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Cheap flights from Panama City to San Francisco from $284

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Francisco departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Avianca Logo
9:45 am - 11:20 pmPTY-SFO
16h 35m2 stops
Avianca Logo
11:10 pm - 4:55 pmSFO-PTY
14h 45m2 stops
$500Avianca
Find Deal
Tue, Jan 27 - Tue, Feb 3
Avianca Logo
2:55 am - 11:20 pmPTY-SFO
23h 25m2 stops
Avianca Logo
11:10 pm - 10:30 amSFO-PTY
8h 20m1 stop
$507Avianca
Find Deal
Mon, Jan 26 - Tue, Feb 3
Avianca Logo
7:50 pm - 12:00 pmPTY-SFO
19h 10m1 stop
Avianca Logo
11:10 pm - 6:55 pmSFO-PTY
16h 45m1 stop
$533Avianca
Find Deal
Wed, Dec 17 - Wed, Jan 7
Avianca Logo
5:50 pm - 11:20 pmPTY-SFO
32h 30m2 stops
Avianca Logo
11:10 pm - 10:30 amSFO-PTY
8h 20m1 stop
$543Avianca
Find Deal
Wed, Dec 17 - Wed, Jan 7
Avianca Logo
2:55 am - 9:50 pmPTY-SFO
21h 55m2 stops
Avianca Logo
11:10 pm - 10:30 amSFO-PTY
8h 20m1 stop
$554Avianca
Find Deal
Tue, Dec 16 - Wed, Jan 7
Multiple Airlines Logo
1:45 pm - 10:03 pmPTY-SFO
11h 18m1 stop
Multiple Airlines Logo
2:13 pm - 5:20 amSFO-PTY
12h 07m1 stop
$556Multiple Airlines
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Fri, Dec 5 - Sun, Dec 7
Avianca Logo
2:55 am - 9:50 pmPTY-SFO
21h 55m2 stops
Avianca Logo
1:35 am - 6:55 pmSFO-PTY
14h 20m1 stop
$561Avianca
Find Deal
Wed, Nov 26 - Sat, Nov 29
Multiple Airlines Logo
5:50 pm - 11:20 pmPTY-SFO
32h 30m2 stops
Multiple Airlines Logo
2:13 pm - 5:20 amSFO-PTY
12h 07m1 stop
$569Multiple Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Multiple Airlines Logo
5:50 pm - 11:20 pmPTY-SFO
32h 30m2 stops
Multiple Airlines Logo
9:57 pm - 5:20 amSFO-PTY
28h 23m1 stop
$571Multiple Airlines
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Mon, Dec 1 - Tue, Dec 9
Avianca Logo
7:50 pm - 12:00 pmPTY-SFO
19h 10m1 stop
Avianca Logo
1:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
$581Avianca
Find Deal
Sun, Nov 23 - Sat, Nov 29

Avianca flights from Panama City to San Francisco

Our best Avianca deals on Panama City to San Francisco flight tickets
Avianca
Jan 27
PTY9:45 amPanama City Tocumen Intl
16h 35m
2 stops
SFO11:20 pmSan Francisco
Feb 3
SFO11:10 pmSan Francisco
14h 45m
2 stops
PTY4:55 pmPanama City Tocumen Intl
$500
Find similar
Avianca
Jan 26
PTY2:55 amPanama City Tocumen Intl
23h 25m
2 stops
SFO11:20 pmSan Francisco
Feb 3
SFO11:10 pmSan Francisco
8h 20m
1 stop
PTY10:30 amPanama City Tocumen Intl
$507
Find similar
Avianca
Dec 17
PTY7:50 pmPanama City Tocumen Intl
19h 10m
1 stop
SFO12:00 pmSan Francisco
Jan 7
SFO11:10 pmSan Francisco
16h 45m
1 stop
PTY6:55 pmPanama City Tocumen Intl
$533
Find similar

Copa Airlines flights from Panama City to San Francisco

Our best Copa Airlines deals on Panama City to San Francisco flight tickets
Copa Airlines
Dec 29
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
Jan 1
SFO12:42 amSan Francisco
7h 04m
PTY10:46 amPanama City Tocumen Intl
$693
Find similar
Copa Airlines
Nov 27
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
Dec 1
SFO12:36 amSan Francisco
7h 10m
PTY10:46 amPanama City Tocumen Intl
$853
Find similar
Copa Airlines
Nov 20
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
Nov 26
SFO12:36 amSan Francisco
7h 10m
PTY10:46 amPanama City Tocumen Intl
$861
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 1/27

