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Cheap flights from Myrtle Beach to San Francisco from $180

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Francisco departing on 2/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:17 pm - 11:10 pm
MYR
-
SFO
10h 53m
1 stop
American Airlines Logo
6:00 am - 4:33 pm
SFO
-
MYR
7h 33m
1 stop
$359American Airlines
Thu, Feb 12 - Mon, Feb 16
American Airlines Logo
3:17 pm - 8:56 pm
MYR
-
SFO
8h 39m
1 stop
American Airlines Logo
7:00 pm - 9:36 am
SFO
-
MYR
11h 36m
2 stops
$364American Airlines
Thu, Feb 12 - Mon, Feb 16
Southwest Logo
8:15 am - 6:05 pm
MYR
-
SFO
12h 50m
2 stops
Southwest Logo
6:05 am - 7:45 pm
SFO
-
MYR
10h 40m
2 stops
$369Southwest
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
3:17 pm - 11:14 pm
MYR
-
SFO
10h 57m
2 stops
American Airlines Logo
6:00 am - 8:45 pm
SFO
-
MYR
11h 45m
2 stops
$370American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
6:30 pm - 11:15 pm
MYR
-
SFO
7h 45m
1 stop
American Airlines Logo
5:34 am - 4:06 pm
SFO
-
MYR
7h 32m
1 stop
$374American Airlines
Thu, Apr 23 - Wed, Apr 29
American Airlines Logo
6:30 pm - 11:15 pm
MYR
-
SFO
7h 45m
1 stop
American Airlines Logo
10:13 am - 10:24 pm
SFO
-
MYR
9h 11m
2 stops
$380American Airlines
Thu, Apr 23 - Wed, Apr 29
American Airlines Logo
5:38 pm - 11:25 pm
MYR
-
SFO
8h 47m
1 stop
American Airlines Logo
12:31 pm - 10:56 pm
SFO
-
MYR
7h 25m
1 stop
$389American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
10:26 am - 7:16 pm
MYR
-
SFO
11h 50m
2 stops
American Airlines Logo
12:31 pm - 10:56 pm
SFO
-
MYR
7h 25m
1 stop
$394American Airlines
Tue, Mar 24 - Tue, Mar 31
Southwest Logo
7:25 am - 4:00 pm
MYR
-
SFO
11h 35m
2 stops
Southwest Logo
4:30 pm - 10:15 am
SFO
-
MYR
14h 45m
2 stops
$399Southwest
Sat, Feb 21 - Tue, Feb 24
American Airlines Logo
10:26 am - 7:16 pm
MYR
-
SFO
11h 50m
2 stops
American Airlines Logo
7:00 pm - 8:32 am
SFO
-
MYR
10h 32m
2 stops
$400American Airlines
Tue, Mar 24 - Tue, Mar 31

American Airlines flights from Myrtle Beach to San Francisco

Our best American Airlines deals on Myrtle Beach to San Francisco flight tickets
American Airlines
Feb 12
MYR3:17 pmMyrtle Beach Intl
10h 53m
1 stop
SFO11:10 pmSan Francisco
Feb 16
SFO6:00 amSan Francisco
7h 33m
1 stop
MYR4:33 pmMyrtle Beach Intl
$359
American Airlines
Feb 12
MYR3:17 pmMyrtle Beach Intl
8h 39m
1 stop
SFO8:56 pmSan Francisco
Feb 16
SFO7:00 pmSan Francisco
11h 36m
2 stops
MYR9:36 amMyrtle Beach Intl
$364
American Airlines
Feb 20
MYR3:17 pmMyrtle Beach Intl
10h 57m
2 stops
SFO11:14 pmSan Francisco
Feb 24
SFO6:00 amSan Francisco
11h 45m
2 stops
MYR8:45 pmMyrtle Beach Intl
$370

