Cheap flights from Des Moines (DSM) from $85

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Fly to

Route

Depart

Return

Price

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Fri 12/19

8:29 pm-9:41 pm

Nonstop2h 12m

$19

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Tue 12/23

2:35 pm-3:45 pm

Nonstop2h 10m

$20

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Sun 12/7

8:30 am-9:46 am

Nonstop3h 16m

$51

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Mon 1/26

8:30 am-9:49 am

Nonstop3h 19m

$52

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Thu 1/22

5:30 am-6:48 am

Nonstop2h 18m

$82

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Mon 12/15

6:20 pm-8:40 pm

Nonstop3h 20m

$89

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Mon 12/8

6:33 pm-12:07 am

1 stop6h 34m

$89

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Sun 1/25

6:54 am-1:35 pm

2 stops7h 41m

$94

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Thu 1/22

5:30 am-6:48 am

Nonstop2h 18m

$96

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Sat 12/13

12:15 pm-8:12 pm

1 stop9h 57m

$99

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Des Moines?

Currently, 14 destinations can be reached directly via flights from Des Moines.

Flights from Des Moines to

Austin

from$75

Flights from Des Moines to

Boston

from$48

Flights from Des Moines to

Fort Lauderdale

from$66

Flights from Des Moines to

Fort Myers

from$111

Flights from Des Moines to

Jacksonville

from$42

Flights from Des Moines to

Las Vegas

from$97

Flights from Des Moines to

Los Angeles

from$137

Flights from Des Moines to

Miami

from$146

Flights from Des Moines to

Nashville

from$59

Flights from Des Moines to

Portland

from$156

Flights from Des Moines to

Punta Gorda

from$88

Flights from Des Moines to

Santa Ana, California

from$125

Flights from Des Moines to

Sarasota

from$103

Flights from Des Moines to

Tampa

from$51

Find the cheapest flights from Des Moines

One-way

Last minute

International

Domestic

Cheap one-way flights from Des Moines

Enter your travel dates to find the best prices.

8:29 pm - 9:41 pmDSM-DEN

2h 12mnonstop

$19Frontier

Find Deal

Fri, Dec 19

2:35 pm - 3:45 pmDSM-DEN

2h 10mnonstop

$20Frontier

Find Deal

Tue, Dec 23

8:30 am - 9:46 amDSM-LAS

3h 16mnonstop

$51Allegiant Air

Find Deal

Sun, Dec 7

8:30 am - 9:49 amDSM-LAS

3h 19mnonstop

$52Allegiant Air

Find Deal

Mon, Jan 26

5:30 am - 6:48 amDSM-DEN

2h 18mnonstop

$82United Airlines

Find Deal

Thu, Jan 22

6:20 pm - 8:40 pmDSM-PHX

3h 20mnonstop

$89American Airlines

Find Deal

Mon, Dec 15

6:33 pm - 12:07 amDSM-DEN

6h 34m1 stop

$89Delta

Find Deal

Mon, Dec 8

6:54 am - 1:35 pmDSM-DEN

7h 41m2 stops

$94Delta

Find Deal

Sun, Jan 25

5:30 am - 6:48 amDSM-DEN

2h 18mnonstop

$96United Airlines

Find Deal

Thu, Jan 22

12:15 pm - 8:12 pmDSM-LAS

9h 57m1 stop

$99American Airlines

Find Deal

Sat, Dec 13

Flights from Des Moines - Travel Insights & Trends

Get data-powered insights and trends into flights from Des Moines to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Des Moines?

From Des Moines, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Gulf Shores, Fort Lauderdale, Jacksonville, Austin, and Chicago the most.

What are the cheapest cities to fly to from Des Moines?

The cheapest city to fly to from Des Moines currently is Jacksonville at $42. The next cheapest destinations are Boston, Tampa, New York, Nashville and Orlando.

Frequently asked questions regarding flights from Des Moines

Which airlines are currently offering the cheapest flights from Des Moines?

Our data suggests that currently, the cheapest flights from Des Moines are being offered by American Airlines, Frontier, and Allegiant Air. For example, American Airlines flights from Des Moines to Houston Hobby Airport, start at $58, Frontier flights from Des Moines to Denver cost around $59, and Allegiant Air flights from Des Moines to Orlando Sanford Intl Airport are around $86.

What is the cheapest flight available from Des Moines?

Currently, the cheapest flight from Des Moines found by our users is for $42 to Jacksonville. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $93 to travel from Des Moines to Jacksonville.

Which destinations have the most frequent flights from Des Moines?

Chicago, Chicago O'Hare Intl Airport and Atlanta are currently the destinations served most frequently from Des Moines, with 15, 15 and 9 flights per day on average, respectively.

Which airlines can you fly with from Des Moines?

Airlines including American Airlines, United Airlines and Delta frequently fly from Des Moines. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Des Moines?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $484.

When did momondo last update prices for flights from Des Moines Airport?

Prices for flights from Des Moines Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport?

There are 26 operators available for flights from Des Moines Airport as of October 2025.

How old do you have to be to fly from Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.