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Cheap flights from Myrtle Beach to San Francisco from $154

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Francisco departing on 12/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
1:25 pm - 7:10 pm
MYR
-
SFO
8h 45m1 stop
Southwest Logo
9:30 pm - 10:00 am
SFO
-
MYR
9h 30m1 stop
$385Southwest
Sat, Jan 31 - Thu, Feb 5
Southwest Logo
1:25 pm - 8:35 pm
MYR
-
SFO
10h 10m2 stops
Southwest Logo
6:25 am - 6:00 pm
SFO
-
MYR
8h 35m1 stop
$390Southwest
Sat, Jan 31 - Thu, Feb 5
Southwest Logo
7:40 am - 4:35 pm
MYR
-
SFO
11h 55m2 stops
Southwest Logo
5:55 pm - 10:00 am
SFO
-
MYR
13h 05m2 stops
$395Southwest
Sat, Jan 31 - Thu, Feb 5
American Airlines Logo
5:44 pm - 11:12 pm
MYR
-
SFO
8h 28m1 stop
American Airlines Logo
6:00 am - 5:04 pm
SFO
-
MYR
8h 04m1 stop
$399American Airlines
Tue, Jan 6 - Sat, Jan 10
American Airlines Logo
5:44 pm - 11:12 pm
MYR
-
SFO
8h 28m1 stop
American Airlines Logo
6:00 am - 8:54 pm
SFO
-
MYR
11h 54m2 stops
$404American Airlines
Tue, Jan 6 - Sat, Jan 10
Delta Logo
1:01 pm - 7:07 pm
MYR
-
SFO
9h 06m1 stop
Delta Logo
10:35 pm - 9:38 am
SFO
-
MYR
8h 03m1 stop
$447Delta
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
5:44 pm - 11:12 pm
MYR
-
SFO
8h 28m1 stop
American Airlines Logo
11:36 pm - 9:48 am
SFO
-
MYR
7h 12m1 stop
$448American Airlines
Tue, Jan 6 - Sun, Jan 11
American Airlines Logo
10:20 am - 7:16 pm
MYR
-
SFO
11h 56m2 stops
American Airlines Logo
9:14 am - 8:45 pm
SFO
-
MYR
8h 31m1 stop
$452American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
5:44 pm - 11:12 pm
MYR
-
SFO
8h 28m1 stop
American Airlines Logo
6:42 am - 8:54 pm
SFO
-
MYR
11h 12m2 stops
$453American Airlines
Tue, Jan 6 - Sun, Jan 11
American Airlines Logo
6:54 am - 3:45 pm
MYR
-
SFO
11h 51m2 stops
American Airlines Logo
12:30 am - 1:28 pm
SFO
-
MYR
9h 58m2 stops
$457American Airlines
Tue, Mar 24 - Mon, Mar 30

Delta flights from Myrtle Beach to San Francisco

Our best Delta deals on Myrtle Beach to San Francisco flight tickets
Delta
Mar 24
MYR1:01 pmMyrtle Beach Intl
9h 06m
1 stop
SFO7:07 pmSan Francisco
Mar 31
SFO10:35 pmSan Francisco
8h 03m
1 stop
MYR9:38 amMyrtle Beach Intl
$447
Find similar
Delta
Dec 31
MYR5:12 pmMyrtle Beach Intl
9h 45m
1 stop
SFO11:57 pmSan Francisco
Jan 4
SFO11:45 pmSan Francisco
7h 01m
1 stop
MYR9:46 amMyrtle Beach Intl
$643
Find similar
Delta
Dec 22
MYR6:00 amMyrtle Beach Intl
7h 43m
1 stop
SFO10:43 amSan Francisco
Dec 28
SFO11:45 pmSan Francisco
7h 39m
1 stop
MYR10:24 amMyrtle Beach Intl
$732
Find similar

