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Cheap flights from Panama City to San Francisco from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to San Francisco departing on 5/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
3:50 pm - 11:40 pm
PTY
-
SFO
9h 50m
1 stop
Avianca Logo
2:35 am - 6:55 pm
SFO
-
PTY
14h 20m
1 stop
$491Avianca
Thu, Mar 19 - Tue, Mar 24
Avianca Logo
9:45 am - 9:50 pm
PTY
-
SFO
15h 05m
2 stops
Avianca Logo
11:10 pm - 6:55 pm
SFO
-
PTY
16h 45m
1 stop
$501Avianca
Tue, Feb 17 - Sun, Feb 22
Avianca Logo
2:55 am - 11:20 pm
PTY
-
SFO
23h 25m
2 stops
Avianca Logo
2:15 pm - 4:30 pm
SFO
-
PTY
24h 15m
2 stops
$503Avianca
Mon, Feb 16 - Fri, Aug 14
Avianca Logo
9:45 am - 10:50 pm
PTY
-
SFO
15h 05m
2 stops
Avianca Logo
2:20 pm - 8:50 am
SFO
-
PTY
16h 30m
2 stops
$505Avianca
Thu, Mar 19 - Wed, Mar 25
Avianca Logo
9:45 am - 10:50 pm
PTY
-
SFO
15h 05m
2 stops
Avianca Logo
12:10 am - 4:55 pm
SFO
-
PTY
14h 45m
2 stops
$506Avianca
Thu, Mar 19 - Tue, Mar 24
Avianca Logo
5:50 pm - 11:20 pm
PTY
-
SFO
32h 30m
2 stops
Avianca Logo
11:10 pm - 10:30 am
SFO
-
PTY
8h 20m
1 stop
$507Avianca
Mon, Feb 23 - Mon, Mar 2
Avianca Logo
7:50 pm - 12:00 pm
PTY
-
SFO
19h 10m
1 stop
Avianca Logo
11:10 pm - 6:55 pm
SFO
-
PTY
16h 45m
1 stop
$511Avianca
Fri, Feb 13 - Wed, Feb 18
Avianca Logo
9:45 am - 11:40 pm
PTY
-
SFO
15h 55m
2 stops
Avianca Logo
12:10 am - 4:55 pm
SFO
-
PTY
14h 45m
2 stops
$513Avianca
Thu, Mar 12 - Wed, Mar 18
Avianca Logo
10:05 pm - 12:50 pm
PTY
-
SFO
16h 45m
2 stops
Avianca Logo
2:15 pm - 10:10 am
SFO
-
PTY
17h 55m
2 stops
$521Avianca
Mon, Apr 13 - Thu, Apr 16
Avianca Logo
10:05 pm - 12:50 pm
PTY
-
SFO
16h 45m
2 stops
Avianca Logo
11:55 pm - 10:30 am
SFO
-
PTY
8h 35m
1 stop
$524Avianca
Mon, Apr 13 - Tue, Apr 21

Avianca flights from Panama City to San Francisco

Our best Avianca deals on Panama City to San Francisco flight tickets
Avianca
Mar 19
PTY3:50 pmPanama City Tocumen Intl
9h 50m
1 stop
SFO11:40 pmSan Francisco
Mar 24
SFO2:35 amSan Francisco
14h 20m
1 stop
PTY6:55 pmPanama City Tocumen Intl
$491
Avianca
Feb 17
PTY9:45 amPanama City Tocumen Intl
15h 05m
2 stops
SFO9:50 pmSan Francisco
Feb 22
SFO11:10 pmSan Francisco
16h 45m
1 stop
PTY6:55 pmPanama City Tocumen Intl
$501
Avianca
Feb 17
PTY9:45 amPanama City Tocumen Intl
16h 35m
2 stops
SFO11:20 pmSan Francisco
Aug 13
SFO11:55 pmSan Francisco
19h 15m
2 stops
PTY9:10 pmPanama City Tocumen Intl
$503