Southwest flights from Myrtle Beach to San Francisco

Our best Southwest deals on Myrtle Beach to San Francisco flight tickets
Southwest
Feb 24
MYR8:15 amMyrtle Beach Intl
12h 50m
2 stops
SFO6:05 pmSan Francisco
Mar 3
SFO6:05 amSan Francisco
10h 40m
2 stops
MYR7:45 pmMyrtle Beach Intl
$369
Southwest
Feb 21
MYR7:25 amMyrtle Beach Intl
11h 35m
2 stops
SFO4:00 pmSan Francisco
Feb 24
SFO4:30 pmSan Francisco
14h 45m
2 stops
MYR10:15 amMyrtle Beach Intl
$399
Southwest
Mar 11
MYR3:40 pmMyrtle Beach Intl
11h 05m
2 stops
SFO11:45 pmSan Francisco
Mar 14
SFO9:20 pmSan Francisco
9h 30m
1 stop
MYR9:50 amMyrtle Beach Intl
$408

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 2/12

3:17 pm-11:10 pm

1 stop10h 53m

San Francisco

Mon 2/16

6:00 am-4:33 pm

1 stop7h 33m

$359

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 2/12

3:17 pm-8:56 pm

1 stop8h 39m

San Francisco

Mon 2/16

7:00 pm-9:36 am

2 stops11h 36m

$364

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 2/24

8:15 am-6:05 pm

2 stops12h 50m

San Francisco

Tue 3/3

6:05 am-7:45 pm

2 stops10h 40m

$369

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Fri 2/20

3:17 pm-11:14 pm

2 stops10h 57m

San Francisco

Tue 2/24

6:00 am-8:45 pm

2 stops11h 45m

$370

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 4/23

6:30 pm-11:15 pm

1 stop7h 45m

San Francisco

Wed 4/29

5:34 am-4:06 pm

1 stop7h 32m

$374

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 4/23

6:30 pm-11:15 pm

1 stop7h 45m

San Francisco

Wed 4/29

10:13 am-10:24 pm

2 stops9h 11m

$380

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

5:38 pm-11:25 pm

1 stop8h 47m

San Francisco

Tue 3/31

12:31 pm-10:56 pm

1 stop7h 25m

$389

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

10:26 am-7:16 pm

2 stops11h 50m

San Francisco

Tue 3/31

12:31 pm-10:56 pm

1 stop7h 25m

$394

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 2/21

7:25 am-4:00 pm

2 stops11h 35m

San Francisco

Tue 2/24

4:30 pm-10:15 am

2 stops14h 45m

$399

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

10:26 am-7:16 pm

2 stops11h 50m

San Francisco

Tue 3/31

7:00 pm-8:32 am

2 stops10h 32m

$400

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Myrtle Beach to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of April, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $392.

How have Myrtle Beach to San Francisco flight prices changed over time?

As of January 2026, prices for Myrtle Beach to San Francisco flights are approximately 8% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Francisco (MYR to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Francisco

Fastest flight time

7h 54m

Direct flights

None
The fastest flight from Myrtle Beach to San Francisco takes 7h 54m
There are no direct flights from Myrtle Beach to San Francisco. There are no popular flight routes from Myrtle Beach to San Francisco.
Search flight deals

  • How far is Myrtle Beach Intl to San Francisco by plane?

    The straight-line distance from Myrtle Beach Intl to San Francisco is 2433.7 mi. In terms of flight time, this usually takes a little over 7h 54m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Francisco Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Francisco Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Francisco?

Best airlines flying from Myrtle Beach to San Francisco

Compare and see reviews for airlines that fly from Myrtle Beach to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $250Free CancellationRating
7.9
8,128 reviews
Search Delta flights
American AirlinesPriceFrom $312Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Salinas
Vallejo
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Francisco?

Finding the right flight to San Francisco from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to San Francisco?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Francisco from Myrtle Beach.

I’m not ready to book a flight from Myrtle Beach to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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