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Cheap flights from Des Moines to Panama City from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 9/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:54 pm - 8:08 pm
DSM
-
ECP
5h 14m
1 stop
Delta Logo
9:27 am - 3:16 pm
ECP
-
DSM
5h 49m
1 stop
$263Delta
Fri, Aug 14 - Sat, Aug 22
Southwest Logo
2:25 pm - 9:35 pm
DSM
-
ECP
7h 10m
1 stop
Southwest Logo
11:45 am - 7:25 pm
ECP
-
DSM
7h 40m
2 stops
$269Southwest
Fri, Aug 14 - Sat, Aug 22
Southwest Logo
5:40 am - 4:35 pm
DSM
-
ECP
10h 55m
2 stops
Southwest Logo
11:45 am - 7:25 pm
ECP
-
DSM
7h 40m
2 stops
$280Southwest
Fri, Aug 14 - Sat, Aug 22
American Airlines Logo
4:48 pm - 9:39 pm
DSM
-
ECP
4h 51m
1 stop
American Airlines Logo
6:40 am - 12:24 pm
ECP
-
DSM
5h 44m
1 stop
$299American Airlines
Tue, Aug 4 - Tue, Aug 11
Southwest Logo
2:25 pm - 9:35 pm
DSM
-
ECP
7h 10m
1 stop
Southwest Logo
11:45 am - 7:25 pm
ECP
-
DSM
7h 40m
2 stops
$305Southwest
Fri, Aug 14 - Sat, Aug 22
Southwest Logo
5:40 am - 4:35 pm
DSM
-
ECP
10h 55m
2 stops
Southwest Logo
11:45 am - 7:25 pm
ECP
-
DSM
7h 40m
2 stops
$316Southwest
Fri, Aug 14 - Sat, Aug 22
Delta Logo
6:54 pm - 11:25 pm
DSM
-
ECP
4h 31m
1 stop
Delta Logo
9:23 am - 1:49 pm
ECP
-
DSM
4h 26m
1 stop
$317Delta
Thu, Sep 17 - Tue, Sep 22
United Airlines Logo
6:24 am - 1:13 pm
DSM
-
ECP
6h 49m
1 stop
United Airlines Logo
1:54 pm - 9:28 pm
ECP
-
DSM
7h 34m
1 stop
$343United Airlines
Tue, Sep 15 - Wed, Sep 16
Delta Logo
5:40 am - 10:42 am
DSM
-
ECP
5h 02m
1 stop
Delta Logo
4:10 pm - 10:37 pm
ECP
-
DSM
6h 27m
1 stop
$348Delta
Tue, Aug 11 - Mon, Aug 17
Southwest Logo
5:10 am - 3:25 pm
DSM
-
ECP
10h 15m
2 stops
Southwest Logo
9:55 am - 9:30 pm
ECP
-
DSM
11h 35m
2 stops
$351Southwest
Fri, Oct 2 - Sun, Oct 4

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United Airlines flights from Des Moines to Panama City, Florida

Our best United Airlines deals on Des Moines to Panama City, Florida flight tickets
United Airlines
Sep 15
DSM6:24 amDes Moines
6h 49m
1 stop
ECP1:13 pmPanama City NW Florida Beaches
Sep 16
ECP1:54 pmPanama City NW Florida Beaches
7h 34m
1 stop
DSM9:28 pmDes Moines
$343
United Airlines
Nov 17
DSM1:05 pmDes Moines
8h 45m
2 stops
ECP9:50 pmPanama City NW Florida Beaches
Nov 18
ECP9:05 amPanama City NW Florida Beaches
11h 24m
2 stops
DSM8:29 pmDes Moines
$353
United Airlines
Sep 15
DSM6:24 amDes Moines
10h 14m
2 stops
ECP4:38 pmPanama City NW Florida Beaches
Sep 16
ECP1:54 pmPanama City NW Florida Beaches
7h 34m
1 stop
DSM9:28 pmDes Moines
$375

