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Cheap flights from Myrtle Beach to San Francisco from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Francisco departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Myrtle Beach to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:27 am - 6:14 pm
MYR
-
SFO
9h 47m
1 stop
Delta Logo
2:00 pm - 11:55 pm
SFO
-
MYR
6h 55m
1 stop
$403Delta
Wed, Jul 15 - Tue, Jul 21
Southwest Logo
7:50 am - 12:55 pm
MYR
-
SFO
8h 05m
1 stop
Southwest Logo
7:25 pm - 10:05 am
SFO
-
MYR
11h 40m
2 stops
$408Southwest
Wed, Sep 16 - Tue, Sep 29
United Airlines Logo
11:24 am - 5:19 pm
MYR
-
SFO
8h 55m
1 stop
United Airlines Logo
12:50 am - 2:12 pm
SFO
-
MYR
10h 22m
1 stop
$409United Airlines
Thu, Jun 4 - Mon, Jun 8
Southwest Logo
2:25 pm - 10:20 pm
MYR
-
SFO
10h 55m
2 stops
Southwest Logo
11:05 pm - 1:50 pm
SFO
-
MYR
11h 45m
2 stops
$413Southwest
Wed, Sep 16 - Tue, Sep 29
Southwest Logo
2:10 pm - 10:25 pm
MYR
-
SFO
11h 15m
2 stops
Southwest Logo
5:15 am - 9:45 pm
SFO
-
MYR
13h 30m
1 stop
$414Southwest
Wed, Jul 15 - Tue, Jul 21
American Airlines Logo
5:18 pm - 12:48 am
MYR
-
SFO
10h 30m
1 stop
American Airlines Logo
12:39 pm - 12:10 am
SFO
-
MYR
8h 31m
1 stop
$415American Airlines
Sat, May 30 - Sat, Jun 6
Delta Logo
2:15 pm - 7:24 pm
MYR
-
SFO
8h 09m
1 stop
Delta Logo
10:45 pm - 10:26 am
SFO
-
MYR
8h 41m
1 stop
$419Delta
Wed, Sep 9 - Mon, Sep 21
Delta Logo
11:42 am - 11:19 pm
MYR
-
SFO
14h 37m
2 stops
Delta Logo
6:00 am - 4:40 pm
SFO
-
MYR
7h 40m
1 stop
$423Delta
Tue, Jul 14 - Wed, Jul 22
Delta Logo
2:15 pm - 7:24 pm
MYR
-
SFO
8h 09m
1 stop
Delta Logo
11:45 pm - 10:09 am
SFO
-
MYR
7h 24m
1 stop
$425Delta
Thu, Sep 10 - Sat, Sep 26
Southwest Logo
7:10 am - 4:20 pm
MYR
-
SFO
12h 10m
2 stops
Southwest Logo
5:20 am - 9:05 pm
SFO
-
MYR
12h 45m
1 stop
$426Southwest
Sat, May 30 - Sat, Jun 6

Delta flights from Myrtle Beach to San Francisco

Our best Delta deals on Myrtle Beach to San Francisco flight tickets
Delta
Jul 15
MYR11:27 amMyrtle Beach Intl
9h 47m
1 stop
SFO6:14 pmSan Francisco
Jul 21
SFO2:00 pmSan Francisco
6h 55m
1 stop
MYR11:55 pmMyrtle Beach Intl
$403
Delta
Sep 9
MYR10:55 amMyrtle Beach Intl
9h 00m
1 stop
SFO4:55 pmSan Francisco
Sep 24
SFO9:30 pmSan Francisco
9h 39m
1 stop
MYR10:09 amMyrtle Beach Intl
$419
Delta
Jul 14
MYR6:00 amMyrtle Beach Intl
15h 52m
2 stops
SFO6:52 pmSan Francisco
Jul 21
SFO7:50 amSan Francisco
8h 17m
1 stop
MYR7:07 pmMyrtle Beach Intl
$423

