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Cheap flights from Des Moines to Amarillo from $397

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Amarillo departing on 9/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Amarillo

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:34 am - 4:12 pm
DSM
-
AMA
4h 38m
1 stop
United Airlines Logo
9:00 am - 2:17 pm
AMA
-
DSM
5h 17m
1 stop
$397United Airlines
Tue, Sep 1 - Wed, Sep 2
American Airlines Logo
5:30 am - 9:44 am
DSM
-
AMA
4h 14m
1 stop
American Airlines Logo
7:06 pm - 11:58 pm
AMA
-
DSM
4h 52m
1 stop
$460American Airlines
Sun, Jun 21 - Wed, Jun 24
Southwest Logo
6:10 am - 4:55 pm
DSM
-
AMA
10h 45m
2 stops
Southwest Logo
1:00 pm - 9:40 pm
AMA
-
DSM
8h 40m
2 stops
$464Southwest
Sun, Jun 21 - Wed, Jun 24
American Airlines Logo
3:20 pm - 7:57 pm
DSM
-
AMA
4h 37m
1 stop
American Airlines Logo
7:07 pm - 11:59 pm
AMA
-
DSM
4h 52m
1 stop
$467American Airlines
Tue, May 12 - Sat, May 16
Southwest Logo
6:55 am - 3:15 pm
DSM
-
AMA
8h 20m
2 stops
Southwest Logo
10:30 am - 6:00 pm
AMA
-
DSM
7h 30m
1 stop
$472Southwest
Tue, May 12 - Sat, May 16
Southwest Logo
6:55 am - 3:15 pm
DSM
-
AMA
8h 20m
2 stops
Southwest Logo
10:30 am - 8:55 pm
AMA
-
DSM
10h 25m
2 stops
$477Southwest
Tue, May 12 - Sat, May 16
Southwest Logo
1:45 pm - 11:25 pm
DSM
-
AMA
9h 40m
2 stops
Southwest Logo
10:15 am - 9:55 pm
AMA
-
DSM
11h 40m
2 stops
$487Southwest
Thu, May 14 - Mon, May 18
United Airlines Logo
3:00 pm - 10:10 pm
DSM
-
AMA
7h 10m
1 stop
United Airlines Logo
9:00 am - 12:34 am
AMA
-
DSM
15h 34m
2 stops
$530United Airlines
Tue, Sep 1 - Wed, Sep 2
Southwest Logo
12:05 pm - 6:40 pm
DSM
-
AMA
6h 35m
1 stop
Southwest Logo
2:05 pm - 10:45 pm
AMA
-
DSM
8h 40m
2 stops
$539Southwest
Sun, Jun 21 - Wed, Jun 24

American Airlines flights from Des Moines to Amarillo

Our best American Airlines deals on Des Moines to Amarillo flight tickets
American Airlines
Jun 21
DSM5:30 amDes Moines
4h 14m
1 stop
AMA9:44 amAmarillo
Jun 24
AMA7:06 pmAmarillo
4h 52m
1 stop
DSM11:58 pmDes Moines
$460
American Airlines
May 12
DSM3:20 pmDes Moines
4h 37m
1 stop
AMA7:57 pmAmarillo
May 16
AMA7:07 pmAmarillo
4h 52m
1 stop
DSM11:59 pmDes Moines
$467

Southwest flights from Des Moines to Amarillo

Our best Southwest deals on Des Moines to Amarillo flight tickets
Southwest
Jun 21
DSM6:10 amDes Moines
10h 45m
2 stops
AMA4:55 pmAmarillo
Jun 24
AMA1:00 pmAmarillo
8h 40m
2 stops
DSM9:40 pmDes Moines
$464
Southwest
May 12
DSM6:55 amDes Moines
8h 20m
2 stops
AMA3:15 pmAmarillo
May 16
AMA10:30 amAmarillo
7h 30m
1 stop
DSM6:00 pmDes Moines
$472
Southwest
May 12
DSM6:55 amDes Moines
8h 20m
2 stops
AMA3:15 pmAmarillo
May 16
AMA10:30 amAmarillo
10h 25m
2 stops
DSM8:55 pmDes Moines
$477

