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Cheap flights from Santo Domingo to San Francisco from $230

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to San Francisco departing on 2/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
6:20 am - 4:56 pm
SDQ
-
SFO
14h 36m
1 stop
JetBlue Logo
7:00 am - 2:55 am
SFO
-
SDQ
15h 55m
1 stop
$436JetBlue
Wed, Feb 25 - Wed, Mar 4
Multiple Airlines Logo
3:32 pm - 10:30 am
SDQ
-
SFO
22h 58m
1 stop
Multiple Airlines Logo
8:30 pm - 4:50 pm
SFO
-
SDQ
16h 20m
1 stop
$458Multiple Airlines
Wed, Feb 4 - Sun, Feb 8
Multiple Airlines Logo
3:32 pm - 11:58 pm
SDQ
-
SFO
12h 26m
1 stop
Multiple Airlines Logo
8:45 pm - 3:55 pm
SFO
-
SDQ
16h 10m
1 stop
$459Multiple Airlines
Fri, Mar 6 - Mon, Mar 16
Copa Airlines Logo
2:13 pm - 11:40 pm
SDQ
-
SFO
12h 27m
1 stop
Copa Airlines Logo
1:54 am - 4:14 pm
SFO
-
SDQ
11h 20m
1 stop
$463Copa Airlines
Wed, Mar 11 - Sun, Mar 15
Multiple Airlines Logo
10:19 am - 12:28 am
SDQ
-
SFO
42h 09m
2 stops
Multiple Airlines Logo
10:58 pm - 9:45 pm
SFO
-
SDQ
18h 47m
2 stops
$469Multiple Airlines
Wed, Feb 25 - Wed, Mar 4
JetBlue Logo
2:28 pm - 9:29 am
SDQ
-
SFO
22h 01m
1 stop
JetBlue Logo
8:45 pm - 3:55 pm
SFO
-
SDQ
16h 10m
1 stop
$471JetBlue
Sun, Mar 8 - Mon, Mar 16
Multiple Airlines Logo
10:19 am - 7:14 pm
SDQ
-
SFO
35h 55m
2 stops
Multiple Airlines Logo
10:54 pm - 5:31 am
SFO
-
SDQ
27h 37m
1 stop
$475Multiple Airlines
Mon, Mar 9 - Mon, Mar 16
Multiple Airlines Logo
10:19 am - 12:28 am
SDQ
-
SFO
42h 09m
2 stops
Multiple Airlines Logo
7:35 am - 11:26 am
SFO
-
SDQ
23h 51m
3 stops
$476Multiple Airlines
Wed, Feb 25 - Wed, Mar 4
Multiple Airlines Logo
10:19 am - 7:14 pm
SDQ
-
SFO
35h 55m
2 stops
Multiple Airlines Logo
6:27 pm - 5:31 am
SFO
-
SDQ
32h 04m
2 stops
$486Multiple Airlines
Mon, Mar 9 - Mon, Mar 16
Multiple Airlines Logo
5:45 pm - 12:00 pm
SDQ
-
SFO
22h 15m
2 stops
Multiple Airlines Logo
8:26 am - 4:36 am
SFO
-
SDQ
16h 10m
1 stop
$487Multiple Airlines
Wed, Feb 4 - Sun, Feb 8

JetBlue flights from Santo Domingo to San Francisco

Our best JetBlue deals on Santo Domingo to San Francisco flight tickets
JetBlue
Mar 8
SDQ2:28 pmSanto Domingo Las Americas
22h 01m
1 stop
SFO9:29 amSan Francisco
Mar 16
SFO8:45 pmSan Francisco
16h 10m
1 stop
SDQ3:55 pmSanto Domingo Las Americas
$471
JetBlue
Mar 10
SDQ2:28 pmSanto Domingo Las Americas
22h 01m
1 stop
SFO9:29 amSan Francisco
Mar 16
SFO8:45 pmSan Francisco
16h 10m
1 stop
SDQ3:55 pmSanto Domingo Las Americas
$495
JetBlue
Feb 4
SDQ6:01 amSanto Domingo Las Americas
16h 54m
1 stop
SFO6:55 pmSan Francisco
Feb 8
SFO8:26 amSan Francisco
16h 10m
1 stop
SDQ4:36 amSanto Domingo Las Americas
$506

Copa Airlines flights from Santo Domingo to San Francisco

Our best Copa Airlines deals on Santo Domingo to San Francisco flight tickets
Copa Airlines
Mar 11
SDQ2:13 pmSanto Domingo Las Americas
12h 27m
1 stop
SFO11:40 pmSan Francisco
Mar 15
SFO1:54 amSan Francisco
11h 20m
1 stop
SDQ4:14 pmSanto Domingo Las Americas
$463
Copa Airlines
Apr 15
SDQ8:43 amSanto Domingo Las Americas
12h 42m
1 stop
SFO6:25 pmSan Francisco
Apr 15
SFO8:35 pmSan Francisco
13h 37m
1 stop
SDQ1:12 pmSanto Domingo Las Americas
$530

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 13, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 2/25

6:20 am-4:56 pm

1 stop14h 36m

San Francisco

Wed 3/4

7:00 am-2:55 am

1 stop15h 55m

$436

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 2/4

3:32 pm-10:30 am

1 stop22h 58m

San Francisco

Sun 2/8

8:30 pm-4:50 pm

1 stop16h 20m

$458

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 3/6

3:32 pm-11:58 pm

1 stop12h 26m

San Francisco

Mon 3/16

8:45 pm-3:55 pm

1 stop16h 10m

$459

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 3/11

2:13 pm-11:40 pm

1 stop12h 27m

San Francisco

Sun 3/15

1:54 am-4:14 pm

1 stop11h 20m

$463

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 2/25

10:19 am-12:28 am

2 stops42h 09m

San Francisco

Wed 3/4

10:58 pm-9:45 pm

2 stops18h 47m

$469

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 3/8

2:28 pm-9:29 am

1 stop22h 01m

San Francisco

Mon 3/16

8:45 pm-3:55 pm

1 stop16h 10m

$471

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 3/9

10:19 am-7:14 pm

2 stops35h 55m

San Francisco

Mon 3/16

10:54 pm-5:31 am

1 stop27h 37m

$475

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 2/25

10:19 am-12:28 am

2 stops42h 09m

San Francisco

Wed 3/4

7:35 am-11:26 am

3 stops23h 51m

$476

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 3/9

10:19 am-7:14 pm

2 stops35h 55m

San Francisco

Mon 3/16

6:27 pm-5:31 am

2 stops32h 04m

$486

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 2/4

5:45 pm-12:00 pm

2 stops22h 15m

San Francisco

Sun 2/8

8:26 am-4:36 am

1 stop16h 10m

$487

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $538.

Can stopping save me money on Santo Domingo to San Francisco flights?

You could potentially save up to 15% on your flight if you consider stops on a Santo Domingo to San Francisco flight.

How have Santo Domingo to San Francisco flight prices changed over time?

As of January 2026, prices for Santo Domingo to San Francisco flights are approximately 4% more expensive when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Fastest flight time

12h 42m

Direct flights

None
The fastest flight from Santo Domingo to San Francisco takes 12h 42m
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3411.1 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 12h 42m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $458Free CancellationRating
7.2
2,884 reviews
Search JetBlue flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Half Moon Bay
Daly City
Vallejo
Livermore
Salinas
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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