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Cheap flights from Florida Keys to San Diego from $153

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florida Keys to San Diego departing on 3/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
3:51 pm - 11:26 pm
MIA
-
SAN
10h 35m
1 stop
Frontier Logo
6:54 pm - 7:50 am
SAN
-
MIA
9h 56m
1 stop
$308Frontier
Sat, Aug 1 - Wed, Aug 5
Frontier Logo
7:00 am - 10:28 pm
MIA
-
SAN
18h 28m
1 stop
Frontier Logo
6:33 pm - 5:38 am
SAN
-
MIA
32h 05m
2 stops
$309Frontier
Thu, Mar 19 - Sun, Mar 22
Multiple Airlines Logo
5:50 am - 12:02 am
MIA
-
SAN
21h 12m
1 stop
Multiple Airlines Logo
12:25 pm - 2:46 pm
SAN
-
MIA
23h 21m
2 stops
$310Multiple Airlines
Sun, Apr 12 - Thu, Apr 16
Frontier Logo
5:50 am - 9:14 pm
MIA
-
SAN
18h 24m
1 stop
Frontier Logo
9:18 pm - 5:34 pm
SAN
-
MIA
17h 16m
2 stops
$313Frontier
Wed, Mar 11 - Fri, Mar 13
Multiple Airlines Logo
7:05 am - 12:08 am
MIA
-
SAN
20h 03m
2 stops
Multiple Airlines Logo
6:55 am - 4:29 pm
SAN
-
MIA
30h 34m
1 stop
$316Multiple Airlines
Thu, Mar 5 - Sun, Mar 8
Delta Logo
7:30 am - 12:50 pm
EYW
-
SAN
8h 20m
1 stop
Delta Logo
9:30 pm - 10:53 am
SAN
-
EYW
10h 23m
1 stop
$335Delta
Thu, May 28 - Sun, May 31
United Airlines Logo
4:38 pm - 9:26 pm
EYW
-
SAN
7h 48m
1 stop
United Airlines Logo
6:15 am - 3:57 pm
SAN
-
EYW
6h 42m
1 stop
$359United Airlines
Fri, Apr 10 - Wed, Apr 15
United Airlines Logo
4:38 pm - 9:26 pm
EYW
-
SAN
7h 48m
1 stop
United Airlines Logo
6:15 am - 3:57 pm
SAN
-
EYW
6h 42m
1 stop
$389United Airlines
Thu, Apr 9 - Wed, Apr 15
American Airlines Logo
2:29 pm - 10:00 pm
EYW
-
SAN
10h 31m
1 stop
American Airlines Logo
10:40 pm - 6:16 pm
SAN
-
EYW
16h 36m
1 stop
$476American Airlines
Thu, Apr 9 - Thu, Apr 16
American Airlines Logo
2:29 pm - 10:00 pm
EYW
-
SAN
10h 31m
1 stop
American Airlines Logo
8:15 am - 10:58 pm
SAN
-
EYW
11h 43m
2 stops
$541American Airlines
Thu, Apr 9 - Thu, Apr 16

American Airlines flights from Florida Keys to San Diego

Our best American Airlines deals on Florida Keys to San Diego flight tickets
American Airlines
Mar 25
MIA9:15 amMiami
5h 55m
SAN12:10 pmSan Diego
Apr 8
SAN9:28 amSan Diego
10h 17m
1 stop
MIA10:45 pmMiami
$331
American Airlines
Mar 25
MIA7:50 pmMiami
6h 00m
SAN10:50 pmSan Diego
Apr 8
SAN10:05 pmSan Diego
4h 55m
MIA6:00 amMiami
$339
American Airlines
Mar 24
MIA1:55 pmMiami
10h 44m
1 stop
SAN9:39 pmSan Diego
Mar 31
SAN1:01 pmSan Diego
5h 01m
MIA9:02 pmMiami
$356

