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Cheap flights from Des Moines to Key West from $232

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 8/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:04 am - 3:02 pmDSM  Des Moines-EYW Key West
27h 58m1 stop Tampa St. Petersburg
Multiple Airlines Logo
11:46 am - 7:57 pmEYW  Key West-DSM Des Moines
33h 11m2 stops Tampa Philadelphia
$232Multiple Airlines
Fri, Aug 28 - Wed, Sep 2
Multiple Airlines Logo
10:04 am - 3:02 pmDSM  Des Moines-EYW Key West
27h 58m1 stop Tampa St. Petersburg
Multiple Airlines Logo
12:53 pm - 7:57 pmEYW  Key West-DSM Des Moines
32h 04m2 stops Tampa St. Petersburg Philadelphia
$267Multiple Airlines
Fri, Aug 28 - Wed, Sep 2
American Airlines Logo
2:08 pm - 9:45 pmDSM  Des Moines-EYW Key West
6h 37m1 stop Charlotte Douglas
American Airlines Logo
4:10 pm - 11:29 pmEYW  Key West-DSM Des Moines
8h 19m1 stop Miami
$299American Airlines
Sat, Dec 5 - Thu, Dec 10
Delta Logo
11:31 am - 8:00 pmDSM  Des Moines-EYW Key West
7h 29m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:19 pm - 10:26 pmEYW  Key West-DSM Des Moines
5h 07m1 stop Atlanta Hartsfield-Jackson
$299Delta
Tue, Sep 15 - Tue, Sep 22
American Airlines Logo
11:22 am - 6:49 pmDSM  Des Moines-EYW Key West
6h 27m1 stop Charlotte Douglas
American Airlines Logo
1:12 pm - 6:54 pmEYW  Key West-DSM Des Moines
6h 42m1 stop Chicago O'Hare Intl
$319American Airlines
Fri, Oct 30 - Wed, Nov 4
United Airlines Logo
6:15 am - 3:06 pmDSM  Des Moines-EYW Key West
7h 51m1 stop Chicago O'Hare Intl
United Airlines Logo
2:00 pm - 9:17 pmEYW  Key West-DSM Des Moines
8h 17m1 stop Chicago O'Hare Intl
$319United Airlines
Sat, Dec 5 - Thu, Dec 10
United Airlines Logo
6:15 am - 3:06 pmDSM  Des Moines-EYW Key West
7h 51m1 stop Chicago O'Hare Intl
United Airlines Logo
4:05 pm - 9:17 pmEYW  Key West-DSM Des Moines
6h 12m1 stop Chicago O'Hare Intl
$319United Airlines
Thu, Dec 10 - Tue, Dec 15
Multiple Airlines Logo
8:59 am - 9:02 amDSM  Des Moines-EYW Key West
23h 03m1 stop Tampa St. Petersburg
Multiple Airlines Logo
10:04 am - 3:25 pmEYW  Key West-DSM Des Moines
30h 21m2 stops Tampa Fort Lauderdale
$321Multiple Airlines
Fri, Oct 30 - Wed, Nov 4
Delta Logo
5:35 am - 12:53 pmDSM  Des Moines-EYW Key West
6h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:40 am - 10:42 amEYW  Key West-DSM Des Moines
28h 02m1 stop Atlanta Hartsfield-Jackson
$498Delta
Tue, Oct 13 - Fri, Oct 16
Delta Logo
5:35 am - 12:53 pmDSM  Des Moines-EYW Key West
6h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:10 pm - 9:42 amEYW  Key West-DSM Des Moines
16h 32m2 stops Atlanta Hartsfield-Jackson Detroit Metropolitan Wayne County
$534Delta
Tue, Oct 13 - Fri, Oct 16

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American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Nov 7
DSM11:09 amDes Moines
5h 47m
1 stop
EYW5:56 pmKey West
Nov 14
EYW4:45 pmKey West
8h 29m
1 stop
DSM12:14 amDes Moines
$339
American Airlines
Dec 8
DSM6:40 amDes Moines
8h 33m
1 stop
EYW4:13 pmKey West
Dec 12
EYW8:00 amKey West
6h 19m
1 stop
DSM1:19 pmDes Moines
$348
American Airlines
Oct 29
DSM11:22 amDes Moines
6h 27m
1 stop
EYW6:49 pmKey West
Nov 2
EYW1:12 pmKey West
6h 42m
1 stop
DSM6:54 pmDes Moines
$379

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets
Delta
Sep 15
DSM11:31 amDes Moines
7h 29m
1 stop
EYW8:00 pmKey West
Sep 22
EYW6:19 pmKey West
5h 07m
1 stop
DSM10:26 pmDes Moines
$299
Delta
Oct 13
DSM5:35 amDes Moines
6h 18m
1 stop
EYW12:53 pmKey West
Oct 16
EYW7:40 amKey West
28h 02m
1 stop
DSM10:42 amDes Moines
$498
Delta
Aug 17
DSM11:28 amDes Moines
4h 52m
1 stop
EYW5:20 pmKey West
Aug 21
EYW7:40 amKey West
7h 25m
1 stop
DSM2:05 pmDes Moines
$857

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Fri 8/28

10:04 am-3:02 pm

1 stop27h 58m

Key West

Wed 9/2

11:46 am-7:57 pm

2 stops33h 11m

$232

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Fri 8/28

10:04 am-3:02 pm

1 stop27h 58m

Key West

Wed 9/2

12:53 pm-7:57 pm

2 stops32h 04m

$267

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

2:08 pm-9:45 pm

1 stop6h 37m

Key West

Thu 12/10

4:10 pm-11:29 pm

1 stop8h 19m

$299
Quickest round-trip

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Tue 9/15

11:31 am-8:00 pm

1 stop7h 29m

Key West

Tue 9/22

6:19 pm-10:26 pm

1 stop5h 07m

$299

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Fri 10/30

11:22 am-6:49 pm

1 stop6h 27m

Key West

Wed 11/4

1:12 pm-6:54 pm

1 stop6h 42m

$319

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

6:15 am-3:06 pm

1 stop7h 51m

Key West

Thu 12/10

2:00 pm-9:17 pm

1 stop8h 17m

$319

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Thu 12/10

6:15 am-3:06 pm

1 stop7h 51m

Key West

Tue 12/15

4:05 pm-9:17 pm

1 stop6h 12m

$319

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Fri 10/30

8:59 am-9:02 am

1 stop23h 03m

Key West

Wed 11/4

10:04 am-3:25 pm

2 stops30h 21m

$321

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Tue 10/13

5:35 am-12:53 pm

1 stop6h 18m

Key West

Fri 10/16

7:40 am-10:42 am

1 stop28h 02m

$498

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Tue 10/13

5:35 am-12:53 pm

1 stop6h 18m

Key West

Fri 10/16

6:10 pm-9:42 am

2 stops16h 32m

$534

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Key West?

Prices are currently low for flights on this route.

Typical prices usually range from $360 to $616.
The lowest price recently found on this route was $232.

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $348. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $378.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time

6h 18m

Direct flights

None
The fastest flight from Des Moines to Key West takes 6h 18m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

Frequently asked questions about flying from Des Moines to Key West

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 6h 18m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $268Free CancellationRating
7.4
10,080 reviews
Search United Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.8
8,499 reviews
Search Delta flights
American AirlinesPriceFrom $282Free CancellationRating
7.1
11,874 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

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