Cheap flights from Des Moines (DSM) from $152

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Fly to

Route

Depart

Return

Price

Cheapest one-way

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Sun 9/6

9:56 pm-11:06 pm

Nonstop3h 10m

$45

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Wed 9/2

2:16 pm-3:23 pm

Nonstop2h 07m

$46

Quickest one-way

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Wed 8/5

6:40 pm-7:35 pm

Nonstop1h 55m

$86

Des MoinesSeattle

DSM - SEA

DSMSEA

Des Moines

Tue 8/25

6:40 pm-11:05 pm

1 stop6h 25m

$122

Des MoinesSeattle

DSM - SEA

DSMSEA

Des Moines

Wed 8/5

5:17 pm-11:10 pm

1 stop7h 53m

$144

Des MoinesSeattle

DSM - SEA

DSMSEA

Des Moines

Wed 8/26

5:56 pm-10:00 pm

1 stop6h 04m

$152

Des MoinesSeattle

DSM - SEA

DSMSEA

Des Moines

Fri 7/3

5:35 am-2:55 pm

1 stop11h 20m

$157

Des MoinesWashington, D.C.

DSM - DCA

DSMDCA

Des Moines

Tue 6/30

3:22 pm-6:59 pm

Nonstop2h 37m

$168

Des MoinesWashington, D.C.

DSM - DCA

DSMDCA

Des Moines

Tue 9/1

8:00 am-2:23 pm

1 stop5h 23m

$173

Des MoinesNew York

DSM - JFK

DSMJFK

Des Moines

Tue 7/7

8:53 am-8:04 pm

1 stop10h 11m

$223

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Des Moines?

Currently, 16 destinations can be reached directly via flights from Des Moines.

Flights from Des Moines to

Austin

from$74

Flights from Des Moines to

Boston

from$78

Flights from Des Moines to

Burbank

from$77

Flights from Des Moines to

Denver

from$117

Flights from Des Moines to

Fort Lauderdale

from$72

Flights from Des Moines to

Fort Myers

from$135

Flights from Des Moines to

Jacksonville

from$79

Flights from Des Moines to

Las Vegas

from$26

Flights from Des Moines to

Los Angeles

from$195

Flights from Des Moines to

Nashville

from$35

Flights from Des Moines to

Portland

from$108

Flights from Des Moines to

Punta Gorda

from$121

Flights from Des Moines to

Santa Ana, California

from$92

Flights from Des Moines to

Sarasota

from$111

Flights from Des Moines to

Tampa

from$179

Flights from Des Moines to

Valparaiso, Florida

from$157

Find the cheapest flights from Des Moines

One-way

Last minute

International

Domestic

Cheap one-way flights from Des Moines

Enter your travel dates to find the best prices.

9:56 pm - 11:06 pm

DSM

LAS

3h 10mnonstop

$45Allegiant Air

Sun, Sep 6

2:16 pm - 3:23 pm

DSM

DEN

2h 07mnonstop

$46Frontier

Wed, Sep 2

6:40 pm - 7:35 pm

DSM

DEN

1h 55mnonstop

$86Southwest

Wed, Aug 5

6:40 pm - 11:05 pm

DSM

SEA

6h 25m

1 stop

$122Southwest

Tue, Aug 25

5:17 pm - 11:10 pm

DSM

SEA

7h 53m

1 stop

$144United Airlines

Wed, Aug 5

5:56 pm - 10:00 pm

DSM

SEA

6h 04m

1 stop

$152Delta

Wed, Aug 26

5:35 am - 2:55 pm

DSM

SEA

11h 20m

1 stop

$157Delta

Fri, Jul 3

3:22 pm - 6:59 pm

DSM

DCA

2h 37mnonstop

$168American Airlines

Tue, Jun 30

8:00 am - 2:23 pm

DSM

DCA

5h 23m

1 stop

$173United Airlines

Tue, Sep 1

8:53 am - 8:04 pm

DSM

JFK

10h 11m

1 stop

$223American Airlines

Tue, Jul 7

Flights from Des Moines - Travel Insights & Trends

Get data-powered insights and trends into flights from Des Moines to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Des Moines?

From Des Moines, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Philadelphia, Orlando, Austin, Los Angeles, and Los Angeles the most.

What are the cheapest cities to fly to from Des Moines?

The cheapest city to fly to from Des Moines currently is Las Vegas at $26. The next cheapest destinations are Nashville, Philadelphia, Orlando, Fort Lauderdale and Austin.

Frequently asked questions regarding flights from Des Moines

Which airlines are currently offering the cheapest flights from Des Moines?

Our data suggests that currently, the cheapest flights from Des Moines are being offered by American Airlines, JetBlue, and Allegiant Air. For example, American Airlines flights from Des Moines to Jacksonville, start at $56, JetBlue flights from Des Moines to Denver cost around $62, and Allegiant Air flights from Des Moines to Tampa are around $112.

What is the cheapest flight available from Des Moines?

Currently, the cheapest flight from Des Moines found by our users is for $35 to Nashville. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $141 to travel from Des Moines to Nashville.

Which destinations have the most frequent flights from Des Moines?

Chicago, Chicago O'Hare Intl Airport and Atlanta are currently the destinations served most frequently from Des Moines, with 42, 41 and 21 flights per day on average, respectively.

Which airlines can you fly with from Des Moines?

Airlines including American Airlines, Delta and United Airlines frequently fly from Des Moines. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Des Moines?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $461.

When did momondo last update prices for flights from Des Moines Airport?

Prices for flights from Des Moines Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport?

There are 25 operators available for flights from Des Moines Airport as of June 2026.

How old do you have to be to fly from Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.