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Cheap flights from Des Moines to Panama City from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 2/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 am - 10:41 am
DSM
-
ECP
5h 41m1 stop
American Airlines Logo
4:34 pm - 9:59 pm
ECP
-
DSM
5h 25m1 stop
$305American Airlines
Sat, Feb 14 - Thu, Feb 19
American Airlines Logo
5:00 am - 10:41 am
DSM
-
ECP
5h 41m1 stop
American Airlines Logo
7:19 am - 6:19 pm
ECP
-
DSM
11h 00m2 stops
$310American Airlines
Sat, Feb 14 - Thu, Feb 19
Delta Logo
12:02 pm - 4:15 pm
DSM
-
ECP
4h 13m1 stop
Delta Logo
12:55 pm - 7:33 pm
ECP
-
DSM
6h 38m1 stop
$319Delta
Tue, Feb 17 - Tue, Feb 24
Delta Logo
5:15 pm - 10:39 pm
DSM
-
ECP
5h 24m1 stop
Delta Logo
12:10 pm - 8:49 pm
ECP
-
DSM
8h 39m2 stops
$324Delta
Tue, Feb 17 - Tue, Feb 24
Delta Logo
6:19 am - 4:15 pm
DSM
-
ECP
9h 56m2 stops
Delta Logo
12:10 pm - 8:49 pm
ECP
-
DSM
8h 39m2 stops
$329Delta
Tue, Feb 17 - Tue, Feb 24
Delta Logo
5:16 pm - 10:40 pm
DSM
-
ECP
5h 24m1 stop
Delta Logo
6:09 pm - 10:29 pm
ECP
-
DSM
4h 20m1 stop
$330Delta
Tue, Jan 27 - Mon, Feb 2
Delta Logo
5:16 pm - 10:40 pm
DSM
-
ECP
5h 24m1 stop
Delta Logo
6:00 am - 5:08 pm
ECP
-
DSM
11h 08m2 stops
$335Delta
Tue, Jan 27 - Mon, Feb 2
Delta Logo
5:24 am - 11:25 am
DSM
-
ECP
6h 01m1 stop
Delta Logo
11:08 am - 4:33 pm
ECP
-
DSM
5h 25m1 stop
$337Delta
Tue, Mar 3 - Wed, Mar 11
Delta Logo
12:25 pm - 10:40 pm
DSM
-
ECP
10h 15m2 stops
Delta Logo
7:20 am - 5:08 pm
ECP
-
DSM
9h 48m2 stops
$340Delta
Tue, Jan 27 - Mon, Feb 2
Delta Logo
5:16 pm - 10:40 pm
DSM
-
ECP
5h 24m1 stop
Delta Logo
6:09 pm - 10:29 pm
ECP
-
DSM
4h 20m1 stop
$341Delta
Mon, Jan 26 - Mon, Feb 2

Southwest flights from Des Moines to Panama City, Florida

Our best Southwest deals on Des Moines to Panama City, Florida flight tickets
Southwest
Feb 14
DSM5:10 amDes Moines
11h 20m
2 stops
ECP4:30 pmPanama City NW Florida Beaches
Feb 19
ECP4:30 pmPanama City NW Florida Beaches
5h 45m
2 stops
DSM10:15 pmDes Moines
$370
Find similar
Southwest
Feb 26
DSM5:10 amDes Moines
9h 55m
2 stops
ECP3:05 pmPanama City NW Florida Beaches
Mar 1
ECP2:45 pmPanama City NW Florida Beaches
8h 50m
2 stops
DSM11:35 pmDes Moines
$374
Find similar
Southwest
Mar 28
DSM6:45 amDes Moines
7h 50m
1 stop
ECP2:35 pmPanama City NW Florida Beaches
Apr 4
ECP11:05 amPanama City NW Florida Beaches
10h 40m
2 stops
DSM9:45 pmDes Moines
$412
Find similar

