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Cheap flights from Des Moines to Panama City from $227

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 4/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:40 am - 2:50 pm
DSM
-
ECP
8h 10m
1 stop
Southwest Logo
3:05 pm - 10:05 pm
ECP
-
DSM
7h 00m
1 stop
$319Southwest
Tue, Mar 10 - Tue, Mar 17
Southwest Logo
5:30 am - 2:30 pm
DSM
-
ECP
9h 00m
2 stops
Southwest Logo
3:05 pm - 10:05 pm
ECP
-
DSM
7h 00m
1 stop
$324Southwest
Tue, Mar 10 - Tue, Mar 17
Southwest Logo
6:40 am - 5:30 pm
DSM
-
ECP
10h 50m
2 stops
Southwest Logo
1:20 pm - 10:05 pm
ECP
-
DSM
8h 45m
2 stops
$329Southwest
Tue, Mar 10 - Tue, Mar 17
Delta Logo
2:44 pm - 7:36 pm
DSM
-
ECP
4h 52m
1 stop
Delta Logo
5:49 am - 11:05 am
ECP
-
DSM
5h 16m
1 stop
$330Delta
Sat, Apr 18 - Wed, Apr 22
Delta Logo
10:28 am - 7:47 pm
DSM
-
ECP
9h 19m
2 stops
Delta Logo
12:28 pm - 7:27 pm
ECP
-
DSM
6h 59m
1 stop
$334Delta
Tue, Mar 17 - Wed, Mar 25
Delta Logo
12:01 pm - 11:12 pm
DSM
-
ECP
11h 11m
2 stops
Delta Logo
5:49 am - 11:05 am
ECP
-
DSM
5h 16m
1 stop
$335Delta
Sat, Apr 18 - Tue, Apr 21
Delta Logo
10:28 am - 7:47 pm
DSM
-
ECP
9h 19m
2 stops
Delta Logo
6:00 am - 4:54 pm
ECP
-
DSM
10h 54m
2 stops
$339Delta
Tue, Mar 17 - Wed, Mar 25
United Airlines Logo
6:20 am - 4:12 pm
DSM
-
ECP
9h 52m
2 stops
United Airlines Logo
6:30 am - 4:15 pm
ECP
-
DSM
9h 45m
2 stops
$340United Airlines
Wed, Apr 8 - Sat, Apr 11
Delta Logo
6:30 pm - 11:12 pm
DSM
-
ECP
4h 42m
1 stop
Delta Logo
5:49 am - 11:05 am
ECP
-
DSM
5h 16m
1 stop
$341Delta
Sat, Apr 18 - Thu, Apr 23
Delta Logo
5:20 pm - 11:04 pm
DSM
-
ECP
5h 44m
1 stop
Delta Logo
7:05 am - 4:54 pm
ECP
-
DSM
9h 49m
2 stops
$345Delta
Tue, Mar 17 - Thu, Mar 26

Southwest flights from Des Moines to Panama City, Florida

Our best Southwest deals on Des Moines to Panama City, Florida flight tickets
Southwest
Mar 10
DSM6:40 amDes Moines
8h 10m
1 stop
ECP2:50 pmPanama City NW Florida Beaches
Mar 17
ECP3:05 pmPanama City NW Florida Beaches
7h 00m
1 stop
DSM10:05 pmDes Moines
$319
Southwest
Mar 10
DSM5:30 amDes Moines
9h 00m
2 stops
ECP2:30 pmPanama City NW Florida Beaches
Mar 17
ECP3:05 pmPanama City NW Florida Beaches
7h 00m
1 stop
DSM10:05 pmDes Moines
$324
Southwest
Mar 10
DSM6:40 amDes Moines
10h 50m
2 stops
ECP5:30 pmPanama City NW Florida Beaches
Mar 17
ECP1:20 pmPanama City NW Florida Beaches
8h 45m
2 stops
DSM10:05 pmDes Moines
$329

