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Cheap flights from Florence, South Carolina to Detroit from $263

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Detroit departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to Detroit

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:36 pm - 10:30 pm
FLO
-
DTW
4h 54m1 stop
American Airlines Logo
6:17 pm - 10:43 pm
DTW
-
FLO
4h 26m1 stop
$263American Airlines
Wed, Jan 21 - Tue, Jan 27
American Airlines Logo
5:36 pm - 11:43 pm
FLO
-
DTW
6h 07m1 stop
American Airlines Logo
6:00 am - 5:09 pm
DTW
-
FLO
11h 09m2 stops
$268American Airlines
Wed, Jan 21 - Tue, Jan 27
American Airlines Logo
6:15 am - 4:50 pm
FLO
-
DTW
10h 35m2 stops
American Airlines Logo
1:08 pm - 10:43 pm
DTW
-
FLO
9h 35m2 stops
$273American Airlines
Wed, Jan 21 - Tue, Jan 27

American Airlines flights from Florence, South Carolina to Detroit Metropolitan Wayne County Airport

Our best American Airlines deals on Florence, South Carolina to Detroit Metropolitan Wayne County Airport flight tickets
American Airlines
Jan 21
FLO5:36 pmFlorence
4h 54m
1 stop
DTW10:30 pmDetroit Metropolitan Wayne County
Jan 27
DTW6:17 pmDetroit Metropolitan Wayne County
4h 26m
1 stop
FLO10:43 pmFlorence
$263
Find similar
American Airlines
Jan 21
FLO5:36 pmFlorence
6h 07m
1 stop
DTW11:43 pmDetroit Metropolitan Wayne County
Jan 27
DTW6:00 amDetroit Metropolitan Wayne County
11h 09m
2 stops
FLO5:09 pmFlorence
$268
Find similar
American Airlines
Jan 21
FLO6:15 amFlorence
10h 35m
2 stops
DTW4:50 pmDetroit Metropolitan Wayne County
Jan 27
DTW1:08 pmDetroit Metropolitan Wayne County
9h 35m
2 stops
FLO10:43 pmFlorence
$273
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Detroit Metropolitan Wayne County Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Florence, South Carolina to Detroit Metropolitan Wayne County Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Wed 1/21

5:36 pm-10:30 pm

1 stop4h 54m

Detroit Metropolitan Wayne County

Tue 1/27

6:17 pm-10:43 pm

1 stop4h 26m

$263

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Wed 1/21

5:36 pm-11:43 pm

1 stop6h 07m

Detroit Metropolitan Wayne County

Tue 1/27

6:00 am-5:09 pm

2 stops11h 09m

$268

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Wed 1/21

6:15 am-4:50 pm

2 stops10h 35m

Detroit Metropolitan Wayne County

Tue 1/27

1:08 pm-10:43 pm

2 stops9h 35m

$273

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Florence, South Carolina to Detroit Metropolitan Wayne County Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Detroit Metropolitan Wayne County Airport?

Delta, American Airlines and Spirit Airlines are the top three most popular airlines that fly to Detroit Metropolitan Wayne County Airport from Florence, South Carolina according to our data. Delta is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Detroit Metropolitan Wayne County Airport. Keep in mind that there are 5 different airlines that fly to Detroit Metropolitan Wayne County Airport on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Detroit Metropolitan Wayne County Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Detroit Metropolitan Wayne County Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Detroit Metropolitan Wayne County Airport (FLO to DTW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Detroit Metropolitan Wayne County Airport

Fastest flight time

3h 35m

Direct flights

None
The fastest flight from Florence, South Carolina to Detroit Metropolitan Wayne County Airport takes 3h 35m
There are no direct flights from Florence, South Carolina to Detroit Metropolitan Wayne County Airport. There are no popular flight routes from Florence, South Carolina to Detroit Metropolitan Wayne County Airport.
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  • How far is Florence to Detroit Metropolitan Wayne County by plane?

    Florence and Detroit Metropolitan Wayne County are 587.3 mi apart from one another. In terms of flight time, this usually takes a little over 3h 35m.

  • When did momondo last update prices for flights from Florence Airport to Detroit Metropolitan Wayne County Airport?

    Prices for flights from Florence Airport to Detroit Metropolitan Wayne County Airport refresh daily.

  • How old do you have to be to fly from Florence Airport to Detroit Metropolitan Wayne County Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to Detroit Metropolitan Wayne County Airport.

  • What documentation or ID do you need to fly to Detroit Metropolitan Wayne County Airport?

    The required travel and health documents for your Detroit Metropolitan Wayne County Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Detroit Metropolitan Wayne County Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
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Royal Oak

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Detroit?

Finding the right flight to Detroit from Florence is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Detroit quick and easy, saving you time and money.

Can I find flights from Florence to Detroit with flexible booking policies on momondo?

Yes. All flights to Detroit from Florence on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florence to Detroit?

Once you have performed a search for Florence to Detroit flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Florence to Detroit right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to Detroit flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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