Cheap flights from Des Moines (DSM) from $96

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Fly to

Route

Depart

Return

Price

Cheapest one-way

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Mon 10/5

2:51 pm-3:56 pm

Nonstop2h 05m

$41

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Sun 8/30

9:50 pm-10:59 pm

Nonstop3h 09m

$45

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Mon 8/17

10:06 pm-11:18 pm

Nonstop3h 12m

$47

Quickest one-way

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Wed 8/5

6:40 pm-7:35 pm

Nonstop1h 55m

$86

Des MoinesLos Angeles

DSM - LAX

DSMLAX

Des Moines

Mon 8/17

10:06 pm-9:29 am

1 stop13h 23m

$91

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Sun 9/6

8:00 am-7:34 am

1 stop24h 34m

$93

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Sat 9/5

3:05 pm-8:55 pm

1 stop6h 50m

$96

Des MoinesSeattle

DSM - SEA

DSMSEA

Des Moines

Wed 8/26

2:54 pm-11:57 pm

1 stop11h 03m

$122

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 9/5

6:45 am-11:14 am

Nonstop3h 29m

$129

Des MoinesHouston

DSM - IAH

DSMIAH

Des Moines

Sat 10/24

4:12 pm-8:29 pm

1 stop4h 17m

$184

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Des Moines?

Currently, 15 destinations can be reached directly via flights from Des Moines.

Flights from Des Moines to

Austin

from$86

Flights from Des Moines to

Boston

from$78

Flights from Des Moines to

Burbank

from$63

Flights from Des Moines to

Fort Lauderdale

from$54

Flights from Des Moines to

Jacksonville

from$64

Flights from Des Moines to

Las Vegas

from$87

Flights from Des Moines to

Los Angeles

from$218

Flights from Des Moines to

Minneapolis

from$136

Flights from Des Moines to

Nashville

from$47

Flights from Des Moines to

Portland

from$96

Flights from Des Moines to

Punta Gorda

from$129

Flights from Des Moines to

Santa Ana, California

from$83

Flights from Des Moines to

Sarasota

from$133

Flights from Des Moines to

Tampa

from$132

Flights from Des Moines to

Valparaiso, Florida

from$97

Find the cheapest flights from Des Moines

One-way

Last minute

International

Domestic

Cheap one-way flights from Des Moines

Enter your travel dates to find the best prices.

2:51 pm - 3:56 pm

DSM

DEN

2h 05mnonstop

$41Frontier

Mon, Oct 5

9:50 pm - 10:59 pm

DSM

LAS

3h 09mnonstop

$45Allegiant Air

Sun, Aug 30

10:06 pm - 11:18 pm

DSM

LAS

3h 12mnonstop

$47Allegiant Air

Mon, Aug 17

6:40 pm - 7:35 pm

DSM

DEN

1h 55mnonstop

$86Southwest

Wed, Aug 5

10:06 pm - 9:29 am

DSM

LAX

13h 23m

1 stop

$91Multiple Airlines

Mon, Aug 17

8:00 am - 7:34 am

DSM

DEN

24h 34m

1 stop

$93Multiple Airlines

Sun, Sep 6

3:05 pm - 8:55 pm

DSM

DEN

6h 50m

1 stop

$96Southwest

Sat, Sep 5

2:54 pm - 11:57 pm

DSM

SEA

11h 03m

1 stop

$122Delta

Wed, Aug 26

6:45 am - 11:14 am

DSM

MIA

3h 29mnonstop

$129American Airlines

Sat, Sep 5

4:12 pm - 8:29 pm

DSM

IAH

4h 17m

1 stop

$184American Airlines

Sat, Oct 24

Flights from Des Moines - Travel Insights & Trends

Get data-powered insights and trends into flights from Des Moines to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Des Moines?

According to searches, the most popular destinations for domestic flights from Des Moines among momondo users are Boston, Fort Lauderdale, New York, Portland and Chicago.

What are the cheapest cities to fly to from Des Moines?

The cheapest city to fly to from Des Moines currently is Philadelphia at $38. The next cheapest destinations are Nashville, Houston, Fort Lauderdale, Burbank and Jacksonville.

Frequently asked questions regarding flights from Des Moines

Which airlines are currently offering the cheapest flights from Des Moines?

Our data suggests that currently, the cheapest flights from Des Moines are being offered by JetBlue, American Airlines, and Allegiant Air. For example, JetBlue flights from Des Moines to Denver, start at $61, American Airlines flights from Des Moines to Jacksonville cost around $64, and Allegiant Air flights from Des Moines to Punta Gorda are around $123.

What is the cheapest flight available from Des Moines?

Currently, the cheapest flight from Des Moines found by our users is for $38 to Philadelphia. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $1,333 to travel from Des Moines to Philadelphia.

Which destinations have the most frequent flights from Des Moines?

Chicago, Chicago O'Hare Intl Airport and Atlanta are currently the destinations served most frequently from Des Moines, with 34, 33 and 19 flights per day on average, respectively.

Which airlines can you fly with from Des Moines?

Airlines including American Airlines, United Airlines and Delta frequently fly from Des Moines. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Des Moines?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $461.

When did momondo last update prices for flights from Des Moines Airport?

Prices for flights from Des Moines Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport?

There are 30 operators available for flights from Des Moines Airport as of July 2026.

How old do you have to be to fly from Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.