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Cheap flights from Des Moines to Charlotte from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charlotte departing on 11/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Charlotte

Cheap round-trip flights

American Airlines Logo
6:40 pm - 8:02 amDSM-CLT
12h 22m1 stop
American Airlines Logo
11:50 am - 1:31 pmCLT-DSM
2h 41mnonstop
$229American Airlines
Find Deal
Sat, Nov 8 - Sun, Nov 9
Delta Logo
5:32 pm - 11:15 pmDSM-CLT
4h 43m1 stop
Delta Logo
6:00 am - 9:20 amCLT-DSM
4h 20m1 stop
$257Delta
Find Deal
Fri, Oct 24 - Sun, Oct 26
Delta Logo
6:39 pm - 11:50 pmDSM-CLT
4h 11m1 stop
Delta Logo
6:45 am - 10:05 amCLT-DSM
4h 20m1 stop
$277Delta
Find Deal
Fri, Oct 10 - Sun, Oct 12
American Airlines Logo
8:00 am - 11:26 amDSM-CLT
2h 26mnonstop
American Airlines Logo
3:25 pm - 4:49 pmCLT-DSM
2h 24mnonstop
$301American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
Frontier Logo
2:34 pm - 10:12 amDSM-CLT
18h 38m2 stops
Frontier Logo
10:42 pm - 1:47 pmCLT-DSM
16h 05m2 stops
$305Frontier
Find Deal
Fri, Nov 14 - Sun, Nov 16
Southwest Logo
4:45 pm - 9:30 pmDSM-CLT
3h 45m1 stop
Southwest Logo
2:00 pm - 9:50 pmCLT-DSM
8h 50m1 stop
$310Southwest
Find Deal
Tue, Oct 14 - Tue, Oct 21
Frontier Logo
2:32 pm - 2:56 pmDSM-CLT
23h 24m2 stops
Frontier Logo
6:07 pm - 1:47 pmCLT-DSM
20h 40m1 stop
$319Frontier
Find Deal
Fri, Oct 31 - Sun, Nov 2
United Airlines Logo
11:31 am - 5:05 pmDSM-CLT
4h 34m1 stop
United Airlines Logo
6:30 am - 10:32 amCLT-DSM
5h 02m1 stop
$321United Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
Southwest Logo
6:15 am - 5:40 pmDSM-CLT
10h 25m2 stops
Southwest Logo
6:10 am - 11:25 amCLT-DSM
6h 15m2 stops
$336Southwest
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Wed, Nov 12 - Mon, Nov 17
United Airlines Logo
2:52 pm - 9:36 pmDSM-CLT
5h 44m1 stop
United Airlines Logo
6:40 am - 10:30 amCLT-DSM
4h 50m1 stop
$340United Airlines
Find Deal
Sat, Nov 8 - Sun, Nov 9

American Airlines flights from Des Moines to Charlotte

Our best American Airlines deals on Des Moines to Charlotte flight tickets
American Airlines
Nov 8
DSM6:40 pmDes Moines
12h 22m
1 stop
CLT8:02 amCharlotte Douglas
Nov 9
CLT11:50 amCharlotte Douglas
2h 41m
DSM1:31 pmDes Moines
$229
Find similar
American Airlines
Sep 30
DSM8:00 amDes Moines
2h 26m
CLT11:26 amCharlotte Douglas
Oct 4
CLT3:25 pmCharlotte Douglas
2h 24m
DSM4:49 pmDes Moines
$301
Find similar
American Airlines
Sep 30
DSM1:40 pmDes Moines
6h 20m
1 stop
CLT9:00 pmCharlotte Douglas
Oct 4
CLT9:43 pmCharlotte Douglas
2h 23m
DSM11:06 pmDes Moines
$311
Find similar

Delta flights from Des Moines to Charlotte

Our best Delta deals on Des Moines to Charlotte flight tickets
Delta
Oct 24
DSM5:32 pmDes Moines
4h 43m
1 stop
CLT11:15 pmCharlotte Douglas
Oct 26
CLT6:00 amCharlotte Douglas
4h 20m
1 stop
DSM9:20 amDes Moines
$257
Find similar
Delta
Oct 10
DSM6:39 pmDes Moines
4h 11m
1 stop
CLT11:50 pmCharlotte Douglas
Oct 12
CLT6:45 amCharlotte Douglas
4h 20m
1 stop
DSM10:05 amDes Moines
$277
Find similar
Delta
Oct 2
DSM2:49 pmDes Moines
7h 45m
1 stop
CLT11:34 pmCharlotte Douglas
Oct 11
CLT12:56 pmCharlotte Douglas
4h 56m
1 stop
DSM4:52 pmDes Moines
$317
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Charlotte that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Charlotte that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 11/8

