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Cheap flights from Columbia, Missouri to San Diego from $338

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to San Diego departing on 5/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbia, Missouri to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:21 pm - 11:56 pm
COU
-
SAN
8h 35m
1 stop
American Airlines Logo
6:15 am - 3:58 pm
SAN
-
COU
7h 43m
1 stop
$338American Airlines
Fri, May 8 - Tue, May 12
American Airlines Logo
5:21 pm - 11:56 pm
COU
-
SAN
8h 35m
1 stop
American Airlines Logo
6:30 am - 4:51 pm
SAN
-
COU
8h 21m
2 stops
$344American Airlines
Fri, May 8 - Tue, May 12
United Airlines Logo
5:00 am - 11:25 am
COU
-
SAN
8h 25m
1 stop
United Airlines Logo
11:00 am - 9:03 pm
SAN
-
COU
8h 03m
1 stop
$388United Airlines
Fri, Apr 3 - Tue, Apr 7
United Airlines Logo
9:02 am - 2:57 pm
COU
-
SAN
7h 55m
1 stop
United Airlines Logo
11:01 am - 9:03 pm
SAN
-
COU
8h 02m
2 stops
$394United Airlines
Fri, Apr 3 - Tue, Apr 7
United Airlines Logo
9:00 am - 2:56 pm
COU
-
SAN
7h 56m
1 stop
United Airlines Logo
11:00 am - 8:49 pm
SAN
-
COU
7h 49m
1 stop
$428United Airlines
Tue, May 5 - Sat, May 9
United Airlines Logo
3:10 pm - 10:39 pm
COU
-
SAN
9h 29m
1 stop
United Airlines Logo
6:20 am - 8:49 pm
SAN
-
COU
12h 29m
2 stops
$434United Airlines
Tue, May 5 - Sat, May 9
United Airlines Logo
11:30 am - 8:14 pm
COU
-
SAN
10h 44m
2 stops
United Airlines Logo
7:15 am - 8:49 pm
SAN
-
COU
11h 34m
2 stops
$439United Airlines
Tue, May 5 - Sat, May 9
United Airlines Logo
3:23 pm - 11:59 pm
COU
-
SAN
10h 36m
2 stops
United Airlines Logo
11:01 am - 9:03 pm
SAN
-
COU
8h 02m
2 stops
$444United Airlines
Fri, Apr 3 - Tue, Apr 7
American Airlines Logo
6:25 pm - 11:28 pm
COU
-
SAN
7h 03m
1 stop
American Airlines Logo
10:45 pm - 9:52 am
SAN
-
COU
9h 07m
1 stop
$676American Airlines
Sun, Jul 12 - Fri, Jul 17
American Airlines Logo
11:45 am - 6:18 pm
COU
-
SAN
8h 33m
2 stops
American Airlines Logo
10:45 pm - 9:52 am
SAN
-
COU
9h 07m
1 stop
$682American Airlines
Sun, Jul 12 - Fri, Jul 17

United Airlines flights from Columbia, Missouri to San Diego

Our best United Airlines deals on Columbia, Missouri to San Diego flight tickets
United Airlines
Apr 3
COU5:00 amColumbia Regional
8h 25m
1 stop
SAN11:25 amSan Diego
Apr 7
SAN11:00 amSan Diego
8h 03m
1 stop
COU9:03 pmColumbia Regional
$388
United Airlines
Apr 3
COU9:02 amColumbia Regional
7h 55m
1 stop
SAN2:57 pmSan Diego
Apr 7
SAN11:01 amSan Diego
8h 02m
2 stops
COU9:03 pmColumbia Regional
$394
United Airlines
May 5
COU9:00 amColumbia Regional
7h 56m
1 stop
SAN2:56 pmSan Diego
May 9
SAN11:00 amSan Diego
7h 49m
1 stop
COU8:49 pmColumbia Regional
$428

