Cheap flights from Medford to San Francisco from $110

If you aren’t able to travel to San Francisco during the month of November, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $236.

The cheapest day to depart from Medford to San Francisco is on a Friday when prices can be found for as low as $425. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $591.

Our data shows that the cheapest Medford to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $410. Flights in the evening are often more expensive with an average ticket price of $698.

Fly from Medford to San Francisco for the best Medford - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Medford when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $267 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Medford for as low as $190 on momondo.

There are 4 cabin classes available to choose from on Medford to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 24% on your flight if you consider stops on a Medford to San Francisco flight.

As of February 2026, prices for Medford to San Francisco flights are approximately 6% more expensive when compared to flights at the same time last year.

Alaska Airlines and Delta are the most popular carriers operating from Medford to San Francisco

United Airlines, Alaska Airlines and Advanced Air are the top three most popular airlines that fly to San Francisco from Medford according to our data. United Airlines is the first choice among our users, with 73% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 4 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

The number of flights available between Medford and San Francisco is 5 per day as of February 2026. The most frequent departure time is 6:00AM, with 40% of daily flights leaving at noon.

As of February 2026, 39 flights take off from Medford and land in San Francisco each week. The most common flight departure day for this route is Mon, with 21% of weekly flights taking off on this day.