Delta flights from Des Moines to Panama City, Florida

Our best Delta deals on Des Moines to Panama City, Florida flight tickets
Delta
Sep 17
DSM6:54 pmDes Moines
4h 31m
1 stop
ECP11:25 pmPanama City NW Florida Beaches
Sep 22
ECP9:23 amPanama City NW Florida Beaches
4h 26m
1 stop
DSM1:49 pmDes Moines
$263
Delta
Sep 17
DSM6:54 pmDes Moines
4h 31m
1 stop
ECP11:25 pmPanama City NW Florida Beaches
Sep 22
ECP9:23 amPanama City NW Florida Beaches
4h 26m
1 stop
DSM1:49 pmDes Moines
$317
Delta
Aug 11
DSM5:40 amDes Moines
5h 02m
1 stop
ECP10:42 amPanama City NW Florida Beaches
Aug 17
ECP4:10 pmPanama City NW Florida Beaches
6h 27m
1 stop
DSM10:37 pmDes Moines
$348

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 13, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 8/14

2:54 pm-8:08 pm

1 stop5h 14m

Panama City NW Florida Beaches

Sat 8/22

9:27 am-3:16 pm

1 stop5h 49m

$263

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 8/14

2:25 pm-9:35 pm

1 stop7h 10m

Panama City NW Florida Beaches

Sat 8/22

11:45 am-7:25 pm

2 stops7h 40m

$269

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 8/14

5:40 am-4:35 pm

2 stops10h 55m

Panama City NW Florida Beaches

Sat 8/22

11:45 am-7:25 pm

2 stops7h 40m

$280

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 8/4

4:48 pm-9:39 pm

1 stop4h 51m

Panama City NW Florida Beaches

Tue 8/11

6:40 am-12:24 pm

1 stop5h 44m

$299

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 8/14

2:25 pm-9:35 pm

1 stop7h 10m

Panama City NW Florida Beaches

Sat 8/22

11:45 am-7:25 pm

2 stops7h 40m

$305

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 8/14

5:40 am-4:35 pm

2 stops10h 55m

Panama City NW Florida Beaches

Sat 8/22

11:45 am-7:25 pm

2 stops7h 40m

$316
Quickest round-trip

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 9/17

6:54 pm-11:25 pm

1 stop4h 31m

Panama City NW Florida Beaches

Tue 9/22

9:23 am-1:49 pm

1 stop4h 26m

$317

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 9/15

6:24 am-1:13 pm

1 stop6h 49m

Panama City NW Florida Beaches

Wed 9/16

1:54 pm-9:28 pm

1 stop7h 34m

$343

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 8/11

5:40 am-10:42 am

1 stop5h 02m

Panama City NW Florida Beaches

Mon 8/17

4:10 pm-10:37 pm

1 stop6h 27m

$348

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 10/2

5:10 am-3:25 pm

2 stops10h 15m

Panama City NW Florida Beaches

Sun 10/4

9:55 am-9:30 pm

2 stops11h 35m

$351

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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2

See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Des Moines is in September. Flight prices, which tend to average around $354, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Des Moines averaging around $363.

Can stopping save me money on Des Moines to Panama City, Florida flights?

You could potentially save up to 49% on your flight if you consider stops on a Des Moines to Panama City, Florida flight.

When to book flights from Des Moines to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City, Florida

Fastest flight time

4h 24m

Direct flights

None
The fastest flight from Des Moines to Panama City, Florida takes 4h 24m
There are no direct flights from Des Moines to Panama City, Florida. There are no popular flight routes from Des Moines to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Des Moines to Panama City, Florida

  • How far is Des Moines to Panama City NW Florida Beaches by plane?

    The straight-line distance from Des Moines to Panama City NW Florida Beaches is 905.2 mi. Typically, this will take 4h 24m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Panama City, Florida?

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $258Free CancellationRating
7.8
8,462 reviews
Search Delta flights
American AirlinesPriceFrom $285Free CancellationRating
7.1
11,811 reviews
Search American Airlines flights
SouthwestPriceFrom $297Free CancellationRating
8.0
4,249 reviews
Search Southwest flights
United AirlinesPriceFrom $342Free CancellationRating
7.4
9,983 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

Finding the right flight to Panama City from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Panama City?

Once you have performed a search for Des Moines to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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