United Airlines flights from Des Moines to Panama City, Florida

Our best United Airlines deals on Des Moines to Panama City, Florida flight tickets
United Airlines
Apr 8
DSM6:20 amDes Moines
9h 52m
2 stops
ECP4:12 pmPanama City NW Florida Beaches
Apr 11
ECP6:30 amPanama City NW Florida Beaches
9h 45m
2 stops
DSM4:15 pmDes Moines
$340
United Airlines
Apr 15
DSM3:04 pmDes Moines
6h 55m
1 stop
ECP9:59 pmPanama City NW Florida Beaches
Apr 21
ECP6:30 amPanama City NW Florida Beaches
9h 40m
2 stops
DSM4:10 pmDes Moines
$394
United Airlines
Apr 15
DSM3:04 pmDes Moines
6h 55m
1 stop
ECP9:59 pmPanama City NW Florida Beaches
Apr 18
ECP6:30 amPanama City NW Florida Beaches
9h 45m
2 stops
DSM4:15 pmDes Moines
$405

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/10

6:40 am-2:50 pm

1 stop8h 10m

Panama City NW Florida Beaches

Tue 3/17

3:05 pm-10:05 pm

1 stop7h 00m

$319

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/10

5:30 am-2:30 pm

2 stops9h 00m

Panama City NW Florida Beaches

Tue 3/17

3:05 pm-10:05 pm

1 stop7h 00m

$324

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/10

6:40 am-5:30 pm

2 stops10h 50m

Panama City NW Florida Beaches

Tue 3/17

1:20 pm-10:05 pm

2 stops8h 45m

$329

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 4/18

2:44 pm-7:36 pm

1 stop4h 52m

Panama City NW Florida Beaches

Wed 4/22

5:49 am-11:05 am

1 stop5h 16m

$330

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/17

10:28 am-7:47 pm

2 stops9h 19m

Panama City NW Florida Beaches

Wed 3/25

12:28 pm-7:27 pm

1 stop6h 59m

$334

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 4/18

12:01 pm-11:12 pm

2 stops11h 11m

Panama City NW Florida Beaches

Tue 4/21

5:49 am-11:05 am

1 stop5h 16m

$335

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/17

10:28 am-7:47 pm

2 stops9h 19m

Panama City NW Florida Beaches

Wed 3/25

6:00 am-4:54 pm

2 stops10h 54m

$339

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 4/8

6:20 am-4:12 pm

2 stops9h 52m

Panama City NW Florida Beaches

Sat 4/11

6:30 am-4:15 pm

2 stops9h 45m

$340

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 4/18

6:30 pm-11:12 pm

1 stop4h 42m

Panama City NW Florida Beaches

Thu 4/23

5:49 am-11:05 am

1 stop5h 16m

$341

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/17

5:20 pm-11:04 pm

1 stop5h 44m

Panama City NW Florida Beaches

Thu 3/26

7:05 am-4:54 pm

2 stops9h 49m

$345

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Des Moines is in August. Flight prices, which tend to average around $337, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Des Moines averaging around $355.

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $425 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Des Moines for as low as $288 on momondo.

Can stopping save me money on Des Moines to Panama City, Florida flights?

You could potentially save up to 36% on your flight if you consider stops on a Des Moines to Panama City, Florida flight.

When to book flights from Des Moines to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City, Florida (DSM to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City, Florida

Fastest flight time

4h 03m

Direct flights

None
The fastest flight from Des Moines to Panama City, Florida takes 4h 03m
There are no direct flights from Des Moines to Panama City, Florida. There are no popular flight routes from Des Moines to Panama City, Florida.
Search flight deals

  • How far is Des Moines to Panama City NW Florida Beaches by plane?

    The straight-line distance from Des Moines to Panama City NW Florida Beaches is 905.2 mi. Typically, this will take 4h 03m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Des Moines Airport to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Panama City, Florida?

Best airlines flying from Des Moines to Panama City, Florida

Compare and see reviews for airlines that fly from Des Moines to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $239Free CancellationRating
7.9
8,180 reviews
Search Delta flights
American AirlinesPriceFrom $283Free CancellationRating
7.2
11,271 reviews
Search American Airlines flights
SouthwestPriceFrom $302Free CancellationRating
8.0
4,280 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

Finding the right flight to Panama City from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Panama City?

Once you have performed a search for Des Moines to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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