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Cheap flights from Columbia, Missouri to San Diego from $328

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to San Diego departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Columbia, Missouri to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:44 pm - 11:55 pmCOU  Columbia Regional-SAN San Diego
6h 11m1 stop Dallas/Fort Worth
American Airlines Logo
10:46 pm - 9:56 amSAN  San Diego-COU Columbia Regional
9h 10m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Sep 10 - Fri, Sep 18
American Airlines Logo
6:24 pm - 11:33 pmCOU  Columbia Regional-SAN San Diego
7h 09m1 stop Chicago O'Hare Intl
American Airlines Logo
10:40 pm - 9:58 amSAN  San Diego-COU Columbia Regional
9h 18m1 stop Chicago O'Hare Intl
$328American Airlines
Fri, Oct 16 - Mon, Oct 19
American Airlines Logo
7:48 pm - 11:59 pmCOU  Columbia Regional-SAN San Diego
6h 11m1 stop Dallas/Fort Worth
American Airlines Logo
10:40 pm - 10:04 amSAN  San Diego-COU Columbia Regional
9h 24m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Nov 19 - Mon, Nov 23
American Airlines Logo
5:14 pm - 9:46 pmCOU  Columbia Regional-SAN San Diego
6h 32m1 stop Dallas/Fort Worth
American Airlines Logo
10:40 pm - 9:53 amSAN  San Diego-COU Columbia Regional
9h 13m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Oct 29 - Sun, Nov 1
American Airlines Logo
6:32 pm - 11:25 pmCOU  Columbia Regional-SAN San Diego
6h 53m1 stop Chicago O'Hare Intl
American Airlines Logo
10:46 pm - 9:56 amSAN  San Diego-COU Columbia Regional
9h 10m1 stop Chicago O'Hare Intl
$328American Airlines
Tue, Sep 15 - Sun, Sep 20
American Airlines Logo
6:32 pm - 11:25 pmCOU  Columbia Regional-SAN San Diego
6h 53m1 stop Chicago O'Hare Intl
American Airlines Logo
10:46 pm - 9:56 amSAN  San Diego-COU Columbia Regional
9h 10m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Sep 17 - Mon, Sep 21
American Airlines Logo
3:31 pm - 11:25 pmCOU  Columbia Regional-SAN San Diego
9h 54m1 stop Chicago O'Hare Intl
American Airlines Logo
6:15 am - 6:02 pmSAN  San Diego-COU Columbia Regional
9h 47m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Sep 17 - Mon, Sep 21
American Airlines Logo
7:44 pm - 11:55 pmCOU  Columbia Regional-SAN San Diego
6h 11m1 stop Dallas/Fort Worth
American Airlines Logo
7:32 am - 6:02 pmSAN  San Diego-COU Columbia Regional
8h 30m1 stop Chicago O'Hare Intl
$328American Airlines
Thu, Sep 17 - Mon, Sep 21
United Airlines Logo
11:15 am - 8:08 pmCOU  Columbia Regional-SAN San Diego
10h 53m2 stops Chicago O'Hare Intl Los Angeles
United Airlines Logo
12:37 pm - 8:33 pmSAN  San Diego-COU Columbia Regional
5h 56m1 stop Denver Intl
$334United Airlines
Thu, Oct 1 - Sat, Oct 10
United Airlines Logo
9:00 am - 1:01 pmCOU  Columbia Regional-SAN San Diego
6h 01m1 stop Denver Intl
United Airlines Logo
7:41 pm - 10:39 amSAN  San Diego-COU Columbia Regional
12h 58m2 stops San Francisco Chicago O'Hare Intl
$364United Airlines
Tue, Sep 15 - Sun, Sep 20

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United Airlines flights from Columbia, Missouri to San Diego

Our best United Airlines deals on Columbia, Missouri to San Diego flight tickets
United Airlines
Oct 1
COU11:15 amColumbia Regional
10h 53m
2 stops
SAN8:08 pmSan Diego
Oct 10
SAN12:37 pmSan Diego
5h 56m
1 stop
COU8:33 pmColumbia Regional
$334
United Airlines
Sep 15
COU9:00 amColumbia Regional
6h 01m
1 stop
SAN1:01 pmSan Diego
Sep 20
SAN7:41 pmSan Diego
12h 58m
2 stops
COU10:39 amColumbia Regional
$364
United Airlines
Nov 19
COU8:00 amColumbia Regional
8h 55m
2 stops
SAN2:55 pmSan Diego
Nov 23
SAN10:40 amSan Diego
8h 57m
1 stop
COU9:37 pmColumbia Regional
$369

