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Cheap flights from Greenville to San Francisco from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to San Francisco departing on 12/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Greenville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:00 pm - 1:18 pmGSP-SFO
24h 18m2 stops
Multiple Airlines Logo
6:29 pm - 9:06 pmSFO-GSP
23h 37m1 stop
$298Multiple Airlines
Find Deal
Thu, Dec 4 - Sun, Dec 7
Delta Logo
2:00 pm - 7:56 pmGSP-SFO
8h 56m1 stop
Delta Logo
12:11 pm - 10:26 pmSFO-GSP
7h 15m1 stop
$359Delta
Find Deal
Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
6:01 am - 1:37 pmGSP-SFO
10h 36m1 stop
American Airlines Logo
12:00 pm - 12:18 amSFO-GSP
9h 18m2 stops
$372American Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 17
Delta Logo
3:23 pm - 8:59 pmGSP-SFO
8h 36m1 stop
Delta Logo
5:50 am - 5:49 pmSFO-GSP
8h 59m1 stop
$380Delta
Find Deal
Tue, Dec 9 - Thu, Dec 11
Southwest Logo
7:40 am - 5:25 pmGSP-SFO
12h 45m2 stops
Southwest Logo
2:15 pm - 9:45 amSFO-GSP
16h 30m2 stops
$383Southwest
Find Deal
Wed, Dec 10 - Wed, Dec 17
Southwest Logo
7:40 am - 1:20 pmGSP-SFO
8h 40m1 stop
Southwest Logo
6:15 pm - 9:45 amSFO-GSP
12h 30m2 stops
$385Southwest
Find Deal
Tue, Dec 9 - Thu, Dec 11
Southwest Logo
3:05 pm - 10:30 pmGSP-SFO
10h 25m2 stops
Southwest Logo
6:15 pm - 9:45 amSFO-GSP
12h 30m2 stops
$390Southwest
Find Deal
Tue, Dec 9 - Thu, Dec 11
Delta Logo
6:45 am - 12:36 pmGSP-SFO
8h 51m1 stop
Delta Logo
5:50 am - 5:49 pmSFO-GSP
8h 59m1 stop
$403Delta
Find Deal
Wed, Dec 10 - Wed, Dec 17
United Airlines Logo
10:00 am - 5:33 pmGSP-SFO
10h 33m1 stop
United Airlines Logo
5:00 am - 3:13 pmSFO-GSP
7h 13m1 stop
$407United Airlines
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Thu, Mar 12 - Wed, Apr 1
Delta Logo
2:00 pm - 7:56 pmGSP-SFO
8h 56m1 stop
Delta Logo
6:00 am - 8:21 pmSFO-GSP
11h 21m1 stop
$418Delta
Find Deal
Sat, Feb 14 - Wed, Feb 18

Delta flights from Greenville to San Francisco

Our best Delta deals on Greenville to San Francisco flight tickets
Delta
Feb 14
GSP2:00 pmGreenville
8h 56m
1 stop
SFO7:56 pmSan Francisco
Feb 18
SFO12:11 pmSan Francisco
7h 15m
1 stop
GSP10:26 pmGreenville
$359
Find similar
Delta
Dec 9
GSP3:23 pmGreenville
8h 36m
1 stop
SFO8:59 pmSan Francisco
Dec 11
SFO5:50 amSan Francisco
8h 59m
1 stop
GSP5:49 pmGreenville
$380
Find similar
Delta
Dec 10
GSP6:45 amGreenville
8h 51m
1 stop
SFO12:36 pmSan Francisco
Dec 17
SFO5:50 amSan Francisco
8h 59m
1 stop
GSP5:49 pmGreenville
$403
Find similar

