What airlines fly to Key West?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Key West from Des Moines according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Key West. Keep in mind that there are 4 different airlines that fly to Key West on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Key West?

Delta is the most popular carrier operating from Des Moines to Key West

When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

Prices for flights from Des Moines Airport to Key West Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of January 2026.

How old do you have to be to fly from Des Moines Airport to Key West Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

What documentation or ID do you need to fly to Key West Airport?

The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$289 Cheap Flights from Des Moines to Key West in 2026

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Find the cheapest flights from Des Moines to Key West

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:52 pm - 10:37 pm

DSM

EYW

7h 45m

1 stop

2:06 pm - 9:59 pm

EYW

DSM

8h 53m

1 stop

$289American Airlines

Wed, Mar 25 - Wed, Apr 1

7:00 am - 3:38 pm

DSM

EYW

7h 38m

1 stop

4:20 pm - 12:11 am

EYW

DSM

8h 51m

2 stops

$294American Airlines

Sat, Apr 4 - Wed, Apr 8

5:03 pm - 9:37 pm

DSM

EYW

27h 34m

1 stop

11:51 am - 1:29 pm

EYW

DSM

26h 38m

2 stops

$299Multiple Airlines

Sat, Mar 21 - Wed, Mar 25

6:00 am - 4:49 pm

DSM

EYW

9h 49m

2 stops

1:55 pm - 10:19 pm

EYW

DSM

9h 24m

2 stops

$300American Airlines

Tue, Feb 17 - Tue, Feb 24

5:03 pm - 9:37 pm

DSM

EYW

27h 34m

1 stop

12:25 pm - 1:29 pm

EYW

DSM

26h 04m

1 stop

$303Multiple Airlines

Sat, Mar 21 - Wed, Mar 25

7:00 am - 1:30 pm

DSM

EYW

29h 30m

2 stops

9:49 am - 10:35 am

EYW

DSM

25h 46m

1 stop

$307Multiple Airlines

Sun, Mar 8 - Fri, Mar 13

1:52 pm - 10:37 pm

DSM

EYW

7h 45m

1 stop

6:49 pm - 11:40 pm

EYW

DSM

5h 51m

1 stop

$309American Airlines

Sat, Mar 21 - Tue, Mar 24

12:06 pm - 10:57 pm

DSM

EYW

9h 51m

2 stops

7:33 pm - 11:51 pm

EYW

DSM

5h 18m

1 stop

$314American Airlines

Mon, May 18 - Wed, May 27

6:00 am - 3:21 pm

DSM

EYW

8h 21m

1 stop

6:54 pm - 11:40 pm

EYW

DSM

5h 46m

1 stop

$316American Airlines

Tue, Feb 17 - Tue, Feb 24

6:00 am - 4:30 pm

DSM

EYW

9h 30m

2 stops

7:33 pm - 11:51 pm

EYW

DSM

5h 18m

1 stop

$321American Airlines

Wed, May 20 - Wed, May 27

United Airlines flights from Des Moines to Key West

Our best United Airlines deals on Des Moines to Key West flight tickets

United Airlines

Jun 5

DSM6:15 amDes Moines

7h 51m

1 stop

EYW3:06 pmKey West

Jun 10

EYW7:00 amKey West

8h 11m

1 stop

DSM2:11 pmDes Moines

$369

United Airlines

Feb 3

DSM8:00 amDes Moines

6h 17m

1 stop

EYW3:17 pmKey West

Feb 7

EYW4:15 pmKey West

6h 35m

1 stop

DSM9:50 pmDes Moines

$406

United Airlines

Jun 5

DSM6:15 amDes Moines

7h 51m

1 stop

EYW3:06 pmKey West

Jun 8

EYW4:05 pmKey West

7h 47m

1 stop

DSM10:52 pmDes Moines

$429

Allegiant Air flights from Des Moines to Key West

Our best Allegiant Air deals on Des Moines to Key West flight tickets

Allegiant Air

May 23

DSM5:16 pmDes Moines

19h 08m

1 stop

EYW1:24 pmKey West

May 31

EYW4:10 pmKey West

29h 02m

1 stop

DSM8:12 pmDes Moines

$394

Allegiant Air

Feb 4

DSM6:14 pmDes Moines

26h 23m

1 stop

EYW9:37 pmKey West

Feb 8

EYW10:27 pmKey West

24h 50m

1 stop

DSM10:17 pmDes Moines

$439

Allegiant Air

Feb 4

DSM6:14 pmDes Moines

26h 23m

1 stop

EYW9:37 pmKey West

Feb 9

EYW3:52 pmKey West

7h 25m

1 stop

DSM10:17 pmDes Moines

$452

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/25

1:52 pm-10:37 pm

1 stop7h 45m

Key West

Wed 4/1

2:06 pm-9:59 pm

1 stop8h 53m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/4

7:00 am-3:38 pm

1 stop7h 38m

Key West

Wed 4/8

4:20 pm-12:11 am

2 stops8h 51m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 3/21

5:03 pm-9:37 pm

1 stop27h 34m

Key West

Wed 3/25

11:51 am-1:29 pm

2 stops26h 38m

$299

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

6:00 am-4:49 pm

2 stops9h 49m

Key West

Tue 2/24

1:55 pm-10:19 pm

2 stops9h 24m

$300

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 3/21

5:03 pm-9:37 pm

1 stop27h 34m

Key West

Wed 3/25

12:25 pm-1:29 pm

1 stop26h 04m

$303

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 3/8

7:00 am-1:30 pm

2 stops29h 30m

Key West

Fri 3/13

9:49 am-10:35 am

1 stop25h 46m

$307

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 3/21

1:52 pm-10:37 pm

1 stop7h 45m

Key West

Tue 3/24

6:49 pm-11:40 pm

1 stop5h 51m

$309

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 5/18

12:06 pm-10:57 pm

2 stops9h 51m

Key West

Wed 5/27

7:33 pm-11:51 pm

1 stop5h 18m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

6:00 am-3:21 pm

1 stop8h 21m

Key West

Tue 2/24

6:54 pm-11:40 pm

1 stop5h 46m

$316

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 5/20

6:00 am-4:30 pm

2 stops9h 30m

Key West

Wed 5/27

7:33 pm-11:51 pm

1 stop5h 18m

$321

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month April is also very affordable. Most momondo users find prices during this month for around $302.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $460 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $284 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time	6h 06m
Direct flights	None

The fastest flight from Des Moines to Key West takes 6h 06m

There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.

Search flight deals

How far is Des Moines to Key West by plane?
The distance between Des Moines and Key West is about 1357.4 mi. 6h 06m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Key West Airport?
Prices for flights from Des Moines Airport to Key West Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Key West Airport?
The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of January 2026.
How old do you have to be to fly from Des Moines Airport to Key West Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.
What documentation or ID do you need to fly to Key West Airport?
The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Key West?
Based on momondo bookings for flights between Des Moines and Key West, the leading airline is American Airlines, making up 52% of the total bookings. Other popular airlines include Delta with 26%, United Airlines with 13%, and Allegiant Air with 9%.

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.2 705 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.2 11,169 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,087 reviews	Search Delta flights
United Airlines	PriceFrom $281	Free Cancellation	Rating 7.4 9,188 reviews	Search United Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.