Cheap flights from Buffalo to San Diego from $144

If you are unable to visit San Diego during the month of October, then departing from Buffalo during the month April is also very affordable. Most momondo users find prices during this month for around $370.

Fly from Buffalo to San Diego for the best Buffalo - San Diego flight prices

You are more likely to see cheaper flights to San Diego from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $406 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Buffalo for as low as $312 on momondo.

There is only 1 cabin class available to choose from on Buffalo to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 25% on your flight if you consider stops on a Buffalo to San Diego flight.

As of August 2026, prices for Buffalo to San Diego flights are approximately 21% cheaper when compared to flights at the same time last year.

Southwest, Delta, and Frontier are the most popular carriers operating from Buffalo to San Diego

Southwest, United Airlines and American Airlines are the top three most popular airlines that fly to San Diego from Buffalo according to our data. Southwest is the first choice among our users, with 30% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 5 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

Detroit (DTW) was the most common stop: 83% of momondo users choosing 1-stop flights on this route connected there.

Flights via Detroit (DTW) offer the lowest average round-trip price of $387.

Flights connecting via Detroit (DTW) have the shortest average one-way travel time: 7h 00m.

Detroit (DTW) has the shortest average layover time for this route: 1h 11m.