Cheap flights from Des Moines from $54

Our data suggests that currently, the cheapest flights from Des Moines are being offered by Frontier, American Airlines, and United Airlines. For example, Frontier flights from Des Moines to Denver, start at $39, American Airlines flights from Des Moines to Houston Hobby Airport cost around $54, and United Airlines flights from Des Moines to St. Louis are around $97.

Currently, the cheapest flight from Des Moines found by our users is for $44 to Nashville. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $96 to travel from Des Moines to Nashville.

Chicago O'Hare Intl Airport, Chicago and Atlanta are currently the destinations served most frequently from Des Moines, with 39, 39 and 20 flights per day on average, respectively.

Airlines including American Airlines, United Airlines and Delta frequently fly from Des Moines. You can view other airlines by performing a quick search in the form above.

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $546.

Prices for flights from Des Moines Airport were last updated today.

There are 27 operators available for flights from Des Moines Airport as of July 2025.

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport.

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.