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Cheap flights from Des Moines to Key West from $289

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 4/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:00 pm - 10:36 pm
DSM
-
EYW
6h 36m
1 stop
American Airlines Logo
6:49 pm - 11:49 pm
EYW
-
DSM
6h 00m
1 stop
$289American Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
11:09 am - 10:36 pm
DSM
-
EYW
10h 27m
2 stops
American Airlines Logo
6:46 pm - 11:49 pm
EYW
-
DSM
6h 03m
1 stop
$294American Airlines
Sat, Apr 25 - Wed, Apr 29
American Airlines Logo
11:09 am - 10:58 pm
DSM
-
EYW
10h 49m
2 stops
American Airlines Logo
6:45 am - 4:31 pm
EYW
-
DSM
10h 46m
2 stops
$300American Airlines
Sat, Apr 25 - Wed, Apr 29
United Airlines Logo
2:04 pm - 10:19 pm
DSM
-
EYW
7h 15m
1 stop
United Airlines Logo
4:05 pm - 9:40 pm
EYW
-
DSM
6h 35m
1 stop
$314United Airlines
Fri, Mar 6 - Wed, Mar 11
American Airlines Logo
1:52 pm - 10:37 pm
DSM
-
EYW
7h 45m
1 stop
American Airlines Logo
7:45 am - 1:07 pm
EYW
-
DSM
6h 22m
1 stop
$316American Airlines
Wed, Mar 25 - Wed, Apr 1
American Airlines Logo
11:09 am - 6:16 pm
DSM
-
EYW
6h 07m
1 stop
American Airlines Logo
6:46 pm - 11:49 pm
EYW
-
DSM
6h 03m
1 stop
$319American Airlines
Fri, Apr 24 - Mon, Apr 27
American Airlines Logo
11:09 am - 10:36 pm
DSM
-
EYW
10h 27m
2 stops
American Airlines Logo
6:49 pm - 11:49 pm
EYW
-
DSM
6h 00m
1 stop
$321American Airlines
Wed, Apr 22 - Tue, Apr 28
American Airlines Logo
11:09 am - 10:36 pm
DSM
-
EYW
10h 27m
2 stops
American Airlines Logo
6:46 pm - 11:49 pm
EYW
-
DSM
6h 03m
1 stop
$324American Airlines
Thu, Apr 23 - Mon, Apr 27
American Airlines Logo
12:00 pm - 10:58 pm
DSM
-
EYW
9h 58m
2 stops
American Airlines Logo
6:45 am - 4:31 pm
EYW
-
DSM
10h 46m
2 stops
$327American Airlines
Sat, Apr 25 - Wed, Apr 29
Multiple Airlines Logo
8:21 pm - 2:24 pm
DSM
-
EYW
41h 03m
2 stops
Multiple Airlines Logo
11:51 am - 9:06 am
EYW
-
DSM
22h 15m
1 stop
$338Multiple Airlines
Fri, Mar 6 - Wed, Mar 11

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Apr 24
DSM3:00 pmDes Moines
6h 36m
1 stop
EYW10:36 pmKey West
Apr 28
EYW6:49 pmKey West
6h 00m
1 stop
DSM11:49 pmDes Moines
$289
American Airlines
Apr 25
DSM11:09 amDes Moines
10h 27m
2 stops
EYW10:36 pmKey West
Apr 29
EYW6:46 pmKey West
6h 03m
1 stop
DSM11:49 pmDes Moines
$294
American Airlines
Apr 25
DSM11:09 amDes Moines
10h 49m
2 stops
EYW10:58 pmKey West
Apr 29
EYW6:45 amKey West
10h 46m
2 stops
DSM4:31 pmDes Moines
$300

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets
Delta
Mar 7
DSM6:19 amDes Moines
12h 23m
2 stops
EYW7:42 pmKey West
Mar 11
EYW7:30 amKey West
10h 24m
2 stops
DSM4:54 pmDes Moines
$489
Delta
Mar 7
DSM6:19 amDes Moines
12h 23m
2 stops
EYW7:42 pmKey West
Mar 11
EYW7:30 amKey West
10h 24m
2 stops
DSM4:54 pmDes Moines
$509
Delta
Mar 7
DSM6:19 amDes Moines
12h 23m
2 stops
EYW7:42 pmKey West
Mar 14
EYW7:30 amKey West
10h 24m
2 stops
DSM4:54 pmDes Moines
$800

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 4/24

3:00 pm-10:36 pm

1 stop6h 36m

Key West

Tue 4/28

6:49 pm-11:49 pm

1 stop6h 00m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:09 am-10:36 pm

2 stops10h 27m

Key West

Wed 4/29

6:46 pm-11:49 pm

1 stop6h 03m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:09 am-10:58 pm

2 stops10h 49m

Key West

Wed 4/29

6:45 am-4:31 pm

2 stops10h 46m

$300

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 3/6

2:04 pm-10:19 pm

1 stop7h 15m

Key West

Wed 3/11

4:05 pm-9:40 pm

1 stop6h 35m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/25

1:52 pm-10:37 pm

1 stop7h 45m

Key West

Wed 4/1

7:45 am-1:07 pm

1 stop6h 22m

$316

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 4/24

11:09 am-6:16 pm

1 stop6h 07m

Key West

Mon 4/27

6:46 pm-11:49 pm

1 stop6h 03m

$319

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 4/22

11:09 am-10:36 pm

2 stops10h 27m

Key West

Tue 4/28

6:49 pm-11:49 pm

1 stop6h 00m

$321

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 4/23

11:09 am-10:36 pm

2 stops10h 27m

Key West

Mon 4/27

6:46 pm-11:49 pm

1 stop6h 03m

$324

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

12:00 pm-10:58 pm

2 stops9h 58m

Key West

Wed 4/29

6:45 am-4:31 pm

2 stops10h 46m

$327

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 3/6

8:21 pm-2:24 pm

2 stops41h 03m

Key West

Wed 3/11

11:51 am-9:06 am

1 stop22h 15m

$338

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $289. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month November is also very affordable. Most momondo users find prices during this month for around $308.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $443 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $215 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time

5h 17m

Direct flights

None
The fastest flight from Des Moines to Key West takes 5h 17m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 5h 17m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.3
711 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
11,338 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,241 reviews
Search Delta flights
United AirlinesPriceFrom $281Free CancellationRating
7.4
9,341 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

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