Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Key West from $287

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 5/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:16 pm - 11:06 am
DSM
-
EYW
43h 50m
2 stops
Multiple Airlines Logo
2:51 pm - 3:35 pm
EYW
-
DSM
25h 44m
1 stop
$287Multiple Airlines
Mon, May 25 - Mon, Jun 1
Delta Logo
11:40 am - 7:53 pm
DSM
-
EYW
7h 13m
1 stop
Delta Logo
6:18 pm - 10:29 pm
EYW
-
DSM
5h 11m
1 stop
$289Delta
Sat, Jul 4 - Tue, Jul 7
Multiple Airlines Logo
7:18 pm - 1:58 pm
DSM
-
EYW
17h 40m
1 stop
Multiple Airlines Logo
11:46 am - 9:27 pm
EYW
-
DSM
34h 41m
2 stops
$292Multiple Airlines
Fri, Jun 5 - Wed, Jun 10
Allegiant Air Logo
4:59 pm - 12:48 pm
DSM
-
EYW
18h 49m
1 stop
Allegiant Air Logo
4:41 pm - 10:15 pm
EYW
-
DSM
6h 34m
1 stop
$306Allegiant Air
Sat, Jul 4 - Fri, Jul 10
American Airlines Logo
8:43 am - 6:49 pm
DSM
-
EYW
9h 06m
2 stops
American Airlines Logo
11:28 am - 10:07 pm
EYW
-
DSM
11h 39m
2 stops
$309American Airlines
Wed, Jul 1 - Wed, Jul 8
Allegiant Air Logo
11:00 am - 3:48 pm
DSM
-
EYW
27h 48m
1 stop
Allegiant Air Logo
12:39 pm - 5:08 pm
EYW
-
DSM
5h 29m
1 stop
$312Allegiant Air
Sat, Apr 25 - Wed, Apr 29
Allegiant Air Logo
4:59 pm - 12:48 pm
DSM
-
EYW
18h 49m
1 stop
Allegiant Air Logo
2:44 pm - 9:43 pm
EYW
-
DSM
7h 59m
1 stop
$313Allegiant Air
Sat, Jul 4 - Sat, Jul 11
American Airlines Logo
6:02 am - 1:41 pm
DSM
-
EYW
6h 39m
1 stop
American Airlines Logo
11:28 am - 10:07 pm
EYW
-
DSM
11h 39m
2 stops
$314American Airlines
Wed, Jul 1 - Wed, Jul 8
American Airlines Logo
6:02 am - 1:41 pm
DSM
-
EYW
6h 39m
1 stop
American Airlines Logo
7:29 pm - 12:10 am
EYW
-
DSM
5h 41m
1 stop
$319American Airlines
Wed, Jun 10 - Tue, Jun 16
Allegiant Air Logo
4:25 pm - 9:03 am
DSM
-
EYW
15h 38m
1 stop
Allegiant Air Logo
8:58 am - 3:35 pm
EYW
-
DSM
7h 37m
1 stop
$320Allegiant Air
Fri, Sep 11 - Fri, Sep 18

United Airlines flights from Des Moines to Key West

Our best United Airlines deals on Des Moines to Key West flight tickets
United Airlines
May 9
DSM5:30 amDes Moines
9h 32m
2 stops
EYW4:02 pmKey West
May 13
EYW4:05 pmKey West
8h 19m
1 stop
DSM11:24 pmDes Moines
$384
United Airlines
Apr 25
DSM6:20 amDes Moines
7h 31m
1 stop
EYW2:51 pmKey West
Apr 29
EYW3:52 pmKey West
8h 25m
1 stop
DSM11:17 pmDes Moines
$477
United Airlines
Apr 25
DSM6:20 amDes Moines
10h 19m
2 stops
EYW5:39 pmKey West
Apr 29
EYW3:52 pmKey West
6h 40m
1 stop
DSM9:32 pmDes Moines
$482

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Jun 10
DSM6:02 amDes Moines
6h 39m
1 stop
EYW1:41 pmKey West
Jun 16
EYW7:29 pmKey West
5h 41m
1 stop
DSM12:10 amDes Moines
$319
American Airlines
Jun 10
DSM7:10 amDes Moines
10h 39m
2 stops
EYW6:49 pmKey West
Jun 16
EYW7:29 pmKey West
5h 41m
1 stop
DSM12:10 amDes Moines
$324
American Airlines
Jun 29
DSM6:02 amDes Moines
6h 39m
1 stop
EYW1:41 pmKey West
Jul 4
EYW7:29 pmKey West
5h 37m
1 stop
DSM12:06 amDes Moines
$329

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 14, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 5/25

2:16 pm-11:06 am

2 stops43h 50m

Key West

Mon 6/1

2:51 pm-3:35 pm

1 stop25h 44m

$287

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 7/4

11:40 am-7:53 pm

1 stop7h 13m

Key West

Tue 7/7

6:18 pm-10:29 pm

1 stop5h 11m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 6/5

7:18 pm-1:58 pm

1 stop17h 40m

Key West

Wed 6/10

11:46 am-9:27 pm

2 stops34h 41m

$292

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 7/4

4:59 pm-12:48 pm

1 stop18h 49m

Key West

Fri 7/10

4:41 pm-10:15 pm

1 stop6h 34m

$306

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 7/1

8:43 am-6:49 pm

2 stops9h 06m

Key West

Wed 7/8

11:28 am-10:07 pm

2 stops11h 39m

$309

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:00 am-3:48 pm

1 stop27h 48m

Key West

Wed 4/29

12:39 pm-5:08 pm

1 stop5h 29m

$312

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 7/4

4:59 pm-12:48 pm

1 stop18h 49m

Key West

Sat 7/11

2:44 pm-9:43 pm

1 stop7h 59m

$313

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 7/1

6:02 am-1:41 pm

1 stop6h 39m

Key West

Wed 7/8

11:28 am-10:07 pm

2 stops11h 39m

$314
Quickest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 6/10

6:02 am-1:41 pm

1 stop6h 39m

Key West

Tue 6/16

7:29 pm-12:10 am

1 stop5h 41m

$319

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/11

4:25 pm-9:03 am

1 stop15h 38m

Key West

Fri 9/18

8:58 am-3:35 pm

1 stop7h 37m

$320

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Key West?

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $289. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $293.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time

5h 47m

Direct flights

None
The fastest flight from Des Moines to Key West takes 5h 47m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

Frequently asked questions about flying from Des Moines to Key West

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 5h 47m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.1
11,573 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,405 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,581 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

An easier way to manage your Key West trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 5/14
Thu 5/21
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States