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Cheap flights from Des Moines to Panama City from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 6/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
4:15 pm - 10:46 pm
DSM
-
ECP
6h 31m
1 stop
Delta Logo
4:10 pm - 10:26 pm
ECP
-
DSM
6h 16m
1 stop
$355Delta
Wed, Sep 9 - Tue, Sep 15
American Airlines Logo
6:02 am - 3:46 pm
DSM
-
ECP
9h 44m
2 stops
American Airlines Logo
7:05 am - 12:56 pm
ECP
-
DSM
5h 51m
1 stop
$360American Airlines
Wed, Jul 1 - Wed, Jul 8
Southwest Logo
6:10 am - 5:00 pm
DSM
-
ECP
10h 50m
2 stops
Southwest Logo
11:30 am - 9:00 pm
ECP
-
DSM
9h 30m
2 stops
$366Southwest
Wed, Sep 9 - Tue, Sep 15
Southwest Logo
5:30 am - 9:55 am
DSM
-
ECP
4h 25m
1 stop
Southwest Logo
2:45 pm - 7:25 pm
ECP
-
DSM
4h 40m
1 stop
$375Southwest
Sat, Aug 8 - Sat, Aug 15
Southwest Logo
5:40 am - 3:45 pm
DSM
-
ECP
10h 05m
1 stop
Southwest Logo
10:30 am - 9:00 pm
ECP
-
DSM
10h 30m
2 stops
$376Southwest
Thu, Sep 17 - Tue, Sep 22
Southwest Logo
5:30 am - 2:05 pm
DSM
-
ECP
8h 35m
2 stops
Southwest Logo
2:45 pm - 7:25 pm
ECP
-
DSM
4h 40m
1 stop
$380Southwest
Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
6:02 am - 12:45 pm
DSM
-
ECP
6h 43m
1 stop
American Airlines Logo
7:05 am - 12:56 pm
ECP
-
DSM
5h 51m
1 stop
$381American Airlines
Wed, Jul 1 - Wed, Jul 8
Southwest Logo
5:40 am - 3:45 pm
DSM
-
ECP
10h 05m
1 stop
Southwest Logo
11:20 am - 9:15 pm
ECP
-
DSM
9h 55m
1 stop
$386Southwest
Thu, Sep 17 - Mon, Sep 21
Delta Logo
6:39 pm - 11:44 pm
DSM
-
ECP
5h 05m
1 stop
Delta Logo
5:08 pm - 10:31 pm
ECP
-
DSM
5h 23m
1 stop
$391Delta
Fri, Jun 12 - Tue, Jun 16
American Airlines Logo
4:48 pm - 10:36 pm
DSM
-
ECP
5h 48m
1 stop
American Airlines Logo
4:16 pm - 12:35 am
ECP
-
DSM
8h 19m
2 stops
$396American Airlines
Fri, Jun 12 - Tue, Jun 16

Southwest flights from Des Moines to Panama City, Florida

Our best Southwest deals on Des Moines to Panama City, Florida flight tickets
Southwest
Sep 9
DSM6:10 amDes Moines
10h 50m
2 stops
ECP5:00 pmPanama City NW Florida Beaches
Sep 15
ECP11:30 amPanama City NW Florida Beaches
9h 30m
2 stops
DSM9:00 pmDes Moines
$366
Southwest
Aug 8
DSM5:30 amDes Moines
4h 25m
1 stop
ECP9:55 amPanama City NW Florida Beaches
Aug 15
ECP2:45 pmPanama City NW Florida Beaches
4h 40m
1 stop
DSM7:25 pmDes Moines
$375
Southwest
Sep 17
DSM5:40 amDes Moines
10h 05m
1 stop
ECP3:45 pmPanama City NW Florida Beaches
Sep 22
ECP10:30 amPanama City NW Florida Beaches
10h 30m
2 stops
DSM9:00 pmDes Moines
$376

