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Cheap flights from Florida Keys to San Diego from $133

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florida Keys to San Diego departing on 2/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:09 pm - 11:59 pm
MIA
-
SAN
31h 50m2 stops
Frontier Logo
12:00 pm - 5:48 am
SAN
-
MIA
14h 48m1 stop
$219Frontier
Wed, Jan 7 - Tue, Jan 13
Frontier Logo
7:09 pm - 9:56 am
MIA
-
SAN
41h 47m2 stops
Frontier Logo
8:45 am - 5:14 am
SAN
-
MIA
17h 29m1 stop
$220Frontier
Fri, Jan 23 - Wed, Mar 4
Southwest Logo
6:55 am - 1:20 pm
MIA
-
SAN
9h 25m2 stops
Southwest Logo
6:20 am - 4:30 pm
SAN
-
MIA
7h 10m1 stop
$222Southwest
Fri, Jan 30 - Mon, Feb 2
Frontier Logo
5:03 pm - 11:36 pm
MIA
-
SAN
9h 33m1 stop
Frontier Logo
3:29 pm - 11:57 am
SAN
-
MIA
17h 28m1 stop
$225Frontier
Fri, Jan 9 - Sat, Jan 10
Multiple Airlines Logo
6:25 am - 9:41 pm
MIA
-
SAN
18h 16m1 stop
Multiple Airlines Logo
8:00 am - 11:40 am
SAN
-
MIA
24h 40m2 stops
$226Multiple Airlines
Wed, Feb 18 - Tue, Mar 3
American Airlines Logo
8:11 pm - 11:09 pm
MIA
-
SAN
5h 58mnonstop
American Airlines Logo
10:25 pm - 6:07 am
SAN
-
MIA
4h 42mnonstop
$237American Airlines
Thu, Jan 29 - Sun, Feb 1
American Airlines Logo
9:30 am - 12:27 pm
MIA
-
SAN
5h 57mnonstop
American Airlines Logo
1:27 pm - 9:26 pm
SAN
-
MIA
4h 59mnonstop
$238American Airlines
Tue, Feb 3 - Tue, Feb 10
Delta Logo
2:45 pm - 10:45 pm
EYW
-
SAN
11h 00m1 stop
Delta Logo
6:30 am - 5:11 pm
SAN
-
EYW
7h 41m1 stop
$325Delta
Thu, Jan 8 - Sun, Jan 11
United Airlines Logo
4:15 pm - 10:33 pm
EYW
-
SAN
9h 18m1 stop
United Airlines Logo
10:40 pm - 1:03 pm
SAN
-
EYW
11h 23m1 stop
$357United Airlines
Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
2:25 pm - 9:28 pm
EYW
-
SAN
10h 03m1 stop
United Airlines Logo
6:00 pm - 1:03 pm
SAN
-
EYW
16h 03m2 stops
$423United Airlines
Fri, Jan 23 - Sun, Jan 25

Frontier flights from Florida Keys to San Diego

Our best Frontier deals on Florida Keys to San Diego flight tickets
Frontier
Jan 7
MIA7:09 pmMiami
31h 50m
2 stops
SAN11:59 pmSan Diego
Jan 13
SAN12:00 pmSan Diego
14h 48m
1 stop
MIA5:48 amMiami
$219
Find similar
Frontier
Jan 23
MIA7:09 pmMiami
41h 47m
2 stops
SAN9:56 amSan Diego
Mar 4
SAN8:45 amSan Diego
17h 29m
1 stop
MIA5:14 amMiami
$220
Find similar
Frontier
Jan 9
MIA5:03 pmMiami
9h 33m
1 stop
SAN11:36 pmSan Diego
Jan 10
SAN3:29 pmSan Diego
17h 28m
1 stop
MIA11:57 amMiami
$225
Find similar

