Cheap flights from Panama City to San Francisco from $280

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $577.

The cheapest day to depart from Panama City to San Francisco is on a Monday when prices can be found for as low as $694. The most expensive day to fly to San Francisco is Thursday, with ticket prices averaging around $805.

Our data shows that the cheapest Panama City to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $562. Flights in the afternoon are often more expensive with an average ticket price of $763.

Fly from Panama City Tocumen Intl to San Francisco for the best Panama City Tocumen Intl - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $644 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama City for as low as $376 on momondo.

There are 4 cabin classes available to choose from on Panama City Tocumen Intl to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 38% on your flight if you consider stops on a Panama City to San Francisco flight.

As of February 2026, prices for Panama City to San Francisco flights are approximately 16% more expensive when compared to flights at the same time last year.

Avianca is the most popular carrier operating from Panama City Tocumen Intl to San Francisco

Copa Airlines, United Airlines and Avianca are the top three most popular airlines that fly to San Francisco from Panama City according to our data. Copa Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 3 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

As of February 2026, 1 flights take off from Panama City and land in San Francisco each day. The most common flight departure time for this route is 6:00PM, with 100% of daily flights taking off in the evening.

12 flights are operational weekly from Panama City to San Francisco as of February 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.