American Airlines flights from Des Moines to Panama City, Florida

Our best American Airlines deals on Des Moines to Panama City, Florida flight tickets
American Airlines
Jul 1
DSM6:02 amDes Moines
9h 44m
2 stops
ECP3:46 pmPanama City NW Florida Beaches
Jul 8
ECP7:05 amPanama City NW Florida Beaches
5h 51m
1 stop
DSM12:56 pmDes Moines
$360
American Airlines
Jul 1
DSM6:02 amDes Moines
6h 43m
1 stop
ECP12:45 pmPanama City NW Florida Beaches
Jul 8
ECP7:05 amPanama City NW Florida Beaches
5h 51m
1 stop
DSM12:56 pmDes Moines
$381
American Airlines
Jun 12
DSM4:48 pmDes Moines
5h 48m
1 stop
ECP10:36 pmPanama City NW Florida Beaches
Jun 16
ECP4:16 pmPanama City NW Florida Beaches
8h 19m
2 stops
DSM12:35 amDes Moines
$396

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 21, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 9/9

4:15 pm-10:46 pm

1 stop6h 31m

Panama City NW Florida Beaches

Tue 9/15

4:10 pm-10:26 pm

1 stop6h 16m

$355

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 7/1

6:02 am-3:46 pm

2 stops9h 44m

Panama City NW Florida Beaches

Wed 7/8

7:05 am-12:56 pm

1 stop5h 51m

$360

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 9/9

6:10 am-5:00 pm

2 stops10h 50m

Panama City NW Florida Beaches

Tue 9/15

11:30 am-9:00 pm

2 stops9h 30m

$366
Quickest round-trip

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 8/8

5:30 am-9:55 am

1 stop4h 25m

Panama City NW Florida Beaches

Sat 8/15

2:45 pm-7:25 pm

1 stop4h 40m

$375

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 9/17

5:40 am-3:45 pm

1 stop10h 05m

Panama City NW Florida Beaches

Tue 9/22

10:30 am-9:00 pm

2 stops10h 30m

$376

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 8/8

5:30 am-2:05 pm

2 stops8h 35m

Panama City NW Florida Beaches

Sat 8/15

2:45 pm-7:25 pm

1 stop4h 40m

$380

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 7/1

6:02 am-12:45 pm

1 stop6h 43m

Panama City NW Florida Beaches

Wed 7/8

7:05 am-12:56 pm

1 stop5h 51m

$381

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 9/17

5:40 am-3:45 pm

1 stop10h 05m

Panama City NW Florida Beaches

Mon 9/21

11:20 am-9:15 pm

1 stop9h 55m

$386

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 6/12

6:39 pm-11:44 pm

1 stop5h 05m

Panama City NW Florida Beaches

Tue 6/16

5:08 pm-10:31 pm

1 stop5h 23m

$391

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 6/12

4:48 pm-10:36 pm

1 stop5h 48m

Panama City NW Florida Beaches

Tue 6/16

4:16 pm-12:35 am

2 stops8h 19m

$396

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Panama City, Florida?

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Des Moines is in August. Flight prices, which tend to average around $339, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Des Moines averaging around $355.

Can stopping save me money on Des Moines to Panama City, Florida flights?

You could potentially save up to 39% on your flight if you consider stops on a Des Moines to Panama City, Florida flight.

When to book flights from Des Moines to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City, Florida

Fastest flight time

4h 25m

Direct flights

None
The fastest flight from Des Moines to Panama City, Florida takes 4h 25m
There are no direct flights from Des Moines to Panama City, Florida. There are no popular flight routes from Des Moines to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Des Moines to Panama City, Florida

  • How far is Des Moines to Panama City NW Florida Beaches by plane?

    The straight-line distance from Des Moines to Panama City NW Florida Beaches is 905.2 mi. Typically, this will take 4h 25m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Panama City, Florida?

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $239Free CancellationRating
7.9
8,452 reviews
Search Delta flights
American AirlinesPriceFrom $262Free CancellationRating
7.1
11,641 reviews
Search American Airlines flights
SouthwestPriceFrom $297Free CancellationRating
7.9
4,282 reviews
Search Southwest flights
United AirlinesPriceFrom $342Free CancellationRating
7.4
9,748 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

Finding the right flight to Panama City from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Panama City?

Once you have performed a search for Des Moines to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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