Cheap flights from Des Moines (DSM) from $86

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Fly to

Route

Depart

Return

Price

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Fri 2/27

7:59 pm-9:02 pm

Nonstop2h 03m

$33

Des MoinesDenver

DSM - DEN

DSMDEN

Des Moines

Thu 2/26

7:27 pm-8:30 pm

Nonstop2h 03m

$46

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Sun 1/25

8:30 am-9:49 am

Nonstop3h 19m

$50

Des MoinesLas Vegas

DSM - LAS

DSMLAS

Des Moines

Sun 1/25

8:30 am-9:49 am

Nonstop3h 19m

$54

Des MoinesHouston

DSM - HOU

DSMHOU

Des Moines

Tue 2/17

3:26 pm-7:55 pm

1 stop4h 29m

$115

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 1/24

10:15 am-7:04 pm

1 stop7h 49m

$119

Des MoinesHouston

DSM - HOU

DSMHOU

Des Moines

Tue 2/17

6:25 am-3:20 pm

2 stops8h 55m

$120

Des MoinesHouston

DSM - HOU

DSMHOU

Des Moines

Sat 1/24

11:35 am-6:06 pm

1 stop6h 31m

$150

Des MoinesHouston

DSM - HOU

DSMHOU

Des Moines

Wed 2/18

6:10 am-2:50 pm

2 stops8h 40m

$155

Des MoinesHouston

DSM - HOU

DSMHOU

Des Moines

Sat 1/24

10:59 am-10:33 pm

2 stops11h 34m

$239

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Des Moines?

Currently, 15 destinations can be reached directly via flights from Des Moines.

Flights from Des Moines to

Austin

from$53

Flights from Des Moines to

Boston

from$48

Flights from Des Moines to

Fort Lauderdale

from$106

Flights from Des Moines to

Fort Myers

from$39

Flights from Des Moines to

Jacksonville

from$277

Flights from Des Moines to

Las Vegas

from$81

Flights from Des Moines to

Los Angeles

from$124

Flights from Des Moines to

Miami

from$289

Flights from Des Moines to

Minneapolis

from$149

Flights from Des Moines to

Nashville

from$46

Flights from Des Moines to

Portland

from$283

Flights from Des Moines to

Punta Gorda

from$122

Flights from Des Moines to

Santa Ana, California

from$100

Flights from Des Moines to

Sarasota

from$202

Flights from Des Moines to

Tampa

from$38

Find the cheapest flights from Des Moines

One-way

Last minute

International

Domestic

Cheap one-way flights from Des Moines

Enter your travel dates to find the best prices.

7:59 pm - 9:02 pm

DSM

DEN

2h 03mnonstop

$33Frontier

Fri, Feb 27

7:27 pm - 8:30 pm

DSM

DEN

2h 03mnonstop

$46Frontier

Thu, Feb 26

8:30 am - 9:49 am

DSM

LAS

3h 19mnonstop

$50Allegiant Air

Sun, Jan 25

8:30 am - 9:49 am

DSM

LAS

3h 19mnonstop

$54Allegiant Air

Sun, Jan 25

3:26 pm - 7:55 pm

DSM

HOU

4h 29m1 stop

$115American Airlines

Tue, Feb 17

10:15 am - 7:04 pm

DSM

MIA

7h 49m1 stop

$119Delta

Sat, Jan 24

6:25 am - 3:20 pm

DSM

HOU

8h 55m2 stops

$120Southwest

Tue, Feb 17

11:35 am - 6:06 pm

DSM

HOU

6h 31m1 stop

$150American Airlines

Sat, Jan 24

6:10 am - 2:50 pm

DSM

HOU

8h 40m2 stops

$155Southwest

Wed, Feb 18

10:59 am - 10:33 pm

DSM

HOU

11h 34m2 stops

$239Delta

Sat, Jan 24

Flights from Des Moines - Travel Insights & Trends

Get data-powered insights and trends into flights from Des Moines to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Des Moines?

According to searches, the most popular destinations for domestic flights from Des Moines among momondo users are Boston, New York, Los Angeles, Phoenix and Chicago.

What are the cheapest cities to fly to from Des Moines?

The cheapest city to fly to from Des Moines currently is Tampa at $38. The next cheapest destinations are Nashville, Boston, Orlando, Austin and Fort Lauderdale.

Frequently asked questions regarding flights from Des Moines

Which airlines are currently offering the cheapest flights from Des Moines?

Our data suggests that currently, the cheapest flights from Des Moines are being offered by American Airlines, Frontier, and Allegiant Air. For example, American Airlines flights from Des Moines to Houston Hobby Airport, start at $54, Frontier flights from Des Moines to Denver cost around $62, and Allegiant Air flights from Des Moines to Orlando Sanford Intl Airport are around $92.

What is the cheapest flight available from Des Moines?

Currently, the cheapest flight from Des Moines found by our users is for $38 to Tampa. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $176 to travel from Des Moines to Tampa.

Which destinations have the most frequent flights from Des Moines?

Chicago, Chicago O'Hare Intl Airport and Atlanta are currently the destinations served most frequently from Des Moines, with 19, 19 and 17 flights per day on average, respectively.

Which airlines can you fly with from Des Moines?

Airlines including American Airlines, United Airlines and Delta frequently fly from Des Moines. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Des Moines?

If you are looking for a cheap first class flight, consider flights to Denver, for which the starting price of a first class seat can be as low as $954.

When did momondo last update prices for flights from Des Moines Airport?

Prices for flights from Des Moines Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport?

There are 25 operators available for flights from Des Moines Airport as of December 2025.

How old do you have to be to fly from Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.