Which layover airport has the shortest travel time from Des Moines to Key West?

Flights connecting via Charlotte (CLT) have the shortest average one-way travel time: 5h 12m.

Which airport is the most popular layover for flights between Des Moines and Key West?

Atlanta (ATL) was the most common stop: 80% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Key West?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Key West from Des Moines according to our data. American Airlines is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Key West. Keep in mind that there are 4 different airlines that fly to Key West on a routine basis, so you have a few additional options to choose from.

Which layover airport offers the lowest fares from Des Moines to Key West?

Flights via Atlanta (ATL) offer the lowest average round-trip price of $506.

Which layover airport has the shortest connection time from Des Moines to Key West?

Charlotte (CLT) has the shortest average layover time for this route: 0h 33m.

When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

Prices for flights from Des Moines Airport to Key West Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of November 2025.

How old do you have to be to fly from Des Moines Airport to Key West Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

What documentation or ID do you need to fly to Key West Airport?

The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$204 Cheap Flights from Des Moines to Key West in 2025/26

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10:38 am - 3:44 pmDSM-EYW

28h 06m1 stop

10:27 pm - 11:12 pmEYW-DSM

25h 45m1 stop

$246Allegiant Air

Find Deal

Sat, Dec 6 - Thu, Dec 11

6:14 pm - 9:37 pmDSM-EYW

26h 23m1 stop

10:27 pm - 10:17 pmEYW-DSM

24h 50m1 stop

$263Allegiant Air

Find Deal

Wed, Jan 28 - Sun, Feb 1

2:00 pm - 10:24 pmDSM-EYW

7h 24m1 stop

8:14 am - 1:06 pmEYW-DSM

5h 52m1 stop

$264American Airlines

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Wed, Feb 18 - Wed, Feb 25

11:23 am - 8:06 pmDSM-EYW

7h 43m1 stop

6:10 pm - 10:34 pmEYW-DSM

5h 24m1 stop

$269Delta

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Sat, Dec 6 - Sat, Dec 13

6:17 am - 8:06 pmDSM-EYW

12h 49m2 stops

6:10 pm - 10:34 pmEYW-DSM

5h 24m1 stop

$274Delta

Find Deal

Sat, Dec 6 - Sat, Dec 13

2:43 pm - 1:15 pmDSM-EYW

21h 32m2 stops

10:26 pm - 9:41 pmEYW-DSM

24h 15m1 stop

$276Allegiant Air

Find Deal

Thu, Nov 20 - Sun, Nov 23

4:32 pm - 10:07 amDSM-EYW

16h 35m1 stop

3:54 pm - 11:12 pmEYW-DSM

8h 18m1 stop

$287Multiple Airlines

Find Deal

Fri, Dec 5 - Mon, Dec 8

6:14 pm - 9:37 pmDSM-EYW

26h 23m1 stop

10:06 am - 10:09 pmEYW-DSM

13h 03m2 stops

$295Multiple Airlines

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Wed, Jan 28 - Sun, Feb 1

6:56 am - 3:23 pmDSM-EYW

7h 27m1 stop

8:10 am - 12:31 pmEYW-DSM

5h 21m1 stop

$299American Airlines

Find Deal

Wed, Mar 25 - Wed, Apr 1

6:46 pm - 12:34 pmDSM-EYW

16h 48m1 stop

4:08 pm - 9:40 pmEYW-DSM

6h 32m1 stop

$458United Airlines

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Sat, Dec 20 - Wed, Dec 24

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets

Delta

Dec 6

DSM11:23 amDes Moines

7h 43m

1 stop

EYW8:06 pmKey West

Dec 13

EYW6:10 pmKey West

5h 24m

1 stop

DSM10:34 pmDes Moines

$269

Find similar

Delta

Dec 6

DSM6:17 amDes Moines

12h 49m

2 stops

EYW8:06 pmKey West

Dec 13

EYW6:10 pmKey West

5h 24m

1 stop

DSM10:34 pmDes Moines

$274

Find similar

Delta

Dec 6

DSM6:17 amDes Moines

12h 49m

2 stops

EYW8:06 pmKey West

Dec 13

EYW7:40 amKey West

10h 18m

2 stops

DSM4:58 pmDes Moines

$279

Find similar

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets

American Airlines

Feb 18

DSM2:00 pmDes Moines

7h 24m

1 stop

EYW10:24 pmKey West

Feb 25

EYW8:14 amKey West

5h 52m

1 stop

DSM1:06 pmDes Moines

$264

Find similar

American Airlines

Mar 25

DSM6:56 amDes Moines

7h 27m

1 stop

EYW3:23 pmKey West

Apr 1

EYW8:10 amKey West

5h 21m

1 stop

DSM12:31 pmDes Moines

$299

Find similar

American Airlines

Mar 25

DSM2:07 pmDes Moines

8h 52m

2 stops

EYW11:59 pmKey West

Apr 1

EYW3:59 pmKey West

7h 26m

1 stop

DSM10:25 pmDes Moines

$304

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

10:38 am-3:44 pm

1 stop28h 06m

Key West

Thu 12/11

10:27 pm-11:12 pm

1 stop25h 45m

$246

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 1/28

6:14 pm-9:37 pm

1 stop26h 23m

Key West

Sun 2/1

10:27 pm-10:17 pm

1 stop24h 50m

$263

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 2/18

2:00 pm-10:24 pm

1 stop7h 24m

Key West

Wed 2/25

8:14 am-1:06 pm

1 stop5h 52m

$264

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

11:23 am-8:06 pm

1 stop7h 43m

Key West

Sat 12/13