American Airlines flights from Myrtle Beach to San Francisco

Our best American Airlines deals on Myrtle Beach to San Francisco flight tickets
American Airlines
May 30
MYR5:18 pmMyrtle Beach Intl
10h 30m
1 stop
SFO12:48 amSan Francisco
Jun 6
SFO12:39 pmSan Francisco
8h 31m
1 stop
MYR12:10 amMyrtle Beach Intl
$415
American Airlines
Jul 10
MYR4:16 pmMyrtle Beach Intl
9h 32m
1 stop
SFO10:48 pmSan Francisco
Jul 15
SFO5:29 amSan Francisco
7h 09m
1 stop
MYR3:38 pmMyrtle Beach Intl
$435
American Airlines
Jul 10
MYR6:10 pmMyrtle Beach Intl
7h 38m
1 stop
SFO10:48 pmSan Francisco
Jul 15
SFO5:29 amSan Francisco
8h 56m
2 stops
MYR5:25 pmMyrtle Beach Intl
$480

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 7/15

11:27 am-6:14 pm

1 stop9h 47m

San Francisco

Tue 7/21

2:00 pm-11:55 pm

1 stop6h 55m

$403

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 9/16

7:50 am-12:55 pm

1 stop8h 05m

San Francisco

Tue 9/29

7:25 pm-10:05 am

2 stops11h 40m

$408

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 6/4

11:24 am-5:19 pm

1 stop8h 55m

San Francisco

Mon 6/8

12:50 am-2:12 pm

1 stop10h 22m

$409

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 9/16

2:25 pm-10:20 pm

2 stops10h 55m

San Francisco

Tue 9/29

11:05 pm-1:50 pm

2 stops11h 45m

$413

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 7/15

2:10 pm-10:25 pm

2 stops11h 15m

San Francisco

Tue 7/21

5:15 am-9:45 pm

1 stop13h 30m

$414

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 5/30

5:18 pm-12:48 am

1 stop10h 30m

San Francisco

Sat 6/6

12:39 pm-12:10 am

1 stop8h 31m

$415

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 9/9

2:15 pm-7:24 pm

1 stop8h 09m

San Francisco

Mon 9/21

10:45 pm-10:26 am

1 stop8h 41m

$419

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 7/14

11:42 am-11:19 pm

2 stops14h 37m

San Francisco

Wed 7/22

6:00 am-4:40 pm

1 stop7h 40m

$423
Quickest round-trip

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 9/10

2:15 pm-7:24 pm

1 stop8h 09m

San Francisco

Sat 9/26

11:45 pm-10:09 am

1 stop7h 24m

$425

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 5/30

7:10 am-4:20 pm

2 stops12h 10m

San Francisco

Sat 6/6

5:20 am-9:05 pm

1 stop12h 45m

$426

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Myrtle Beach to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $428.

How have Myrtle Beach to San Francisco flight prices changed over time?

As of May 2026, prices for Myrtle Beach to San Francisco flights are approximately 0% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Francisco (MYR to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Francisco

Fastest flight time

7h 10m

Direct flights

None
The fastest flight from Myrtle Beach to San Francisco takes 7h 10m
There are no direct flights from Myrtle Beach to San Francisco. There are no popular flight routes from Myrtle Beach to San Francisco.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to San Francisco

  • How far is Myrtle Beach Intl to San Francisco by plane?

    The straight-line distance from Myrtle Beach Intl to San Francisco is 2433.2 mi. In terms of flight time, this usually takes a little over 7h 10m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Francisco Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Francisco?

Best airlines flying from Myrtle Beach to San Francisco

Compare and see reviews for airlines that fly from Myrtle Beach to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $306Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights
DeltaPriceFrom $312Free CancellationRating
7.9
8,456 reviews
Search Delta flights
SouthwestPriceFrom $382Free CancellationRating
7.9
4,302 reviews
Search Southwest flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Berkeley
Hayward
Santa Clara
Fremont
Vallejo
Big Sur
Calistoga
Sunnyvale
South San Francisco
Salinas
Daly City
Half Moon Bay
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Francisco?

Finding the right flight to San Francisco from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to San Francisco?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Francisco from Myrtle Beach.

I’m not ready to book a flight from Myrtle Beach to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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