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Cheap flights from Myrtle Beach to San Francisco from $185

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Francisco departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:11 am - 3:46 pm
MYR
-
SFO
7h 35m
1 stop
American Airlines Logo
10:28 pm - 8:24 am
SFO
-
MYR
6h 56m
1 stop
$383American Airlines
Wed, Apr 15 - Wed, Apr 22
Southwest Logo
2:10 pm - 9:25 pm
MYR
-
SFO
10h 15m
1 stop
Southwest Logo
5:25 am - 8:30 pm
SFO
-
MYR
12h 05m
2 stops
$388Southwest
Wed, Apr 15 - Wed, Apr 22
Southwest Logo
4:05 pm - 11:15 pm
MYR
-
SFO
10h 10m
2 stops
Southwest Logo
5:25 am - 8:30 pm
SFO
-
MYR
12h 05m
2 stops
$393Southwest
Wed, Apr 15 - Wed, Apr 22
American Airlines Logo
4:52 pm - 10:04 pm
MYR
-
SFO
8h 12m
1 stop
American Airlines Logo
6:40 pm - 8:24 am
SFO
-
MYR
10h 44m
2 stops
$405American Airlines
Tue, May 5 - Wed, May 6
Southwest Logo
4:05 pm - 8:55 pm
MYR
-
SFO
7h 50m
1 stop
Southwest Logo
9:15 pm - 10:05 am
SFO
-
MYR
9h 50m
1 stop
$425Southwest
Wed, Apr 15 - Sun, Apr 19
American Airlines Logo
10:33 am - 7:04 pm
MYR
-
SFO
11h 31m
2 stops
American Airlines Logo
9:00 am - 10:24 pm
SFO
-
MYR
10h 24m
2 stops
$427American Airlines
Tue, May 5 - Wed, May 6
Southwest Logo
2:10 pm - 10:05 pm
MYR
-
SFO
10h 55m
2 stops
Southwest Logo
5:20 am - 4:10 pm
SFO
-
MYR
7h 50m
1 stop
$430Southwest
Wed, Apr 15 - Sun, Apr 19
Southwest Logo
4:05 pm - 8:55 pm
MYR
-
SFO
7h 50m
1 stop
Southwest Logo
5:20 am - 4:10 pm
SFO
-
MYR
7h 50m
1 stop
$432Southwest
Wed, Apr 29 - Sun, May 3
Southwest Logo
2:10 pm - 10:10 pm
MYR
-
SFO
11h 00m
2 stops
Southwest Logo
11:25 pm - 4:10 pm
SFO
-
MYR
13h 45m
2 stops
$435Southwest
Wed, May 13 - Fri, May 15
Southwest Logo
4:05 pm - 11:15 pm
MYR
-
SFO
10h 10m
2 stops
Southwest Logo
5:20 am - 4:10 pm
SFO
-
MYR
7h 50m
1 stop
$437Southwest
Wed, Apr 29 - Sun, May 3

American Airlines flights from Myrtle Beach to San Francisco

Our best American Airlines deals on Myrtle Beach to San Francisco flight tickets
American Airlines
Apr 15
MYR11:11 amMyrtle Beach Intl
7h 35m
1 stop
SFO3:46 pmSan Francisco
Apr 22
SFO10:28 pmSan Francisco
6h 56m
1 stop
MYR8:24 amMyrtle Beach Intl
$383
American Airlines
May 5
MYR4:52 pmMyrtle Beach Intl
8h 12m
1 stop
SFO10:04 pmSan Francisco
May 6
SFO6:40 pmSan Francisco
10h 44m
2 stops
MYR8:24 amMyrtle Beach Intl
$405
American Airlines
May 5
MYR10:33 amMyrtle Beach Intl
11h 31m
2 stops
SFO7:04 pmSan Francisco
May 6
SFO9:00 amSan Francisco
10h 24m
2 stops
MYR10:24 pmMyrtle Beach Intl
$427

