What airlines fly to Panama City, Florida?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama City, Florida from Des Moines according to our data. American Airlines is the first choice among our users, with 42% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 5 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

The number of operators available for flights from Des Moines Airport to Panama City NW Florida Beaches Airport is 4 as of August 2026.

How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.

What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$325 Cheap Flights from Des Moines to Panama City, Florida in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama City

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:29 pm - 8:59 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 30m1 stop Dallas/Fort Worth

6:03 pm - 11:20 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 17m1 stop Charlotte Douglas

$325American Airlines

Mon, Jan 25 - Mon, Feb 1

5:15 pm - 10:47 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 32m1 stop Atlanta Hartsfield-Jackson

3:30 pm - 10:29 pmECP Panama City NW Florida Beaches-DSM Des Moines

6h 59m1 stop Atlanta Hartsfield-Jackson

$343Delta

Tue, Jan 26 - Tue, Feb 2

4:10 pm - 11:05 pmDSM Des Moines-ECP Panama City NW Florida Beaches

6h 55m1 stop Atlanta Hartsfield-Jackson

9:23 am - 3:15 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 52m1 stop Atlanta Hartsfield-Jackson

$343Delta

Sat, Sep 26 - Sat, Oct 3

5:15 pm - 10:47 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 32m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:18 amECP Panama City NW Florida Beaches-DSM Des Moines

4h 18m1 stop Atlanta Hartsfield-Jackson

$343Delta

Mon, Jan 25 - Wed, Feb 3

11:22 am - 6:42 pmDSM Des Moines-ECP Panama City NW Florida Beaches

7h 20m1 stop Charlotte Douglas

7:01 pm - 11:57 pmECP Panama City NW Florida Beaches-DSM Des Moines

4h 56m1 stop Charlotte Douglas

$345American Airlines

Sat, Oct 31 - Fri, Nov 6

4:12 pm - 9:17 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 05m1 stop Dallas/Fort Worth

6:42 pm - 11:58 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 16m1 stop Charlotte Douglas

$345American Airlines

Sat, Oct 24 - Fri, Oct 30

6:00 am - 11:06 amDSM Des Moines-ECP Panama City NW Florida Beaches

5h 06m1 stop Houston George Bush Intcntl

9:06 am - 9:55 pmECP Panama City NW Florida Beaches-DSM Des Moines

12h 49m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$350United Airlines

Sat, Oct 24 - Fri, Oct 30

8:00 am - 1:32 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 32m1 stop Chicago O'Hare Intl

9:06 am - 8:36 pmECP Panama City NW Florida Beaches-DSM Des Moines

11h 30m2 stops Houston George Bush Intcntl Denver Intl

$350United Airlines

Sat, Oct 31 - Fri, Nov 6

5:50 am - 2:50 pmDSM Des Moines-ECP Panama City NW Florida Beaches

9h 00m2 stops Chicago Midway Nashville Intl

10:55 am - 10:20 pmECP Panama City NW Florida Beaches-DSM Des Moines

11h 25m2 stops Nashville Intl Denver Intl

$364Southwest

Sat, Oct 24 - Fri, Oct 30

5:55 am - 6:10 pmDSM Des Moines-ECP Panama City NW Florida Beaches

12h 15m2 stops Chicago Midway Nashville Intl

7:55 am - 8:40 pmECP Panama City NW Florida Beaches-DSM Des Moines

12h 45m2 stops Nashville Intl Denver Intl

$376Southwest

Mon, Jan 25 - Mon, Feb 1

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American Airlines flights from Des Moines to Panama City, Florida

Our best American Airlines deals on Des Moines to Panama City, Florida flight tickets

