What is the cheapest airline that flies from Des Moines to Panama City NW Florida Beaches?

Delta, American Airlines, and Southwest are the most popular carriers operating from Des Moines to Panama City NW Florida Beaches

What airlines fly to Panama City, Florida?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama City, Florida from Des Moines according to our data. American Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 5 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

The number of operators available for flights from Des Moines Airport to Panama City NW Florida Beaches Airport is 4 as of October 2026.

How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.

What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$239 Cheap Flights from Des Moines to Panama City, Florida in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama City

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:00 am - 1:17 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 17m1 stop Chicago O'Hare Intl

4:50 pm - 10:21 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 31m1 stop Houston George Bush Intcntl

$323United Airlines

Wed, Dec 9 - Mon, Dec 14

3:31 pm - 9:09 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 38m1 stop Dallas/Fort Worth

11:09 am - 7:02 pmECP Panama City NW Florida Beaches-DSM Des Moines

7h 53m1 stop Chicago O'Hare Intl

$324American Airlines

Tue, Feb 9 - Tue, Feb 16

8:00 am - 1:17 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 17m1 stop Chicago O'Hare Intl

9:05 am - 8:33 pmECP Panama City NW Florida Beaches-DSM Des Moines

11h 28m2 stops Houston George Bush Intcntl Denver Intl

$339United Airlines

Wed, Dec 9 - Mon, Dec 14

9:25 am - 9:40 pmDSM Des Moines-ECP Panama City NW Florida Beaches

12h 15m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

3:00 pm - 10:33 pmECP Panama City NW Florida Beaches-DSM Des Moines

7h 33m1 stop Houston George Bush Intcntl

$363United Airlines

Tue, Feb 9 - Tue, Feb 16

6:00 am - 3:35 pmDSM Des Moines-ECP Panama City NW Florida Beaches

9h 35m2 stops Chicago Midway Austin Bergstrom

10:05 am - 8:50 pmECP Panama City NW Florida Beaches-DSM Des Moines

10h 45m2 stops Austin Bergstrom Denver Intl

$386Southwest

Wed, Dec 9 - Mon, Dec 14

5:45 am - 12:39 pmDSM Des Moines-ECP Panama City NW Florida Beaches

6h 54m1 stop Atlanta Hartsfield-Jackson

7:45 am - 12:13 pmECP Panama City NW Florida Beaches-DSM Des Moines

4h 28m1 stop Atlanta Hartsfield-Jackson

$391Delta

Sat, Feb 27 - Sat, Mar 6

5:45 am - 12:39 pmDSM Des Moines-ECP Panama City NW Florida Beaches

6h 54m1 stop Atlanta Hartsfield-Jackson

7:45 am - 12:13 pmECP Panama City NW Florida Beaches-DSM Des Moines

4h 28m1 stop Atlanta Hartsfield-Jackson

$391Delta

Sat, Feb 27 - Sat, Mar 6

5:55 am - 6:10 pmDSM Des Moines-ECP Panama City NW Florida Beaches

12h 15m2 stops Chicago Midway Nashville Intl

7:50 am - 10:15 pmECP Panama City NW Florida Beaches-DSM Des Moines

14h 25m2 stops Nashville Intl Chicago Midway

$425Southwest

Tue, Feb 9 - Tue, Feb 16

5:07 am - 12:35 pmDSM Des Moines-ECP Panama City NW Florida Beaches

7h 28m1 stop Washington, D.C. Reagan-National

7:35 am - 3:41 pmECP Panama City NW Florida Beaches-DSM Des Moines

8h 06m1 stop Charlotte Douglas

$446American Airlines

Thu, Feb 11 - Sat, Feb 20

3:31 pm - 8:59 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 28m1 stop Dallas/Fort Worth

3:56 pm - 11:23 pmECP Panama City NW Florida Beaches-DSM Des Moines

7h 27m1 stop Dallas/Fort Worth

$457American Airlines

Mon, Nov 16 - Mon, Nov 23

Cheap last minute flights

Enter your travel dates to find the best prices.

6:14 am - 11:38 amDSM Des Moines-ECP Panama City NW Florida Beaches

5h 24m1 stop Dallas/Fort Worth

6:42 pm - 11:58 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 16m1 stop Charlotte Douglas

$932American Airlines

Thu, Oct 22 - Thu, Oct 29

4:12 pm - 9:17 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 05m1 stop Dallas/Fort Worth

6:42 pm - 11:58 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 16m1 stop Charlotte Douglas

$932American Airlines

Fri, Oct 23 - Thu, Oct 29

6:00 am - 11:06 amDSM Des Moines-ECP Panama City NW Florida Beaches

5h 06m1 stop Houston George Bush Intcntl

9:06 am - 2:20 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 14m1 stop Houston George Bush Intcntl

