Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santo Domingo to San Francisco from $286

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to San Francisco departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
3:59 pm - 11:17 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
10h 18m1 stop Fort Lauderdale
JetBlue Logo
10:30 am - 11:59 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 29m1 stop Fort Lauderdale
$572JetBlue
Thu, Sep 24 - Thu, Oct 8
JetBlue Logo
3:59 pm - 11:17 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
10h 18m1 stop Fort Lauderdale
JetBlue Logo
11:10 pm - 2:49 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
12h 39m1 stop Fort Lauderdale
$578JetBlue
Wed, Sep 23 - Wed, Sep 30
JetBlue Logo
4:15 am - 1:20 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
13h 05m1 stop Boston Logan Intl
JetBlue Logo
10:50 am - 12:51 amSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 01m1 stop Fort Lauderdale
$589JetBlue
Mon, Nov 16 - Thu, Nov 26
JetBlue Logo
3:59 pm - 11:17 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
10h 18m1 stop Fort Lauderdale
JetBlue Logo
11:10 pm - 3:16 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
13h 06m1 stop Fort Lauderdale
$600JetBlue
Thu, Sep 24 - Thu, Oct 8
JetBlue Logo
2:28 pm - 11:35 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
13h 07m1 stop Fort Lauderdale
JetBlue Logo
10:50 am - 12:51 amSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 01m1 stop Fort Lauderdale
$604JetBlue
Wed, Nov 4 - Mon, Nov 23
JetBlue Logo
3:59 pm - 11:17 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
10h 18m1 stop Fort Lauderdale
JetBlue Logo
11:10 pm - 3:16 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
13h 06m1 stop Fort Lauderdale
$604JetBlue
Fri, Sep 18 - Thu, Oct 22
Avianca Logo
6:50 pm - 12:50 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 00m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
11:55 pm - 5:55 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
15h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$614Avianca
Fri, Sep 18 - Thu, Oct 22
Avianca Logo
6:50 pm - 12:50 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 00m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
2:15 pm - 11:50 amSFO  San Francisco-SDQ Santo Domingo Las Americas
18h 35m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$614Avianca
Sat, Sep 5 - Sat, Sep 12
Avianca Logo
6:50 pm - 12:50 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 00m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
11:55 pm - 5:55 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
15h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$614Avianca
Mon, Sep 21 - Mon, Sep 28
Avianca Logo
6:50 pm - 12:50 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 00m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
2:15 pm - 11:50 amSFO  San Francisco-SDQ Santo Domingo Las Americas
18h 35m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$614Avianca
Fri, Sep 11 - Fri, Sep 18

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Avianca flights from Santo Domingo to San Francisco

Our best Avianca deals on Santo Domingo to San Francisco flight tickets
Avianca
Sep 21
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Sep 28
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
$614
Avianca
Sep 21
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Sep 28
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
$617
Avianca
Sep 21
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Sep 28
SFO2:15 pmSan Francisco
18h 35m
2 stops
SDQ11:50 amSanto Domingo Las Americas
$618

American Airlines flights from Santo Domingo to San Francisco

Our best American Airlines deals on Santo Domingo to San Francisco flight tickets
American Airlines
Nov 4
SDQ4:59 pmSanto Domingo Las Americas
19h 57m
2 stops
SFO8:56 amSan Francisco
Nov 23
SFO9:35 pmSan Francisco
13h 17m
1 stop
SDQ2:52 pmSanto Domingo Las Americas
$645
American Airlines
Nov 4
SDQ7:00 amSanto Domingo Las Americas
15h 28m
2 stops
SFO6:28 pmSan Francisco
Nov 23
SFO11:23 pmSan Francisco
14h 50m
2 stops
SDQ6:13 pmSanto Domingo Las Americas
$672
American Airlines
Sep 23
SDQ9:30 amSanto Domingo Las Americas
10h 27m
1 stop
SFO4:57 pmSan Francisco
Sep 30
SFO10:54 pmSan Francisco
16h 40m
1 stop
SDQ6:34 pmSanto Domingo Las Americas
$678

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Thu 9/24

3:59 pm-11:17 pm

1 stop10h 18m

San Francisco

Thu 10/8

10:30 am-11:59 pm

1 stop10h 29m

$572

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Wed 9/23

3:59 pm-11:17 pm

1 stop10h 18m

San Francisco

Wed 9/30

11:10 pm-2:49 pm

1 stop12h 39m

$578

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Mon 11/16

4:15 am-1:20 pm

1 stop13h 05m

San Francisco

Thu 11/26

10:50 am-12:51 am

1 stop10h 01m

$589

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Thu 9/24

3:59 pm-11:17 pm

1 stop10h 18m

San Francisco

Thu 10/8

11:10 pm-3:16 pm

1 stop13h 06m

$600

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Wed 11/4

2:28 pm-11:35 pm

1 stop13h 07m

San Francisco

Mon 11/23

10:50 am-12:51 am

1 stop10h 01m

$604

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Fri 9/18

3:59 pm-11:17 pm

1 stop10h 18m

San Francisco

Thu 10/22

11:10 pm-3:16 pm

1 stop13h 06m

$604

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Fri 9/18

6:50 pm-12:50 pm

2 stops21h 00m

San Francisco

Thu 10/22

11:55 pm-5:55 pm

2 stops15h 00m

$614

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Sat 9/5

6:50 pm-12:50 pm

2 stops21h 00m

San Francisco

Sat 9/12

2:15 pm-11:50 am

2 stops18h 35m

$614

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Mon 9/21

6:50 pm-12:50 pm

2 stops21h 00m

San Francisco

Mon 9/28

11:55 pm-5:55 pm

2 stops15h 00m

$614

Santo DomingoSan Francisco

SDQ Santo Domingo Las Americas - SFO San Francisco

SDQSFO

Santo Domingo Las Americas

Fri 9/11

6:50 pm-12:50 pm

2 stops21h 00m

San Francisco

Fri 9/18

2:15 pm-11:50 am

2 stops18h 35m

$614

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Francisco from

How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of March, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $538.

How have Santo Domingo to San Francisco flight prices changed over time?

As of August 2026, prices for Santo Domingo to San Francisco flights are approximately 20% cheaper when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Fastest flight time

10h 18m

Direct flights

None
The fastest flight from Santo Domingo to San Francisco takes 10h 18m
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

Frequently asked questions about flying from Santo Domingo to San Francisco

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3410.4 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 10h 18m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $458Free CancellationRating
7.1
3,031 reviews
Search JetBlue flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Berkeley
Bodega Bay
Hayward
Walnut Creek
Santa Clara
Vallejo
Roseville
Sonoma
Salinas
Sunnyvale
Milpitas
Daly City
Burlingame
Marina
Palo Alto

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 9/10
Thu 9/17
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States