Delta flights from Myrtle Beach to San Francisco

Our best Delta deals on Myrtle Beach to San Francisco flight tickets
Delta
May 4
MYR7:03 pmMyrtle Beach Intl
7h 52m
1 stop
SFO11:55 pmSan Francisco
May 10
SFO1:45 pmSan Francisco
7h 13m
1 stop
MYR11:58 pmMyrtle Beach Intl
$441
Delta
Jun 3
MYR11:32 amMyrtle Beach Intl
9h 17m
1 stop
SFO5:49 pmSan Francisco
Jun 7
SFO11:45 pmSan Francisco
7h 41m
1 stop
MYR10:26 amMyrtle Beach Intl
$443
Delta
Jun 3
MYR1:30 pmMyrtle Beach Intl
8h 35m
1 stop
SFO7:05 pmSan Francisco
Jun 7
SFO10:30 pmSan Francisco
9h 03m
1 stop
MYR10:33 amMyrtle Beach Intl
$485

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/15

11:11 am-3:46 pm

1 stop7h 35m

San Francisco

Wed 4/22

10:28 pm-8:24 am

1 stop6h 56m

$383

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/15

2:10 pm-9:25 pm

1 stop10h 15m

San Francisco

Wed 4/22

5:25 am-8:30 pm

2 stops12h 05m

$388

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/15

4:05 pm-11:15 pm

2 stops10h 10m

San Francisco

Wed 4/22

5:25 am-8:30 pm

2 stops12h 05m

$393

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 5/5

4:52 pm-10:04 pm

1 stop8h 12m

San Francisco

Wed 5/6

6:40 pm-8:24 am

2 stops10h 44m

$405

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/15

4:05 pm-8:55 pm

1 stop7h 50m

San Francisco

Sun 4/19

9:15 pm-10:05 am

1 stop9h 50m

$425

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 5/5

10:33 am-7:04 pm

2 stops11h 31m

San Francisco

Wed 5/6

9:00 am-10:24 pm

2 stops10h 24m

$427

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/15

2:10 pm-10:05 pm

2 stops10h 55m

San Francisco

Sun 4/19

5:20 am-4:10 pm

1 stop7h 50m

$430

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/29

4:05 pm-8:55 pm

1 stop7h 50m

San Francisco

Sun 5/3

5:20 am-4:10 pm

1 stop7h 50m

$432

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 5/13

2:10 pm-10:10 pm

2 stops11h 00m

San Francisco

Fri 5/15

11:25 pm-4:10 pm

2 stops13h 45m

$435

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/29

4:05 pm-11:15 pm

2 stops10h 10m

San Francisco

Sun 5/3

5:20 am-4:10 pm

1 stop7h 50m

$437

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Myrtle Beach to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $391.

How have Myrtle Beach to San Francisco flight prices changed over time?

As of March 2026, prices for Myrtle Beach to San Francisco flights are approximately 57% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Francisco (MYR to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Francisco

Fastest flight time

7h 35m

Direct flights

None
The fastest flight from Myrtle Beach to San Francisco takes 7h 35m
There are no direct flights from Myrtle Beach to San Francisco. There are no popular flight routes from Myrtle Beach to San Francisco.
Search flight deals

  • How far is Myrtle Beach Intl to San Francisco by plane?

    The straight-line distance from Myrtle Beach Intl to San Francisco is 2433.7 mi. In terms of flight time, this usually takes a little over 7h 35m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Francisco Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Francisco?

Best airlines flying from Myrtle Beach to San Francisco

Compare and see reviews for airlines that fly from Myrtle Beach to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $312Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights
DeltaPriceFrom $312Free CancellationRating
7.9
8,314 reviews
Search Delta flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Big Sur
Fremont
Calistoga
Vallejo
Salinas
Half Moon Bay
Daly City
Milpitas
Pacific Grove
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Francisco?

Finding the right flight to San Francisco from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to San Francisco?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Francisco from Myrtle Beach.

I’m not ready to book a flight from Myrtle Beach to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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