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Amarillo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from Des Moines to Amarillo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Tue 9/1

11:34 am-4:12 pm

1 stop4h 38m

Amarillo

Wed 9/2

9:00 am-2:17 pm

1 stop5h 17m

$397
Quickest round-trip

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Sun 6/21

5:30 am-9:44 am

1 stop4h 14m

Amarillo

Wed 6/24

7:06 pm-11:58 pm

1 stop4h 52m

$460

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Sun 6/21

6:10 am-4:55 pm

2 stops10h 45m

Amarillo

Wed 6/24

1:00 pm-9:40 pm

2 stops8h 40m

$464

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Tue 5/12

3:20 pm-7:57 pm

1 stop4h 37m

Amarillo

Sat 5/16

7:07 pm-11:59 pm

1 stop4h 52m

$467

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Tue 5/12

6:55 am-3:15 pm

2 stops8h 20m

Amarillo

Sat 5/16

10:30 am-6:00 pm

1 stop7h 30m

$472

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Tue 5/12

6:55 am-3:15 pm

2 stops8h 20m

Amarillo

Sat 5/16

10:30 am-8:55 pm

2 stops10h 25m

$477

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Thu 5/14

1:45 pm-11:25 pm

2 stops9h 40m

Amarillo

Mon 5/18

10:15 am-9:55 pm

2 stops11h 40m

$487

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Tue 9/1

3:00 pm-10:10 pm

1 stop7h 10m

Amarillo

Wed 9/2

9:00 am-12:34 am

2 stops15h 34m

$530

Des MoinesAmarillo

DSM - AMA

DSMAMA

Des Moines

Sun 6/21

12:05 pm-6:40 pm

1 stop6h 35m

Amarillo

Wed 6/24

2:05 pm-10:45 pm

2 stops8h 40m

$539

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Des Moines to Amarillo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Amarillo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Amarillo (DSM to AMA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Amarillo

Fastest flight time

5h 05m

Direct flights

None
The fastest flight from Des Moines to Amarillo takes 5h 05m
There are no direct flights from Des Moines to Amarillo. There are no popular flight routes from Des Moines to Amarillo.
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Frequently asked questions about flying from Des Moines to Amarillo

  • How far is Des Moines to Amarillo by plane?

    The straight-line distance from Des Moines to Amarillo is 623.9 mi. 5h 05m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Amarillo Airport?

    Prices for flights from Des Moines Airport to Amarillo Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Amarillo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Amarillo Airport.

  • What documentation or ID do you need to fly to Amarillo Airport?

    The required travel and health documents for your Amarillo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Amarillo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Frequently asked questions about flying from Des Moines to Amarillo

  • How do I get Price Alerts for flights from Des Moines to Amarillo?

    Search flight deals from Des Moines to Amarillo. While viewing offers you’ll have the option to create a Price Alert.

  • How can I save money on flights from Des Moines to Amarillo with momondo?

    Leverage our AI within our “Price Forecast” tool, which predicts if it’s better to book now or wait until prices decrease. You can strategically pick the best days to fly and save money on your trip by using our “Price Calendar” tool. “Explore” shows an overview of how much it costs to fly to anywhere from a selected city or airport. Our “Discover” content is a great option for travel inspiration and money-saving tips, while “Price Alerts” will update you when prices change, so you can book when fares are right.

  • How does momondo find its flight prices?

    We aggregate our prices from over 700+ competitors from airlines to OTAs. We operate in over 30 markets worldwide to show you a wide range of travel options.

Traveling to a place near Amarillo?

Book flights to Amarillo if you plan to visit one of these locations
Dumas
Dalhart
Vega

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Amarillo?

Finding the right flight to Amarillo from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Amarillo quick and easy, saving you time and money.

Can I find flights from Des Moines to Amarillo with flexible booking policies on momondo?

Flights from Des Moines to Amarillo with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Amarillo?

momondo provides multiple filters to help you find the best flight to Amarillo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Amarillo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Amarillo, momondo offers a useful price alert feature which will track prices for flights to Amarillo from Des Moines and alert you when they change.

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