What is the cheapest airline that flies from Des Moines to Key West?

Delta and American Airlines are the most popular carriers operating from Des Moines to Key West

What airlines fly to Key West?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Key West from Des Moines according to our data. American Airlines is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Key West. Keep in mind that there are 4 different airlines that fly to Key West on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

Prices for flights from Des Moines Airport to Key West Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of January 2026.

How old do you have to be to fly from Des Moines Airport to Key West Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

What documentation or ID do you need to fly to Key West Airport?

The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$289 Cheap Flights from Des Moines to Key West in 2026

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Find the cheapest flights from Des Moines to Key West

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:02 pm - 10:37 pm

DSM

EYW

7h 35m

1 stop

4:40 pm - 9:59 pm

EYW

DSM

6h 19m

1 stop

$289American Airlines

sáb., feb. 21 - jue., feb. 26

11:35 am - 11:56 pm

DSM

EYW

11h 21m

2 stops

7:45 am - 1:17 pm

EYW

DSM

6h 32m

1 stop

$294American Airlines

vie., feb. 6 - jue., feb. 12

5:58 pm - 2:56 pm

DSM

EYW

19h 58m

1 stop

10:27 pm - 10:17 pm

EYW

DSM

24h 50m

1 stop

$296Allegiant Air

sáb., ene. 31 - jue., feb. 5

11:35 am - 11:56 pm

DSM

EYW

11h 21m

2 stops

6:06 am - 3:15 pm

EYW

DSM

10h 09m

2 stops

$300American Airlines

vie., feb. 6 - mar., feb. 10

2:02 pm - 10:37 pm

DSM

EYW

7h 35m

1 stop

6:53 pm - 11:40 pm

EYW

DSM

5h 47m

1 stop

$309American Airlines

vie., feb. 27 - mié., mar. 4

2:02 pm - 10:37 pm

DSM

EYW

7h 35m

1 stop

6:53 pm - 11:40 pm

EYW

DSM

5h 47m

1 stop

$310American Airlines

vie., feb. 27 - vie., mar. 6

2:02 pm - 10:37 pm

DSM

EYW

7h 35m

1 stop

1:55 pm - 11:40 pm

EYW

DSM

10h 45m

2 stops

$314American Airlines

vie., feb. 27 - mié., mar. 4

11:42 am - 11:56 pm

DSM

EYW

11h 14m

2 stops

6:43 pm - 11:08 pm

EYW

DSM

5h 25m

1 stop

$319American Airlines

sáb., ene. 31 - jue., feb. 5

11:42 am - 9:47 pm

DSM

EYW

9h 05m

2 stops

1:33 pm - 9:04 pm

EYW

DSM

8h 31m

2 stops

$325American Airlines

sáb., ene. 31 - jue., feb. 5

9:00 am - 1:30 pm

DSM

EYW

27h 30m

2 stops

2:25 pm - 11:12 pm

EYW

DSM

9h 47m

1 stop

$334Multiple Airlines

dom., feb. 15 - jue., feb. 19

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets

American Airlines

Feb 21

DSM2:02 pmDes Moines

7h 35m

1 stop

EYW10:37 pmKey West

Feb 26

EYW4:40 pmKey West

6h 19m

1 stop

DSM9:59 pmDes Moines

$289

American Airlines

Feb 6

DSM11:35 amDes Moines

11h 21m

2 stops

EYW11:56 pmKey West

Feb 10

EYW6:43 pmKey West

5h 25m

1 stop

DSM11:08 pmDes Moines

$294

American Airlines

Feb 6

DSM11:35 amDes Moines

11h 21m

2 stops

EYW11:56 pmKey West

Feb 12

EYW2:06 pmKey West

10h 34m

2 stops

DSM11:40 pmDes Moines

$300

United Airlines flights from Des Moines to Key West

Our best United Airlines deals on Des Moines to Key West flight tickets

United Airlines

Jan 22

DSM8:00 amDes Moines

6h 17m

1 stop

EYW3:17 pmKey West

Feb 4

EYW4:15 pmKey West

6h 35m

1 stop

DSM9:50 pmDes Moines

$455

United Airlines

Jan 27

DSM8:00 amDes Moines

6h 17m

1 stop

EYW3:17 pmKey West

Jan 30

EYW4:15 pmKey West

23h 18m

1 stop

DSM2:33 pmDes Moines

$537

United Airlines

Jan 27

DSM8:00 amDes Moines

6h 17m

1 stop

EYW3:17 pmKey West

Jan 30

EYW2:25 pmKey West

21h 30m

2 stops

DSM10:55 amDes Moines

$542

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

sáb. 2/21

2:02 pm-10:37 pm

1 stop7h 35m

Key West

jue. 2/26

4:40 pm-9:59 pm

1 stop6h 19m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

vie. 2/6

11:35 am-11:56 pm

2 stops11h 21m

Key West

jue. 2/12

7:45 am-1:17 pm

1 stop6h 32m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

sáb. 1/31

5:58 pm-2:56 pm

1 stop19h 58m

Key West

jue. 2/5

10:27 pm-10:17 pm

1 stop24h 50m

$296

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

vie. 2/6

11:35 am-11:56 pm

2 stops11h 21m

Key West

mar. 2/10

6:06 am-3:15 pm

2 stops10h 09m

$300

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

vie. 2/27

2:02 pm-10:37 pm

1 stop7h 35m

Key West

mié. 3/4

6:53 pm-11:40 pm

1 stop5h 47m

$309

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

vie. 2/27

2:02 pm-10:37 pm

1 stop7h 35m

Key West

vie. 3/6

6:53 pm-11:40 pm

1 stop5h 47m

$310

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

vie. 2/27

2:02 pm-10:37 pm

1 stop7h 35m

Key West

mié. 3/4

1:55 pm-11:40 pm

2 stops10h 45m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

sáb. 1/31

11:42 am-11:56 pm

2 stops11h 14m

Key West

jue. 2/5

6:43 pm-11:08 pm

1 stop5h 25m

$319

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

sáb. 1/31

11:42 am-9:47 pm

2 stops9h 05m

Key West

jue. 2/5

1:33 pm-9:04 pm

2 stops8h 31m

$325

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

dom. 2/15

9:00 am-1:30 pm

2 stops27h 30m

Key West

jue. 2/19

2:25 pm-11:12 pm

1 stop9h 47m

$334

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month April is also very affordable. Most momondo users find prices during this month for around $302.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $458 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $284 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time	5h 51m
Direct flights	None

The fastest flight from Des Moines to Key West takes 5h 51m

There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.

Search flight deals

How far is Des Moines to Key West by plane?
The distance between Des Moines and Key West is about 1357.4 mi. 5h 51m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Key West Airport?
Prices for flights from Des Moines Airport to Key West Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Key West Airport?
The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of January 2026.
How old do you have to be to fly from Des Moines Airport to Key West Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.
What documentation or ID do you need to fly to Key West Airport?
The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Key West?
Based on momondo bookings for flights between Des Moines and Key West, the leading airline is American Airlines, making up 53% of the total bookings. Other popular airlines include Delta with 28%, United Airlines with 11%, and Allegiant Air with 9%.

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.2 702 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.2 11,119 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,040 reviews	Search Delta flights
United Airlines	PriceFrom $281	Free Cancellation	Rating 7.4 9,156 reviews	Search United Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.