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Cheap flights from Santo Domingo to San Francisco from $248

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to San Francisco departing on 12/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
1:35 am - 10:49 amSDQ-SFO
12h 14m1 stop
JetBlue Logo
7:00 am - 12:24 amSFO-SDQ
14h 24m1 stop
$481JetBlue
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Wed, Mar 11 - Tue, Mar 17
Avianca Logo
12:20 pm - 1:00 pmSDQ-SFO
27h 40m2 stops
Avianca Logo
2:20 pm - 4:50 pmSFO-SDQ
23h 30m2 stops
$532Avianca
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Thu, Mar 12 - Tue, Mar 17
JetBlue Logo
5:29 am - 7:28 pmSDQ-SFO
17h 59m1 stop
JetBlue Logo
10:39 pm - 1:18 pmSFO-SDQ
11h 39m1 stop
$545JetBlue
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Sun, Mar 8 - Mon, Mar 9
Multiple Airlines Logo
3:35 pm - 12:25 amSDQ-SFO
36h 50m2 stops
Multiple Airlines Logo
11:27 am - 7:18 amSFO-SDQ
39h 51m2 stops
$566Multiple Airlines
Find Deal
Thu, Feb 5 - Thu, Feb 12
Multiple Airlines Logo
11:01 am - 8:59 pmSDQ-SFO
12h 58m1 stop
Multiple Airlines Logo
12:10 am - 4:50 pmSFO-SDQ
13h 40m2 stops
$580Multiple Airlines
Find Deal
Thu, Mar 12 - Mon, Mar 16
Multiple Airlines Logo
3:35 pm - 12:25 amSDQ-SFO
36h 50m2 stops
Multiple Airlines Logo
3:46 pm - 11:30 amSFO-SDQ
63h 44m3 stops
$584Multiple Airlines
Find Deal
Thu, Feb 5 - Thu, Feb 12
Copa Airlines Logo
2:13 pm - 11:40 pmSDQ-SFO
12h 27m1 stop
Copa Airlines Logo
1:54 am - 10:40 pmSFO-SDQ
17h 46m1 stop
$599Copa Airlines
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Thu, Mar 12 - Mon, Mar 16
Frontier Logo
3:23 pm - 9:01 pmSDQ-SFO
33h 38m2 stops
Frontier Logo
6:00 am - 4:49 pmSFO-SDQ
30h 49m2 stops
$726Frontier
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Sat, Dec 20 - Sun, Jan 4
American Airlines Logo
6:00 am - 4:13 pmSDQ-SFO
14h 13m2 stops
American Airlines Logo
3:50 pm - 12:21 pmSFO-SDQ
16h 31m2 stops
$734American Airlines
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Sat, Dec 20 - Tue, Jan 6
Copa Airlines Logo
11:56 am - 11:40 pmSDQ-SFO
14h 44m1 stop
Copa Airlines Logo
1:54 am - 4:14 pmSFO-SDQ
11h 20m1 stop
$751Copa Airlines
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Sun, Mar 8 - Sun, Mar 8

JetBlue flights from Santo Domingo to San Francisco

Our best JetBlue deals on Santo Domingo to San Francisco flight tickets
JetBlue
Mar 11
SDQ1:35 amSanto Domingo Las Americas
12h 14m
1 stop
SFO10:49 amSan Francisco
Mar 17
SFO7:00 amSan Francisco
14h 24m
1 stop
SDQ12:24 amSanto Domingo Las Americas
$481
Find similar
JetBlue
Mar 8
SDQ5:29 amSanto Domingo Las Americas
17h 59m
1 stop
SFO7:28 pmSan Francisco
Mar 9
SFO10:39 pmSan Francisco
11h 39m
1 stop
SDQ1:18 pmSanto Domingo Las Americas
$545
Find similar
JetBlue
Nov 12
SDQ3:27 pmSanto Domingo Las Americas
12h 04m
1 stop
SFO11:31 pmSan Francisco
Nov 14
SFO9:44 pmSan Francisco
8h 48m
1 stop
SDQ10:32 amSanto Domingo Las Americas
$620
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Copa Airlines flights from Santo Domingo to San Francisco

