Cheap flights from Missouri to Detroit from $64

The cheapest month to fly to Detroit from Missouri is in January. Flight prices, which tend to average around $409, are often lower during this time because this is during the off-season. If you’re not able to fly to Detroit in January, then April is your next best option. Flight prices from Missouri to Detroit during April average around $415.

On average, the least expensive day to fly to Detroit from Missouri is on a Saturday. momondo users have found tickets for Saturday departures for as low as $456. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Detroit for around $725.

In the evening is the cheapest time of day to fly from Missouri to Detroit when you can find flight prices for as low as $310. Flying to Detroit in the evening is an ideal time because this is during off-peak travel hours. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $922 on average. Flights to Detroit from Missouri at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Lambert-St Louis to Detroit Metropolitan Wayne County for the best Missouri - Detroit flight prices

You are more likely to see cheaper flights to Detroit from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Detroit for around $371 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Detroit from Missouri for as low as $279 on momondo.

There are 4 cabin classes available to choose from on Missouri to Detroit flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Delta, Southwest, and American Airlines are the most popular carriers operating from Missouri to Detroit

Delta, Southwest and United Airlines are the top three most popular airlines that fly to Detroit from Missouri according to our data. Delta is the first choice among our users, with 62% of people opting to fly with this airline when traveling to Detroit. Keep in mind that there are 5 different airlines that fly to Detroit on a routine basis, so you have a few additional options to choose from.

27 flights are operational daily from Missouri to Detroit as of October 2026. The most popular departure time for this route is 10:00AM, with 50% of flights per day taking off at noon.

As of October 2026, 193 flights take off from Missouri and land in Detroit each week. The most common flight departure day for this route is Tue, with 18% of weekly flights taking off on this day.