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Cheap flights from Des Moines to Key West from $157

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:43 am - 7:34 pmDSM  Des Moines-EYW Key West
33h 51m2 stops Philadelphia Tampa
Multiple Airlines Logo
8:36 pm - 8:25 amEYW  Key West-DSM Des Moines
12h 49m1 stop Orlando Sanford Intl
$291Multiple Airlines
Sun, Oct 18 - Thu, Oct 22
Delta Logo
11:35 am - 8:02 pmDSM  Des Moines-EYW Key West
7h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:06 pm - 10:38 pmEYW  Key West-DSM Des Moines
5h 32m1 stop Atlanta Hartsfield-Jackson
$299Delta
Sat, Dec 5 - Wed, Dec 9
Multiple Airlines Logo
12:59 pm - 11:20 amDSM  Des Moines-EYW Key West
21h 21m1 stop Orlando Sanford Intl
Multiple Airlines Logo
10:45 am - 4:46 pmEYW  Key West-DSM Des Moines
31h 01m2 stops Tampa Fort Lauderdale
$318Multiple Airlines
Sat, Dec 5 - Wed, Dec 9
Delta Logo
11:35 am - 8:02 pmDSM  Des Moines-EYW Key West
7h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:06 pm - 10:38 pmEYW  Key West-DSM Des Moines
5h 32m1 stop Atlanta Hartsfield-Jackson
$319Delta
Sat, Dec 5 - Wed, Dec 9
Delta Logo
11:35 am - 8:02 pmDSM  Des Moines-EYW Key West
7h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:25 am - 2:13 pmEYW  Key West-DSM Des Moines
7h 48m1 stop Atlanta Hartsfield-Jackson
$319Delta
Sat, Dec 5 - Wed, Dec 9
Multiple Airlines Logo
12:59 pm - 11:20 amDSM  Des Moines-EYW Key West
21h 21m1 stop Orlando Sanford Intl
Multiple Airlines Logo
10:45 am - 4:46 pmEYW  Key West-DSM Des Moines
31h 01m2 stops Tampa Fort Lauderdale
$340Multiple Airlines
Sat, Dec 5 - Wed, Dec 9
American Airlines Logo
9:45 am - 4:55 pmDSM  Des Moines-EYW Key West
6h 10m1 stop Dallas/Fort Worth
American Airlines Logo
6:25 pm - 12:26 amEYW  Key West-DSM Des Moines
7h 01m1 stop Chicago O'Hare Intl
$348American Airlines
Sat, Dec 5 - Wed, Dec 9
American Airlines Logo
7:00 am - 1:35 pmDSM  Des Moines-EYW Key West
5h 35m1 stop Charlotte Douglas
American Airlines Logo
4:45 pm - 11:58 pmEYW  Key West-DSM Des Moines
8h 13m1 stop Charlotte Douglas
$348American Airlines
Tue, Oct 20 - Sat, Oct 24
United Airlines Logo
6:00 am - 3:24 pmDSM  Des Moines-EYW Key West
8h 24m1 stop Chicago O'Hare Intl
United Airlines Logo
2:51 pm - 5:27 pmEYW  Key West-DSM Des Moines
27h 36m2 stops Newark Chicago O'Hare Intl
$582United Airlines
Sat, Oct 24 - Wed, Oct 28
United Airlines Logo
6:00 am - 2:18 pmDSM  Des Moines-EYW Key West
7h 18m1 stop Chicago O'Hare Intl
United Airlines Logo
2:51 pm - 8:36 pmEYW  Key West-DSM Des Moines
30h 45m2 stops Newark Denver Intl
$617United Airlines
Sat, Oct 24 - Wed, Oct 28

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Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets
Delta
Dec 5
DSM11:35 amDes Moines
7h 27m
1 stop
EYW8:02 pmKey West
Dec 9
EYW6:06 pmKey West
5h 32m
1 stop
DSM10:38 pmDes Moines
$299
Delta
Dec 5
DSM11:35 amDes Moines
7h 27m
1 stop
EYW8:02 pmKey West
Dec 9
EYW7:25 amKey West
7h 48m
1 stop
DSM2:13 pmDes Moines
$319
Delta
Sep 26
DSM11:31 amDes Moines
7h 29m
1 stop
EYW8:00 pmKey West
Sep 29
EYW7:40 amKey West
7h 09m
1 stop
DSM1:49 pmDes Moines
$339

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Dec 8
DSM11:09 amDes Moines
5h 52m
1 stop
EYW6:01 pmKey West
Dec 12
EYW1:14 pmKey West
6h 42m
1 stop
DSM6:56 pmDes Moines
$348
American Airlines
Oct 19
DSM11:22 amDes Moines
6h 27m
1 stop
EYW6:49 pmKey West
Oct 24
EYW7:19 pmKey West
5h 39m
1 stop
DSM11:58 pmDes Moines
$368
American Airlines
Dec 5
DSM7:23 amDes Moines
11h 04m
2 stops
EYW7:27 pmKey West
Dec 9
EYW6:25 pmKey West
7h 01m
1 stop
DSM12:26 amDes Moines
$387

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sun 10/18

8:43 am-7:34 pm

2 stops33h 51m

Key West

Thu 10/22

8:36 pm-8:25 am

1 stop12h 49m

$291
Quickest round-trip

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

11:35 am-8:02 pm

1 stop7h 27m

Key West

Wed 12/9

6:06 pm-10:38 pm

1 stop5h 32m

$299

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

12:59 pm-11:20 am

1 stop21h 21m

Key West

Wed 12/9

10:45 am-4:46 pm

2 stops31h 01m

$318

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

11:35 am-8:02 pm

1 stop7h 27m

Key West

Wed 12/9

6:06 pm-10:38 pm

1 stop5h 32m

$319

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

11:35 am-8:02 pm

1 stop7h 27m

Key West

Wed 12/9

7:25 am-2:13 pm

1 stop7h 48m

$319

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

12:59 pm-11:20 am

1 stop21h 21m

Key West

Wed 12/9

10:45 am-4:46 pm

2 stops31h 01m

$340

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

9:45 am-4:55 pm

1 stop6h 10m

Key West

Wed 12/9

6:25 pm-12:26 am

1 stop7h 01m

$348

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Tue 10/20

7:00 am-1:35 pm

1 stop5h 35m

Key West

Sat 10/24

4:45 pm-11:58 pm

1 stop8h 13m

$348

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 10/24

6:00 am-3:24 pm

1 stop8h 24m

Key West

Wed 10/28

2:51 pm-5:27 pm

2 stops27h 36m

$582

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 10/24

6:00 am-2:18 pm

1 stop7h 18m

Key West

Wed 10/28

2:51 pm-8:36 pm

2 stops30h 45m

$617

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, July is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $378. If you are unable to visit Key West during the month of July, then departing from Des Moines during the month April is also very affordable. Most momondo users find prices during this month for around $447.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Best Price Found

$157

Fastest flight time

6h 18m

Direct flights

None
The best one-way flight to Key West from Des Moines in the past 72 hours is $157. The best round-trip flight deal from Des Moines to Key West found on momondo in the last 72 hours is $291.
The fastest flight from Des Moines to Key West takes 6h 18m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

Frequently asked questions about flying from Des Moines to Key West

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 6h 18m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $268Free CancellationRating
7.8
8,557 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
10,173 reviews
Search United Airlines flights
American AirlinesPriceFrom $289Free CancellationRating
7.1
12,039 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

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