Our best Copa Airlines deals on Santo Domingo to San Francisco flight tickets
Copa Airlines
Mar 12
SDQ2:13 pmSanto Domingo Las Americas
12h 27m
1 stop
SFO11:40 pmSan Francisco
Mar 16
SFO1:54 amSan Francisco
17h 46m
1 stop
SDQ10:40 pmSanto Domingo Las Americas
$599
Find similar
Copa Airlines
Mar 8
SDQ11:56 amSanto Domingo Las Americas
14h 44m
1 stop
SFO11:40 pmSan Francisco
Mar 8
SFO1:54 amSan Francisco
11h 20m
1 stop
SDQ4:14 pmSanto Domingo Las Americas
$751
Find similar
Copa Airlines
Feb 20
SDQ2:11 pmSanto Domingo Las Americas
13h 09m
1 stop
SFO11:20 pmSan Francisco
Feb 22
SFO12:42 amSan Francisco
21h 35m
1 stop
SDQ2:17 amSanto Domingo Las Americas
$812
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 3/11

1:35 am-10:49 am

1 stop12h 14m

San Francisco

Tue 3/17

7:00 am-12:24 am

1 stop14h 24m

$481

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 3/12

12:20 pm-1:00 pm

2 stops27h 40m

San Francisco

Tue 3/17

2:20 pm-4:50 pm

2 stops23h 30m

$532

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 3/8

5:29 am-7:28 pm

1 stop17h 59m

San Francisco

Mon 3/9

10:39 pm-1:18 pm

1 stop11h 39m

$545

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 2/5

3:35 pm-12:25 am

2 stops36h 50m

San Francisco

Thu 2/12

11:27 am-7:18 am

2 stops39h 51m

$566

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 3/12

11:01 am-8:59 pm

1 stop12h 58m

San Francisco

Mon 3/16

12:10 am-4:50 pm

2 stops13h 40m

$580

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 2/5

3:35 pm-12:25 am

2 stops36h 50m

San Francisco

Thu 2/12

3:46 pm-11:30 am

3 stops63h 44m

$584

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 3/12

2:13 pm-11:40 pm

1 stop12h 27m

San Francisco

Mon 3/16

1:54 am-10:40 pm

1 stop17h 46m

$599

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 12/20

3:23 pm-9:01 pm

2 stops33h 38m

San Francisco

Sun 1/4

6:00 am-4:49 pm

2 stops30h 49m

$726

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 12/20

6:00 am-4:13 pm

2 stops14h 13m

San Francisco

Tue 1/6

3:50 pm-12:21 pm

2 stops16h 31m

$734

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 3/8

11:56 am-11:40 pm

1 stop14h 44m

San Francisco

Sun 3/8

1:54 am-4:14 pm

1 stop11h 20m

$751

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $544.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Santo Domingo to San Francisco is on a Thursday when prices can be found for as low as $631. The most expensive day to fly to San Francisco is Friday, with ticket prices averaging around $894.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Santo Domingo to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $265. Flights at noon are often more expensive with an average ticket price of $798.

Can stopping save me money on Santo Domingo to San Francisco flights?

You could potentially save up to 6% on your flight if you consider stops on a Santo Domingo to San Francisco flight.

How have Santo Domingo to San Francisco flight prices changed over time?

As of November 2025, prices for Santo Domingo to San Francisco flights are approximately 21% more expensive when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Direct flights

None
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3411.1 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 11h 47m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $486Free CancellationRating
7.2
2,907 reviews
Search JetBlue flights
American AirlinesPriceFrom $689Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Calistoga
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Turlock
Livermore
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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