Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santo Domingo to San Francisco from $297

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to San Francisco departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Santo Domingo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
12:12 pm - 11:40 pm
SDQ
-
SFO
14h 28m
1 stop
Copa Airlines Logo
8:21 pm - 2:25 am
SFO
-
SDQ
27h 04m
1 stop
$583Copa Airlines
Thu, Sep 24 - Sun, Sep 27
Multiple Airlines Logo
6:10 am - 10:34 pm
SDQ
-
SFO
19h 24m
1 stop
Multiple Airlines Logo
7:17 pm - 4:29 pm
SFO
-
SDQ
17h 12m
2 stops
$617Multiple Airlines
Fri, Oct 23 - Tue, Nov 3
Copa Airlines Logo
12:42 pm - 11:40 pm
SDQ
-
SFO
13h 58m
1 stop
Copa Airlines Logo
1:12 am - 10:56 pm
SFO
-
SDQ
18h 44m
1 stop
$627Copa Airlines
Thu, Sep 24 - Fri, Oct 2
Copa Airlines Logo
8:47 am - 11:40 pm
SDQ
-
SFO
17h 53m
1 stop
Copa Airlines Logo
7:21 pm - 10:55 pm
SFO
-
SDQ
23h 34m
1 stop
$639Copa Airlines
Fri, Oct 23 - Sun, Nov 1
Multiple Airlines Logo
6:10 am - 9:27 pm
SDQ
-
SFO
18h 17m
1 stop
Multiple Airlines Logo
9:43 pm - 4:29 pm
SFO
-
SDQ
39h 46m
2 stops
$641Multiple Airlines
Fri, Jun 5 - Mon, Jun 15
Multiple Airlines Logo
6:10 am - 9:27 pm
SDQ
-
SFO
18h 17m
1 stop
Multiple Airlines Logo
9:43 pm - 4:29 pm
SFO
-
SDQ
39h 46m
2 stops
$653Multiple Airlines
Fri, Jun 5 - Mon, Jun 15
Multiple Airlines Logo
7:10 pm - 12:53 pm
SDQ
-
SFO
20h 43m
1 stop
Multiple Airlines Logo
9:05 am - 4:26 pm
SFO
-
SDQ
27h 21m
1 stop
$657Multiple Airlines
Wed, Oct 21 - Tue, Nov 3
JetBlue Logo
4:44 pm - 11:50 pm
SDQ
-
SFO
10h 06m
1 stop
JetBlue Logo
10:40 pm - 12:24 pm
SFO
-
SDQ
10h 44m
1 stop
$664JetBlue
Thu, Aug 27 - Mon, Aug 31
Multiple Airlines Logo
6:10 am - 8:14 pm
SDQ
-
SFO
17h 04m
1 stop
Multiple Airlines Logo
7:17 pm - 4:29 pm
SFO
-
SDQ
17h 12m
2 stops
$671Multiple Airlines
Sat, Oct 24 - Tue, Nov 3
Multiple Airlines Logo
6:10 am - 10:34 pm
SDQ
-
SFO
19h 24m
1 stop
Multiple Airlines Logo
6:18 am - 5:25 am
SFO
-
SDQ
19h 07m
1 stop
$672Multiple Airlines
Thu, Oct 22 - Tue, Nov 3

Frontier flights from Santo Domingo to San Francisco

Our best Frontier deals on Santo Domingo to San Francisco flight tickets
Frontier
Jun 11
SDQ11:55 amSanto Domingo Las Americas
23h 56m
2 stops
SFO8:51 amSan Francisco
Jun 15
SFO12:38 pmSan Francisco
19h 12m
2 stops
SDQ10:50 amSanto Domingo Las Americas
$682
Frontier
Jun 11
SDQ11:55 amSanto Domingo Las Americas
23h 56m
2 stops
SFO8:51 amSan Francisco
Jun 15
SFO12:38 pmSan Francisco
19h 12m
2 stops
SDQ10:50 amSanto Domingo Las Americas
$705