Frontier flights from Florida Keys to San Diego

Our best Frontier deals on Florida Keys to San Diego flight tickets
Frontier
Aug 1
MIA3:51 pmMiami
10h 35m
1 stop
SAN11:26 pmSan Diego
Aug 5
SAN6:54 pmSan Diego
9h 56m
1 stop
MIA7:50 amMiami
$308
Frontier
Mar 19
MIA7:00 amMiami
18h 28m
1 stop
SAN10:28 pmSan Diego
Mar 22
SAN6:33 pmSan Diego
32h 05m
2 stops
MIA5:38 amMiami
$309
Frontier
Feb 27
MIA10:17 pmMiami
15h 09m
1 stop
SAN10:26 amSan Diego
Mar 2
SAN2:00 pmSan Diego
41h 28m
2 stops
MIA10:28 amMiami
$310

momondo Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 8/1

3:51 pm-11:26 pm

1 stop10h 35m

San Diego

Wed 8/5

6:54 pm-7:50 am

1 stop9h 56m

$308

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 3/19

7:00 am-10:28 pm

1 stop18h 28m

San Diego

Sun 3/22

6:33 pm-5:38 am

2 stops32h 05m

$309

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 4/12

5:50 am-12:02 am

1 stop21h 12m

San Diego

Thu 4/16

12:25 pm-2:46 pm

2 stops23h 21m

$310

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 3/11

5:50 am-9:14 pm

1 stop18h 24m

San Diego

Fri 3/13

9:18 pm-5:34 pm

2 stops17h 16m

$313

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 3/5

7:05 am-12:08 am

2 stops20h 03m

San Diego

Sun 3/8

6:55 am-4:29 pm

1 stop30h 34m

$316

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 5/28

7:30 am-12:50 pm

1 stop8h 20m

San Diego

Sun 5/31

9:30 pm-10:53 am

1 stop10h 23m

$335

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 4/10

4:38 pm-9:26 pm

1 stop7h 48m

San Diego

Wed 4/15

6:15 am-3:57 pm

1 stop6h 42m

$359

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/9

4:38 pm-9:26 pm

1 stop7h 48m

San Diego

Wed 4/15

6:15 am-3:57 pm

1 stop6h 42m

$389

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/9

2:29 pm-10:00 pm

1 stop10h 31m

San Diego

Thu 4/16

10:40 pm-6:16 pm

1 stop16h 36m

$476

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/9

2:29 pm-10:00 pm

1 stop10h 31m

San Diego

Thu 4/16

8:15 am-10:58 pm

2 stops11h 43m

$541

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Florida Keys to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of January, then departing from Florida Keys during the month April is also very affordable. Most momondo users find prices during this month for around $354.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Florida Keys to San Diego is on a Thursday. Travelers who choose to depart for San Diego on a Thursday will often find tickets for as low as $407. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $552. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the morning when flights can be purchased for as low as $425. Flights in the afternoon are often more expensive with an average ticket price of $450.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Florida Keys when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $425 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Florida Keys for as low as $327 on momondo.

Can stopping save me money on Florida Keys to San Diego flights?

No. A direct flight is the cheapest option for a flight between Florida Keys to San Diego.

Cheap Florida Keys to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florida Keys to San Diego

Fastest flight time

5h 13m

Direct flights

Every day

Airports in San Diego

1 airport
The fastest flight from Florida Keys to San Diego takes 5h 13m
Direct flights go from Florida Keys to San Diego every day.
There is 1 airport in San Diego. From Florida Keys there are direct flights to San Diego (SAN).
Search flight deals

  • When did momondo last update prices for flights from Florida Keys to San Diego Airport?

    Prices for flights from Florida Keys to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Florida Keys to San Diego Airport?

  • How old do you have to be to fly from Florida Keys to San Diego Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florida Keys to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents you'll need for your trip to San Diego Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Diego Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Florida Keys to San Diego?

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
San Ysidro
Borrego Springs
La Mesa
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Florida Keys to San Diego?

It is quick and easy to find Florida Keys to San Diego flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Diego that suits you.

Can I find flights from Florida Keys to San Diego with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Diego from Florida Keys which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florida Keys to San Diego?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Florida Keys to San Diego.

I’m not ready to book a flight from Florida Keys to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Florida Keys. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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