$932United Airlines

Thu, Oct 22 - Fri, Oct 30

6:00 am - 11:06 amDSM Des Moines-ECP Panama City NW Florida Beaches

5h 06m1 stop Houston George Bush Intcntl

9:06 am - 2:20 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 14m1 stop Houston George Bush Intcntl

$932United Airlines

Thu, Oct 22 - Tue, Oct 27

11:22 am - 6:42 pmDSM Des Moines-ECP Panama City NW Florida Beaches

7h 20m1 stop Charlotte Douglas

6:42 pm - 11:58 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 16m1 stop Charlotte Douglas

$932American Airlines

Wed, Oct 21 - Thu, Oct 29

6:00 am - 1:03 pmDSM Des Moines-ECP Panama City NW Florida Beaches

7h 03m1 stop Chicago O'Hare Intl

9:06 am - 2:20 pmECP Panama City NW Florida Beaches-DSM Des Moines

5h 14m1 stop Houston George Bush Intcntl

$932United Airlines

Wed, Oct 21 - Tue, Oct 27

6:20 am - 5:05 pmDSM Des Moines-ECP Panama City NW Florida Beaches

10h 45m1 stop Denver Intl

1:30 pm - 9:35 pmECP Panama City NW Florida Beaches-DSM Des Moines

8h 05m1 stop Denver Intl

$937Southwest

Thu, Oct 22 - Sun, Oct 25

5:10 am - 3:25 pmDSM Des Moines-ECP Panama City NW Florida Beaches

10h 15m2 stops Chicago Midway Houston Hobby

1:30 pm - 9:35 pmECP Panama City NW Florida Beaches-DSM Des Moines

8h 05m1 stop Denver Intl

$937Southwest

Fri, Oct 23 - Sun, Oct 25

3:03 pm - 9:06 pmDSM Des Moines-ECP Panama City NW Florida Beaches

6h 03m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:42 amECP Panama City NW Florida Beaches-DSM Des Moines

4h 42m1 stop Atlanta Hartsfield-Jackson

$973Delta

Thu, Oct 22 - Mon, Oct 26

11:27 am - 4:37 pmDSM Des Moines-ECP Panama City NW Florida Beaches

5h 10m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:42 amECP Panama City NW Florida Beaches-DSM Des Moines

4h 42m1 stop Atlanta Hartsfield-Jackson

$973Delta

Wed, Oct 21 - Mon, Oct 26

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Delta flights from Des Moines to Panama City, Florida

Our best Delta deals on Des Moines to Panama City, Florida flight tickets

Delta

Feb 27

DSM5:45 amDes Moines

6h 54m

1 stop

ECP12:39 pmPanama City NW Florida Beaches

Mar 6

ECP7:45 amPanama City NW Florida Beaches

4h 28m

1 stop

DSM12:13 pmDes Moines

$391

Delta

Feb 27

DSM5:45 amDes Moines

6h 54m

1 stop

ECP12:39 pmPanama City NW Florida Beaches

Mar 6

ECP7:45 amPanama City NW Florida Beaches

4h 28m

1 stop

DSM12:13 pmDes Moines

$445

Delta

Dec 3

DSM6:53 pmDes Moines

4h 24m

1 stop

ECP11:17 pmPanama City NW Florida Beaches

Dec 6

ECP4:06 pmPanama City NW Florida Beaches

6h 32m

1 stop

DSM10:38 pmDes Moines

$455

American Airlines flights from Des Moines to Panama City, Florida

Our best American Airlines deals on Des Moines to Panama City, Florida flight tickets

American Airlines

Feb 9

DSM3:31 pmDes Moines

5h 38m

1 stop

ECP9:09 pmPanama City NW Florida Beaches

Feb 16

ECP11:09 amPanama City NW Florida Beaches

7h 53m

1 stop

DSM7:02 pmDes Moines

$324

American Airlines

Feb 11

DSM5:07 amDes Moines

7h 28m

1 stop

ECP12:35 pmPanama City NW Florida Beaches

Feb 20

ECP7:35 amPanama City NW Florida Beaches

8h 06m

1 stop

DSM3:41 pmDes Moines

$446

American Airlines

Nov 16

DSM3:31 pmDes Moines

5h 28m

1 stop

ECP8:59 pmPanama City NW Florida Beaches

Nov 23

ECP3:56 pmPanama City NW Florida Beaches

7h 27m

1 stop

DSM11:23 pmDes Moines

$457

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

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Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Wed 12/9

