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Cheap flights from Santo Domingo to San Francisco from $340

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to San Francisco departing on 7/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
8:57 am - 6:25 pm
SDQ
-
SFO
12h 28m
1 stop
Copa Airlines Logo
7:36 pm - 4:12 pm
SFO
-
SDQ
16h 36m
1 stop
$580Copa Airlines
Wed, Oct 28 - Wed, Nov 11
Copa Airlines Logo
2:16 pm - 11:40 pm
SDQ
-
SFO
12h 24m
1 stop
Copa Airlines Logo
1:12 am - 2:25 am
SFO
-
SDQ
22h 13m
1 stop
$651Copa Airlines
Thu, Sep 24 - Fri, Oct 2
Multiple Airlines Logo
10:19 am - 4:57 pm
SDQ
-
SFO
33h 38m
2 stops
Multiple Airlines Logo
7:35 am - 5:29 am
SFO
-
SDQ
18h 54m
1 stop
$656Multiple Airlines
Fri, Sep 18 - Thu, Oct 22
Multiple Airlines Logo
10:19 am - 4:57 pm
SDQ
-
SFO
33h 38m
2 stops
Multiple Airlines Logo
7:35 am - 5:29 am
SFO
-
SDQ
18h 54m
1 stop
$662Multiple Airlines
Fri, Sep 18 - Thu, Oct 22
Copa Airlines Logo
12:42 pm - 11:40 pm
SDQ
-
SFO
13h 58m
1 stop
Copa Airlines Logo
8:21 pm - 11:41 am
SFO
-
SDQ
12h 20m
1 stop
$678Copa Airlines
Fri, Sep 18 - Thu, Oct 22
Multiple Airlines Logo
7:10 pm - 5:17 pm
SDQ
-
SFO
25h 07m
2 stops
Multiple Airlines Logo
1:15 pm - 11:12 pm
SFO
-
SDQ
29h 57m
2 stops
$729Multiple Airlines
Wed, Oct 28 - Wed, Nov 11
JetBlue Logo
1:28 pm - 11:30 pm
SDQ
-
SFO
13h 02m
1 stop
JetBlue Logo
8:55 pm - 2:10 pm
SFO
-
SDQ
13h 15m
1 stop
$733JetBlue
Thu, Oct 29 - Tue, Nov 10
Multiple Airlines Logo
6:10 am - 8:08 pm
SDQ
-
SFO
16h 58m
1 stop
Multiple Airlines Logo
4:40 pm - 4:30 pm
SFO
-
SDQ
20h 50m
2 stops
$740Multiple Airlines
Fri, Sep 18 - Thu, Oct 22
JetBlue Logo
7:22 pm - 9:10 am
SDQ
-
SFO
16h 48m
1 stop
JetBlue Logo
10:10 pm - 3:53 pm
SFO
-
SDQ
14h 43m
1 stop
$757JetBlue
Thu, Oct 22 - Mon, Oct 26
Multiple Airlines Logo
2:29 pm - 11:19 pm
SDQ
-
SFO
11h 50m
1 stop
Multiple Airlines Logo
11:55 pm - 6:46 am
SFO
-
SDQ
27h 51m
1 stop
$764Multiple Airlines
Mon, Sep 14 - Fri, Sep 18

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JetBlue flights from Santo Domingo to San Francisco

Our best JetBlue deals on Santo Domingo to San Francisco flight tickets
JetBlue
Oct 29
SDQ1:28 pmSanto Domingo Las Americas
13h 02m
1 stop
SFO11:30 pmSan Francisco
Nov 10
SFO8:55 pmSan Francisco
13h 15m
1 stop
SDQ2:10 pmSanto Domingo Las Americas
$733
JetBlue
Oct 22
SDQ7:22 pmSanto Domingo Las Americas
16h 48m
1 stop
SFO9:10 amSan Francisco
Oct 26
SFO10:10 pmSan Francisco
14h 43m
1 stop
SDQ3:53 pmSanto Domingo Las Americas
$757
JetBlue
Oct 9
SDQ4:36 pmSanto Domingo Las Americas
19h 27m
1 stop
SFO9:03 amSan Francisco
Oct 13
SFO10:30 amSan Francisco
10h 29m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
$792

Avianca flights from Santo Domingo to San Francisco

Our best Avianca deals on Santo Domingo to San Francisco flight tickets
Avianca
Sep 14
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Sep 18
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
$767
Avianca
Sep 18
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Oct 22
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
$776
Avianca
Jul 20
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Jul 27
SFO2:15 pmSan Francisco
18h 35m
2 stops
SDQ11:50 amSanto Domingo Las Americas
$802

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 20, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 10/28

8:57 am-6:25 pm

1 stop12h 28m

San Francisco

Wed 11/11

7:36 pm-4:12 pm

1 stop16h 36m

$580

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 9/24

2:16 pm-11:40 pm

1 stop12h 24m

San Francisco

Fri 10/2

1:12 am-2:25 am

1 stop22h 13m

$651

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 9/18

10:19 am-4:57 pm

2 stops33h 38m

San Francisco

Thu 10/22

7:35 am-5:29 am

1 stop18h 54m

$656

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 9/18

10:19 am-4:57 pm

2 stops33h 38m

San Francisco

Thu 10/22

7:35 am-5:29 am

1 stop18h 54m

$662

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 9/18

12:42 pm-11:40 pm

1 stop13h 58m

San Francisco

Thu 10/22

8:21 pm-11:41 am

1 stop12h 20m

$678

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 10/28

7:10 pm-5:17 pm

2 stops25h 07m

San Francisco

Wed 11/11

1:15 pm-11:12 pm

2 stops29h 57m

$729
Quickest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 10/29

1:28 pm-11:30 pm

1 stop13h 02m

San Francisco

Tue 11/10

8:55 pm-2:10 pm

1 stop13h 15m

$733

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 9/18

6:10 am-8:08 pm

1 stop16h 58m

San Francisco

Thu 10/22

4:40 pm-4:30 pm

2 stops20h 50m

$740

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 10/22

7:22 pm-9:10 am

1 stop16h 48m

San Francisco

Mon 10/26

10:10 pm-3:53 pm

1 stop14h 43m

$757

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 9/14

2:29 pm-11:19 pm

1 stop11h 50m

San Francisco

Fri 9/18

11:55 pm-6:46 am

1 stop27h 51m

$764

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of March, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $544.

Can stopping save me money on Santo Domingo to San Francisco flights?

You could potentially save up to 19% on your flight if you consider stops on a Santo Domingo to San Francisco flight.

How have Santo Domingo to San Francisco flight prices changed over time?

As of June 2026, prices for Santo Domingo to San Francisco flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Fastest flight time

13h 52m

Direct flights

None
The fastest flight from Santo Domingo to San Francisco takes 13h 52m
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

Frequently asked questions about flying from Santo Domingo to San Francisco

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3410.4 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 13h 52m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $458Free CancellationRating
7.1
2,989 reviews
Search JetBlue flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Hayward
Bodega Bay
Roseville
Fremont
Walnut Creek
Santa Clara
South San Francisco
Berkeley
Vallejo
Sunnyvale
Salinas
Big Sur
Pacific Grove
Daly City
Burlingame
Calistoga

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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