6:10 pm-10:34 pm

1 stop5h 24m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

6:17 am-8:06 pm

2 stops12h 49m

Key West

Sat 12/13

6:10 pm-10:34 pm

1 stop5h 24m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 11/20

2:43 pm-1:15 pm

2 stops21h 32m

Key West

Sun 11/23

10:26 pm-9:41 pm

1 stop24h 15m

$276

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 12/5

4:32 pm-10:07 am

1 stop16h 35m

Key West

Mon 12/8

3:54 pm-11:12 pm

1 stop8h 18m

$287

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 1/28

6:14 pm-9:37 pm

1 stop26h 23m

Key West

Sun 2/1

10:06 am-10:09 pm

2 stops13h 03m

$295

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/25

6:56 am-3:23 pm

1 stop7h 27m

Key West

Wed 4/1

8:10 am-12:31 pm

1 stop5h 21m

$299

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/20

6:46 pm-12:34 pm

1 stop16h 48m

Key West

Wed 12/24

4:08 pm-9:40 pm

1 stop6h 32m

$458

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Key West?

In general, April is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of April, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $293.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $331. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Key West for around $558.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Des Moines to Key West at noon for as low as $380. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $445 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $365 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Direct flights	None

There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.

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How far is Des Moines to Key West by plane?
The distance between Des Moines and Key West is about 1357.4 mi. 5h 43m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Key West Airport?
Prices for flights from Des Moines Airport to Key West Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Key West Airport?
The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of November 2025.
How old do you have to be to fly from Des Moines Airport to Key West Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.
What documentation or ID do you need to fly to Key West Airport?
The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Key West?
Based on momondo bookings for flights between Des Moines and Key West, the leading airline is American Airlines, making up 53% of the total bookings. Other popular airlines include Delta with 26%, United Airlines with 15%, and Allegiant Air with 6%.

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.2 697 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.2 11,041 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,004 reviews	Search Delta flights
United Airlines	PriceFrom $281	Free Cancellation	Rating 7.4 9,003 reviews	Search United Airlines flights

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Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

An easier way to manage your Key West trip

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Cheap flights from Des Moines to Key West from $246

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

What is the cheapest day to depart on your flight to Key West?

What is the cheapest time of day to depart on your flight to Key West?

How far in advance should I book a flight to Key West?

What airlines fly to Key West?

Which airport is the most popular layover for flights between Des Moines and Key West?

Atlanta (ATL) was the most common stop: 80% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Des Moines to Key West?

Flights via Atlanta (ATL) offer the lowest average round-trip price of $506.

Which layover airport has the shortest travel time from Des Moines to Key West?

Flights connecting via Charlotte (CLT) have the shortest average one-way travel time: 5h 12m.

Which layover airport has the shortest connection time from Des Moines to Key West?

Charlotte (CLT) has the shortest average layover time for this route: 0h 33m.

When to book flights from Des Moines to Key West

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Direct flights

How far is Des Moines to Key West by plane?

When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

How old do you have to be to fly from Des Moines Airport to Key West Airport?

What documentation or ID do you need to fly to Key West Airport?

What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo

Traveling to a place near Key West?

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

How can momondo help me find flights from Des Moines to Key West?

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

An easier way to manage your Key West trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Florida