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

Tue 2/3

11:10 pm-4:55 pm

2 stops14h 45m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 1/26

2:55 am-11:20 pm

2 stops23h 25m

San Francisco

Tue 2/3

11:10 pm-10:30 am

1 stop8h 20m

$507

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 12/17

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Wed 1/7

11:10 pm-6:55 pm

1 stop16h 45m

$533

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 12/17

5:50 pm-11:20 pm

2 stops32h 30m

San Francisco

Wed 1/7

11:10 pm-10:30 am

1 stop8h 20m

$543

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 12/16

2:55 am-9:50 pm

2 stops21h 55m

San Francisco

Wed 1/7

11:10 pm-10:30 am

1 stop8h 20m

$554

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 12/5

1:45 pm-10:03 pm

1 stop11h 18m

San Francisco

Sun 12/7

2:13 pm-5:20 am

1 stop12h 07m

$556

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 11/26

2:55 am-9:50 pm

2 stops21h 55m

San Francisco

Sat 11/29

1:35 am-6:55 pm

1 stop14h 20m

$561

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 12/5

5:50 pm-11:20 pm

2 stops32h 30m

San Francisco

Sun 12/7

2:13 pm-5:20 am

1 stop12h 07m

$569

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 12/1

5:50 pm-11:20 pm

2 stops32h 30m

San Francisco

Tue 12/9

9:57 pm-5:20 am

1 stop28h 23m

$571

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 11/23

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Sat 11/29

1:20 pm-10:30 am

1 stop18h 10m

$581

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama City to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $579.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama City to San Francisco is on a Monday when prices can be found for as low as $656. The most expensive day to fly to San Francisco is Wednesday, with ticket prices averaging around $1,163.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Panama City to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $433. Flights in the afternoon are often more expensive with an average ticket price of $747.

What is the cheapest Panama City Tocumen Intl to San Francisco flight route?

Fly from Panama City Tocumen Intl to San Francisco for the best Panama City Tocumen Intl - San Francisco flight prices

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $631 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama City for as low as $463 on momondo.

What cabin class options are available on Panama City Tocumen Intl to San Francisco flights?

There are 4 cabin classes available to choose from on Panama City Tocumen Intl to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Francisco flights?

You could potentially save up to 40% on your flight if you consider stops on a Panama City to San Francisco flight.

How have Panama City to San Francisco flight prices changed over time?

As of November 2025, prices for Panama City to San Francisco flights are approximately 31% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Francisco (PTY to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Francisco

Best Price Found

$540

Fastest flight time

7h 49m

Direct flights

Every day

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Panama City in the past 72 hours is $540. The best round-trip flight deal from Panama City to San Francisco found on momondo in the last 72 hours is $625.
The fastest flight from Panama City to San Francisco takes 7h 49m
Direct flights go from Panama City to San Francisco every day.
There is 1 airport near San Francisco: San Francisco (SFO)
Search flight deals

  • How far is Panama City Tocumen Intl to San Francisco by plane?

    Panama City Tocumen Intl and San Francisco are 3322.3 mi apart from one another. By plane, this route typically takes 7h 50m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Francisco?

  • What is the most popular airline from Panama City to San Francisco?

Best airlines flying from Panama City to San Francisco

Compare and see reviews for airlines that fly from Panama City to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $465Free CancellationRating
6.6
2,475 reviews
Search Avianca flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
9,015 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $506Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Panama City to San Francisco

    Copa Airlines is one of the most popular airlines flying from Panama City to San Francisco, operating 14 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Francisco starts from $506 round-trip, up to an average price of $634. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Francisco

    Across 9,015 United Airlines reviews on momondo, the average score is 7.4/10. United Airlines flies from Panama City to San Francisco about 14 times each week, with ticket deals ranging from $506 to $664. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Calistoga
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Livermore
Turlock
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Panama City.

Can I find flights from Panama City to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Panama City with this policy.

How can momondo help me find flights from Panama City to San Francisco?

Once you have performed a search for Panama City to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Francisco trip

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