American Airlines flights from Columbia, Missouri to San Diego

Our best American Airlines deals on Columbia, Missouri to San Diego flight tickets
American Airlines
May 8
COU5:21 pmColumbia Regional
8h 35m
1 stop
SAN11:56 pmSan Diego
May 12
SAN6:15 amSan Diego
7h 43m
1 stop
COU3:58 pmColumbia Regional
$338
American Airlines
May 8
COU5:21 pmColumbia Regional
8h 35m
1 stop
SAN11:56 pmSan Diego
May 12
SAN6:30 amSan Diego
8h 21m
2 stops
COU4:51 pmColumbia Regional
$344
American Airlines
Jul 12
COU6:25 pmColumbia Regional
7h 03m
1 stop
SAN11:28 pmSan Diego
Jul 17
SAN10:45 pmSan Diego
9h 07m
1 stop
COU9:52 amColumbia Regional
$676

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Fri 5/8

5:21 pm-11:56 pm

1 stop8h 35m

San Diego

Tue 5/12

6:15 am-3:58 pm

1 stop7h 43m

$338

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Fri 5/8

5:21 pm-11:56 pm

1 stop8h 35m

San Diego

Tue 5/12

6:30 am-4:51 pm

2 stops8h 21m

$344

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Fri 4/3

5:00 am-11:25 am

1 stop8h 25m

San Diego

Tue 4/7

11:00 am-9:03 pm

1 stop8h 03m

$388

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Fri 4/3

9:02 am-2:57 pm

1 stop7h 55m

San Diego

Tue 4/7

11:01 am-9:03 pm

2 stops8h 02m

$394
Quickest round-trip

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 5/5

9:00 am-2:56 pm

1 stop7h 56m

San Diego

Sat 5/9

11:00 am-8:49 pm

1 stop7h 49m

$428

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 5/5

3:10 pm-10:39 pm

1 stop9h 29m

San Diego

Sat 5/9

6:20 am-8:49 pm

2 stops12h 29m

$434

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 5/5

11:30 am-8:14 pm

2 stops10h 44m

San Diego

Sat 5/9

7:15 am-8:49 pm

2 stops11h 34m

$439

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Fri 4/3

3:23 pm-11:59 pm

2 stops10h 36m

San Diego

Tue 4/7

11:01 am-9:03 pm

2 stops8h 02m

$444

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sun 7/12

6:25 pm-11:28 pm

1 stop7h 03m

San Diego

Fri 7/17

10:45 pm-9:52 am

1 stop9h 07m

$676

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sun 7/12

11:45 am-6:18 pm

2 stops8h 33m

San Diego

Fri 7/17

10:45 pm-9:52 am

1 stop9h 07m

$682

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Columbia, Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Columbia Regional to San Diego?

American Airlines and United Airlines are the most popular carriers operating from Columbia Regional to San Diego

When to book flights from Columbia, Missouri to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to San Diego (COU to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to San Diego

Fastest flight time

5h 50m

Direct flights

None
The fastest flight from Columbia, Missouri to San Diego takes 5h 50m
There are no direct flights from Columbia, Missouri to San Diego. There are no popular flight routes from Columbia, Missouri to San Diego.
Search flight deals

  • How far is Columbia Regional to San Diego by plane?

    The distance between Columbia Regional and San Diego is about 1449.4 mi. Flights usually cover this in 5h 50m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Columbia Regional Airport to San Diego Airport?

    Prices for flights from Columbia Regional Airport to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbia Regional Airport to San Diego Airport?

  • How old do you have to be to fly from Columbia Regional Airport to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbia, Missouri to San Diego?

Best airlines flying from Columbia, Missouri to San Diego

Compare and see reviews for airlines that fly from Columbia, Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $258Free CancellationRating
7.4
9,461 reviews
Search United Airlines flights
American AirlinesPriceFrom $429Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
Imperial Beach
La Mesa
Borrego Springs
Alpine
Santee
Lemon Grove

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Columbia to San Diego for you.

Can I find flights from Columbia to San Diego with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Diego from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to San Diego?

momondo provides multiple filters to help you find the best flight to San Diego from Columbia. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbia to San Diego right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Diego, momondo offers a useful price alert feature which will track prices for flights to San Diego from Columbia and alert you when they change.

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