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Cheap flights from St. Louis to Los Angeles from $125

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
3:04 pm - 10:57 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
21h 53m1 stop Denver Intl
Frontier Logo
12:08 pm - 10:57 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
20h 49m1 stop Denver Intl
$174Frontier
Wed, Nov 25 - Thu, Dec 3
Frontier Logo
3:04 pm - 3:34 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
26h 30m2 stops Denver Intl Phoenix Sky Harbor Intl
Frontier Logo
12:08 pm - 10:57 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
20h 49m1 stop Denver Intl
$198Frontier
Wed, Nov 25 - Thu, Dec 3
Frontier Logo
7:58 pm - 11:23 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
17h 25m1 stop Denver Intl
Frontier Logo
12:08 pm - 10:57 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
20h 49m1 stop Denver Intl
$205Frontier
Wed, Dec 2 - Fri, Dec 4
American Airlines Logo
8:00 am - 11:50 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
5h 50m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
2:53 pm - 11:33 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 40m1 stop Dallas/Fort Worth
$341American Airlines
Mon, Nov 9 - Sat, Nov 14
American Airlines Logo
6:00 am - 12:35 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
8h 35m1 stop Dallas/Fort Worth
American Airlines Logo
3:23 pm - 11:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 36m1 stop Chicago O'Hare Intl
$341American Airlines
Thu, Nov 12 - Sat, Nov 14
United Airlines Logo
1:40 pm - 5:33 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
5h 53m1 stop Denver Intl
United Airlines Logo
11:10 am - 9:40 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
8h 30m2 stops Denver Intl Chicago O'Hare Intl
$346United Airlines
Thu, Nov 12 - Sat, Nov 14
Southwest Logo
2:35 pm - 7:00 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 25m1 stop Denver Intl
Southwest Logo
9:35 am - 9:10 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
9h 35m2 stops Sacramento Intl Dallas Love Field
$352Southwest
Wed, Dec 2 - Fri, Dec 4
Southwest Logo
12:40 pm - 7:20 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
8h 40m2 stops Kansas City Las Vegas Harry Reid Intl
Southwest Logo
9:35 am - 9:10 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
9h 35m2 stops Sacramento Intl Dallas Love Field
$358Southwest
Wed, Dec 2 - Fri, Dec 4
American Airlines Logo
5:00 am - 12:19 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
9h 19m1 stop Dallas/Fort Worth
American Airlines Logo
4:37 pm - 12:16 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
5h 39m1 stop Dallas/Fort Worth
$399American Airlines
Thu, Dec 24 - Tue, Dec 29
United Airlines Logo
6:09 pm - 9:56 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
5h 47m1 stop Denver Intl
United Airlines Logo
6:30 pm - 5:06 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
8h 36m1 stop San Francisco
$439United Airlines
Fri, Dec 25 - Wed, Dec 30

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Frontier flights from St. Louis to Santa Ana, California

Our best Frontier deals on St. Louis to Santa Ana, California flight tickets
Frontier
Nov 25
STL3:04 pmLambert-St Louis
21h 53m
1 stop
SNA10:57 amSanta Ana J. Wayne/Orange Cnty
Dec 3
SNA12:08 pmSanta Ana J. Wayne/Orange Cnty
20h 49m
1 stop
STL10:57 amLambert-St Louis
$174
Frontier
Nov 25
STL3:04 pmLambert-St Louis
26h 30m
2 stops
SNA3:34 pmSanta Ana J. Wayne/Orange Cnty
Dec 3
SNA12:08 pmSanta Ana J. Wayne/Orange Cnty
20h 49m
1 stop
STL10:57 amLambert-St Louis
$198
Frontier
Dec 2
STL7:58 pmLambert-St Louis
17h 25m
1 stop
SNA11:23 amSanta Ana J. Wayne/Orange Cnty
Dec 4
SNA12:08 pmSanta Ana J. Wayne/Orange Cnty
20h 49m
1 stop
STL10:57 amLambert-St Louis
$205

United Airlines flights from St. Louis to Santa Ana, California

Our best United Airlines deals on St. Louis to Santa Ana, California flight tickets
United Airlines
Nov 2
STL4:39 pmLambert-St Louis
6h 40m
1 stop
SNA9:19 pmSanta Ana J. Wayne/Orange Cnty
Nov 4
SNA9:36 amSanta Ana J. Wayne/Orange Cnty
6h 29m
1 stop
STL6:05 pmLambert-St Louis
$633
United Airlines
Nov 2
STL1:08 pmLambert-St Louis
10h 11m
2 stops
SNA9:19 pmSanta Ana J. Wayne/Orange Cnty
Nov 4
SNA8:46 amSanta Ana J. Wayne/Orange Cnty
6h 11m
1 stop
STL4:57 pmLambert-St Louis
$638
United Airlines
Oct 30
STL8:30 amLambert-St Louis
14h 15m
2 stops
SNA8:45 pmSanta Ana J. Wayne/Orange Cnty
Nov 5
SNA7:00 amSanta Ana J. Wayne/Orange Cnty
9h 05m
1 stop
STL6:05 pmLambert-St Louis
$663

momondo Fare Finder

 
Use the filters below to find and compare flights from St. Louis to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Wed 11/25

