stop
Avianca Logo
11:10 pm - 6:55 pm
SFO
-
PTY
16h 45m
1 stop
$511Avianca
Fri, Feb 13 - Tue, Feb 17
Avianca Logo
2:55 am - 10:50 pm
PTY
-
SFO
21h 55m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
PTY
22h 00m
2 stops
$512Avianca
Thu, Mar 19 - Tue, Mar 31
Avianca Logo
2:55 am - 11:40 pm
PTY
-
SFO
22h 45m
2 stops
Avianca Logo
2:20 pm - 2:00 pm
SFO
-
PTY
21h 40m
2 stops
$513Avianca
Fri, Mar 13 - Sat, Mar 21
Avianca Logo
5:50 pm - 12:00 pm
PTY
-
SFO
21h 10m
2 stops
Avianca Logo
1:20 pm - 8:50 am
SFO
-
PTY
16h 30m
2 stops
$520Avianca
Sun, Feb 15 - Sat, Feb 21
Avianca Logo
5:50 pm - 12:00 pm
PTY
-
SFO
21h 10m
2 stops
Avianca Logo
1:20 pm - 8:50 am
SFO
-
PTY
16h 30m
2 stops
$521Avianca
Fri, Feb 27 - Fri, Mar 6
Avianca Logo
7:50 pm - 1:00 pm
PTY
-
SFO
19h 10m
1 stop
Avianca Logo
12:10 am - 10:30 am
SFO
-
PTY
8h 20m
1 stop
$523Avianca
Thu, Mar 12 - Wed, Mar 25

Avianca flights from Panama City to San Francisco

Our best Avianca deals on Panama City to San Francisco flight tickets
Avianca
Feb 17
PTY3:50 pmPanama City Tocumen Intl
10h 30m
1 stop
SFO11:20 pmSan Francisco
Feb 22
SFO11:10 pmSan Francisco
16h 45m
1 stop
PTY6:55 pmPanama City Tocumen Intl
$500
Avianca
Feb 17
PTY3:50 pmPanama City Tocumen Intl
10h 30m
1 stop
SFO11:20 pmSan Francisco
Feb 22
SFO11:10 pmSan Francisco
8h 20m
1 stop
PTY10:30 amPanama City Tocumen Intl
$501
Avianca
Feb 24
PTY9:45 amPanama City Tocumen Intl
16h 35m
2 stops
SFO11:20 pmSan Francisco
Feb 28
SFO1:20 pmSan Francisco
21h 40m
2 stops
PTY2:00 pmPanama City Tocumen Intl
$503

Copa Airlines flights from Panama City to San Francisco

Our best Copa Airlines deals on Panama City to San Francisco flight tickets
Copa Airlines
Apr 7
PTY5:53 pmPanama City Tocumen Intl
7h 47m
SFO11:40 pmSan Francisco
Apr 13
SFO1:23 amSan Francisco
7h 04m
PTY10:27 amPanama City Tocumen Intl
$592
Copa Airlines
Mar 10
PTY5:51 pmPanama City Tocumen Intl
7h 49m
SFO11:40 pmSan Francisco
Mar 16
SFO1:54 amSan Francisco
6h 52m
PTY10:46 amPanama City Tocumen Intl
$628
Copa Airlines
Feb 24
PTY6:27 pmPanama City Tocumen Intl
7h 53m
SFO11:20 pmSan Francisco
Feb 27
SFO12:42 amSan Francisco
7h 04m
PTY10:46 amPanama City Tocumen Intl
$664

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 2/17

3:50 pm-11:20 pm

1 stop10h 30m

San Francisco

Sun 2/22

11:10 pm-6:55 pm

1 stop16h 45m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 2/17

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

Sun 2/22

11:10 pm-4:55 pm

2 stops14h 45m

$501

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 2/24

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

Sat 2/28

1:20 pm-2:00 pm

2 stops21h 40m

$503

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 3/20

9:45 am-10:50 pm

2 stops15h 05m

San Francisco

Tue 3/31

2:15 pm-1:55 am

1 stop9h 40m

$507

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 2/13

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Tue 2/17

11:10 pm-6:55 pm

1 stop16h 45m

$511

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 3/19

2:55 am-10:50 pm

2 stops21h 55m

San Francisco

Tue 3/31

2:15 pm-2:15 pm

2 stops22h 00m

$512

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 3/13

2:55 am-11:40 pm

2 stops22h 45m

San Francisco

Sat 3/21

2:20 pm-2:00 pm

2 stops21h 40m

$513

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 2/15

5:50 pm-12:00 pm

2 stops21h 10m

San Francisco

Sat 2/21

1:20 pm-8:50 am

2 stops16h 30m

$520

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 2/27

5:50 pm-12:00 pm

2 stops21h 10m

San Francisco

Fri 3/6

1:20 pm-8:50 am

2 stops16h 30m

$521

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 3/12

7:50 pm-1:00 pm

1 stop19h 10m

San Francisco

Wed 3/25

12:10 am-10:30 am

1 stop8h 20m

$523

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama City to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $577.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama City to San Francisco is on a Tuesday when prices can be found for as low as $692. The most expensive day to fly to San Francisco is Saturday, with ticket prices averaging around $807.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Panama City to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $562. Flights in the afternoon are often more expensive with an average ticket price of $755.

What is the cheapest Panama City Tocumen Intl to San Francisco flight route?

Fly from Panama City Tocumen Intl to San Francisco for the best Panama City Tocumen Intl - San Francisco flight prices

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $649 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama City for as low as $495 on momondo.

What cabin class options are available on Panama City Tocumen Intl to San Francisco flights?

There are 4 cabin classes available to choose from on Panama City Tocumen Intl to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Francisco flights?

You could potentially save up to 38% on your flight if you consider stops on a Panama City to San Francisco flight.

How have Panama City to San Francisco flight prices changed over time?

As of January 2026, prices for Panama City to San Francisco flights are approximately 62% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Francisco (PTY to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Francisco

Best Price Found

$956

Fastest flight time

7h 47m

Direct flights

Every day

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Panama City in the past 72 hours is $956. The best round-trip flight deal from Panama City to San Francisco found on momondo in the last 72 hours is $411.
The fastest flight from Panama City to San Francisco takes 7h 47m
Direct flights go from Panama City to San Francisco every day.
There is 1 airport in San Francisco. From Panama City there are direct flights to San Francisco (SFO).
Search flight deals

  • How far is Panama City Tocumen Intl to San Francisco by plane?

    Panama City Tocumen Intl and San Francisco are 3322.3 mi apart from one another. By plane, this route typically takes 7h 47m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Francisco?

  • What is the most popular airline from Panama City to San Francisco?

Best airlines flying from Panama City to San Francisco

Compare and see reviews for airlines that fly from Panama City to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $335Free CancellationRating
7.5
1,560 reviews
Search Copa Airlines flights
AviancaPriceFrom $465Free CancellationRating
6.6
2,490 reviews
Search Avianca flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
9,213 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Francisco

    Copa Airlines is one of the most popular airlines flying from Panama City to San Francisco, operating 7 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Francisco starts from $335 round-trip, up to an average price of $648. Our users have rated Copa Airlines at 7.5/10.

  • United Airlines Flights From Panama City to San Francisco

    Across 9,214 United Airlines reviews on momondo, the average score is 7.4/10. United Airlines flies from Panama City to San Francisco about 7 times each week, with ticket deals ranging from $506 to $674. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Salinas
Vallejo
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Panama City.

Can I find flights from Panama City to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Panama City with this policy.

How can momondo help me find flights from Panama City to San Francisco?

Once you have performed a search for Panama City to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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