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Cheap flights from Panama City to San Francisco from $287

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Francisco departing on 11/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Avianca Logo
9:55 am - 10:45 pmPTY-SFO
14h 50m2 stops
Avianca Logo
12:05 am - 10:25 amSFO-PTY
32h 20m1 stop
$499Avianca
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Sat, Oct 11 - Tue, Oct 14
Avianca Logo
3:35 pm - 9:50 pmPTY-SFO
9h 15m1 stop
Avianca Logo
1:35 am - 6:55 pmSFO-PTY
14h 20m1 stop
$502Avianca
Find Deal
Fri, Feb 13 - Tue, Feb 17
Avianca Logo
2:55 am - 10:50 pmPTY-SFO
21h 55m2 stops
Avianca Logo
11:10 pm - 1:00 amSFO-PTY
22h 50m2 stops
$506Avianca
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Thu, Oct 30 - Mon, Nov 3
Copa Airlines Logo
6:27 pm - 11:17 pmPTY-SFO
7h 50mnonstop
Copa Airlines Logo
12:36 am - 10:46 amSFO-PTY
7h 10mnonstop
$649Copa Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
Delta Logo
3:46 pm - 12:01 amPTY-SFO
11h 15m1 stop
Delta Logo
9:30 pm - 2:21 pmSFO-PTY
13h 51m1 stop
$654Delta
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Fri, Dec 5 - Mon, Dec 8
United Airlines Logo
3:35 pm - 8:29 pmPTY-SFO
7h 54mnonstop
United Airlines Logo
7:16 am - 7:38 pmSFO-PTY
9h 22m1 stop
$664United Airlines
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Thu, Nov 20 - Thu, Nov 27
United Airlines Logo
3:35 pm - 8:29 pmPTY-SFO
7h 54mnonstop
United Airlines Logo
11:59 pm - 2:45 pmSFO-PTY
11h 46m1 stop
$668United Airlines
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Wed, Nov 26 - Tue, Dec 30
American Airlines Logo
2:43 pm - 11:27 amPTY-SFO
23h 44m2 stops
American Airlines Logo
3:54 pm - 1:47 pmSFO-PTY
18h 53m2 stops
$675American Airlines
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Thu, Nov 27 - Thu, Dec 4
Copa Airlines Logo
6:27 pm - 11:17 pmPTY-SFO
7h 50mnonstop
Copa Airlines Logo
12:36 am - 10:46 amSFO-PTY
7h 10mnonstop
$709Copa Airlines
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Sat, Dec 6 - Sun, Dec 14
American Airlines Logo
2:43 pm - 11:27 amPTY-SFO
23h 44m2 stops
American Airlines Logo
12:25 am - 3:37 pmSFO-PTY
12h 12m2 stops
$720American Airlines
Find Deal
Thu, Nov 27 - Wed, Dec 3

United Airlines flights from Panama City to San Francisco

Our best United Airlines deals on Panama City to San Francisco flight tickets
United Airlines
Nov 20
PTY3:35 pmPanama City Tocumen Intl
7h 54m
SFO8:29 pmSan Francisco
Nov 27
SFO7:16 amSan Francisco
9h 22m
1 stop
PTY7:38 pmPanama City Tocumen Intl
$664
Find similar
United Airlines
Nov 26
PTY3:35 pmPanama City Tocumen Intl
7h 54m
SFO8:29 pmSan Francisco
Dec 30
SFO11:59 pmSan Francisco
11h 46m
1 stop
PTY2:45 pmPanama City Tocumen Intl
$668
Find similar
United Airlines
Dec 6
PTY4:41 pmPanama City Tocumen Intl
18h 06m
1 stop
SFO7:47 amSan Francisco
Dec 15
SFO11:59 pmSan Francisco
14h 08m
1 stop
PTY5:07 pmPanama City Tocumen Intl
$669
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American Airlines flights from Panama City to San Francisco

Our best American Airlines deals on Panama City to San Francisco flight tickets
American Airlines
Nov 27
PTY2:43 pmPanama City Tocumen Intl
23h 44m
2 stops
SFO11:27 amSan Francisco
Dec 4
SFO3:54 pmSan Francisco
18h 53m
2 stops
PTY1:47 pmPanama City Tocumen Intl
$675
Find similar
American Airlines
Nov 27
PTY2:43 pmPanama City Tocumen Intl
23h 44m
2 stops
SFO11:27 amSan Francisco
Dec 3
SFO12:25 amSan Francisco
12h 12m
2 stops
PTY3:37 pmPanama City Tocumen Intl
$720
Find similar
American Airlines
Sep 30
PTY1:45 pmPanama City Tocumen Intl
11h 09m
1 stop
SFO10:54 pmSan Francisco
Oct 8
SFO11:59 pmSan Francisco
12h 04m
1 stop
PTY2:03 pmPanama City Tocumen Intl
$814
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momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 10/11

