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Cheap flights from Santo Domingo to San Francisco from $266

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to San Francisco departing on 4/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:35 pm - 6:45 pm
SDQ
-
SFO
30h 10m
2 stops
Multiple Airlines Logo
9:19 pm - 5:29 am
SFO
-
SDQ
29h 10m
1 stop
$539Multiple Airlines
Tue, Apr 28 - Tue, May 5
JetBlue Logo
4:05 am - 2:21 pm
SDQ
-
SFO
13h 16m
1 stop
JetBlue Logo
11:10 pm - 1:51 pm
SFO
-
SDQ
11h 41m
1 stop
$542JetBlue
Sat, May 2 - Sat, May 9
JetBlue Logo
7:30 pm - 9:23 am
SDQ
-
SFO
16h 53m
1 stop
JetBlue Logo
11:05 pm - 12:28 pm
SFO
-
SDQ
10h 23m
1 stop
$557JetBlue
Fri, Apr 24 - Mon, Apr 27
Multiple Airlines Logo
4:08 pm - 7:14 pm
SDQ
-
SFO
30h 06m
1 stop
Multiple Airlines Logo
11:55 pm - 5:55 pm
SFO
-
SDQ
15h 00m
2 stops
$559Multiple Airlines
Wed, Apr 1 - Wed, Apr 8
JetBlue Logo
7:30 pm - 9:23 am
SDQ
-
SFO
16h 53m
1 stop
JetBlue Logo
6:55 am - 1:54 am
SFO
-
SDQ
15h 59m
1 stop
$566JetBlue
Tue, Apr 28 - Tue, May 5
JetBlue Logo
7:26 pm - 9:23 am
SDQ
-
SFO
16h 57m
1 stop
JetBlue Logo
12:20 pm - 2:27 am
SFO
-
SDQ
11h 07m
1 stop
$568JetBlue
Fri, May 1 - Fri, May 8
Multiple Airlines Logo
3:35 pm - 6:45 pm
SDQ
-
SFO
30h 10m
2 stops
Multiple Airlines Logo
9:19 pm - 5:29 am
SFO
-
SDQ
29h 10m
1 stop
$577Multiple Airlines
Tue, Apr 28 - Tue, May 5
JetBlue Logo
7:30 pm - 9:23 am
SDQ
-
SFO
16h 53m
1 stop
JetBlue Logo
7:00 am - 2:27 am
SFO
-
SDQ
16h 27m
1 stop
$580JetBlue
Tue, Apr 28 - Tue, May 5
JetBlue Logo
7:26 pm - 9:23 am
SDQ
-
SFO
16h 57m
1 stop
JetBlue Logo
12:20 pm - 2:27 am
SFO
-
SDQ
11h 07m
1 stop
$586JetBlue
Fri, May 1 - Fri, May 8
Multiple Airlines Logo
7:26 pm - 9:23 am
SDQ
-
SFO
16h 57m
1 stop
Multiple Airlines Logo
11:55 pm - 5:55 pm
SFO
-
SDQ
15h 00m
2 stops
$588Multiple Airlines
Thu, Apr 30 - Thu, May 7

Frontier flights from Santo Domingo to San Francisco

Our best Frontier deals on Santo Domingo to San Francisco flight tickets
Frontier
Apr 10
SDQ4:08 pmSanto Domingo Las Americas
30h 11m
1 stop
SFO7:19 pmSan Francisco
Apr 12
SFO10:23 pmSan Francisco
13h 30m
1 stop
SDQ2:53 pmSanto Domingo Las Americas
$613
Frontier
Mar 27
SDQ10:51 amSanto Domingo Las Americas
13h 47m
2 stops
SFO9:38 pmSan Francisco
Apr 5
SFO10:23 pmSan Francisco
13h 30m
1 stop
SDQ2:53 pmSanto Domingo Las Americas
$959
Frontier
Mar 28
SDQ10:56 amSanto Domingo Las Americas
13h 42m
2 stops
SFO9:38 pmSan Francisco
Apr 5
SFO10:23 pmSan Francisco
13h 30m
1 stop
SDQ2:53 pmSanto Domingo Las Americas
$1,052

JetBlue flights from Santo Domingo to San Francisco

Our best JetBlue deals on Santo Domingo to San Francisco flight tickets
JetBlue
May 2
SDQ4:05 amSanto Domingo Las Americas
13h 16m
1 stop
SFO2:21 pmSan Francisco
May 9
SFO11:10 pmSan Francisco
11h 41m
1 stop
SDQ1:51 pmSanto Domingo Las Americas
$542
JetBlue
Apr 24
SDQ7:30 pmSanto Domingo Las Americas
16h 53m
1 stop
SFO9:23 amSan Francisco
Apr 27
SFO11:05 pmSan Francisco
10h 23m
1 stop
SDQ12:28 pmSanto Domingo Las Americas
$557
JetBlue
Apr 28
SDQ7:30 pmSanto Domingo Las Americas
16h 53m
1 stop
SFO9:23 amSan Francisco
May 5
SFO6:55 amSan Francisco
15h 59m
1 stop
SDQ1:54 amSanto Domingo Las Americas
$566

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 19, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 4/28

3:35 pm-6:45 pm

2 stops30h 10m

San Francisco

Tue 5/5

9:19 pm-5:29 am

1 stop29h 10m

$539
Quickest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 5/2

4:05 am-2:21 pm

1 stop13h 16m

San Francisco

Sat 5/9

11:10 pm-1:51 pm

1 stop11h 41m

$542

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 4/24

7:30 pm-9:23 am

1 stop16h 53m

San Francisco

Mon 4/27

11:05 pm-12:28 pm

1 stop10h 23m

$557

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 4/1

4:08 pm-7:14 pm

1 stop30h 06m

San Francisco

Wed 4/8

11:55 pm-5:55 pm

2 stops15h 00m

$559

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 4/28

7:30 pm-9:23 am

1 stop16h 53m

San Francisco

Tue 5/5

6:55 am-1:54 am

1 stop15h 59m

$566

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 5/1

7:26 pm-9:23 am

1 stop16h 57m

San Francisco

Fri 5/8

12:20 pm-2:27 am

1 stop11h 07m

$568

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 4/28

3:35 pm-6:45 pm

2 stops30h 10m

San Francisco

Tue 5/5

9:19 pm-5:29 am

1 stop29h 10m

$577

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 4/28

7:30 pm-9:23 am

1 stop16h 53m

San Francisco

Tue 5/5

7:00 am-2:27 am

1 stop16h 27m

$580

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 5/1

7:26 pm-9:23 am

1 stop16h 57m

San Francisco

Fri 5/8

12:20 pm-2:27 am

1 stop11h 07m

$586

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 4/30

7:26 pm-9:23 am

1 stop16h 57m

San Francisco

Thu 5/7

11:55 pm-5:55 pm

2 stops15h 00m

$588

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of June, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $490.

Can stopping save me money on Santo Domingo to San Francisco flights?

You could potentially save up to 3% on your flight if you consider stops on a Santo Domingo to San Francisco flight.

How have Santo Domingo to San Francisco flight prices changed over time?

As of March 2026, prices for Santo Domingo to San Francisco flights are approximately 7% more expensive when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Fastest flight time

12h 23m

Direct flights

None
The fastest flight from Santo Domingo to San Francisco takes 12h 23m
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3411.1 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 12h 23m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $388Free CancellationRating
7.2
2,909 reviews
Search JetBlue flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Big Sur
Fremont
Calistoga
Vallejo
Salinas
Half Moon Bay
Daly City
Milpitas
Pacific Grove
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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