Cheap flights from Detroit to San Francisco from $106

If you aren’t able to travel to San Francisco during the month of July, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $354.

The cheapest day to depart from Detroit to San Francisco is on a Thursday when prices can be found for as low as $478. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $646.

Our data shows that the cheapest Detroit to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $497. Flights in the afternoon are often more expensive with an average ticket price of $540.

Fly from Detroit Metropolitan Wayne County to San Francisco for the best Detroit - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $436 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Detroit for as low as $354 on momondo.

There are 4 cabin classes available to choose from on Detroit to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest and United Airlines are the most popular carriers operating from Detroit to San Francisco

Delta, United Airlines and Southwest are the top three most popular airlines that fly to San Francisco from Detroit according to our data. Delta is the first choice among our users, with 55% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 8 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 38% of momondo users choosing 1-stop flights on this route connected there.

Flights via Phoenix (PHX) offer the lowest average round-trip price of $208.

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 6h 52m.

Charlotte (CLT) has the shortest average layover time for this route: 1h 09m.

As of March 2026, there are 11 flights per day flying from Detroit to San Francisco. The most common time of day flights depart is 7:00AM, with 42% of flights taking off at noon.

79 flights are operational weekly from Detroit to San Francisco as of March 2026. The most popular departure day for this route is Tue, with 15% of flights per week taking off on this day.