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Cheap flights from Palermo to San Francisco from $454

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Palermo to San Francisco departing on 10/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Palermo to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
ITA Airways Logo
7:05 pm - 1:15 pmPMO  Palermo Punta Raisi-SFO San Francisco
27h 10m1 stop Rome Fiumicino
ITA Airways Logo
3:15 pm - 3:15 pmSFO  San Francisco-PMO Palermo Punta Raisi
15h 00m1 stop Rome Fiumicino
$572ITA Airways
Mon, Sep 28 - Mon, Oct 5
ITA Airways Logo
6:10 am - 1:05 pmPMO  Palermo Punta Raisi-SFO San Francisco
15h 55m1 stop Rome Fiumicino
ITA Airways Logo
3:05 pm - 11:10 pmSFO  San Francisco-PMO Palermo Punta Raisi
23h 05m1 stop Rome Fiumicino
$572ITA Airways
Tue, Nov 24 - Thu, Dec 3
ITA Airways Logo
7:15 am - 1:15 pmPMO  Palermo Punta Raisi-SFO San Francisco
15h 00m1 stop Rome Fiumicino
ITA Airways Logo
3:15 pm - 9:05 amSFO  San Francisco-PMO Palermo Punta Raisi
32h 50m1 stop Rome Fiumicino
$574ITA Airways
Sun, Sep 6 - Sun, Sep 13
ITA Airways Logo
6:10 am - 1:15 pmPMO  Palermo Punta Raisi-SFO San Francisco
16h 05m1 stop Rome Fiumicino
ITA Airways Logo
3:15 pm - 9:05 pmSFO  San Francisco-PMO Palermo Punta Raisi
20h 50m1 stop Rome Fiumicino
$574ITA Airways
Thu, Sep 24 - Mon, Sep 28
Multiple Airlines Logo
6:10 am - 5:54 pmPMO  Palermo Punta Raisi-SFO San Francisco
20h 44m2 stops Rome Fiumicino Los Angeles
Multiple Airlines Logo
3:05 pm - 11:10 pmSFO  San Francisco-PMO Palermo Punta Raisi
23h 05m1 stop Rome Fiumicino
$574Multiple Airlines
Tue, Nov 24 - Thu, Dec 3
ITA Airways Logo
7:05 pm - 1:15 pmPMO  Palermo Punta Raisi-SFO San Francisco
27h 10m1 stop Rome Fiumicino
ITA Airways Logo
3:15 pm - 9:05 amSFO  San Francisco-PMO Palermo Punta Raisi
32h 50m1 stop Rome Fiumicino
$576ITA Airways
Thu, Sep 3 - Mon, Sep 7
ITA Airways Logo
6:10 am - 1:15 pmPMO  Palermo Punta Raisi-SFO San Francisco
16h 05m1 stop Rome Fiumicino
ITA Airways Logo
3:15 pm - 10:30 pmSFO  San Francisco-PMO Palermo Punta Raisi
22h 15m1 stop Rome Fiumicino
$599ITA Airways
Thu, Sep 10 - Thu, Sep 17
ITA Airways Logo
6:10 am - 1:15 pmPMO  Palermo Punta Raisi-SFO San Francisco
16h 05m1 stop Rome Fiumicino
ITA Airways Logo
3:15 pm - 6:20 pmSFO  San Francisco-PMO Palermo Punta Raisi
18h 05m1 stop Rome Fiumicino
$600ITA Airways
Fri, Sep 4 - Sat, Sep 19
Multiple Airlines Logo
7:50 pm - 7:48 pmPMO  Palermo Punta Raisi-SFO San Francisco
32h 58m2 stops Madrid Barajas Chicago O'Hare Intl
Multiple Airlines Logo
4:35 pm - 6:40 pmSFO  San Francisco-PMO Palermo Punta Raisi
17h 05m1 stop London Heathrow
$603Multiple Airlines
Thu, Sep 3 - Thu, Sep 10
SWISS Logo
9:45 am - 4:15 pmPMO  Palermo Punta Raisi-SFO San Francisco
15h 30m1 stop Zurich
SWISS Logo
7:35 pm - 9:00 amSFO  San Francisco-PMO Palermo Punta Raisi
28h 25m1 stop Zurich
$608SWISS
Thu, Sep 3 - Mon, Sep 7

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ITA Airways flights from Palermo to San Francisco

Our best ITA Airways deals on Palermo to San Francisco flight tickets
ITA Airways
Sep 28
PMO7:05 pmPalermo Punta Raisi
27h 10m
1 stop
SFO1:15 pmSan Francisco
Oct 5
SFO3:15 pmSan Francisco
15h 00m
1 stop
PMO3:15 pmPalermo Punta Raisi
$572
ITA Airways
Sep 6
PMO7:15 amPalermo Punta Raisi
15h 00m
1 stop
SFO1:15 pmSan Francisco
Sep 13
SFO3:15 pmSan Francisco
32h 50m
1 stop
PMO9:05 amPalermo Punta Raisi
$574
ITA Airways
Sep 10
PMO6:10 amPalermo Punta Raisi
16h 05m
1 stop
SFO1:15 pmSan Francisco
Sep 17
SFO3:15 pmSan Francisco
22h 15m
1 stop
PMO10:30 pmPalermo Punta Raisi
$599

