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Cheap flights from Des Moines to Key West from $213

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 12/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

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American Airlines Logo
2:08 pm - 9:50 pmDSM-EYW
6h 42m1 stop
American Airlines Logo
4:59 pm - 10:59 pmEYW-DSM
7h 00m1 stop
$269American Airlines
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Sat, Dec 6 - Sat, Dec 13
American Airlines Logo
2:08 pm - 9:50 pmDSM-EYW
6h 42m1 stop
American Airlines Logo
7:00 am - 3:09 pmEYW-DSM
9h 09m2 stops
$274American Airlines
Find Deal
Sat, Dec 6 - Sat, Dec 13
Delta Logo
2:13 pm - 8:06 pmDSM-EYW
4h 53m1 stop
Delta Logo
6:17 pm - 10:30 pmEYW-DSM
5h 13m1 stop
$294Delta
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Wed, Oct 29 - Mon, Nov 3
Delta Logo
5:47 am - 11:27 amDSM-EYW
4h 40m1 stop
Delta Logo
6:17 pm - 10:30 pmEYW-DSM
5h 13m1 stop
$324Delta
Find Deal
Mon, Oct 20 - Mon, Nov 3
Multiple Airlines Logo
6:14 pm - 9:37 pmDSM-EYW
26h 23m1 stop
Multiple Airlines Logo
2:25 pm - 10:46 pmEYW-DSM
9h 21m1 stop
$388Multiple Airlines
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Wed, Jan 28 - Sun, Feb 1
United Airlines Logo
8:00 am - 3:00 pmDSM-EYW
6h 00m1 stop
United Airlines Logo
4:53 pm - 10:30 pmEYW-DSM
6h 37m1 stop
$419United Airlines
Find Deal
Tue, Mar 3 - Sat, Mar 7
Allegiant Air Logo
6:15 am - 2:39 pmDSM-EYW
7h 24m1 stop
Allegiant Air Logo
10:37 pm - 3:40 pmEYW-DSM
18h 03m1 stop
$431Allegiant Air
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Wed, Dec 31 - Sun, Jan 4
Multiple Airlines Logo
3:45 pm - 1:30 pmDSM-EYW
20h 45m1 stop
Multiple Airlines Logo
10:37 pm - 3:40 pmEYW-DSM
18h 03m1 stop
$437Multiple Airlines
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Tue, Dec 30 - Sun, Jan 4
United Airlines Logo
8:00 am - 3:00 pmDSM-EYW
6h 00m1 stop
United Airlines Logo
4:53 pm - 10:30 pmEYW-DSM
6h 37m1 stop
$444United Airlines
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Tue, Mar 3 - Sat, Mar 7
Allegiant Air Logo
9:00 am - 9:11 pmDSM-EYW
11h 11m1 stop
Allegiant Air Logo
10:35 pm - 5:25 pmEYW-DSM
19h 50m1 stop
$519Allegiant Air
Find Deal
Mon, Dec 29 - Sat, Jan 3

Allegiant Air flights from Des Moines to Key West

Our best Allegiant Air deals on Des Moines to Key West flight tickets
Allegiant Air
Dec 31
DSM6:15 amDes Moines
7h 24m
1 stop
EYW2:39 pmKey West
Jan 4
EYW10:37 pmKey West
18h 03m
1 stop
DSM3:40 pmDes Moines
$431
Find similar
Allegiant Air
Dec 29
DSM9:00 amDes Moines
11h 11m
1 stop
EYW9:11 pmKey West
Jan 3
EYW10:35 pmKey West
19h 50m
1 stop
DSM5:25 pmDes Moines
$519
Find similar
Allegiant Air
Dec 26
DSM10:53 amDes Moines
26h 31m
1 stop
EYW2:24 pmKey West
Dec 29
EYW10:01 pmKey West
26h 00m
1 stop
DSM11:01 pmDes Moines
$655
Find similar

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Dec 6
DSM2:08 pmDes Moines
6h 42m
1 stop
EYW9:50 pmKey West
Dec 13
EYW4:59 pmKey West
7h 00m
1 stop
DSM10:59 pmDes Moines
$269
Find similar
American Airlines
Dec 6
DSM2:08 pmDes Moines
6h 42m
1 stop
EYW9:50 pmKey West
Dec 13
EYW7:00 amKey West
9h 09m
2 stops
DSM3:09 pmDes Moines
$274
Find similar
American Airlines
Jan 9
DSM7:00 amDes Moines
10h 01m
2 stops
EYW6:01 pmKey West
Jan 14
EYW4:24 pmKey West
7h 56m
2 stops
DSM11:20 pmDes Moines
$279
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 9, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

2:08 pm-9:50 pm

1 stop6h 42m

Key West

Sat 12/13

4:59 pm-10:59 pm

1 stop7h 00m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

2:08 pm-9:50 pm

1 stop6h 42m

Key West

Sat 12/13

7:00 am-3:09 pm

2 stops9h 09m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 10/29

2:13 pm-8:06 pm

1 stop4h 53m

Key West

Mon 11/3

6:17 pm-10:30 pm

1 stop5h 13m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 10/20

5:47 am-11:27 am

1 stop4h 40m

Key West

Mon 11/3

6:17 pm-10:30 pm

1 stop5h 13m

$324

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 1/28

6:14 pm-9:37 pm

1 stop26h 23m

Key West

Sun 2/1

2:25 pm-10:46 pm

1 stop9h 21m

$388

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 3/3

8:00 am-3:00 pm

1 stop6h 00m

Key West

Sat 3/7

4:53 pm-10:30 pm

1 stop6h 37m

$419

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 12/31

6:15 am-2:39 pm

1 stop7h 24m

Key West

Sun 1/4

10:37 pm-3:40 pm

1 stop18h 03m

$431

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 12/30

3:45 pm-1:30 pm

1 stop20h 45m

Key West

Sun 1/4

10:37 pm-3:40 pm

1 stop18h 03m

$437

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 3/3

8:00 am-3:00 pm

1 stop6h 00m

Key West

Sat 3/7

4:53 pm-10:30 pm

1 stop6h 37m

$444

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 12/29

9:00 am-9:11 pm

1 stop11h 11m

Key West

Sat 1/3

10:35 pm-5:25 pm

1 stop19h 50m

$519

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, April is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of April, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $293.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $331. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Key West for around $558.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Des Moines to Key West at noon for as low as $380. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $441 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $365 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Direct flights

None
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
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  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 4h 40m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
697 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
7,969 reviews
Search Delta flights
United AirlinesPriceFrom $281Free CancellationRating
7.4
8,968 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

An easier way to manage your Key West trip

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