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Cheap flights from Portland to Florence from $292

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland to Florence departing on 3/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Portland to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 10:42 pm
PDX
-
FLO
13h 42m
2 stops
American Airlines Logo
4:16 pm - 9:03 pm
FLO
-
PDX
7h 47m
1 stop
$599American Airlines
Tue, May 5 - Sun, May 17
American Airlines Logo
7:13 am - 10:42 pm
PDX
-
FLO
12h 29m
2 stops
American Airlines Logo
4:16 pm - 11:57 pm
FLO
-
PDX
10h 41m
2 stops
$604American Airlines
Tue, May 5 - Sun, May 17
American Airlines Logo
11:23 pm - 11:53 pm
PDX
-
FLO
21h 30m
1 stop
American Airlines Logo
5:24 am - 9:03 pm
FLO
-
PDX
18h 39m
1 stop
$839American Airlines
Tue, May 5 - Sun, May 17

American Airlines flights from Portland to Florence, South Carolina

Our best American Airlines deals on Portland to Florence, South Carolina flight tickets
American Airlines
May 5
PDX6:00 amPortland
13h 42m
2 stops
FLO10:42 pmFlorence
May 17
FLO4:16 pmFlorence
7h 47m
1 stop
PDX9:03 pmPortland
$599
American Airlines
May 5
PDX7:13 amPortland
12h 29m
2 stops
FLO10:42 pmFlorence
May 17
FLO4:16 pmFlorence
10h 41m
2 stops
PDX11:57 pmPortland
$604
American Airlines
May 5
PDX11:23 pmPortland
21h 30m
1 stop
FLO11:53 pmFlorence
May 17
FLO5:24 amFlorence
18h 39m
1 stop
PDX9:03 pmPortland
$839

momondo Fare Finder

 
Customize your flight search to find flights from Portland to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Portland to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Tue 5/5

6:00 am-10:42 pm

2 stops13h 42m

Florence

Sun 5/17

4:16 pm-9:03 pm

1 stop7h 47m

$599

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Tue 5/5

7:13 am-10:42 pm

2 stops12h 29m

Florence

Sun 5/17

4:16 pm-11:57 pm

2 stops10h 41m

$604

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Tue 5/5

11:23 pm-11:53 pm

1 stop21h 30m

Florence

Sun 5/17

5:24 am-9:03 pm

1 stop18h 39m

$839

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Mon 3/16

11:59 pm-5:21 pm

2 stops14h 22m

$292

PortlandFlorence

PDX - FLO

PDXFLO

Portland

Mon 3/16

9:44 pm-11:08 pm

1 stop22h 24m

$873

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Portland to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Portland to Florence?

American Airlines is the most popular carrier operating from Portland to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Florence, South Carolina from Portland according to our data. American Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Portland to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Portland to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland to Florence, South Carolina (PDX to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland to Florence, South Carolina

Fastest flight time

13h 42m

Direct flights

None
The fastest flight from Portland to Florence, South Carolina takes 13h 42m
There are no direct flights from Portland to Florence, South Carolina. There are no popular flight routes from Portland to Florence, South Carolina.
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  • How far is Portland to Florence by plane?

    There are 2372.9 mi between Portland and Florence. In terms of flight time, this usually takes a little over 13h 42m.

  • When did momondo last update prices for flights from Portland Airport to Florence Airport?

    Prices for flights from Portland Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Portland Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Portland to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Portland to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Portland with this policy.

How can momondo help me find flights from Portland to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Portland.

I’m not ready to book a flight from Portland to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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