Cheap flights from Des Moines to Charlotte from $136

The cheapest month to fly to Charlotte from Des Moines is in April. Flight prices, which tend to average around $395, are often lower during this time because this is during the off-season. If you are unable to visit Charlotte during the month of April, then departing from Des Moines during the month January is also very affordable. Most momondo users find prices during this month for around $421.

The cheapest day to depart on your flight to Charlotte is on a Wednesday when prices can be found for as low as $444. This is often the case because there is less demand to fly during this day of the week. The most expensive day to fly to Charlotte is Monday, with ticket prices averaging around $569.

Flying to Charlotte from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $414 when looking at flights departing in the afternoon. In contrast, the most expensive time of day to depart to Charlotte is in the morning when prices are around $525.

Fly from Des Moines to Charlotte Douglas for the best Des Moines - Charlotte Douglas flight prices

You are more likely to see cheaper flights to Charlotte from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Charlotte for around $492 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charlotte from Des Moines for as low as $385 on momondo.

There are 4 cabin classes available to choose from on Des Moines to Charlotte flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 44% on your flight if you consider stops on a Des Moines to Charlotte flight.

As of September 2026, prices for Des Moines to Charlotte flights are approximately 24% more expensive when compared to flights at the same time last year.

Southwest is the most popular carrier operating from Des Moines to Charlotte Douglas

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Charlotte from Des Moines according to our data. American Airlines is the first choice among our users, with 80% of people opting to fly with this airline when traveling to Charlotte. Keep in mind that there are 4 different airlines that fly to Charlotte on a routine basis, so you have a few additional options to choose from.

The number of flights available between Des Moines and Charlotte is 2 per day as of September 2026. The most frequent departure time is 8:00AM, with 50% of daily flights leaving at noon.

As of September 2026, 14 flights take off from Des Moines and land in Charlotte each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.