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Cheap flights from Panama City to San Francisco from $283

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Francisco departing on 3/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Avianca Logo
10:05 pm - 11:55 pmPTY-SFO
27h 50m2 stops
Avianca Logo
2:30 am - 2:45 pmSFO-PTY
10h 15m1 stop
$494Avianca
Find Deal
Fri, Apr 24 - Tue, Apr 28
Avianca Logo
9:55 am - 11:55 pmPTY-SFO
16h 00m2 stops
Avianca Logo
12:05 am - 4:30 pmSFO-PTY
14h 25m2 stops
$500Avianca
Find Deal
Tue, Apr 7 - Wed, Apr 22
Copa Airlines Logo
6:27 pm - 11:20 pmPTY-SFO
7h 53mnonstop
Copa Airlines Logo
12:42 am - 10:46 amSFO-PTY
7h 04mnonstop
$649Copa Airlines
Find Deal
Tue, Jan 27 - Sun, Feb 1
Multiple Airlines Logo
7:50 pm - 12:00 pmPTY-SFO
19h 10m1 stop
Multiple Airlines Logo
9:56 pm - 5:20 amSFO-PTY
28h 24m2 stops
$661Multiple Airlines
Find Deal
Sun, Dec 21 - Sun, Dec 28
United Airlines Logo
4:41 pm - 9:53 amPTY-SFO
20h 12m1 stop
United Airlines Logo
12:43 am - 2:45 pmSFO-PTY
11h 02m1 stop
$670United Airlines
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Sat, Feb 14 - Fri, Mar 6
Copa Airlines Logo
6:27 pm - 11:17 pmPTY-SFO
7h 50mnonstop
Copa Airlines Logo
12:42 am - 10:46 amSFO-PTY
7h 04mnonstop
$671Copa Airlines
Find Deal
Mon, Dec 29 - Thu, Jan 1
American Airlines Logo
2:27 pm - 9:17 amPTY-SFO
21h 50m2 stops
American Airlines Logo
12:17 am - 3:38 pmSFO-PTY
12h 21m2 stops
$679American Airlines
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Tue, Jan 27 - Sun, Feb 1
United Airlines Logo
3:35 pm - 8:29 pmPTY-SFO
7h 54mnonstop
United Airlines Logo
12:30 am - 7:38 pmSFO-PTY
16h 08m1 stop
$702United Airlines
Find Deal
Mon, Dec 8 - Thu, Dec 25
Multiple Airlines Logo
7:50 pm - 12:00 pmPTY-SFO
19h 10m1 stop
Multiple Airlines Logo
10:16 pm - 5:20 amSFO-PTY
28h 04m1 stop
$709Multiple Airlines
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Sun, Dec 21 - Sun, Dec 28
American Airlines Logo
2:27 pm - 11:07 amPTY-SFO
23h 40m1 stop
American Airlines Logo
12:17 am - 3:38 pmSFO-PTY
12h 21m2 stops
$750American Airlines
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Tue, Jan 27 - Sun, Feb 1

United Airlines flights from Panama City to San Francisco

Our best United Airlines deals on Panama City to San Francisco flight tickets
United Airlines
Feb 14
PTY4:41 pmPanama City Tocumen Intl
20h 12m
1 stop
SFO9:53 amSan Francisco
Mar 6
SFO12:43 amSan Francisco
11h 02m
1 stop
PTY2:45 pmPanama City Tocumen Intl
$670
Find similar
United Airlines
Dec 8
PTY3:35 pmPanama City Tocumen Intl
7h 54m
SFO8:29 pmSan Francisco
Dec 25
SFO12:30 amSan Francisco
16h 08m
1 stop
PTY7:38 pmPanama City Tocumen Intl
$702
Find similar
United Airlines
Dec 8
PTY11:35 amPanama City Tocumen Intl
14h 24m
1 stop
SFO10:59 pmSan Francisco
Dec 25
SFO12:30 amSan Francisco
11h 15m
1 stop
PTY2:45 pmPanama City Tocumen Intl
$707
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Avianca flights from Panama City to San Francisco

