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Cheap flights from Santo Domingo to San Francisco from $291

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
7:05 pm - 5:25 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
26h 20m1 stop Panama City Tocumen Intl
Copa Airlines Logo
7:36 pm - 2:04 amSFO  San Francisco-SDQ Santo Domingo Las Americas
26h 28m1 stop Panama City Tocumen Intl
$597Copa Airlines
Sun, Jan 24 - Sun, Jan 31
Copa Airlines Logo
8:54 am - 11:17 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
18h 23m1 stop Panama City Tocumen Intl
Copa Airlines Logo
6:55 pm - 1:29 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 34m1 stop Panama City Tocumen Intl
$597Copa Airlines
Wed, Feb 17 - Wed, Mar 3
JetBlue Logo
1:32 pm - 10:34 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
12h 02m1 stop Fort Lauderdale
JetBlue Logo
11:15 am - 1:14 amSFO  San Francisco-SDQ Santo Domingo Las Americas
9h 59m1 stop Fort Lauderdale
$609JetBlue
Thu, Oct 29 - Tue, Nov 10
JetBlue Logo
3:50 pm - 12:07 amSDQ  Santo Domingo Las Americas-SFO San Francisco
11h 17m1 stop Fort Lauderdale
JetBlue Logo
11:25 pm - 3:18 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
12h 53m1 stop Fort Lauderdale
$609JetBlue
Thu, Oct 22 - Sun, Oct 25
American Airlines Logo
3:55 pm - 12:12 amSDQ  Santo Domingo Las Americas-SFO San Francisco
12h 17m1 stop Miami
American Airlines Logo
8:35 am - 9:43 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
9h 08m1 stop Miami
$609American Airlines
Sat, Nov 7 - Sat, Nov 14
American Airlines Logo
7:19 pm - 10:53 amSDQ  Santo Domingo Las Americas-SFO San Francisco
19h 34m1 stop Miami
American Airlines Logo
9:35 pm - 2:55 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
13h 20m1 stop Miami
$609American Airlines
Thu, Nov 5 - Fri, Nov 13
American Airlines Logo
11:09 am - 12:58 amSDQ  Santo Domingo Las Americas-SFO San Francisco
17h 49m1 stop Miami
American Airlines Logo
11:07 pm - 1:54 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 47m1 stop Philadelphia
$609American Airlines
Fri, Nov 20 - Tue, Dec 1
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
11:00 pm - 5:50 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 50m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$614Avianca
Sun, Nov 22 - Tue, Dec 8
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
1:15 pm - 11:50 amSFO  San Francisco-SDQ Santo Domingo Las Americas
18h 35m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$614Avianca
Sun, Nov 22 - Tue, Dec 8
JetBlue Logo
5:01 am - 12:09 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
11h 08m1 stop Fort Lauderdale
JetBlue Logo
6:00 am - 12:34 amSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 34m1 stop New York John F Kennedy Intl
$618JetBlue
Sun, Nov 22 - Tue, Dec 8

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American Airlines flights from Santo Domingo to San Francisco

Our best American Airlines deals on Santo Domingo to San Francisco flight tickets
American Airlines
Oct 24
SDQ7:00 amSanto Domingo Las Americas
12h 10m
2 stops
SFO4:10 pmSan Francisco
Oct 31
SFO12:42 pmSan Francisco
18h 27m
2 stops
SDQ10:09 amSanto Domingo Las Americas
$613
American Airlines
Nov 4
SDQ7:00 amSanto Domingo Las Americas
19h 47m
1 stop
SFO10:47 pmSan Francisco
Nov 11
SFO11:47 pmSan Francisco
14h 32m
1 stop
SDQ6:19 pmSanto Domingo Las Americas
$615
American Airlines
Nov 4
SDQ7:00 amSanto Domingo Las Americas
19h 32m
2 stops
SFO10:32 pmSan Francisco
Nov 11
SFO11:47 pmSan Francisco
14h 32m
1 stop
SDQ6:19 pmSanto Domingo Las Americas
$619

Avianca flights from Santo Domingo to San Francisco

Our best Avianca deals on Santo Domingo to San Francisco flight tickets
Avianca
Oct 6
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Oct 20
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
$614
Avianca
Oct 6
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Oct 20
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
$623
Avianca
Oct 6
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Oct 20
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
$635

momondo Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

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Price

Cheapest round-trip

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sun 1/24

7:05 pm-5:25 pm

1 stop26h 20m

San Francisco

Sun 1/31

7:36 pm-2:04 am

1 stop26h 28m

$597

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Wed 2/17

8:54 am-11:17 pm

1 stop18h 23m

San Francisco

Wed 3/3

6:55 pm-1:29 pm

1 stop14h 34m

$597

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Thu 10/29

1:32 pm-10:34 pm

1 stop12h 02m

San Francisco

Tue 11/10

11:15 am-1:14 am

1 stop9h 59m

$609

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Thu 10/22

3:50 pm-12:07 am

1 stop11h 17m

San Francisco

Sun 10/25

11:25 pm-3:18 pm

1 stop12h 53m

$609
Quickest round-trip

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sat 11/7

3:55 pm-12:12 am

1 stop12h 17m

San Francisco

Sat 11/14

8:35 am-9:43 pm

1 stop9h 08m

$609

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Thu 11/5

7:19 pm-10:53 am

1 stop19h 34m

San Francisco

Fri 11/13

9:35 pm-2:55 pm

1 stop13h 20m

$609

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Fri 11/20

11:09 am-12:58 am

1 stop17h 49m

San Francisco

Tue 12/1

11:07 pm-1:54 pm

1 stop10h 47m

$609

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sun 11/22

6:45 pm-11:55 am

2 stops21h 10m

San Francisco

Tue 12/8

11:00 pm-5:50 pm

2 stops14h 50m

$614

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sun 11/22

6:45 pm-11:55 am

2 stops21h 10m

San Francisco

Tue 12/8

1:15 pm-11:50 am

2 stops18h 35m

$614

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sun 11/22

5:01 am-12:09 pm

1 stop11h 08m

San Francisco

Tue 12/8

6:00 am-12:34 am

1 stop14h 34m

$618

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and San Francisco?

Prices are currently typical for flights on this route.

Typical prices usually range from $549 to $611.
The lowest price recently found on this route was $597.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $557.

Can stopping save me money on Santo Domingo to San Francisco flights?

You could potentially save up to 36% on your flight if you consider stops on a Santo Domingo to San Francisco flight.

How have Santo Domingo to San Francisco flight prices changed over time?

As of September 2026, prices for Santo Domingo to San Francisco flights are approximately 20% cheaper when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Best Price Found

$291

Fastest flight time

11h 17m

Direct flights

None
The best one-way flight to San Francisco from Santo Domingo in the past 72 hours is $291. The best round-trip flight deal from Santo Domingo to San Francisco found on momondo in the last 72 hours is $597.
The fastest flight from Santo Domingo to San Francisco takes 11h 17m
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

Frequently asked questions about flying from Santo Domingo to San Francisco

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3410.4 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 11h 17m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $458Free CancellationRating
7.1
3,042 reviews
Search JetBlue flights
American AirlinesPriceFrom $634Free CancellationRating
7.0
12,089 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Berkeley
Hayward
Bodega Bay
Fremont
Santa Clara
Walnut Creek
Sunnyvale
Vallejo
Half Moon Bay
Roseville
Salinas
Sonoma
Daly City
Milpitas
Pacific Grove
Marina

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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