3:04 pm-10:57 am

1 stop21h 53m

Santa Ana J. Wayne/Orange Cnty

Thu 12/3

12:08 pm-10:57 am

1 stop20h 49m

$174

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Wed 11/25

3:04 pm-3:34 pm

2 stops26h 30m

Santa Ana J. Wayne/Orange Cnty

Thu 12/3

12:08 pm-10:57 am

1 stop20h 49m

$198

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Wed 12/2

7:58 pm-11:23 am

1 stop17h 25m

Santa Ana J. Wayne/Orange Cnty

Fri 12/4

12:08 pm-10:57 am

1 stop20h 49m

$205
Quickest round-trip

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Mon 11/9

8:00 am-11:50 am

1 stop5h 50m

Santa Ana J. Wayne/Orange Cnty

Sat 11/14

2:53 pm-11:33 pm

1 stop6h 40m

$341

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Thu 11/12

6:00 am-12:35 pm

1 stop8h 35m

Santa Ana J. Wayne/Orange Cnty

Sat 11/14

3:23 pm-11:59 pm

1 stop6h 36m

$341

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Thu 11/12

1:40 pm-5:33 pm

1 stop5h 53m

Santa Ana J. Wayne/Orange Cnty

Sat 11/14

11:10 am-9:40 pm

2 stops8h 30m

$346

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Wed 12/2

2:35 pm-7:00 pm

1 stop6h 25m

Santa Ana J. Wayne/Orange Cnty

Fri 12/4

9:35 am-9:10 pm

2 stops9h 35m

$352

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Wed 12/2

12:40 pm-7:20 pm

2 stops8h 40m

Santa Ana J. Wayne/Orange Cnty

Fri 12/4

9:35 am-9:10 pm

2 stops9h 35m

$358

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Thu 12/24

5:00 am-12:19 pm

1 stop9h 19m

Santa Ana J. Wayne/Orange Cnty

Tue 12/29

4:37 pm-12:16 am

1 stop5h 39m

$399

St. LouisSanta Ana

STL Lambert-St Louis - SNA Santa Ana J. Wayne/Orange Cnty

STLSNA

Lambert-St Louis

Fri 12/25

6:09 pm-9:56 pm

1 stop5h 47m

Santa Ana J. Wayne/Orange Cnty

Wed 12/30

6:30 pm-5:06 am

1 stop8h 36m

$439

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from St. Louis to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Santa Ana, California?

Prices are currently low for flights on this route.

Typical prices usually range from $406 to $668.
The lowest price recently found on this route was $174.

What is the cheapest month to fly to Santa Ana, California?

In general, April is the cheapest month to fly from St. Louis to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $349. If you aren’t able to travel during the month of April, then book flights to Santa Ana, California from St. Louis during February instead. Flights to Santa Ana, California in February, while not as cheap as those in April, still average around $379.

How far in advance should I book a flight from St. Louis to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $498 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from St. Louis for as low as $325 on momondo.

How have St. Louis to Santa Ana, California flight prices changed over time?

As of October 2026, prices for St. Louis to Santa Ana, California flights are approximately 19% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santa Ana, California (STL to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santa Ana, California

Best Price Found

$125

Fastest flight time

5h 50m

Direct flights

None
The best one-way flight to Santa Ana, California from St. Louis in the past 72 hours is $125. The best round-trip flight deal from St. Louis to Santa Ana, California found on momondo in the last 72 hours is $174.
The fastest flight from St. Louis to Santa Ana, California takes 5h 50m
There are no direct flights from St. Louis to Santa Ana, California. There are no popular flight routes from St. Louis to Santa Ana, California.
Search flight deals

Frequently asked questions about flying from St. Louis to Santa Ana, California

  • How far is Lambert-St Louis to Santa Ana J. Wayne/Orange Cnty by plane?

    Lambert-St Louis and Santa Ana J. Wayne/Orange Cnty are 1572.0 mi apart from one another. A reasonable flight in good conditions will take 5h 50m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Lambert-St Louis Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Santa Ana, California?

Best airlines flying from St. Louis to Santa Ana, California

Compare and see reviews for airlines that fly from St. Louis to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $159Free CancellationRating
5.5
2,527 reviews
Search Frontier flights
American AirlinesPriceFrom $328Free CancellationRating
7.0
12,178 reviews
Search American Airlines flights
United AirlinesPriceFrom $332Free CancellationRating
7.3
10,388 reviews
Search United Airlines flights
SouthwestPriceFrom $377Free CancellationRating
7.9
4,212 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santa Ana?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Santa Ana. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Santa Ana with flexible booking policies on momondo?

All flight searches from St. Louis to Santa Ana on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from St. Louis to Santa Ana?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santa Ana from St. Louis.

I’m not ready to book a flight from St. Louis to Santa Ana right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santa Ana from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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