Cheap flights from Des Moines (DSM) from $78

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Fly to

Route

Depart

Return

Price

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Fri 2/27

7:59 pm-9:02 pm

Nonstop2h 03m

$33

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Sun 3/1

7:27 pm-8:30 pm

Nonstop2h 03m

$54

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Mon 1/12

8:30 am-9:49 am

Nonstop3h 19m

$66

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Mon 2/2

8:30 am-9:49 am

Nonstop3h 19m

$70

Des MoinesOrlando

DSM - MCO

DSMMCO

Des Moines

Sat 3/7

6:56 pm-10:53 pm

Nonstop2h 57m

$71

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Thu 2/5

4:30 pm-8:21 am

1 stop16h 51m

$96

Des MoinesNew York

DSM - LGA

DSMLGA

Des Moines

Sun 3/22

8:30 am-11:03 am

1 stop25h 33m

$96

Des MoinesLos Angeles

DSM - LAX

DSMLAX

Des Moines

Wed 2/4

8:35 am-12:10 pm

1 stop5h 35m

$111

Des MoinesLos Angeles

DSM - LAX

DSMLAX

Des Moines

Wed 2/4

8:35 am-2:30 pm

2 stops7h 55m

$116

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 2/21

10:56 am-6:54 pm

1 stop6h 58m

$119

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Des Moines?

Currently, 15 destinations can be reached directly via flights from Des Moines.

Flights from Des Moines to

Austin

from$58

Flights from Des Moines to

Boston

from$48

Flights from Des Moines to

Fort Lauderdale

from$106

Flights from Des Moines to

Fort Myers

from$39

Flights from Des Moines to

Jacksonville

from$277

Flights from Des Moines to

Las Vegas

from$57

Flights from Des Moines to

Los Angeles

from$160

Flights from Des Moines to

Miami

from$289

Flights from Des Moines to

Minneapolis

from$156

Flights from Des Moines to

Nashville

from$76

Flights from Des Moines to

Portland

from$283

Flights from Des Moines to

Punta Gorda

from$122

Flights from Des Moines to

Santa Ana, California

from$126

Flights from Des Moines to

Sarasota

from$202

Flights from Des Moines to

Tampa

from$38

Find the cheapest flights from Des Moines

One-way

Last minute

International

Domestic

Cheap one-way flights from Des Moines

Enter your travel dates to find the best prices.

7:59 pm - 9:02 pm

DSM

DEN

2h 03mnonstop

$33Frontier

Fri, Feb 27

7:27 pm - 8:30 pm

DSM

DEN

2h 03mnonstop

$54Frontier

Sun, Mar 1

8:30 am - 9:49 am

DSM

LAS

3h 19mnonstop

$66Allegiant Air

Mon, Jan 12

8:30 am - 9:49 am

DSM

LAS

3h 19mnonstop

$70Allegiant Air

Mon, Feb 2

6:56 pm - 10:53 pm

DSM

MCO

2h 57mnonstop

$71Frontier

Sat, Mar 7

4:30 pm - 8:21 am

DSM

DEN

16h 51m1 stop

$96Multiple Airlines

Thu, Feb 5

8:30 am - 11:03 am

DSM

LGA

25h 33m1 stop

$96Multiple Airlines

Sun, Mar 22

8:35 am - 12:10 pm

DSM

LAX

5h 35m1 stop

$111Southwest

Wed, Feb 4

8:35 am - 2:30 pm

DSM

LAX

7h 55m2 stops

$116Southwest

Wed, Feb 4

10:56 am - 6:54 pm

DSM

MIA

6h 58m1 stop

$119Delta

Sat, Feb 21

Flights from Des Moines - Travel Insights & Trends

Get data-powered insights and trends into flights from Des Moines to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Des Moines?

According to searches, the most popular destinations for domestic flights from Des Moines among momondo users are Boston, Los Angeles, Chicago, Phoenix and Los Angeles.

What are the cheapest cities to fly to from Des Moines?

The cheapest city to fly to from Des Moines currently is Tampa at $38. The next cheapest destinations are Boston, Orlando, Las Vegas, Austin and New York.

Frequently asked questions regarding flights from Des Moines

Which airlines are currently offering the cheapest flights from Des Moines?

Our data suggests that currently, the cheapest flights from Des Moines are being offered by American Airlines, Frontier, and Allegiant Air. For example, American Airlines flights from Des Moines to Houston Hobby Airport, start at $54, Frontier flights from Des Moines to Denver cost around $62, and Allegiant Air flights from Des Moines to Orlando Sanford Intl Airport are around $91.

What is the cheapest flight available from Des Moines?

Currently, the cheapest flight from Des Moines found by our users is for $38 to Tampa. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $193 to travel from Des Moines to Tampa.

Which destinations have the most frequent flights from Des Moines?

Chicago, Chicago O'Hare Intl Airport and Atlanta are currently the destinations served most frequently from Des Moines, with 19, 19 and 8 flights per day on average, respectively.

Which airlines can you fly with from Des Moines?

Airlines including American Airlines, Delta and United Airlines frequently fly from Des Moines. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Des Moines?

If you are looking for a cheap first class flight, consider flights to Denver, for which the starting price of a first class seat can be as low as $954.

When did momondo last update prices for flights from Des Moines Airport?

Prices for flights from Des Moines Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport?

There are 25 operators available for flights from Des Moines Airport as of January 2026.

How old do you have to be to fly from Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.