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Cheap flights from Florida Keys to San Diego from $154

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florida Keys to San Diego departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Florida Keys to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:50 pm - 10:28 pm
MIA
-
SAN
5h 38mnonstop
American Airlines Logo
12:36 pm - 8:55 pm
SAN
-
MIA
5h 19mnonstop
$378American Airlines
Wed, May 20 - Wed, May 27
American Airlines Logo
8:40 am - 11:16 am
MIA
-
SAN
5h 36mnonstop
American Airlines Logo
12:36 pm - 8:55 pm
SAN
-
MIA
5h 19mnonstop
$379American Airlines
Wed, May 20 - Tue, May 26
American Airlines Logo
8:40 am - 11:16 am
MIA
-
SAN
5h 36mnonstop
American Airlines Logo
10:25 pm - 6:36 am
SAN
-
MIA
5h 11mnonstop
$380American Airlines
Wed, May 20 - Wed, May 27
Frontier Logo
8:47 pm - 9:12 pm
MIA
-
SAN
27h 25m
2 stops
Frontier Logo
6:25 am - 7:00 am
SAN
-
MIA
21h 35m
2 stops
$386Frontier
Wed, May 20 - Wed, May 27
Frontier Logo
6:00 am - 6:30 pm
MIA
-
SAN
15h 30m
1 stop
Frontier Logo
8:29 pm - 11:34 pm
SAN
-
MIA
24h 05m
2 stops
$387Frontier
Sun, Jun 7 - Fri, Jun 12
Multiple Airlines Logo
5:05 am - 11:24 am
MIA
-
SAN
9h 19m
1 stop
Multiple Airlines Logo
6:25 am - 7:16 am
SAN
-
MIA
21h 51m
2 stops
$388Multiple Airlines
Sun, May 17 - Tue, Sep 8
Multiple Airlines Logo
5:05 am - 11:24 am
MIA
-
SAN
9h 19m
1 stop
Multiple Airlines Logo
1:38 pm - 5:38 am
SAN
-
MIA
13h 00m
2 stops
$390Multiple Airlines
Thu, May 14 - Thu, May 14
Delta Logo
2:40 pm - 8:50 pm
EYW
-
SAN
9h 10m
1 stop
Delta Logo
10:30 pm - 10:46 am
SAN
-
EYW
9h 16m
1 stop
$449Delta
Thu, Apr 23 - Sat, Apr 25
United Airlines Logo
4:47 pm - 9:25 pm
EYW
-
SAN
7h 38m
1 stop
United Airlines Logo
10:20 pm - 1:43 pm
SAN
-
EYW
12h 23m
1 stop
$499United Airlines
Thu, Apr 30 - Mon, May 4
United Airlines Logo
4:47 pm - 9:25 pm
EYW
-
SAN
7h 38m
1 stop
United Airlines Logo
10:20 pm - 1:43 pm
SAN
-
EYW
12h 23m
1 stop
$519United Airlines
Thu, Apr 30 - Mon, May 4

American Airlines flights from Florida Keys to San Diego

Our best American Airlines deals on Florida Keys to San Diego flight tickets
American Airlines
May 20
MIA7:50 pmMiami
5h 38m
SAN10:28 pmSan Diego
May 27
SAN12:36 pmSan Diego
5h 19m
MIA8:55 pmMiami
$378
American Airlines
May 20
MIA8:40 amMiami
5h 36m
SAN11:16 amSan Diego
May 26
SAN12:36 pmSan Diego
5h 19m
MIA8:55 pmMiami
$379
American Airlines
May 20
MIA8:40 amMiami
5h 36m
SAN11:16 amSan Diego
May 27
SAN10:25 pmSan Diego
5h 11m
MIA6:36 amMiami
$380