American Airlines flights from Myrtle Beach to San Francisco

Our best American Airlines deals on Myrtle Beach to San Francisco flight tickets
American Airlines
Jan 6
MYR5:44 pmMyrtle Beach Intl
8h 28m
1 stop
SFO11:12 pmSan Francisco
Jan 10
SFO6:00 amSan Francisco
8h 04m
1 stop
MYR5:04 pmMyrtle Beach Intl
$399
Find similar
American Airlines
Jan 6
MYR5:44 pmMyrtle Beach Intl
8h 28m
1 stop
SFO11:12 pmSan Francisco
Jan 10
SFO6:00 amSan Francisco
11h 54m
2 stops
MYR8:54 pmMyrtle Beach Intl
$404
Find similar
American Airlines
Jan 6
MYR5:44 pmMyrtle Beach Intl
8h 28m
1 stop
SFO11:12 pmSan Francisco
Jan 11
SFO11:36 pmSan Francisco
7h 12m
1 stop
MYR9:48 amMyrtle Beach Intl
$448
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 1/31

1:25 pm-7:10 pm

1 stop8h 45m

San Francisco

Thu 2/5

9:30 pm-10:00 am

1 stop9h 30m

$385

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 1/31

1:25 pm-8:35 pm

2 stops10h 10m

San Francisco

Thu 2/5

6:25 am-6:00 pm

1 stop8h 35m

$390

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 1/31

7:40 am-4:35 pm

2 stops11h 55m

San Francisco

Thu 2/5

5:55 pm-10:00 am

2 stops13h 05m

$395

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 1/6

5:44 pm-11:12 pm

1 stop8h 28m

San Francisco

Sat 1/10

6:00 am-5:04 pm

1 stop8h 04m

$399

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 1/6

5:44 pm-11:12 pm

1 stop8h 28m

San Francisco

Sat 1/10

6:00 am-8:54 pm

2 stops11h 54m

$404

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

1:01 pm-7:07 pm

1 stop9h 06m

San Francisco

Tue 3/31

10:35 pm-9:38 am

1 stop8h 03m

$447

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 1/6

5:44 pm-11:12 pm

1 stop8h 28m

San Francisco

Sun 1/11

11:36 pm-9:48 am

1 stop7h 12m

$448

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

10:20 am-7:16 pm

2 stops11h 56m

San Francisco

Tue 3/31

9:14 am-8:45 pm

1 stop8h 31m

$452

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 1/6

5:44 pm-11:12 pm

1 stop8h 28m

San Francisco

Sun 1/11

6:42 am-8:54 pm

2 stops11h 12m

$453

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

6:54 am-3:45 pm

2 stops11h 51m

San Francisco

Mon 3/30

12:30 am-1:28 pm

2 stops9h 58m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Myrtle Beach to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of April, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $392.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Myrtle Beach to San Francisco is on a Thursday when prices can be found for as low as $412. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $546.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Myrtle Beach to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $457. Flights in the afternoon are often more expensive with an average ticket price of $492.

How have Myrtle Beach to San Francisco flight prices changed over time?

As of December 2025, prices for Myrtle Beach to San Francisco flights are approximately 74% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Francisco (MYR to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Francisco

Fastest flight time

7h 40m

Direct flights

None
The fastest flight from Myrtle Beach to San Francisco takes 7h 40m
There are no direct flights from Myrtle Beach to San Francisco. There are no popular flight routes from Myrtle Beach to San Francisco.
Search flight deals

  • How far is Myrtle Beach Intl to San Francisco by plane?

    The straight-line distance from Myrtle Beach Intl to San Francisco is 2433.7 mi. In terms of flight time, this usually takes a little over 7h 40m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Francisco Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Francisco?

Best airlines flying from Myrtle Beach to San Francisco

Compare and see reviews for airlines that fly from Myrtle Beach to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $250Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $306Free CancellationRating
7.2
11,049 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Berkeley
Santa Clara
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Salinas
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Francisco?

Finding the right flight to San Francisco from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to San Francisco?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Francisco from Myrtle Beach.

I’m not ready to book a flight from Myrtle Beach to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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