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Cheap flights from Des Moines to Key West from $172

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:00 am - 3:00 pm
DSM
-
EYW
27h 00m
1 stop
Multiple Airlines Logo
11:51 am - 4:00 pm
EYW
-
DSM
29h 09m
2 stops
$287Multiple Airlines
Sat, Apr 11 - Wed, Apr 15
Allegiant Air Logo
11:00 am - 1:07 pm
DSM
-
EYW
25h 07m
1 stop
Allegiant Air Logo
10:22 am - 4:35 pm
EYW
-
DSM
7h 13m
1 stop
$311Allegiant Air
Sat, May 9 - Wed, May 20
Multiple Airlines Logo
11:00 am - 1:19 pm
DSM
-
EYW
25h 19m
1 stop
Multiple Airlines Logo
11:46 am - 3:15 pm
EYW
-
DSM
28h 29m
2 stops
$317Multiple Airlines
Sat, May 2 - Wed, May 6
Multiple Airlines Logo
3:21 pm - 1:37 pm
DSM
-
EYW
21h 16m
1 stop
Multiple Airlines Logo
1:57 pm - 9:33 am
EYW
-
DSM
20h 36m
1 stop
$318Multiple Airlines
Sun, Apr 5 - Thu, Apr 9
Allegiant Air Logo
11:00 am - 1:07 pm
DSM
-
EYW
25h 07m
1 stop
Allegiant Air Logo
3:08 pm - 5:43 pm
EYW
-
DSM
27h 35m
1 stop
$323Allegiant Air
Sat, May 9 - Thu, May 14
Multiple Airlines Logo
11:00 am - 3:48 pm
DSM
-
EYW
27h 48m
1 stop
Multiple Airlines Logo
11:51 am - 10:06 pm
EYW
-
DSM
35h 15m
2 stops
$326Multiple Airlines
Sat, Apr 25 - Wed, Apr 29
Multiple Airlines Logo
11:00 am - 1:19 pm
DSM
-
EYW
25h 19m
1 stop
Multiple Airlines Logo
1:14 pm - 1:31 pm
EYW
-
DSM
25h 17m
2 stops
$329Multiple Airlines
Sat, May 2 - Tue, May 12
Multiple Airlines Logo
11:00 am - 1:07 pm
DSM
-
EYW
25h 07m
1 stop
Multiple Airlines Logo
1:14 pm - 1:31 pm
EYW
-
DSM
25h 17m
2 stops
$330Multiple Airlines
Sat, May 9 - Tue, May 19
Multiple Airlines Logo
11:00 am - 3:48 pm
DSM
-
EYW
27h 48m
1 stop
Multiple Airlines Logo
12:26 pm - 10:06 pm
EYW
-
DSM
10h 40m
1 stop
$332Multiple Airlines
Sat, Apr 25 - Thu, Apr 30
Allegiant Air Logo
11:00 am - 1:19 pm
DSM
-
EYW
25h 19m
1 stop
Allegiant Air Logo
1:57 pm - 10:57 pm
EYW
-
DSM
34h 00m
2 stops
$334Allegiant Air
Sat, May 2 - Thu, May 7

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets
Delta
Apr 8
DSM11:33 amDes Moines
4h 57m
1 stop
EYW5:30 pmKey West
Apr 15
EYW7:33 amKey West
7h 22m
1 stop
DSM1:55 pmDes Moines
$374
Delta
Apr 4
DSM11:33 amDes Moines
4h 57m
1 stop
EYW5:30 pmKey West
Apr 7
EYW6:25 pmKey West
5h 13m
1 stop
DSM10:38 pmDes Moines
$434

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Apr 25
DSM11:09 amDes Moines
6h 07m
1 stop
EYW6:16 pmKey West
Apr 29
EYW2:01 pmKey West
10h 48m
2 stops
DSM11:49 pmDes Moines
$354
American Airlines
Apr 25
DSM6:00 amDes Moines
9h 13m
2 stops
EYW4:13 pmKey West
Apr 29
EYW4:20 pmKey West
8h 39m
2 stops
DSM11:59 pmDes Moines
$359
American Airlines
Apr 8
DSM1:25 pmDes Moines
8h 11m
2 stops
EYW10:36 pmKey West
Apr 15
EYW4:20 pmKey West
6h 58m
1 stop
DSM10:18 pmDes Moines
$379

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/11

11:00 am-3:00 pm

1 stop27h 00m

Key West

Wed 4/15

11:51 am-4:00 pm

2 stops29h 09m

$287
Quickest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/9

11:00 am-1:07 pm

1 stop25h 07m

Key West

Wed 5/20

10:22 am-4:35 pm

1 stop7h 13m

$311

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/2

11:00 am-1:19 pm

1 stop25h 19m

Key West

Wed 5/6

11:46 am-3:15 pm

2 stops28h 29m

$317

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 4/5

3:21 pm-1:37 pm

1 stop21h 16m

Key West

Thu 4/9

1:57 pm-9:33 am

1 stop20h 36m

$318

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/9

11:00 am-1:07 pm

1 stop25h 07m

Key West

Thu 5/14

3:08 pm-5:43 pm

1 stop27h 35m

$323

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:00 am-3:48 pm

1 stop27h 48m

Key West

Wed 4/29

11:51 am-10:06 pm

2 stops35h 15m

$326

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/2

11:00 am-1:19 pm

1 stop25h 19m

Key West

Tue 5/12

1:14 pm-1:31 pm

2 stops25h 17m

$329

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/9

11:00 am-1:07 pm

1 stop25h 07m

Key West

Tue 5/19

1:14 pm-1:31 pm

2 stops25h 17m

$330

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:00 am-3:48 pm

1 stop27h 48m

Key West

Thu 4/30

12:26 pm-10:06 pm

1 stop10h 40m

$332

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/2

11:00 am-1:19 pm

1 stop25h 19m

Key West

Thu 5/7

1:57 pm-10:57 pm

2 stops34h 00m

$334

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $289. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $298.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time

5h 01m

Direct flights

None
The fastest flight from Des Moines to Key West takes 5h 01m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 5h 01m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.3
710 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.1
11,494 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,327 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,477 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

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