Southwest flights from Florida Keys to San Diego

Our best Southwest deals on Florida Keys to San Diego flight tickets
Southwest
Jan 30
MIA6:55 amMiami
9h 25m
2 stops
SAN1:20 pmSan Diego
Feb 2
SAN6:20 amSan Diego
7h 10m
1 stop
MIA4:30 pmMiami
$222
Find similar
Southwest
Jan 9
MIA12:00 pmMiami
9h 40m
2 stops
SAN6:40 pmSan Diego
Jan 11
SAN10:30 amSan Diego
6h 50m
1 stop
MIA8:20 pmMiami
$282
Find similar
Southwest
Jan 30
MIA6:55 amMiami
9h 25m
2 stops
SAN1:20 pmSan Diego
Feb 2
SAN9:40 amSan Diego
9h 20m
2 stops
MIA10:00 pmMiami
$284
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 1/7

7:09 pm-11:59 pm

2 stops31h 50m

San Diego

Tue 1/13

12:00 pm-5:48 am

1 stop14h 48m

$219

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/23

7:09 pm-9:56 am

2 stops41h 47m

San Diego

Wed 3/4

8:45 am-5:14 am

1 stop17h 29m

$220

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/30

6:55 am-1:20 pm

2 stops9h 25m

San Diego

Mon 2/2

6:20 am-4:30 pm

1 stop7h 10m

$222

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/9

5:03 pm-11:36 pm

1 stop9h 33m

San Diego

Sat 1/10

3:29 pm-11:57 am

1 stop17h 28m

$225

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 2/18

6:25 am-9:41 pm

1 stop18h 16m

San Diego

Tue 3/3

8:00 am-11:40 am

2 stops24h 40m

$226

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/29

8:11 pm-11:09 pm

Nonstop5h 58m

San Diego

Sun 2/1

10:25 pm-6:07 am

Nonstop4h 42m

$237

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 2/3

9:30 am-12:27 pm

Nonstop5h 57m

San Diego

Tue 2/10

1:27 pm-9:26 pm

Nonstop4h 59m

$238

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 1/8

2:45 pm-10:45 pm

1 stop11h 00m

San Diego

Sun 1/11

6:30 am-5:11 pm

1 stop7h 41m

$325

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 1/23

4:15 pm-10:33 pm

1 stop9h 18m

San Diego

Sun 1/25

10:40 pm-1:03 pm

1 stop11h 23m

$357

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 1/23

2:25 pm-9:28 pm

1 stop10h 03m

San Diego

Sun 1/25

6:00 pm-1:03 pm

2 stops16h 03m

$423

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Florida Keys to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of April, then departing from Florida Keys during the month February is also very affordable. Most momondo users find prices during this month for around $367.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Florida Keys to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $390. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $569. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $258. Flights in the afternoon are often more expensive with an average ticket price of $446.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Florida Keys when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Florida Keys for as low as $332 on momondo.

Can stopping save me money on Florida Keys to San Diego flights?

No. A direct flight is the cheapest option for a flight between Florida Keys to San Diego.

Cheap Florida Keys to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florida Keys to San Diego

Fastest flight time

5h 14m

Direct flights

Every day

Airports in San Diego

1 airport
The fastest flight from Florida Keys to San Diego takes 5h 14m
Direct flights go from Florida Keys to San Diego every day.
There is 1 airport in San Diego. From Florida Keys there are direct flights to San Diego (SAN).
Search flight deals

  • When did momondo last update prices for flights from Florida Keys to San Diego Airport?

    Prices for flights from Florida Keys to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Florida Keys to San Diego Airport?

  • How old do you have to be to fly from Florida Keys to San Diego Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florida Keys to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents you'll need for your trip to San Diego Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Diego Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Florida Keys to San Diego?

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Borrego Springs
Imperial Beach
La Mesa
San Ysidro
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Florida Keys to San Diego?

It is quick and easy to find Florida Keys to San Diego flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Diego that suits you.

Can I find flights from Florida Keys to San Diego with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Diego from Florida Keys which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florida Keys to San Diego?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Florida Keys to San Diego.

I’m not ready to book a flight from Florida Keys to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Florida Keys. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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