Cheap flights from Missouri to Detroit from $66

The cheapest month to fly to Detroit Metropolitan Wayne County Airport from Missouri is in January. Flight prices, which tend to average around $378, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to Detroit Metropolitan Wayne County Airport from Missouri during October instead. Flights to Detroit Metropolitan Wayne County Airport in October, while not as cheap as those in January, still average around $382.

The cheapest day to depart from Missouri to Detroit Metropolitan Wayne County Airport is on a Friday when prices can be found for as low as $481. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Detroit Metropolitan Wayne County Airport on Tuesday is $694.

Flying to Detroit Metropolitan Wayne County Airport from Missouri in the evening is the least expensive time of day to depart. momondo users have found prices as low as $299 when looking at flights departing in the evening. Flights to Detroit Metropolitan Wayne County Airport are more costly at noon, with an average ticket price of $895. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Lambert-St Louis to Detroit Metropolitan Wayne County for the best Missouri - Detroit Metropolitan Wayne County flight prices

You are more likely to see cheaper flights to Detroit Metropolitan Wayne County Airport from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Detroit Metropolitan Wayne County Airport for around $357 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Detroit Metropolitan Wayne County Airport from Missouri for as low as $269 on momondo.

There are 4 cabin classes available to choose from on Missouri to Detroit Metropolitan Wayne County Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, Delta, and United Airlines are the most popular carriers operating from Missouri to Detroit Metropolitan Wayne County

Delta, Southwest and Frontier are the top three most popular airlines that fly to Detroit Metropolitan Wayne County Airport from Missouri according to our data. Delta is the first choice among our users, with 65% of people opting to fly with this airline when traveling to Detroit Metropolitan Wayne County Airport. Keep in mind that there are 5 different airlines that fly to Detroit Metropolitan Wayne County Airport on a routine basis, so you have a few additional options to choose from.

31 flights are operational daily from Missouri to Detroit Metropolitan Wayne County Airport as of August 2026. The most popular departure time for this route is 10:00AM, with 53% of flights per day taking off at noon.

As of August 2026, 222 flights take off from Missouri and land in Detroit Metropolitan Wayne County Airport each week. The most common flight departure day for this route is Fri, with 16% of weekly flights taking off on this day.