Our best Avianca deals on Panama City to San Francisco flight tickets
Avianca
Apr 24
PTY10:05 pmPanama City Tocumen Intl
27h 50m
2 stops
SFO11:55 pmSan Francisco
Apr 28
SFO2:30 amSan Francisco
10h 15m
1 stop
PTY2:45 pmPanama City Tocumen Intl
$494
Find similar
Avianca
Apr 7
PTY9:55 amPanama City Tocumen Intl
16h 00m
2 stops
SFO11:55 pmSan Francisco
Apr 22
SFO12:05 amSan Francisco
14h 25m
2 stops
PTY4:30 pmPanama City Tocumen Intl
$500
Find similar
Avianca
Apr 6
PTY3:25 amPanama City Tocumen Intl
22h 30m
2 stops
SFO11:55 pmSan Francisco
Apr 22
SFO12:05 amSan Francisco
22h 05m
2 stops
PTY12:10 amPanama City Tocumen Intl
$502
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momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 4/24

10:05 pm-11:55 pm

2 stops27h 50m

San Francisco

Tue 4/28

2:30 am-2:45 pm

1 stop10h 15m

$494

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 4/7

9:55 am-11:55 pm

2 stops16h 00m

San Francisco

Wed 4/22

12:05 am-4:30 pm

2 stops14h 25m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 1/27

6:27 pm-11:20 pm

Nonstop7h 53m

San Francisco

Sun 2/1

12:42 am-10:46 am

Nonstop7h 04m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/21

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Sun 12/28

9:56 pm-5:20 am

2 stops28h 24m

$661

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 2/14

4:41 pm-9:53 am

1 stop20h 12m

San Francisco

Fri 3/6

12:43 am-2:45 pm

1 stop11h 02m

$670

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 12/29

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

Thu 1/1

12:42 am-10:46 am

Nonstop7h 04m

$671

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 1/27

2:27 pm-9:17 am

2 stops21h 50m

San Francisco

Sun 2/1

12:17 am-3:38 pm

2 stops12h 21m

$679

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 12/8

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Thu 12/25

12:30 am-7:38 pm

1 stop16h 08m

$702

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/21

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Sun 12/28

10:16 pm-5:20 am

1 stop28h 04m

$709

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 1/27

2:27 pm-11:07 am

1 stop23h 40m

San Francisco

Sun 2/1

12:17 am-3:38 pm

2 stops12h 21m

$750

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama City to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $579.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama City to San Francisco is on a Monday when prices can be found for as low as $656. The most expensive day to fly to San Francisco is Wednesday, with ticket prices averaging around $1,163.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Panama City to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $433. Flights in the afternoon are often more expensive with an average ticket price of $747.

What is the cheapest Panama City Tocumen Intl to San Francisco flight route?

Fly from Panama City Tocumen Intl to San Francisco for the best Panama City Tocumen Intl - San Francisco flight prices

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $630 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama City for as low as $489 on momondo.

What cabin class options are available on Panama City Tocumen Intl to San Francisco flights?

There are 4 cabin classes available to choose from on Panama City Tocumen Intl to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Francisco flights?

You could potentially save up to 40% on your flight if you consider stops on a Panama City to San Francisco flight.

How have Panama City to San Francisco flight prices changed over time?

As of November 2025, prices for Panama City to San Francisco flights are approximately 35% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Francisco (PTY to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Francisco

Best Price Found

$540

Fastest flight time

7h 49m

Direct flights

Every day

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Panama City in the past 72 hours is $540. The best round-trip flight deal from Panama City to San Francisco found on momondo in the last 72 hours is $625.
The fastest flight from Panama City to San Francisco takes 7h 49m
Direct flights go from Panama City to San Francisco every day.
There is 1 airport near San Francisco: San Francisco (SFO)
Search flight deals

  • How far is Panama City Tocumen Intl to San Francisco by plane?

    Panama City Tocumen Intl and San Francisco are 3322.3 mi apart from one another. By plane, this route typically takes 7h 50m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Francisco?

  • What is the most popular airline from Panama City to San Francisco?

Best airlines flying from Panama City to San Francisco

Compare and see reviews for airlines that fly from Panama City to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $465Free CancellationRating
6.6
2,468 reviews
Search Avianca flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $506Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Panama City to San Francisco

    Copa Airlines is one of the most popular airlines flying from Panama City to San Francisco, operating 14 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Francisco starts from $506 round-trip, up to an average price of $634. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Francisco

    Across 9,003 United Airlines reviews on momondo, the average score is 7.4/10. United Airlines flies from Panama City to San Francisco about 14 times each week, with ticket deals ranging from $506 to $664. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Calistoga
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Livermore
Turlock
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Panama City.

Can I find flights from Panama City to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Panama City with this policy.

How can momondo help me find flights from Panama City to San Francisco?

Once you have performed a search for Panama City to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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