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Cheap flights from Greenville to San Francisco from $150

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to San Francisco departing on 9/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Greenville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:10 am - 6:48 pm
GSP
-
SFO
10h 38m
1 stop
Delta Logo
2:00 pm - 11:38 pm
SFO
-
GSP
6h 38m
1 stop
$299Delta
Tue, Sep 22 - Tue, Sep 29
Southwest Logo
7:00 am - 12:35 pm
GSP
-
SFO
8h 35m
2 stops
Southwest Logo
10:30 pm - 10:15 am
SFO
-
GSP
8h 45m
1 stop
$305Southwest
Tue, Sep 22 - Tue, Sep 29
Southwest Logo
7:00 am - 12:35 pm
GSP
-
SFO
8h 35m
2 stops
Southwest Logo
11:40 pm - 12:25 pm
SFO
-
GSP
9h 45m
2 stops
$310Southwest
Tue, Sep 22 - Tue, Sep 29
Delta Logo
7:20 am - 2:15 pm
GSP
-
SFO
9h 55m
1 stop
Delta Logo
10:55 pm - 10:35 am
SFO
-
GSP
8h 40m
1 stop
$321Delta
Tue, May 19 - Tue, May 26
United Airlines Logo
5:41 pm - 12:30 am
GSP
-
SFO
9h 49m
1 stop
United Airlines Logo
11:30 pm - 10:11 am
SFO
-
GSP
7h 41m
1 stop
$331United Airlines
Sat, Jun 6 - Tue, Jun 9
American Airlines Logo
7:54 pm - 12:48 am
GSP
-
SFO
7h 54m
1 stop
American Airlines Logo
11:49 pm - 10:08 am
SFO
-
GSP
7h 19m
1 stop
$340American Airlines
Wed, May 27 - Mon, Jun 1
Delta Logo
7:45 am - 1:25 pm
GSP
-
SFO
8h 40m
1 stop
Delta Logo
7:00 am - 11:38 pm
SFO
-
GSP
13h 38m
2 stops
$353Delta
Tue, Sep 22 - Tue, Sep 29
American Airlines Logo
5:25 pm - 12:48 am
GSP
-
SFO
10h 23m
1 stop
American Airlines Logo
5:23 am - 4:33 pm
SFO
-
GSP
8h 10m
1 stop
$357American Airlines
Wed, Jun 3 - Sat, Jun 6
Delta Logo
7:55 pm - 12:02 am
GSP
-
SFO
7h 07m
1 stop
Delta Logo
2:00 pm - 11:38 pm
SFO
-
GSP
6h 38m
1 stop
$358Delta
Mon, Sep 21 - Wed, Sep 30
American Airlines Logo
2:13 pm - 7:13 pm
GSP
-
SFO
8h 00m
1 stop
American Airlines Logo
6:36 am - 7:33 pm
SFO
-
GSP
9h 57m
1 stop
$363American Airlines
Sat, Aug 29 - Thu, Sep 10

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Southwest flights from Greenville to San Francisco

Our best Southwest deals on Greenville to San Francisco flight tickets
Southwest
Sep 22
GSP7:00 amGreenville
8h 35m
2 stops
SFO12:35 pmSan Francisco
Sep 29
SFO10:30 pmSan Francisco
8h 45m
1 stop
GSP10:15 amGreenville
$305
Southwest
Sep 22
GSP7:00 amGreenville
8h 35m
2 stops
SFO12:35 pmSan Francisco
Sep 29
SFO11:40 pmSan Francisco
9h 45m
2 stops
GSP12:25 pmGreenville
$310
Southwest
Aug 6
GSP1:05 pmGreenville
9h 25m
2 stops
SFO7:30 pmSan Francisco
Aug 11
SFO10:30 pmSan Francisco
8h 45m
1 stop
GSP10:15 amGreenville
$388