6:40 pm-8:02 am

1 stop12h 22m

Charlotte Douglas

Sun 11/9

11:50 am-1:31 pm

Nonstop2h 41m

$229

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 10/24

5:32 pm-11:15 pm

1 stop4h 43m

Charlotte Douglas

Sun 10/26

6:00 am-9:20 am

1 stop4h 20m

$257

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 10/10

6:39 pm-11:50 pm

1 stop4h 11m

Charlotte Douglas

Sun 10/12

6:45 am-10:05 am

1 stop4h 20m

$277

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 9/30

8:00 am-11:26 am

Nonstop2h 26m

Charlotte Douglas

Sat 10/4

3:25 pm-4:49 pm

Nonstop2h 24m

$301

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 11/14

2:34 pm-10:12 am

2 stops18h 38m

Charlotte Douglas

Sun 11/16

10:42 pm-1:47 pm

2 stops16h 05m

$305

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 10/14

4:45 pm-9:30 pm

1 stop3h 45m

Charlotte Douglas

Tue 10/21

2:00 pm-9:50 pm

1 stop8h 50m

$310

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 10/31

2:32 pm-2:56 pm

2 stops23h 24m

Charlotte Douglas

Sun 11/2

6:07 pm-1:47 pm

1 stop20h 40m

$319

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 9/30

11:31 am-5:05 pm

1 stop4h 34m

Charlotte Douglas

Sat 10/4

6:30 am-10:32 am

1 stop5h 02m

$321

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Wed 11/12

6:15 am-5:40 pm

2 stops10h 25m

Charlotte Douglas

Mon 11/17

6:10 am-11:25 am

2 stops6h 15m

$336

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 11/8

2:52 pm-9:36 pm

1 stop5h 44m

Charlotte Douglas

Sun 11/9

6:40 am-10:30 am

1 stop4h 50m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charlotte from

How to get the cheapest flight ticket from Des Moines to Charlotte

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Charlotte?

The cheapest month to fly to Charlotte from Des Moines is in November. Flight prices, which tend to average around $373, are often lower during this time because this is during the off-season. If you are unable to visit Charlotte during the month of November, then departing from Des Moines during the month February is also very affordable. Most momondo users find prices during this month for around $374.

What is the cheapest day to depart on your flight to Charlotte?

The cheapest day to depart on your flight to Charlotte is on a Wednesday when prices can be found for as low as $389. This is often the case because there is less demand to fly during this day of the week. The most expensive day to fly to Charlotte is Sunday, with ticket prices averaging around $541.

What is the cheapest time of day to depart on your flight to Charlotte?

Flying to Charlotte from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $372 when looking at flights departing in the afternoon. In contrast, the most expensive time of day to depart to Charlotte is in the morning when prices are around $491.

What is the cheapest Des Moines to Charlotte Douglas flight route?

Fly from Des Moines to Charlotte Douglas for the best Des Moines - Charlotte Douglas flight prices

How far in advance should I book a flight to Charlotte?

You are more likely to see cheaper flights to Charlotte from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Charlotte for around $413 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charlotte from Des Moines for as low as $230 on momondo.

What cabin class options are available on Des Moines to Charlotte Douglas flights?

There are 3 cabin classes available to choose from on Des Moines to Charlotte Douglas flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Charlotte flights?

You could potentially save up to 69% on your flight if you consider stops on a Des Moines to Charlotte flight.

How have Des Moines to Charlotte flight prices changed over time?

When to book flights from Des Moines to Charlotte

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charlotte according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Charlotte (DSM to CLT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charlotte

Best Price Found

$179

Fastest flight time

2h 18m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in Charlotte

1 airport
The best one-way flight to Charlotte from Des Moines in the past 72 hours is $179. The best round-trip flight deal from Des Moines to Charlotte found on momondo in the last 72 hours is $313.
The fastest flight from Des Moines to Charlotte takes 2h 18m
Direct flights go from Des Moines to Charlotte on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near Charlotte: Charlotte Douglas (CLT)
Search flight deals

  • How far is Des Moines to Charlotte Douglas by plane?

    The distance between Des Moines and Charlotte Douglas is about 818.0 mi. In terms of flight time, this usually takes a little over 2h 23m.

  • When did momondo last update prices for flights from Des Moines Airport to Charlotte Douglas Airport?

    Prices for flights from Des Moines Airport to Charlotte Douglas Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Charlotte Douglas Airport?

  • How old do you have to be to fly from Des Moines Airport to Charlotte Douglas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Charlotte Douglas Airport.

  • What documentation or ID do you need to fly to Charlotte Douglas Airport?

    The travel and health documents required for your trip to Charlotte Douglas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charlotte Douglas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Des Moines to Charlotte?

  • What is the most popular airline from Des Moines to Charlotte?

Best airlines flying from Des Moines to Charlotte

Compare and see reviews for airlines that fly from Des Moines to Charlotte with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $131Free CancellationRating
7.9
7,961 reviews
Search Delta flights
American AirlinesPriceFrom $257Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

  • American Airlines Flights From Des Moines to Charlotte

    The lowest priced American Airlines flight from Des Moines to Charlotte from the last 72 hours was $257. Generally, American Airlines has 10 flights on this route every week with an average price of $410. American Airlines is rated 7.2/10 by our users.

Traveling to a place near Charlotte?

Book flights to Charlotte if you plan to visit one of these locations
Spartanburg
Rock Hill
Gastonia
Boone
Hickory
Blowing Rock
Mooresville
Salisbury
Kannapolis
Pineville
Shelby
Kings Mountain
Statesville
Gaffney
Fort Mill
Huntersville
Matthews
Morganton
Cornelius
Lancaster

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charlotte?

It is quick and easy to find Des Moines to Charlotte flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Charlotte that suits you.

Can I find flights from Des Moines to Charlotte with flexible booking policies on momondo?

All flight searches from Des Moines to Charlotte on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Charlotte?

Once all potential Des Moines to Charlotte flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Charlotte right now. Can momondo alert me if prices change?

Price alerts on flights to Charlotte from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Charlotte trip

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