Frontier flights from Florida Keys to San Diego

Our best Frontier deals on Florida Keys to San Diego flight tickets
Frontier
Apr 17
MIA1:15 pmMiami
13h 44m
2 stops
SAN11:59 pmSan Diego
Apr 19
SAN7:20 amSan Diego
10h 59m
1 stop
MIA9:19 pmMiami
$378
Frontier
May 23
MIA6:30 amMiami
20h 20m
1 stop
SAN11:50 pmSan Diego
May 26
SAN6:25 amSan Diego
20h 08m
1 stop
MIA5:33 amMiami
$382
Frontier
May 20
MIA8:47 pmMiami
27h 25m
2 stops
SAN9:12 pmSan Diego
May 27
SAN6:25 amSan Diego
21h 35m
2 stops
MIA7:00 amMiami
$386

momondo Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 5/20

7:50 pm-10:28 pm

Nonstop5h 38m

San Diego

Wed 5/27

12:36 pm-8:55 pm

Nonstop5h 19m

$378

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 5/20

8:40 am-11:16 am

Nonstop5h 36m

San Diego

Tue 5/26

12:36 pm-8:55 pm

Nonstop5h 19m

$379
Quickest round-trip

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 5/20

8:40 am-11:16 am

Nonstop5h 36m

San Diego

Wed 5/27

10:25 pm-6:36 am

Nonstop5h 11m

$380

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 5/20

8:47 pm-9:12 pm

2 stops27h 25m

San Diego

Wed 5/27

6:25 am-7:00 am

2 stops21h 35m

$386

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 6/7

6:00 am-6:30 pm

1 stop15h 30m

San Diego

Fri 6/12

8:29 pm-11:34 pm

2 stops24h 05m

$387

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 5/17

5:05 am-11:24 am

1 stop9h 19m

San Diego

Tue 9/8

6:25 am-7:16 am

2 stops21h 51m

$388

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 5/14

5:05 am-11:24 am

1 stop9h 19m

San Diego

Thu 5/14

1:38 pm-5:38 am

2 stops13h 00m

$390

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/23

2:40 pm-8:50 pm

1 stop9h 10m

San Diego

Sat 4/25

10:30 pm-10:46 am

1 stop9h 16m

$449

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/30

4:47 pm-9:25 pm

1 stop7h 38m

San Diego

Mon 5/4

10:20 pm-1:43 pm

1 stop12h 23m

$499

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/30

4:47 pm-9:25 pm

1 stop7h 38m

San Diego

Mon 5/4

10:20 pm-1:43 pm

1 stop12h 23m

$519

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Florida Keys to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of January, then departing from Florida Keys during the month May is also very affordable. Most momondo users find prices during this month for around $409.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Florida Keys to San Diego is on a Saturday. Travelers who choose to depart for San Diego on a Saturday will often find tickets for as low as $409. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $565. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $357. Flights in the morning are often more expensive with an average ticket price of $465.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Florida Keys when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $447 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Florida Keys for as low as $319 on momondo.

Can stopping save me money on Florida Keys to San Diego flights?

No. A direct flight is the cheapest option for a flight between Florida Keys to San Diego.

Cheap Florida Keys to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florida Keys to San Diego

Fastest flight time

5h 18m

Direct flights

Every day

Airports in San Diego

1 airport
The fastest flight from Florida Keys to San Diego takes 5h 18m
Direct flights go from Florida Keys to San Diego every day.
There is 1 airport in San Diego. From Florida Keys there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from Florida Keys to San Diego

  • When did momondo last update prices for flights from Florida Keys to San Diego Airport?

    Prices for flights from Florida Keys to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Florida Keys to San Diego Airport?

  • How old do you have to be to fly from Florida Keys to San Diego Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florida Keys to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents you'll need for your trip to San Diego Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Diego Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Florida Keys to San Diego?

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
Imperial Beach
La Mesa
Lemon Grove
Borrego Springs
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Florida Keys to San Diego?

It is quick and easy to find Florida Keys to San Diego flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Diego that suits you.

Can I find flights from Florida Keys to San Diego with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Diego from Florida Keys which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florida Keys to San Diego?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Florida Keys to San Diego.

I’m not ready to book a flight from Florida Keys to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Florida Keys. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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