9:55 am-10:45 pm

2 stops14h 50m

San Francisco

Tue 10/14

12:05 am-10:25 am

1 stop32h 20m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 2/13

3:35 pm-9:50 pm

1 stop9h 15m

San Francisco

Tue 2/17

1:35 am-6:55 pm

1 stop14h 20m

$502

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 10/30

2:55 am-10:50 pm

2 stops21h 55m

San Francisco

Mon 11/3

11:10 pm-1:00 am

2 stops22h 50m

$506

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/13

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

Sun 11/16

12:36 am-10:46 am

Nonstop7h 10m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 12/5

3:46 pm-12:01 am

1 stop11h 15m

San Francisco

Mon 12/8

9:30 pm-2:21 pm

1 stop13h 51m

$654

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/20

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Thu 11/27

7:16 am-7:38 pm

1 stop9h 22m

$664

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 11/26

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Tue 12/30

11:59 pm-2:45 pm

1 stop11h 46m

$668

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/27

2:43 pm-11:27 am

2 stops23h 44m

San Francisco

Thu 12/4

3:54 pm-1:47 pm

2 stops18h 53m

$675

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 12/6

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

Sun 12/14

12:36 am-10:46 am

Nonstop7h 10m

$709

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/27

2:43 pm-11:27 am

2 stops23h 44m

San Francisco

Wed 12/3

12:25 am-3:37 pm

2 stops12h 12m

$720

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama City to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $602.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama City to San Francisco is on a Monday when prices can be found for as low as $634. The most expensive day to fly to San Francisco is Tuesday, with ticket prices averaging around $815.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Panama City to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $433. Flights in the afternoon are often more expensive with an average ticket price of $778.

What is the cheapest Panama City Tocumen Intl to San Francisco flight route?

Fly from Panama City Tocumen Intl to San Francisco for the best Panama City Tocumen Intl - San Francisco flight prices

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $632 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama City for as low as $487 on momondo.

What cabin class options are available on Panama City Tocumen Intl to San Francisco flights?

There are 4 cabin classes available to choose from on Panama City Tocumen Intl to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Francisco flights?

You could potentially save up to 37% on your flight if you consider stops on a Panama City to San Francisco flight.

How have Panama City to San Francisco flight prices changed over time?

As of September 2025, prices for Panama City to San Francisco flights are approximately 35% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Francisco (PTY to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Francisco

Best Price Found

$423

Fastest flight time

7h 33m

Direct flights

Every day

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Panama City in the past 72 hours is $423. The best round-trip flight deal from Panama City to San Francisco found on momondo in the last 72 hours is $582.
The fastest flight from Panama City to San Francisco takes 7h 33m
Direct flights go from Panama City to San Francisco every day.
There is 1 airport near San Francisco: San Francisco (SFO)
Search flight deals

  • How far is Panama City Tocumen Intl to San Francisco by plane?

    Panama City Tocumen Intl and San Francisco are 3322.3 mi apart from one another. By plane, this route typically takes 7h 49m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Francisco?

  • What is the most popular airline from Panama City to San Francisco?

Best airlines flying from Panama City to San Francisco

Compare and see reviews for airlines that fly from Panama City to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $366Free CancellationRating
7.6
1,533 reviews
Search Copa Airlines flights
AviancaPriceFrom $474Free CancellationRating
6.7
2,436 reviews
Search Avianca flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Francisco

    Copa Airlines is one of the most popular airlines flying from Panama City to San Francisco, operating 14 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Francisco starts from $366 round-trip, up to an average price of $631. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Francisco

    Across 8,926 United Airlines reviews on momondo, the average score is 7.4/10. United Airlines flies from Panama City to San Francisco about 14 times each week, with ticket deals ranging from $506 to $633. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Calistoga
Bodega Bay
Roseville
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Half Moon Bay
Walnut Creek
Vallejo
Redwood City
Salinas
South San Francisco
Fairfield

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Panama City.

Can I find flights from Panama City to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Panama City with this policy.

How can momondo help me find flights from Panama City to San Francisco?

Once you have performed a search for Panama City to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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