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Cheap flights from Des Moines to Key West from $112

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 1/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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Multiple Airlines Logo
2:58 pm - 1:30 pmDSM-EYW
21h 32m1 stop
Multiple Airlines Logo
12:15 pm - 10:46 pmEYW-DSM
11h 31m1 stop
$257Multiple Airlines
Find Deal
Sun, Jan 25 - Thu, Jan 29
Multiple Airlines Logo
2:58 pm - 1:30 pmDSM-EYW
21h 32m1 stop
Multiple Airlines Logo
10:06 am - 10:19 amEYW-DSM
25h 13m2 stops
$262Multiple Airlines
Find Deal
Sun, Jan 25 - Thu, Jan 29
American Airlines Logo
8:45 am - 5:55 pmDSM-EYW
8h 10m1 stop
American Airlines Logo
4:04 pm - 11:08 pmEYW-DSM
8h 04m1 stop
$265American Airlines
Find Deal
Thu, Jan 1 - Thu, Jan 8
American Airlines Logo
2:07 pm - 10:44 pmDSM-EYW
7h 37m1 stop
American Airlines Logo
6:43 pm - 11:08 pmEYW-DSM
5h 25m1 stop
$269American Airlines
Find Deal
Fri, Jan 2 - Fri, Jan 9
American Airlines Logo
8:45 am - 5:55 pmDSM-EYW
8h 10m1 stop
American Airlines Logo
12:00 pm - 8:02 pmEYW-DSM
9h 02m2 stops
$270American Airlines
Find Deal
Thu, Jan 1 - Thu, Jan 8
American Airlines Logo
6:00 am - 6:01 pmDSM-EYW
11h 01m2 stops
American Airlines Logo
6:43 pm - 11:08 pmEYW-DSM
5h 25m1 stop
$274American Airlines
Find Deal
Fri, Jan 9 - Wed, Jan 14
American Airlines Logo
7:39 am - 6:01 pmDSM-EYW
9h 22m2 stops
American Airlines Logo
4:37 pm - 11:08 pmEYW-DSM
7h 31m2 stops
$279American Airlines
Find Deal
Fri, Jan 9 - Mon, Jan 12
United Airlines Logo
8:00 am - 3:24 pmDSM-EYW
6h 24m1 stop
United Airlines Logo
4:10 pm - 9:40 pmEYW-DSM
6h 30m1 stop
$288United Airlines
Find Deal
Sun, Dec 14 - Sun, Dec 21
American Airlines Logo
6:00 am - 3:32 pmDSM-EYW
8h 32m1 stop
American Airlines Logo
4:40 pm - 10:23 pmEYW-DSM
6h 43m1 stop
$299American Airlines
Find Deal
Wed, Feb 25 - Thu, Mar 5
American Airlines Logo
2:08 pm - 9:50 pmDSM-EYW
6h 42m1 stop
American Airlines Logo
4:59 pm - 10:59 pmEYW-DSM
7h 00m1 stop
$304American Airlines
Find Deal
Sat, Dec 6 - Sat, Dec 13

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Jan 1
DSM8:45 amDes Moines
8h 10m
1 stop
EYW5:55 pmKey West
Jan 8
EYW4:04 pmKey West
8h 04m
1 stop
DSM11:08 pmDes Moines
$265
Find similar
American Airlines
Jan 2
DSM2:07 pmDes Moines
7h 37m
1 stop
EYW10:44 pmKey West
Jan 9
EYW6:43 pmKey West
5h 25m
1 stop
DSM11:08 pmDes Moines
$269
Find similar
American Airlines
Jan 1
DSM8:45 amDes Moines
8h 10m
1 stop
EYW5:55 pmKey West
Jan 8
EYW12:00 pmKey West
9h 02m
2 stops
DSM8:02 pmDes Moines
$270
Find similar

United Airlines flights from Des Moines to Key West

Our best United Airlines deals on Des Moines to Key West flight tickets
United Airlines
Dec 14
DSM8:00 amDes Moines
6h 24m
1 stop
EYW3:24 pmKey West
Dec 21
EYW4:10 pmKey West
6h 30m
1 stop
DSM9:40 pmDes Moines
$288
Find similar
United Airlines
Jan 17
DSM7:50 amDes Moines
6h 27m
1 stop
EYW3:17 pmKey West
Jan 21
EYW4:15 pmKey West
6h 35m
1 stop
DSM9:50 pmDes Moines
$357
Find similar
United Airlines
Jan 1
DSM8:00 amDes Moines
6h 12m
1 stop
EYW3:12 pmKey West
Jan 8
EYW4:15 pmKey West
6h 35m
1 stop
DSM9:50 pmDes Moines
$424
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 19, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 1/25

2:58 pm-1:30 pm

1 stop21h 32m

Key West

Thu 1/29

12:15 pm-10:46 pm

1 stop11h 31m

$257

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 1/25

2:58 pm-1:30 pm

1 stop21h 32m

Key West

Thu 1/29

10:06 am-10:19 am

2 stops25h 13m

$262

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 1/1

8:45 am-5:55 pm

1 stop8h 10m

Key West

Thu 1/8

4:04 pm-11:08 pm

1 stop8h 04m

$265

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/2

2:07 pm-10:44 pm

1 stop7h 37m

Key West

Fri 1/9

6:43 pm-11:08 pm

1 stop5h 25m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 1/1

8:45 am-5:55 pm

1 stop8h 10m

Key West

Thu 1/8

12:00 pm-8:02 pm

2 stops9h 02m

$270

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

6:00 am-6:01 pm

2 stops11h 01m

Key West

Wed 1/14

6:43 pm-11:08 pm

1 stop5h 25m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

7:39 am-6:01 pm

2 stops9h 22m

Key West

Mon 1/12

4:37 pm-11:08 pm

2 stops7h 31m

$279

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 12/14

8:00 am-3:24 pm

1 stop6h 24m

Key West

Sun 12/21

4:10 pm-9:40 pm

1 stop6h 30m

$288

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 2/25

6:00 am-3:32 pm

1 stop8h 32m

Key West

Thu 3/5

4:40 pm-10:23 pm

1 stop6h 43m

$299

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

2:08 pm-9:50 pm

1 stop6h 42m

Key West

Sat 12/13

4:59 pm-10:59 pm

1 stop7h 00m

$304

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, April is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of April, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $293.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $331. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Key West for around $558.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Des Moines to Key West at noon for as low as $380. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $451 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $338 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Direct flights

None
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
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  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 5h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
700 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
11,046 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,004 reviews
Search Delta flights
United AirlinesPriceFrom $281Free CancellationRating
7.4
9,025 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

An easier way to manage your Key West trip

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