American Airlines flights from Greenville to San Francisco

Our best American Airlines deals on Greenville to San Francisco flight tickets
American Airlines
Dec 10
GSP6:01 amGreenville
10h 36m
1 stop
SFO1:37 pmSan Francisco
Dec 17
SFO12:00 pmSan Francisco
9h 18m
2 stops
GSP12:18 amGreenville
$372
Find similar
American Airlines
Dec 9
GSP6:00 amGreenville
10h 34m
1 stop
SFO1:34 pmSan Francisco
Dec 10
SFO12:25 amSan Francisco
7h 26m
1 stop
GSP10:51 amGreenville
$433
Find similar
American Airlines
Dec 9
GSP12:17 pmGreenville
9h 57m
2 stops
SFO7:14 pmSan Francisco
Dec 10
SFO12:25 amSan Francisco
7h 26m
1 stop
GSP10:51 amGreenville
$438
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Greenville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 12/4

4:00 pm-1:18 pm

2 stops24h 18m

San Francisco

Sun 12/7

6:29 pm-9:06 pm

1 stop23h 37m

$298

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Sat 2/14

2:00 pm-7:56 pm

1 stop8h 56m

San Francisco

Wed 2/18

12:11 pm-10:26 pm

1 stop7h 15m

$359

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/10

6:01 am-1:37 pm

1 stop10h 36m

San Francisco

Wed 12/17

12:00 pm-12:18 am

2 stops9h 18m

$372

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 12/9

3:23 pm-8:59 pm

1 stop8h 36m

San Francisco

Thu 12/11

5:50 am-5:49 pm

1 stop8h 59m

$380

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/10

7:40 am-5:25 pm

2 stops12h 45m

San Francisco

Wed 12/17

2:15 pm-9:45 am

2 stops16h 30m

$383

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 12/9

7:40 am-1:20 pm

1 stop8h 40m

San Francisco

Thu 12/11

6:15 pm-9:45 am

2 stops12h 30m

$385

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 12/9

3:05 pm-10:30 pm

2 stops10h 25m

San Francisco

Thu 12/11

6:15 pm-9:45 am

2 stops12h 30m

$390

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/10

6:45 am-12:36 pm

1 stop8h 51m

San Francisco

Wed 12/17

5:50 am-5:49 pm

1 stop8h 59m

$403

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 3/12

10:00 am-5:33 pm

1 stop10h 33m

San Francisco

Wed 4/1

5:00 am-3:13 pm

1 stop7h 13m

$407

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Sat 2/14

2:00 pm-7:56 pm

1 stop8h 56m

San Francisco

Wed 2/18

6:00 am-8:21 pm

1 stop11h 21m

$418

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Greenville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $398.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Greenville to San Francisco is on a Wednesday when prices can be found for as low as $419. The most expensive day to fly to San Francisco is Thursday, with ticket prices averaging around $575.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Greenville to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $498. Flights in the afternoon are often more expensive with an average ticket price of $528.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Greenville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $464 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Greenville for as low as $335 on momondo.

How have Greenville to San Francisco flight prices changed over time?

As of November 2025, prices for Greenville to San Francisco flights are approximately 14% cheaper when compared to flights at the same time last year.

When to book flights from Greenville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to San Francisco (GSP to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to San Francisco

Direct flights

None
There are no direct flights from Greenville to San Francisco. There are no popular flight routes from Greenville to San Francisco.
Search flight deals

  • How far is Greenville to San Francisco by plane?

    San Francisco is 2218.5 mi away from Greenville. A reasonable flight in good conditions will take 7h 41m.

  • When did momondo last update prices for flights from Greenville Airport to San Francisco Airport?

    Prices for flights from Greenville Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to San Francisco Airport?

  • How old do you have to be to fly from Greenville Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to San Francisco?

Best airlines flying from Greenville to San Francisco

Compare and see reviews for airlines that fly from Greenville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $276Free CancellationRating
7.9
8,007 reviews
Search Delta flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,017 reviews
Search United Airlines flights
SouthwestPriceFrom $330Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
American AirlinesPriceFrom $340Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Calistoga
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Livermore
Turlock
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to San Francisco?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Greenville to San Francisco for you.

Can I find flights from Greenville to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Greenville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Greenville to San Francisco?

momondo helps you find the best flight between Greenville and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Greenville to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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