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 3/19

3:50 pm-11:40 pm

1 stop9h 50m

San Francisco

Tue 3/24

2:35 am-6:55 pm

1 stop14h 20m

$491

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 2/17

9:45 am-9:50 pm

2 stops15h 05m

San Francisco

Sun 2/22

11:10 pm-6:55 pm

1 stop16h 45m

$501

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 2/16

2:55 am-11:20 pm

2 stops23h 25m

San Francisco

Fri 8/14

2:15 pm-4:30 pm

2 stops24h 15m

$503

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 3/19

9:45 am-10:50 pm

2 stops15h 05m

San Francisco

Wed 3/25

2:20 pm-8:50 am

2 stops16h 30m

$505

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 3/19

9:45 am-10:50 pm

2 stops15h 05m

San Francisco

Tue 3/24

12:10 am-4:55 pm

2 stops14h 45m

$506

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 2/23

5:50 pm-11:20 pm

2 stops32h 30m

San Francisco

Mon 3/2

11:10 pm-10:30 am

1 stop8h 20m

$507

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 2/13

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Wed 2/18

11:10 pm-6:55 pm

1 stop16h 45m

$511

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 3/12

9:45 am-11:40 pm

2 stops15h 55m

San Francisco

Wed 3/18

12:10 am-4:55 pm

2 stops14h 45m

$513

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 4/13

10:05 pm-12:50 pm

2 stops16h 45m

San Francisco

Thu 4/16

2:15 pm-10:10 am

2 stops17h 55m

$521

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 4/13

10:05 pm-12:50 pm

2 stops16h 45m

San Francisco

Tue 4/21

11:55 pm-10:30 am

1 stop8h 35m

$524

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama City to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $577.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama City to San Francisco is on a Tuesday when prices can be found for as low as $692. The most expensive day to fly to San Francisco is Saturday, with ticket prices averaging around $807.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Panama City to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $562. Flights in the afternoon are often more expensive with an average ticket price of $755.

What is the cheapest Panama City Tocumen Intl to San Francisco flight route?

Fly from Panama City Tocumen Intl to San Francisco for the best Panama City Tocumen Intl - San Francisco flight prices

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $649 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama City for as low as $495 on momondo.

What cabin class options are available on Panama City Tocumen Intl to San Francisco flights?

There are 4 cabin classes available to choose from on Panama City Tocumen Intl to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to San Francisco flights?

You could potentially save up to 38% on your flight if you consider stops on a Panama City to San Francisco flight.

How have Panama City to San Francisco flight prices changed over time?

As of January 2026, prices for Panama City to San Francisco flights are approximately 62% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to San Francisco (PTY to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to San Francisco

Best Price Found

$956

Fastest flight time

7h 21m

Direct flights

Every day

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Panama City in the past 72 hours is $956. The best round-trip flight deal from Panama City to San Francisco found on momondo in the last 72 hours is $411.
The fastest flight from Panama City to San Francisco takes 7h 21m
Direct flights go from Panama City to San Francisco every day.
There is 1 airport in San Francisco. From Panama City there are direct flights to San Francisco (SFO).
Search flight deals

  • How far is Panama City Tocumen Intl to San Francisco by plane?

    Panama City Tocumen Intl and San Francisco are 3322.3 mi apart from one another. By plane, this route typically takes 7h 21m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

    Prices for flights from Panama City Tocumen Intl Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to San Francisco?

  • What is the most popular airline from Panama City to San Francisco?

Best airlines flying from Panama City to San Francisco

Compare and see reviews for airlines that fly from Panama City to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $335Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
AviancaPriceFrom $465Free CancellationRating
6.6
2,492 reviews
Search Avianca flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
9,200 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to San Francisco

    Copa Airlines is one of the most popular airlines flying from Panama City to San Francisco, operating 7 flights/week on average for this route. A good Copa Airlines flight deal for Panama City to San Francisco starts from $335 round-trip, up to an average price of $648. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Panama City to San Francisco

    Across 9,200 United Airlines reviews on momondo, the average score is 7.4/10. United Airlines flies from Panama City to San Francisco about 7 times each week, with ticket deals ranging from $506 to $674. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Salinas
Vallejo
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Panama City.

Can I find flights from Panama City to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Panama City with this policy.

How can momondo help me find flights from Panama City to San Francisco?

Once you have performed a search for Panama City to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Francisco trip

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