Avianca flights from Santo Domingo to San Francisco

Our best Avianca deals on Santo Domingo to San Francisco flight tickets
Avianca
Sep 14
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Sep 20
SFO2:15 pmSan Francisco
18h 35m
2 stops
SDQ11:50 amSanto Domingo Las Americas
$767
Avianca
Sep 11
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Sep 27
SFO2:15 pmSan Francisco
18h 35m
2 stops
SDQ11:50 amSanto Domingo Las Americas
$769
Avianca
May 22
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
Jun 7
SFO2:15 pmSan Francisco
18h 35m
2 stops
SDQ11:50 amSanto Domingo Las Americas
$779

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 9/24

12:12 pm-11:40 pm

1 stop14h 28m

San Francisco

Sun 9/27

8:21 pm-2:25 am

1 stop27h 04m

$583

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 10/23

6:10 am-10:34 pm

1 stop19h 24m

San Francisco

Tue 11/3

7:17 pm-4:29 pm

2 stops17h 12m

$617

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 9/24

12:42 pm-11:40 pm

1 stop13h 58m

San Francisco

Fri 10/2

1:12 am-10:56 pm

1 stop18h 44m

$627

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 10/23

8:47 am-11:40 pm

1 stop17h 53m

San Francisco

Sun 11/1

7:21 pm-10:55 pm

1 stop23h 34m

$639

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 6/5

6:10 am-9:27 pm

1 stop18h 17m

San Francisco

Mon 6/15

9:43 pm-4:29 pm

2 stops39h 46m

$641

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 6/5

6:10 am-9:27 pm

1 stop18h 17m

San Francisco

Mon 6/15

9:43 pm-4:29 pm

2 stops39h 46m

$653

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 10/21

7:10 pm-12:53 pm

1 stop20h 43m

San Francisco

Tue 11/3

9:05 am-4:26 pm

1 stop27h 21m

$657
Quickest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 8/27

4:44 pm-11:50 pm

1 stop10h 06m

San Francisco

Mon 8/31

10:40 pm-12:24 pm

1 stop10h 44m

$664

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 10/24

6:10 am-8:14 pm

1 stop17h 04m

San Francisco

Tue 11/3

7:17 pm-4:29 pm

2 stops17h 12m

$671

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 10/22

6:10 am-10:34 pm

1 stop19h 24m

San Francisco

Tue 11/3

6:18 am-5:25 am

1 stop19h 07m

$672

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Francisco from

How to get the cheapest flight ticket from Santo Domingo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $544.

Can stopping save me money on Santo Domingo to San Francisco flights?

You could potentially save up to 23% on your flight if you consider stops on a Santo Domingo to San Francisco flight.

How have Santo Domingo to San Francisco flight prices changed over time?

As of May 2026, prices for Santo Domingo to San Francisco flights are approximately 81% more expensive when compared to flights at the same time last year.

When to book flights from Santo Domingo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to San Francisco (SDQ to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to San Francisco

Fastest flight time

13h 58m

Direct flights

None
The fastest flight from Santo Domingo to San Francisco takes 13h 58m
There are no direct flights from Santo Domingo to San Francisco. There are no popular flight routes from Santo Domingo to San Francisco.
Search flight deals

Frequently asked questions about flying from Santo Domingo to San Francisco

  • How far is Santo Domingo Las Americas to San Francisco by plane?

    There are 3410.4 mi between Santo Domingo Las Americas and San Francisco. By plane, this route typically takes 13h 58m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

    Prices for flights from Santo Domingo Las Americas Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to San Francisco Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to San Francisco?

Best airlines flying from Santo Domingo to San Francisco

Compare and see reviews for airlines that fly from Santo Domingo to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $458Free CancellationRating
7.1
2,977 reviews
Search JetBlue flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Vallejo
Fremont
Big Sur
Calistoga
Daly City
South San Francisco
Pacific Grove
Sunnyvale
Salinas
Milpitas

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santo Domingo to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santo Domingo to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Santo Domingo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santo Domingo to San Francisco?

Once you have performed a search for Santo Domingo to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santo Domingo to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 6/4
Thu 6/11
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States