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Cheap flights from Greenville to San Francisco from $182

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to San Francisco departing on 10/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Greenville to San Francisco

Cheap round-trip flights

Multiple Airlines Logo
9:01 am - 10:55 amGSP-SFO
28h 54m1 stop
Multiple Airlines Logo
10:23 pm - 7:23 pmSFO-GSP
18h 00m2 stops
$351Multiple Airlines
Find Deal
Fri, Oct 24 - Sun, Oct 26
Southwest Logo
6:05 am - 1:30 pmGSP-SFO
10h 25m1 stop
Southwest Logo
9:05 pm - 9:55 amSFO-GSP
9h 50m1 stop
$363Southwest
Find Deal
Wed, Oct 22 - Wed, Oct 22
Multiple Airlines Logo
4:47 pm - 9:58 pmGSP-SFO
32h 11m2 stops
Multiple Airlines Logo
10:23 am - 8:06 pmSFO-GSP
30h 43m1 stop
$365Multiple Airlines
Find Deal
Thu, Oct 23 - Thu, Oct 30
Southwest Logo
6:05 am - 5:05 pmGSP-SFO
14h 00m2 stops
Southwest Logo
9:05 pm - 9:55 amSFO-GSP
9h 50m1 stop
$368Southwest
Find Deal
Wed, Oct 22 - Wed, Oct 22
United Airlines Logo
6:05 am - 2:43 pmGSP-SFO
11h 38m1 stop
United Airlines Logo
11:33 pm - 11:47 amSFO-GSP
9h 14m1 stop
$377United Airlines
Find Deal
Sat, Oct 25 - Sat, Oct 25
American Airlines Logo
2:37 pm - 9:51 pmGSP-SFO
10h 14m1 stop
American Airlines Logo
12:27 am - 10:50 amSFO-GSP
7h 23m1 stop
$398American Airlines
Find Deal
Sat, Nov 1 - Wed, Nov 5
United Airlines Logo
5:34 pm - 11:00 pmGSP-SFO
8h 26m1 stop
United Airlines Logo
11:56 pm - 10:16 amSFO-GSP
7h 20m1 stop
$405United Airlines
Find Deal
Tue, Jan 13 - Fri, Jan 16
American Airlines Logo
7:45 am - 2:16 pmGSP-SFO
9h 31m2 stops
American Airlines Logo
7:45 am - 7:04 pmSFO-GSP
8h 19m1 stop
$438American Airlines
Find Deal
Tue, Jan 13 - Fri, Jan 16
Delta Logo
5:30 am - 9:58 amGSP-SFO
7h 28m1 stop
Delta Logo
11:58 am - 11:55 pmSFO-GSP
8h 57m1 stop
$507Delta
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Tue, Oct 7 - Sat, Oct 11
Delta Logo
10:03 am - 11:49 pmGSP-SFO
16h 46m1 stop
Delta Logo
6:00 am - 5:29 pmSFO-GSP
8h 29m1 stop
$513Delta
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Wed, Dec 24 - Thu, Dec 25

American Airlines flights from Greenville to San Francisco

Our best American Airlines deals on Greenville to San Francisco flight tickets
American Airlines
Nov 1
GSP2:37 pmGreenville
10h 14m
1 stop
SFO9:51 pmSan Francisco
Nov 5
SFO12:27 amSan Francisco
7h 23m
1 stop
GSP10:50 amGreenville
$398
Find similar
American Airlines
Jan 13
GSP7:45 amGreenville
9h 31m
2 stops
SFO2:16 pmSan Francisco
Jan 16
SFO7:45 amSan Francisco
8h 19m
1 stop
GSP7:04 pmGreenville
$438
Find similar
American Airlines
Dec 8
GSP12:17 pmGreenville
9h 45m
2 stops
SFO7:02 pmSan Francisco
Dec 10
SFO7:14 amSan Francisco
8h 59m
2 stops
GSP7:13 pmGreenville
$500
Find similar