American Airlines flights from Des Moines to Panama City, Florida

Our best American Airlines deals on Des Moines to Panama City, Florida flight tickets
American Airlines
Feb 14
DSM5:00 amDes Moines
5h 41m
1 stop
ECP10:41 amPanama City NW Florida Beaches
Feb 19
ECP4:34 pmPanama City NW Florida Beaches
5h 25m
1 stop
DSM9:59 pmDes Moines
$305
Find similar
American Airlines
Feb 14
DSM5:00 amDes Moines
5h 41m
1 stop
ECP10:41 amPanama City NW Florida Beaches
Feb 19
ECP7:19 amPanama City NW Florida Beaches
11h 00m
2 stops
DSM6:19 pmDes Moines
$310
Find similar
American Airlines
Feb 12
DSM7:44 pmDes Moines
18h 40m
1 stop
ECP2:24 pmPanama City NW Florida Beaches
Feb 17
ECP1:18 pmPanama City NW Florida Beaches
8h 33m
1 stop
DSM9:51 pmDes Moines
$353
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 1, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 2/14

5:00 am-10:41 am

1 stop5h 41m

Panama City NW Florida Beaches

Thu 2/19

4:34 pm-9:59 pm

1 stop5h 25m

$305

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 2/14

5:00 am-10:41 am

1 stop5h 41m

Panama City NW Florida Beaches

Thu 2/19

7:19 am-6:19 pm

2 stops11h 00m

$310

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 2/17

12:02 pm-4:15 pm

1 stop4h 13m

Panama City NW Florida Beaches

Tue 2/24

12:55 pm-7:33 pm

1 stop6h 38m

$319

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 2/17

5:15 pm-10:39 pm

1 stop5h 24m

Panama City NW Florida Beaches

Tue 2/24

12:10 pm-8:49 pm

2 stops8h 39m

$324

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 2/17

6:19 am-4:15 pm

2 stops9h 56m

Panama City NW Florida Beaches

Tue 2/24

12:10 pm-8:49 pm

2 stops8h 39m

$329

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 1/27

5:16 pm-10:40 pm

1 stop5h 24m

Panama City NW Florida Beaches

Mon 2/2

6:09 pm-10:29 pm

1 stop4h 20m

$330

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 1/27

5:16 pm-10:40 pm

1 stop5h 24m

Panama City NW Florida Beaches

Mon 2/2

6:00 am-5:08 pm

2 stops11h 08m

$335

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/3

5:24 am-11:25 am

1 stop6h 01m

Panama City NW Florida Beaches

Wed 3/11

11:08 am-4:33 pm

1 stop5h 25m

$337

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 1/27

12:25 pm-10:40 pm

2 stops10h 15m

Panama City NW Florida Beaches

Mon 2/2

7:20 am-5:08 pm

2 stops9h 48m

$340

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 1/26

5:16 pm-10:40 pm

1 stop5h 24m

Panama City NW Florida Beaches

Mon 2/2

6:09 pm-10:29 pm

1 stop4h 20m

$341

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Des Moines is in August. Flight prices, which tend to average around $339, are often lower during this time because this is during the off-season. The month of July is another great option to travel to Panama City, Florida, with average flight prices from Des Moines averaging around $363.

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $448 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Des Moines for as low as $331 on momondo.

Can stopping save me money on Des Moines to Panama City, Florida flights?

You could potentially save up to 64% on your flight if you consider stops on a Des Moines to Panama City, Florida flight.

When to book flights from Des Moines to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City, Florida

Fastest flight time

4h 13m

Direct flights

None
The fastest flight from Des Moines to Panama City, Florida takes 4h 13m
There are no direct flights from Des Moines to Panama City, Florida. There are no popular flight routes from Des Moines to Panama City, Florida.
Search flight deals

  • How far is Des Moines to Panama City NW Florida Beaches by plane?

    The straight-line distance from Des Moines to Panama City NW Florida Beaches is 905.2 mi. Typically, this will take 4h 13m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Panama City, Florida?

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $239Free CancellationRating
7.9
8,013 reviews
Search Delta flights
American AirlinesPriceFrom $283Free CancellationRating
7.2
11,070 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,128 reviews
Search United Airlines flights
SouthwestPriceFrom $302Free CancellationRating
8.0
4,253 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

Finding the right flight to Panama City from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Panama City?

Once you have performed a search for Des Moines to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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