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Cheap flights from Columbia, Missouri to San Diego from $289

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to San Diego departing on 1/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbia, Missouri to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:56 am - 10:26 pm
COU
-
SAN
12h 30m1 stop
American Airlines Logo
6:20 am - 9:10 pm
SAN
-
COU
12h 50m1 stop
$334American Airlines
Wed, Jan 28 - Sun, Feb 1
United Airlines Logo
8:09 am - 5:28 pm
COU
-
SAN
11h 19m2 stops
United Airlines Logo
1:00 pm - 8:33 pm
SAN
-
COU
5h 33m1 stop
$344United Airlines
Sat, Jan 10 - Tue, Jan 13
United Airlines Logo
8:09 am - 5:28 pm
COU
-
SAN
11h 19m2 stops
United Airlines Logo
9:00 am - 9:37 pm
SAN
-
COU
10h 37m2 stops
$349United Airlines
Sat, Jan 10 - Tue, Jan 13
United Airlines Logo
8:09 am - 7:54 pm
COU
-
SAN
13h 45m2 stops
United Airlines Logo
11:10 am - 8:33 pm
SAN
-
COU
7h 23m1 stop
$364United Airlines
Sat, Jan 10 - Tue, Jan 13
United Airlines Logo
8:09 am - 5:28 pm
COU
-
SAN
11h 19m2 stops
United Airlines Logo
9:00 am - 9:37 pm
SAN
-
COU
10h 37m2 stops
$369United Airlines
Sat, Jan 10 - Tue, Jan 13
United Airlines Logo
8:09 am - 3:36 pm
COU
-
SAN
9h 27m1 stop
United Airlines Logo
11:10 am - 8:33 pm
SAN
-
COU
7h 23m1 stop
$373United Airlines
Sat, Jan 10 - Tue, Jan 13
United Airlines Logo
8:45 am - 3:04 pm
COU
-
SAN
8h 19m1 stop
United Airlines Logo
11:10 am - 8:33 pm
SAN
-
COU
7h 23m1 stop
$383United Airlines
Sat, Jan 10 - Tue, Jan 13
United Airlines Logo
8:09 am - 3:04 pm
COU
-
SAN
8h 55m2 stops
United Airlines Logo
6:15 am - 8:33 pm
SAN
-
COU
12h 18m2 stops
$387United Airlines
Wed, Jan 28 - Sun, Feb 1
United Airlines Logo
8:09 am - 3:36 pm
COU
-
SAN
9h 27m1 stop
United Airlines Logo
6:00 pm - 10:42 am
SAN
-
COU
14h 42m2 stops
$389United Airlines
Wed, Jan 28 - Sun, Feb 1
United Airlines Logo
8:45 am - 3:01 pm
COU
-
SAN
8h 16m1 stop
United Airlines Logo
7:00 am - 5:25 pm
SAN
-
COU
8h 25m1 stop
$502United Airlines
Thu, Dec 25 - Mon, Dec 29

United Airlines flights from Columbia, Missouri to San Diego

Our best United Airlines deals on Columbia, Missouri to San Diego flight tickets
United Airlines
Dec 24
COU8:45 amColumbia Regional
8h 16m
1 stop
SAN3:01 pmSan Diego
Dec 28
SAN10:56 amSan Diego
8h 23m
1 stop
COU9:19 pmColumbia Regional
$328
Find similar
United Airlines
Jan 10
COU8:09 amColumbia Regional
11h 19m
2 stops
SAN5:28 pmSan Diego
Jan 13
SAN1:00 pmSan Diego
5h 33m
1 stop
COU8:33 pmColumbia Regional
$344
Find similar
United Airlines
Jan 10
COU8:09 amColumbia Regional
11h 19m
2 stops
SAN5:28 pmSan Diego
Jan 13
SAN9:00 amSan Diego
10h 37m
2 stops
COU9:37 pmColumbia Regional
$349
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Columbia, Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Wed 1/28

11:56 am-10:26 pm

1 stop12h 30m

San Diego

Sun 2/1

6:20 am-9:10 pm

1 stop12h 50m

$334

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/10

8:09 am-5:28 pm

2 stops11h 19m

San Diego

Tue 1/13

1:00 pm-8:33 pm

1 stop5h 33m

$344

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/10

8:09 am-5:28 pm

2 stops11h 19m

San Diego

Tue 1/13

9:00 am-9:37 pm

2 stops10h 37m

$349

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/10

8:09 am-7:54 pm

2 stops13h 45m

San Diego

Tue 1/13

11:10 am-8:33 pm

1 stop7h 23m

$364

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/10

8:09 am-5:28 pm

2 stops11h 19m

San Diego

Tue 1/13

9:00 am-9:37 pm

2 stops10h 37m

$369

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/10

8:09 am-3:36 pm

1 stop9h 27m

San Diego

Tue 1/13

11:10 am-8:33 pm

1 stop7h 23m

$373

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/10

8:45 am-3:04 pm

1 stop8h 19m

San Diego

Tue 1/13

11:10 am-8:33 pm

1 stop7h 23m

$383

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Wed 1/28

8:09 am-3:04 pm

2 stops8h 55m

San Diego

Sun 2/1

6:15 am-8:33 pm

2 stops12h 18m

$387

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Wed 1/28

8:09 am-3:36 pm

1 stop9h 27m

San Diego

Sun 2/1

6:00 pm-10:42 am

2 stops14h 42m

$389

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Thu 12/25

8:45 am-3:01 pm

1 stop8h 16m

San Diego

Mon 12/29

7:00 am-5:25 pm

1 stop8h 25m

$502

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Columbia, Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Columbia, Missouri to San Diego is on a Tuesday. Travelers who choose to depart for San Diego on a Tuesday will often find tickets for as low as $483. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $650. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $569. Flights in the morning are often more expensive with an average ticket price of $620.

When to book flights from Columbia, Missouri to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to San Diego (COU to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to San Diego

Fastest flight time

7h 55m

Direct flights

None
The fastest flight from Columbia, Missouri to San Diego takes 7h 55m
There are no direct flights from Columbia, Missouri to San Diego. There are no popular flight routes from Columbia, Missouri to San Diego.
Search flight deals

  • How far is Columbia Regional to San Diego by plane?

    The distance between Columbia Regional and San Diego is about 1449.4 mi. Flights usually cover this in 7h 55m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Columbia Regional Airport to San Diego Airport?

    Prices for flights from Columbia Regional Airport to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbia Regional Airport to San Diego Airport?

  • How old do you have to be to fly from Columbia Regional Airport to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbia, Missouri to San Diego?

Best airlines flying from Columbia, Missouri to San Diego

Compare and see reviews for airlines that fly from Columbia, Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $429Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Imperial Beach
Poway
La Mesa
Borrego Springs
San Ysidro
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Columbia to San Diego for you.

Can I find flights from Columbia to San Diego with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Diego from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to San Diego?

momondo provides multiple filters to help you find the best flight to San Diego from Columbia. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbia to San Diego right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Diego, momondo offers a useful price alert feature which will track prices for flights to San Diego from Columbia and alert you when they change.

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