What is the cheapest airline that flies from Florence to Detroit?

American Airlines is the most popular carrier operating from Florence to Detroit

What airlines fly to Detroit?

American Airlines, Delta and Frontier are the top three most popular airlines that fly to Detroit from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Detroit. Keep in mind that there are 6 different airlines that fly to Detroit on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Florence Airport to Detroit?

Prices for flights from Florence Airport to Detroit refresh daily.

How old do you have to be to fly from Florence Airport to Detroit?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to Detroit.

What documentation or ID do you need to fly to Detroit?

The required travel and health documents for your Detroit trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Detroit. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$246 Cheap Flights from Florence, South Carolina to Detroit in 2026

Find the cheapest flights from Florence, South Carolina to Detroit

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:22 am - 11:21 amFLO Florence-DTW Detroit Metropolitan Wayne County

4h 59m1 stop Charlotte Douglas

6:43 pm - 10:59 pmDTW Detroit Metropolitan Wayne County-FLO Florence

4h 16m1 stop Charlotte Douglas

$551American Airlines

Sat, Aug 15 - Wed, Aug 19

3:22 pm - 7:44 pmFLO Florence-DTW Detroit Metropolitan Wayne County

4h 22m1 stop Charlotte Douglas

6:43 pm - 10:59 pmDTW Detroit Metropolitan Wayne County-FLO Florence

4h 16m1 stop Charlotte Douglas

$558American Airlines

Tue, Sep 1 - Mon, Sep 7

6:22 am - 9:33 pmFLO Florence-DTW Detroit Metropolitan Wayne County

15h 11m2 stops Charlotte Douglas Chicago O'Hare Intl

6:43 pm - 10:59 pmDTW Detroit Metropolitan Wayne County-FLO Florence

4h 16m1 stop Charlotte Douglas

$621American Airlines

Tue, Sep 1 - Mon, Sep 7

6:22 am - 6:54 pmFLO Florence-DTW Detroit Metropolitan Wayne County

12h 32m2 stops Charlotte Douglas New York LaGuardia

6:43 pm - 10:59 pmDTW Detroit Metropolitan Wayne County-FLO Florence

4h 16m1 stop Charlotte Douglas

$644American Airlines

Sat, Aug 15 - Wed, Aug 19

6:22 am - 4:33 pmFLO Florence-DTW Detroit Metropolitan Wayne County

10h 11m2 stops Charlotte Douglas Philadelphia

4:08 pm - 10:59 pmDTW Detroit Metropolitan Wayne County-FLO Florence

6h 51m2 stops Chicago O'Hare Intl Charlotte Douglas

$705American Airlines

Sat, Aug 15 - Wed, Aug 19

6:22 am - 3:33 pmFLO Florence-DTW Detroit Metropolitan Wayne County

9h 11m2 stops Charlotte Douglas Philadelphia

12:58 pm - 10:59 pmDTW Detroit Metropolitan Wayne County-FLO Florence

10h 01m2 stops Philadelphia Charlotte Douglas

$806American Airlines

Tue, Sep 1 - Mon, Sep 7

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American Airlines flights from Florence, South Carolina to Detroit

Our best American Airlines deals on Florence, South Carolina to Detroit flight tickets

American Airlines

Aug 15

FLO6:22 amFlorence

4h 59m

1 stop

DTW11:21 amDetroit Metropolitan Wayne County

Aug 19

DTW6:43 pmDetroit Metropolitan Wayne County

4h 16m

1 stop

FLO10:59 pmFlorence

$551

American Airlines

Sep 1

FLO3:22 pmFlorence

4h 22m

1 stop

DTW7:44 pmDetroit Metropolitan Wayne County

Sep 7

DTW6:43 pmDetroit Metropolitan Wayne County

4h 16m

1 stop

FLO10:59 pmFlorence

$558

American Airlines

Sep 1

FLO6:22 amFlorence

15h 11m

2 stops

DTW9:33 pmDetroit Metropolitan Wayne County

Sep 7

DTW6:43 pmDetroit Metropolitan Wayne County

4h 16m

1 stop

FLO10:59 pmFlorence

$621

momondo Fare Finder

Use the filters below to find and compare flights from Florence, South Carolina to Detroit that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Sat 8/15

6:22 am-11:21 am

1 stop4h 59m

Detroit Metropolitan Wayne County

Wed 8/19

6:43 pm-10:59 pm

1 stop4h 16m

$551

Quickest round-trip

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Tue 9/1

3:22 pm-7:44 pm

1 stop4h 22m

Detroit Metropolitan Wayne County

Mon 9/7

6:43 pm-10:59 pm

1 stop4h 16m

$558

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Tue 9/1

6:22 am-9:33 pm

2 stops15h 11m

Detroit Metropolitan Wayne County

Mon 9/7

6:43 pm-10:59 pm

1 stop4h 16m

$621

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Sat 8/15

6:22 am-6:54 pm

2 stops12h 32m

Detroit Metropolitan Wayne County

Wed 8/19

6:43 pm-10:59 pm

1 stop4h 16m

$644

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Sat 8/15

6:22 am-4:33 pm

2 stops10h 11m

Detroit Metropolitan Wayne County

Wed 8/19

4:08 pm-10:59 pm

2 stops6h 51m

$705

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Tue 9/1

6:22 am-3:33 pm

2 stops9h 11m

Detroit Metropolitan Wayne County

Mon 9/7

12:58 pm-10:59 pm

2 stops10h 01m

$806

Cheapest one-way

Quickest one-way

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Sat 9/5

9:00 am-12:47 pm

1 stop3h 47m

$246

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Fri 9/11

6:24 am-7:03 pm

2 stops12h 39m

$283

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Sat 9/5

9:00 am-8:13 pm

2 stops11h 13m

$339

FlorenceDetroit

FLO Florence - DTW Detroit Metropolitan Wayne County

FLODTW

Florence

Sun 9/6

9:00 am-9:33 pm

2 stops12h 33m

$354

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from Florence, South Carolina to Detroit

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Can stopping save me money on Florence, South Carolina to Detroit flights?

You could potentially save up to 12% on your flight if you consider stops on a Florence, South Carolina to Detroit flight.

When to book flights from Florence, South Carolina to Detroit

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Detroit according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Florence, South Carolina to Detroit (FLO to DTT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Detroit

Fastest flight time	4h 59m
Direct flights	None

The fastest flight from Florence, South Carolina to Detroit takes 4h 59m

There are no direct flights from Florence, South Carolina to Detroit. There are no popular flight routes from Florence, South Carolina to Detroit.

Search flight deals

Frequently asked questions about flying from Florence, South Carolina to Detroit

How far is Florence to Detroit by plane?
The distance between Florence and Detroit is about 589.7 mi. A reasonable flight in good conditions will take 4h 59m.
When did momondo last update prices for flights from Florence Airport to Detroit?
Prices for flights from Florence Airport to Detroit refresh daily.
How old do you have to be to fly from Florence Airport to Detroit?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to Detroit.
What documentation or ID do you need to fly to Detroit?
The required travel and health documents for your Detroit trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Detroit. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Roseville

Port Huron

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Detroit?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Florence to Detroit for you.

Can I find flights from Florence to Detroit with flexible booking policies on momondo?

Flights from Florence to Detroit with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Florence to Detroit?

momondo helps you find the best flight between Florence and Detroit by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Florence to Detroit right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Detroit from Florence. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.