8:00 am-1:17 pm

1 stop5h 17m

Panama City NW Florida Beaches

Mon 12/14

4:50 pm-10:21 pm

1 stop5h 31m

$323

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Tue 2/9

3:31 pm-9:09 pm

1 stop5h 38m

Panama City NW Florida Beaches

Tue 2/16

11:09 am-7:02 pm

1 stop7h 53m

$324

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Wed 12/9

8:00 am-1:17 pm

1 stop5h 17m

Panama City NW Florida Beaches

Mon 12/14

9:05 am-8:33 pm

2 stops11h 28m

$339

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Tue 2/9

9:25 am-9:40 pm

2 stops12h 15m

Panama City NW Florida Beaches

Tue 2/16

3:00 pm-10:33 pm

1 stop7h 33m

$363

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Wed 12/9

6:00 am-3:35 pm

2 stops9h 35m

Panama City NW Florida Beaches

Mon 12/14

10:05 am-8:50 pm

2 stops10h 45m

$386

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 2/27

5:45 am-12:39 pm

1 stop6h 54m

Panama City NW Florida Beaches

Sat 3/6

7:45 am-12:13 pm

1 stop4h 28m

$391

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Sat 2/27

5:45 am-12:39 pm

1 stop6h 54m

Panama City NW Florida Beaches

Sat 3/6

7:45 am-12:13 pm

1 stop4h 28m

$391

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Tue 2/9

5:55 am-6:10 pm

2 stops12h 15m

Panama City NW Florida Beaches

Tue 2/16

7:50 am-10:15 pm

2 stops14h 25m

$425

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Thu 2/11

5:07 am-12:35 pm

1 stop7h 28m

Panama City NW Florida Beaches

Sat 2/20

7:35 am-3:41 pm

1 stop8h 06m

$446

Des MoinesPanama City

DSM Des Moines - ECP Panama City NW Florida Beaches

DSMECP

Des Moines

Mon 11/16

3:31 pm-8:59 pm

1 stop5h 28m

Panama City NW Florida Beaches

Mon 11/23

3:56 pm-11:23 pm

1 stop7h 27m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Des Moines is in September. Flight prices, which tend to average around $324, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Des Moines averaging around $363.

Can stopping save me money on Des Moines to Panama City, Florida flights?

You could potentially save up to 4% on your flight if you consider stops on a Des Moines to Panama City, Florida flight.

When to book flights from Des Moines to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City, Florida

Best Price Found	$239
Fastest flight time	4h 04m
Direct flights	None

The best one-way flight to Panama City, Florida from Des Moines in the past 72 hours is $239. The best round-trip flight deal from Des Moines to Panama City, Florida found on momondo in the last 72 hours is $323.

The fastest flight from Des Moines to Panama City, Florida takes 4h 04m

There are no direct flights from Des Moines to Panama City, Florida. There are no popular flight routes from Des Moines to Panama City, Florida.

Search flight deals

Frequently asked questions about flying from Des Moines to Panama City, Florida

How far is Des Moines to Panama City NW Florida Beaches by plane?
The straight-line distance from Des Moines to Panama City NW Florida Beaches is 905.2 mi. Typically, this will take 4h 04m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?
Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?
The number of operators available for flights from Des Moines Airport to Panama City NW Florida Beaches Airport is 4 as of October 2026.
How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.
What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?
The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Panama City, Florida?
Based on momondo bookings for flights between Des Moines and Panama City, Florida, the leading airline is Delta, making up 36% of the total bookings. Other popular airlines include American Airlines with 31%, United Airlines with 20%, and Southwest with 13%.

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $271	Free Cancellation	Rating 7.8 8,651 reviews	Search Delta flights
American Airlines	PriceFrom $285	Free Cancellation	Rating 7.0 12,177 reviews	Search American Airlines flights
United Airlines	PriceFrom $342	Free Cancellation	Rating 7.3 10,388 reviews	Search United Airlines flights
Southwest	PriceFrom $374	Free Cancellation	Rating 7.9 4,210 reviews	Search Southwest flights

Panama City Beach

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Port St. Joe

Seaside

Mexico Beach

Seagrove Beach

Freeport

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Why should I use momondo to find a flight deal from Des Moines to Panama City?

Finding the right flight to Panama City from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Panama City?

Once you have performed a search for Des Moines to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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Cheap flights from Des Moines to Panama City from $239

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from Des Moines to Panama City, Florida

Our best Delta deals on Des Moines to Panama City, Florida flight tickets

American Airlines flights from Des Moines to Panama City, Florida

Our best American Airlines deals on Des Moines to Panama City, Florida flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

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How to get the cheapest flight ticket from Des Moines to Panama City, Florida

What is the cheapest month to fly to Panama City, Florida?

Can stopping save me money on Des Moines to Panama City, Florida flights?

What is the cheapest airline that flies from Des Moines to Panama City NW Florida Beaches?

What airlines fly to Panama City, Florida?

When to book flights from Des Moines to Panama City, Florida

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Des Moines to Panama City, Florida

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo

Traveling to a place near Panama City?

Why use momondo?

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Florida

Fly your favorite airline to Panama City

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama City

List of cabin classes available on flights landing in Panama City. Availability may vary depending on flight origin and airline.

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