United Airlines flights from Greenville to San Francisco

Our best United Airlines deals on Greenville to San Francisco flight tickets
United Airlines
Jun 6
GSP5:41 pmGreenville
9h 49m
1 stop
SFO12:30 amSan Francisco
Jun 9
SFO11:30 pmSan Francisco
7h 41m
1 stop
GSP10:11 amGreenville
$331
United Airlines
Jun 3
GSP7:40 pmGreenville
8h 35m
1 stop
SFO1:15 amSan Francisco
Jun 7
SFO10:38 pmSan Francisco
8h 33m
1 stop
GSP10:11 amGreenville
$414
United Airlines
Sep 1
GSP5:26 pmGreenville
9h 50m
1 stop
SFO12:16 amSan Francisco
Sep 2
SFO5:00 amSan Francisco
7h 10m
1 stop
GSP3:10 pmGreenville
$441

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from Greenville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/22

11:10 am-6:48 pm

1 stop10h 38m

San Francisco

Tue 9/29

2:00 pm-11:38 pm

1 stop6h 38m

$299

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/22

7:00 am-12:35 pm

2 stops8h 35m

San Francisco

Tue 9/29

10:30 pm-10:15 am

1 stop8h 45m

$305

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/22

7:00 am-12:35 pm

2 stops8h 35m

San Francisco

Tue 9/29

11:40 pm-12:25 pm

2 stops9h 45m

$310

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 5/19

7:20 am-2:15 pm

1 stop9h 55m

San Francisco

Tue 5/26

10:55 pm-10:35 am

1 stop8h 40m

$321

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Sat 6/6

5:41 pm-12:30 am

1 stop9h 49m

San Francisco

Tue 6/9

11:30 pm-10:11 am

1 stop7h 41m

$331

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 5/27

7:54 pm-12:48 am

1 stop7h 54m

San Francisco

Mon 6/1

11:49 pm-10:08 am

1 stop7h 19m

$340

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/22

7:45 am-1:25 pm

1 stop8h 40m

San Francisco

Tue 9/29

7:00 am-11:38 pm

2 stops13h 38m

$353

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 6/3

5:25 pm-12:48 am

1 stop10h 23m

San Francisco

Sat 6/6

5:23 am-4:33 pm

1 stop8h 10m

$357
Quickest round-trip

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Mon 9/21

7:55 pm-12:02 am

1 stop7h 07m

San Francisco

Wed 9/30

2:00 pm-11:38 pm

1 stop6h 38m

$358

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Sat 8/29

2:13 pm-7:13 pm

1 stop8h 00m

San Francisco

Thu 9/10

6:36 am-7:33 pm

1 stop9h 57m

$363

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Greenville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Greenville and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $440.

How far in advance should I book a flight from Greenville to San Francisco?

You are more likely to see cheaper flights to San Francisco from Greenville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $512 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Greenville for as low as $312 on momondo.

How have Greenville to San Francisco flight prices changed over time?

As of April 2026, prices for Greenville to San Francisco flights are approximately 8% cheaper when compared to flights at the same time last year.

When to book flights from Greenville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to San Francisco (GSP to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to San Francisco

Fastest flight time

7h 59m

Direct flights

None
The fastest flight from Greenville to San Francisco takes 7h 59m
There are no direct flights from Greenville to San Francisco. There are no popular flight routes from Greenville to San Francisco.
Search flight deals

Frequently asked questions about flying from Greenville to San Francisco

  • How far is Greenville to San Francisco by plane?

    San Francisco is 2218.0 mi away from Greenville. A reasonable flight in good conditions will take 7h 59m.

  • When did momondo last update prices for flights from Greenville Airport to San Francisco Airport?

    Prices for flights from Greenville Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to San Francisco Airport?

  • How old do you have to be to fly from Greenville Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to San Francisco?

Best airlines flying from Greenville to San Francisco

Compare and see reviews for airlines that fly from Greenville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $276Free CancellationRating
7.9
8,458 reviews
Search Delta flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,650 reviews
Search United Airlines flights
SouthwestPriceFrom $330Free CancellationRating
8.0
4,333 reviews
Search Southwest flights
American AirlinesPriceFrom $331Free CancellationRating
7.1
11,672 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Santa Clara
Berkeley
Fremont
Vallejo
Big Sur
Calistoga
Daly City
Salinas
South San Francisco
Sunnyvale
Milpitas
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to San Francisco?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Greenville to San Francisco for you.

Can I find flights from Greenville to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Greenville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Greenville to San Francisco?

momondo helps you find the best flight between Greenville and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Greenville to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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