SWISS flights from Palermo to San Francisco

Our best SWISS deals on Palermo to San Francisco flight tickets
SWISS
Sep 3
PMO9:45 amPalermo Punta Raisi
15h 30m
1 stop
SFO4:15 pmSan Francisco
Sep 7
SFO7:35 pmSan Francisco
28h 25m
1 stop
PMO9:00 amPalermo Punta Raisi
$608
SWISS
Sep 3
PMO2:55 pmPalermo Punta Raisi
34h 20m
1 stop
SFO4:15 pmSan Francisco
Sep 10
SFO7:35 pmSan Francisco
28h 25m
1 stop
PMO9:00 amPalermo Punta Raisi
$748

momondo Fare Finder

 
Customize your flight search to find flights from Palermo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Palermo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Mon 9/28

7:05 pm-1:15 pm

1 stop27h 10m

San Francisco

Mon 10/5

3:15 pm-3:15 pm

1 stop15h 00m

$572

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Tue 11/24

6:10 am-1:05 pm

1 stop15h 55m

San Francisco

Thu 12/3

3:05 pm-11:10 pm

1 stop23h 05m

$572

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Sun 9/6

7:15 am-1:15 pm

1 stop15h 00m

San Francisco

Sun 9/13

3:15 pm-9:05 am

1 stop32h 50m

$574

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Thu 9/24

6:10 am-1:15 pm

1 stop16h 05m

San Francisco

Mon 9/28

3:15 pm-9:05 pm

1 stop20h 50m

$574

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Tue 11/24

6:10 am-5:54 pm

2 stops20h 44m

San Francisco

Thu 12/3

3:05 pm-11:10 pm

1 stop23h 05m

$574

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Thu 9/3

7:05 pm-1:15 pm

1 stop27h 10m

San Francisco

Mon 9/7

3:15 pm-9:05 am

1 stop32h 50m

$576

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Thu 9/10

6:10 am-1:15 pm

1 stop16h 05m

San Francisco

Thu 9/17

3:15 pm-10:30 pm

1 stop22h 15m

$599
Quickest round-trip

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Fri 9/4

6:10 am-1:15 pm

1 stop16h 05m

San Francisco

Sat 9/19

3:15 pm-6:20 pm

1 stop18h 05m

$600

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Thu 9/3

7:50 pm-7:48 pm

2 stops32h 58m

San Francisco

Thu 9/10

4:35 pm-6:40 pm

1 stop17h 05m

$603

PalermoSan Francisco

PMO Palermo Punta Raisi - SFO San Francisco

PMOSFO

Palermo Punta Raisi

Thu 9/3

9:45 am-4:15 pm

1 stop15h 30m

San Francisco

Mon 9/7

7:35 pm-9:00 am

1 stop28h 25m

$608

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Palermo to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Palermo to San Francisco flights?

You could potentially save up to 18% on your flight if you consider stops on a Palermo to San Francisco flight.

When to book flights from Palermo to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Palermo to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Palermo to San Francisco (PMO to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Palermo to San Francisco

Fastest flight time

15h 30m

Direct flights

None
The fastest flight from Palermo to San Francisco takes 15h 30m
There are no direct flights from Palermo to San Francisco. There are no popular flight routes from Palermo to San Francisco.
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Frequently asked questions about flying from Palermo to San Francisco

  • How far is Palermo Punta Raisi to San Francisco by plane?

    San Francisco is 6480.7 mi away from Palermo Punta Raisi. A reasonable flight in good conditions will take 15h 30m.

  • When did momondo last update prices for flights from Palermo Punta Raisi Airport to San Francisco Airport?

    Prices for flights from Palermo Punta Raisi Airport to San Francisco Airport were last updated today.

  • How old do you have to be to fly from Palermo Punta Raisi Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Palermo Punta Raisi Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Berkeley
Bodega Bay
Hayward
Walnut Creek
Santa Clara
Vallejo
Roseville
Sonoma
Salinas
Sunnyvale
Milpitas
Daly City
Burlingame
Marina
Palo Alto

Why use momondo?

Why should I use momondo to find a flight deal from Palermo to San Francisco?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Palermo to San Francisco for you.

Can I find flights from Palermo to San Francisco with flexible booking policies on momondo?

All flight searches from Palermo to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Palermo to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Palermo. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Palermo to San Francisco right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Palermo to San Francisco now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Francisco and let you know when they change.

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