American Airlines

Jan 25

DSM3:29 pmDes Moines

5h 30m

1 stop

ECP8:59 pmPanama City NW Florida Beaches

Feb 1

ECP6:03 pmPanama City NW Florida Beaches

5h 17m

1 stop

DSM11:20 pmDes Moines

$325

American Airlines

Sep 26

DSM4:14 pmDes Moines

4h 53m

1 stop

ECP9:07 pmPanama City NW Florida Beaches

Oct 2

ECP4:27 pmPanama City NW Florida Beaches

6h 45m

1 stop

DSM11:12 pmDes Moines

$345

American Airlines

Sep 26

DSM4:14 pmDes Moines

4h 53m

1 stop

ECP9:07 pmPanama City NW Florida Beaches

Oct 3

ECP3:17 pmPanama City NW Florida Beaches

7h 55m

1 stop

DSM11:12 pmDes Moines

$391

Delta flights from Des Moines to Panama City, Florida

Our best Delta deals on Des Moines to Panama City, Florida flight tickets

Delta

Jan 23

DSM5:45 amDes Moines

5h 19m

1 stop

ECP11:04 amPanama City NW Florida Beaches

Feb 3

ECP3:30 pmPanama City NW Florida Beaches

6h 59m

1 stop

DSM10:29 pmDes Moines

$343

Delta

Jan 23

DSM5:45 amDes Moines

5h 19m

1 stop

ECP11:04 amPanama City NW Florida Beaches

Jan 29

ECP6:00 amPanama City NW Florida Beaches

4h 18m

1 stop

DSM10:18 amDes Moines

$363

Delta

Jan 24

DSM5:45 amDes Moines

5h 19m

1 stop

ECP11:04 amPanama City NW Florida Beaches

Feb 3

ECP12:00 pmPanama City NW Florida Beaches

4h 27m

1 stop

DSM4:27 pmDes Moines

$389

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Mon 1/25

3:29 pm-8:59 pm

1 stop5h 30m

Panama City NW Florida Beaches

Mon 2/1

6:03 pm-11:20 pm

1 stop5h 17m

$325

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Tue 1/26

5:15 pm-10:47 pm

1 stop5h 32m

Panama City NW Florida Beaches

Tue 2/2

3:30 pm-10:29 pm

1 stop6h 59m

$343

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 9/26

4:10 pm-11:05 pm

1 stop6h 55m

Panama City NW Florida Beaches

Sat 10/3

9:23 am-3:15 pm

1 stop5h 52m

$343

Quickest round-trip

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Mon 1/25

5:15 pm-10:47 pm

1 stop5h 32m

Panama City NW Florida Beaches

Wed 2/3

6:00 am-10:18 am

1 stop4h 18m

$343

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 10/31

11:22 am-6:42 pm

1 stop7h 20m

Panama City NW Florida Beaches

Fri 11/6

7:01 pm-11:57 pm

1 stop4h 56m

$345

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 10/24

4:12 pm-9:17 pm

1 stop5h 05m

Panama City NW Florida Beaches

Fri 10/30

6:42 pm-11:58 pm

1 stop5h 16m

$345

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 10/24

6:00 am-11:06 am

1 stop5h 06m

Panama City NW Florida Beaches

Fri 10/30

9:06 am-9:55 pm

2 stops12h 49m

$350

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 10/31

8:00 am-1:32 pm

1 stop5h 32m

Panama City NW Florida Beaches

Fri 11/6

9:06 am-8:36 pm

2 stops11h 30m

$350

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 10/24

5:50 am-2:50 pm

2 stops9h 00m

Panama City NW Florida Beaches

Fri 10/30

10:55 am-10:20 pm

2 stops11h 25m

$364

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Mon 1/25

5:55 am-6:10 pm

2 stops12h 15m

Panama City NW Florida Beaches

Mon 2/1

7:55 am-8:40 pm

2 stops12h 45m

$376

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Des Moines is in September. Flight prices, which tend to average around $354, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Des Moines averaging around $373.

Can stopping save me money on Des Moines to Panama City, Florida flights?

You could potentially save up to 4% on your flight if you consider stops on a Des Moines to Panama City, Florida flight.

When to book flights from Des Moines to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City, Florida

Best Price Found	$325
Fastest flight time	4h 00m
Direct flights	None

The best flight deal from Des Moines to Panama City, Florida found on momondo in the last 72 hours is $325

The fastest flight from Des Moines to Panama City, Florida takes 4h 00m

There are no direct flights from Des Moines to Panama City, Florida. There are no popular flight routes from Des Moines to Panama City, Florida.

Search flight deals

Frequently asked questions about flying from Des Moines to Panama City, Florida

How far is Des Moines to Panama City NW Florida Beaches by plane?
The straight-line distance from Des Moines to Panama City NW Florida Beaches is 905.2 mi. Typically, this will take 4h 00m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?
Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?
The number of operators available for flights from Des Moines Airport to Panama City NW Florida Beaches Airport is 4 as of August 2026.
How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.
What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?
The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Panama City, Florida?
Based on momondo bookings for flights between Des Moines and Panama City, Florida, the leading airline is Delta, making up 33% of the total bookings. Other popular airlines include American Airlines with 32%, United Airlines with 20%, and Southwest with 15%.

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $271	Free Cancellation	Rating 7.8 8,533 reviews	Search Delta flights
American Airlines	PriceFrom $285	Free Cancellation	Rating 7.1 12,019 reviews	Search American Airlines flights
Southwest	PriceFrom $297	Free Cancellation	Rating 8.0 4,195 reviews	Search Southwest flights
United Airlines	PriceFrom $342	Free Cancellation	Rating 7.4 10,146 reviews	Search United Airlines flights

Panama City Beach

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Mexico Beach

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Freeport

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Why should I use momondo to find a flight deal from Des Moines to Panama City?

Finding the right flight to Panama City from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Panama City?

Once you have performed a search for Des Moines to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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Cheap flights from Des Moines to Panama City from $325

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 1/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from Des Moines to Panama City, Florida

Our best American Airlines deals on Des Moines to Panama City, Florida flight tickets

Delta flights from Des Moines to Panama City, Florida

Our best Delta deals on Des Moines to Panama City, Florida flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

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How to get the cheapest flight ticket from Des Moines to Panama City, Florida

What is the cheapest month to fly to Panama City, Florida?

Can stopping save me money on Des Moines to Panama City, Florida flights?

What airlines fly to Panama City, Florida?

When to book flights from Des Moines to Panama City, Florida

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Des Moines to Panama City, Florida

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo

Traveling to a place near Panama City?

Why use momondo?

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

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List of cabin classes available on flights landing in Panama City. Availability may vary depending on flight origin and airline.

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