American Airlines flights from Columbia, Missouri to San Diego

Our best American Airlines deals on Columbia, Missouri to San Diego flight tickets
American Airlines
Sep 17
COU7:44 pmColumbia Regional
6h 11m
1 stop
SAN11:55 pmSan Diego
Sep 21
SAN7:32 amSan Diego
8h 30m
1 stop
COU6:02 pmColumbia Regional
$328
American Airlines
Aug 28
COU5:17 pmColumbia Regional
5h 46m
1 stop
SAN9:03 pmSan Diego
Aug 30
SAN7:24 amSan Diego
8h 39m
1 stop
COU6:03 pmColumbia Regional
$398
American Airlines
Nov 16
COU7:48 pmColumbia Regional
6h 08m
1 stop
SAN11:56 pmSan Diego
Nov 22
SAN10:40 pmSan Diego
9h 24m
1 stop
COU10:04 amColumbia Regional
$418

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Thu 9/10

7:44 pm-11:55 pm

1 stop6h 11m

San Diego

Fri 9/18

10:46 pm-9:56 am

1 stop9h 10m

$328

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Fri 10/16

6:24 pm-11:33 pm

1 stop7h 09m

San Diego

Mon 10/19

10:40 pm-9:58 am

1 stop9h 18m

$328

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Thu 11/19

7:48 pm-11:59 pm

1 stop6h 11m

San Diego

Mon 11/23

10:40 pm-10:04 am

1 stop9h 24m

$328

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Thu 10/29

5:14 pm-9:46 pm

1 stop6h 32m

San Diego

Sun 11/1

10:40 pm-9:53 am

1 stop9h 13m

$328

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Tue 9/15

6:32 pm-11:25 pm

1 stop6h 53m

San Diego

Sun 9/20

10:46 pm-9:56 am

1 stop9h 10m

$328

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Thu 9/17

6:32 pm-11:25 pm

1 stop6h 53m

San Diego

Mon 9/21

10:46 pm-9:56 am

1 stop9h 10m

$328

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Thu 9/17

3:31 pm-11:25 pm

1 stop9h 54m

San Diego

Mon 9/21

6:15 am-6:02 pm

1 stop9h 47m

$328
Quickest round-trip

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Thu 9/17

7:44 pm-11:55 pm

1 stop6h 11m

San Diego

Mon 9/21

7:32 am-6:02 pm

1 stop8h 30m

$328

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Thu 10/1

11:15 am-8:08 pm

2 stops10h 53m

San Diego

Sat 10/10

12:37 pm-8:33 pm

1 stop5h 56m

$334

ColumbiaSan Diego

COU Columbia Regional - SAN San Diego

COUSAN

Columbia Regional

Tue 9/15

9:00 am-1:01 pm

1 stop6h 01m

San Diego

Sun 9/20

7:41 pm-10:39 am

2 stops12h 58m

$364

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to San Diego from

How to get the cheapest flight ticket from Columbia, Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Columbia, Missouri and San Diego?

Prices are currently low for flights on this route.

Typical prices usually range from $353 to $601.
The lowest price recently found on this route was $328.

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of April, then departing from Columbia, Missouri during the month February is also very affordable. Most momondo users find prices during this month for around $310.

When to book flights from Columbia, Missouri to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to San Diego (COU to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to San Diego

Best Price Found

$328

Fastest flight time

7h 00m

Direct flights

None
The best flight deal from Columbia, Missouri to San Diego found on momondo in the last 72 hours is $328
The fastest flight from Columbia, Missouri to San Diego takes 7h 00m
There are no direct flights from Columbia, Missouri to San Diego. There are no popular flight routes from Columbia, Missouri to San Diego.
Search flight deals

Frequently asked questions about flying from Columbia, Missouri to San Diego

  • How far is Columbia Regional to San Diego by plane?

    The distance between Columbia Regional and San Diego is about 1449.4 mi. Flights usually cover this in 7h 00m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Columbia Regional Airport to San Diego Airport?

    Prices for flights from Columbia Regional Airport to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbia Regional Airport to San Diego Airport?

  • How old do you have to be to fly from Columbia Regional Airport to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbia, Missouri to San Diego?

Best airlines flying from Columbia, Missouri to San Diego

Compare and see reviews for airlines that fly from Columbia, Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $288Free CancellationRating
7.4
10,106 reviews
Search United Airlines flights
American AirlinesPriceFrom $318Free CancellationRating
7.1
11,944 reviews
Search American Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
National City
Julian
La Mesa
Poway
San Ysidro
Imperial Beach
Santee
Borrego Springs
Lemon Grove
Alpine

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Columbia to San Diego for you.

Can I find flights from Columbia to San Diego with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Diego from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to San Diego?

momondo provides multiple filters to help you find the best flight to San Diego from Columbia. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbia to San Diego right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Diego, momondo offers a useful price alert feature which will track prices for flights to San Diego from Columbia and alert you when they change.

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