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Cheap flights from Santo Domingo to San Francisco from $291

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
11:00 pm - 5:50 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 50m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$598Avianca
Sun, Jan 24 - Sun, Jan 31
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
1:15 pm - 11:50 amSFO  San Francisco-SDQ Santo Domingo Las Americas
18h 35m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$598Avianca
Sun, Jan 24 - Sun, Jan 31
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
11:00 pm - 5:50 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 50m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$598Avianca
Fri, Feb 12 - Sun, Feb 21
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
11:00 pm - 5:50 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 50m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$598Avianca
Wed, Feb 24 - Sat, Mar 13
American Airlines Logo
4:58 pm - 12:53 amSDQ  Santo Domingo Las Americas-SFO San Francisco
11h 55m1 stop Miami
American Airlines Logo
11:09 pm - 1:31 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 22m1 stop Philadelphia
$621American Airlines
Fri, Feb 12 - Sun, Feb 21
American Airlines Logo
3:41 pm - 12:53 amSDQ  Santo Domingo Las Americas-SFO San Francisco
13h 12m1 stop Miami
American Airlines Logo
9:35 pm - 6:22 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
16h 47m1 stop Miami
$621American Airlines
Sat, Feb 13 - Fri, Feb 19
American Airlines Logo
2:22 pm - 10:17 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
11h 55m1 stop Philadelphia
American Airlines Logo
12:02 pm - 9:48 amSFO  San Francisco-SDQ Santo Domingo Las Americas
17h 46m1 stop Miami
$621American Airlines
Thu, Dec 3 - Thu, Dec 31
JetBlue Logo
2:43 pm - 10:24 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
11h 41m1 stop Fort Lauderdale
JetBlue Logo
1:02 pm - 3:56 amSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 54m1 stop Boston Logan Intl
$1,149JetBlue
Fri, Dec 4 - Thu, Dec 10
JetBlue Logo
2:43 pm - 10:24 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
11h 41m1 stop Fort Lauderdale
JetBlue Logo
1:02 pm - 3:56 amSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 54m1 stop Boston Logan Intl
$1,149JetBlue
Thu, Dec 3 - Thu, Dec 10
JetBlue Logo
2:43 pm - 10:24 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
11h 41m1 stop Fort Lauderdale
JetBlue Logo
8:00 am - 1:15 amSFO  San Francisco-SDQ Santo Domingo Las Americas
13h 15m1 stop Fort Lauderdale
$1,346JetBlue
Wed, Dec 2 - Sun, Dec 13

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American Airlines flights from Santo Domingo to San Francisco

Our best American Airlines deals on Santo Domingo to San Francisco flight tickets
American Airlines
Dec 3
SDQ2:22 pmSanto Domingo Las Americas
11h 55m
1 stop
SFO10:17 pmSan Francisco
Dec 31
SFO12:02 pmSan Francisco
17h 46m
1 stop
SDQ9:48 amSanto Domingo Las Americas
$621
American Airlines
Dec 24
SDQ2:46 pmSanto Domingo Las Americas
12h 41m
1 stop
SFO11:27 pmSan Francisco
Dec 31
SFO2:05 pmSan Francisco
15h 43m
2 stops
SDQ9:48 amSanto Domingo Las Americas
$626
American Airlines
Jan 20
SDQ4:17 pmSanto Domingo Las Americas
11h 05m
1 stop
SFO11:22 pmSan Francisco
Jan 25
SFO11:59 pmSan Francisco
14h 25m
1 stop
SDQ6:24 pmSanto Domingo Las Americas
$645

Frontier flights from Santo Domingo to San Francisco

Our best Frontier deals on Santo Domingo to San Francisco flight tickets
Frontier
Dec 3
SDQ2:33 pmSanto Domingo Las Americas
22h 43m
2 stops
SFO9:16 amSan Francisco
Dec 9
SFO7:26 pmSan Francisco
13h 44m
2 stops
SDQ1:10 pmSanto Domingo Las Americas
$715
Frontier
Dec 3
SDQ2:33 pmSanto Domingo Las Americas
22h 43m
2 stops
SFO9:16 amSan Francisco
Dec 9
SFO7:26 pmSan Francisco
13h 44m
2 stops
SDQ1:10 pmSanto Domingo Las Americas
$775

momondo Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

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Route

Depart

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Price

Cheapest round-trip

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sun 1/24

6:45 pm-11:55 am

2 stops21h 10m

San Francisco

Sun 1/31

11:00 pm-5:50 pm

2 stops14h 50m

$598

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sun 1/24

6:45 pm-11:55 am

2 stops21h 10m

San Francisco

Sun 1/31

1:15 pm-11:50 am

2 stops18h 35m

$598

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Fri 2/12

6:45 pm-11:55 am

2 stops21h 10m

San Francisco

Sun 2/21

11:00 pm-5:50 pm

2 stops14h 50m

$598

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Wed 2/24

6:45 pm-11:55 am

2 stops21h 10m

San Francisco

Sat 3/13

11:00 pm-5:50 pm

2 stops14h 50m

$598
Quickest round-trip

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Fri 2/12

4:58 pm-12:53 am

1 stop11h 55m

San Francisco

Sun 2/21

11:09 pm-1:31 pm

1 stop10h 22m

$621

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sat 2/13

3:41 pm-12:53 am

1 stop13h 12m

San Francisco

Fri 2/19

9:35 pm-6:22 pm

1 stop16h 47m

$621

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Thu 12/3

2:22 pm-10:17 pm

1 stop11h 55m

San Francisco

Thu 12/31

12:02 pm-9:48 am

1 stop17h 46m

$621

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Fri 12/4

2:43 pm-10:24 pm

1 stop11h 41m

San Francisco

Thu 12/10

1:02 pm-3:56 am

1 stop10h 54m

$1,149

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Thu 12/3

2:43 pm-10:24 pm

1 stop11h 41m

San Francisco

Thu 12/10

1:02 pm-3:56 am

1 stop10h 54m

$1,149

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Wed 12/2

2:43 pm-10:24 pm

1 stop11h 41m

San Francisco

Sun 12/13

8:00 am-1:15 am

1 stop13h 15m

$1,346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and San Francisco?

Prices are currently typical for flights on this route.

Typical prices usually range from $578 to $930.
The lowest price recently found on this route was $598.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of January, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $564.

Can stopping save me money on Santo Domingo to San Francisco flights?

You could potentially save up to 15% on your flight if you consider stops on a Santo Domingo to San Francisco flight.

How have Santo Domingo to San Francisco flight prices changed over time?

As of November 2026, prices for Santo Domingo to San Francisco flights are approximately 8% cheaper when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Best Price Found

$291

Fastest flight time

12h 03m

Direct flights

None
The best one-way flight to San Francisco from Santo Domingo in the past 72 hours is $291. The best round-trip flight deal from Santo Domingo to San Francisco found on momondo in the last 72 hours is $598.
The fastest flight from Santo Domingo to San Francisco takes 12h 03m
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

Frequently asked questions about flying from Santo Domingo to San Francisco

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3410.4 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 12h 03m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $456Free CancellationRating
7.1
3,075 reviews
Search JetBlue flights
American AirlinesPriceFrom $634Free CancellationRating
7.0
12,235 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Hayward
Santa Clara
Bodega Bay
Fremont
Walnut Creek
Berkeley
Sunnyvale
Half Moon Bay
Vallejo
Roseville
Salinas
Sonoma
Milpitas
Palo Alto
Burlingame
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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