Southwest flights from Greenville to San Francisco

Our best Southwest deals on Greenville to San Francisco flight tickets
Southwest
Oct 22
GSP6:05 amGreenville
10h 25m
1 stop
SFO1:30 pmSan Francisco
Oct 22
SFO9:05 pmSan Francisco
9h 50m
1 stop
GSP9:55 amGreenville
$363
Find similar
Southwest
Oct 22
GSP6:05 amGreenville
14h 00m
2 stops
SFO5:05 pmSan Francisco
Oct 22
SFO9:05 pmSan Francisco
9h 50m
1 stop
GSP9:55 amGreenville
$368
Find similar
Southwest
Dec 24
GSP3:05 pmGreenville
9h 45m
2 stops
SFO9:50 pmSan Francisco
Dec 25
SFO9:25 pmSan Francisco
9h 40m
1 stop
GSP10:05 amGreenville
$375
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Greenville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Fri 10/24

9:01 am-10:55 am

1 stop28h 54m

San Francisco

Sun 10/26

10:23 pm-7:23 pm

2 stops18h 00m

$351

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 10/22

6:05 am-1:30 pm

1 stop10h 25m

San Francisco

Wed 10/22

9:05 pm-9:55 am

1 stop9h 50m

$363

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 10/23

4:47 pm-9:58 pm

2 stops32h 11m

San Francisco

Thu 10/30

10:23 am-8:06 pm

1 stop30h 43m

$365

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 10/22

6:05 am-5:05 pm

2 stops14h 00m

San Francisco

Wed 10/22

9:05 pm-9:55 am

1 stop9h 50m

$368

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Sat 10/25

6:05 am-2:43 pm

1 stop11h 38m

San Francisco

Sat 10/25

11:33 pm-11:47 am

1 stop9h 14m

$377

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Sat 11/1

2:37 pm-9:51 pm

1 stop10h 14m

San Francisco

Wed 11/5

12:27 am-10:50 am

1 stop7h 23m

$398

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 1/13

5:34 pm-11:00 pm

1 stop8h 26m

San Francisco

Fri 1/16

11:56 pm-10:16 am

1 stop7h 20m

$405

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 1/13

7:45 am-2:16 pm

2 stops9h 31m

San Francisco

Fri 1/16

7:45 am-7:04 pm

1 stop8h 19m

$438

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 10/7

5:30 am-9:58 am

1 stop7h 28m

San Francisco

Sat 10/11

11:58 am-11:55 pm

1 stop8h 57m

$507

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/24

10:03 am-11:49 pm

1 stop16h 46m

San Francisco

Thu 12/25

6:00 am-5:29 pm

1 stop8h 29m

$513

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Greenville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $398.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Greenville to San Francisco is on a Wednesday when prices can be found for as low as $419. The most expensive day to fly to San Francisco is Thursday, with ticket prices averaging around $575.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Greenville to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $498. Flights in the afternoon are often more expensive with an average ticket price of $528.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Greenville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $462 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Greenville for as low as $363 on momondo.

How have Greenville to San Francisco flight prices changed over time?

As of September 2025, prices for Greenville to San Francisco flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Greenville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to San Francisco (GSP to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to San Francisco

Direct flights

None
There are no direct flights from Greenville to San Francisco. There are no popular flight routes from Greenville to San Francisco.
Search flight deals

  • How far is Greenville to San Francisco by plane?

    San Francisco is 2218.5 mi away from Greenville. A reasonable flight in good conditions will take 7h 25m.

  • When did momondo last update prices for flights from Greenville Airport to San Francisco Airport?

    Prices for flights from Greenville Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to San Francisco Airport?

  • How old do you have to be to fly from Greenville Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to San Francisco?

Best airlines flying from Greenville to San Francisco

Compare and see reviews for airlines that fly from Greenville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $276Free CancellationRating
7.9
7,973 reviews
Search Delta flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
SouthwestPriceFrom $330Free CancellationRating
8.0
4,244 reviews
Search Southwest flights
American AirlinesPriceFrom $340Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Calistoga
Bodega Bay
Roseville
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Half Moon Bay
Walnut Creek
Vallejo
Salinas
Redwood City
South San Francisco
Fairfield

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to San Francisco?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Greenville to San Francisco for you.

Can I find flights from Greenville to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Greenville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Greenville to San Francisco?

momondo helps you find the best flight between Greenville and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Greenville to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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