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Cheap flights from Des Moines to Key West from $183

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
4:22 pm - 3:12 pm
DSM
-
EYW
21h 50m
1 stop
Allegiant Air Logo
2:48 pm - 10:52 pm
EYW
-
DSM
9h 04m
1 stop
$263Allegiant Air
Sat, Jun 20 - Sat, Jun 27
American Airlines Logo
3:00 pm - 10:36 pm
DSM
-
EYW
6h 36m
1 stop
American Airlines Logo
6:49 pm - 11:49 pm
EYW
-
DSM
6h 00m
1 stop
$289American Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
11:09 am - 10:36 pm
DSM
-
EYW
10h 27m
2 stops
American Airlines Logo
6:49 pm - 11:49 pm
EYW
-
DSM
6h 00m
1 stop
$294American Airlines
Fri, Apr 24 - Tue, Apr 28
Allegiant Air Logo
4:22 pm - 3:12 pm
DSM
-
EYW
21h 50m
1 stop
Allegiant Air Logo
2:48 pm - 10:52 pm
EYW
-
DSM
9h 04m
1 stop
$297Allegiant Air
Sat, Jun 20 - Sat, Jun 27
Multiple Airlines Logo
7:45 am - 11:11 am
DSM
-
EYW
26h 26m
1 stop
Multiple Airlines Logo
4:36 pm - 1:35 pm
EYW
-
DSM
21h 59m
1 stop
$311Multiple Airlines
Sun, May 17 - Fri, May 22
Multiple Airlines Logo
11:00 am - 3:46 pm
DSM
-
EYW
27h 46m
1 stop
Multiple Airlines Logo
11:51 am - 1:46 pm
EYW
-
DSM
26h 55m
2 stops
$325Multiple Airlines
Sat, Mar 28 - Wed, Apr 1
American Airlines Logo
11:09 am - 10:58 pm
DSM
-
EYW
10h 49m
2 stops
American Airlines Logo
6:45 am - 1:46 pm
EYW
-
DSM
8h 01m
2 stops
$327American Airlines
Sat, Apr 25 - Wed, Apr 29
Allegiant Air Logo
4:22 pm - 9:41 am
DSM
-
EYW
40h 19m
2 stops
Allegiant Air Logo
2:48 pm - 10:52 pm
EYW
-
DSM
9h 04m
1 stop
$328Allegiant Air
Sat, Jun 20 - Sat, Jun 27
American Airlines Logo
6:06 am - 3:24 pm
DSM
-
EYW
8h 18m
1 stop
American Airlines Logo
7:29 pm - 11:59 pm
EYW
-
DSM
5h 30m
1 stop
$336American Airlines
Sat, May 16 - Sat, May 23
Multiple Airlines Logo
8:30 am - 1:35 pm
DSM
-
EYW
28h 05m
1 stop
Multiple Airlines Logo
4:22 pm - 1:09 pm
EYW
-
DSM
21h 47m
2 stops
$340Multiple Airlines
Sun, Apr 19 - Thu, Apr 23

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Apr 22
DSM2:02 pmDes Moines
7h 34m
1 stop
EYW10:36 pmKey West
Apr 28
EYW6:49 pmKey West
6h 00m
1 stop
DSM11:49 pmDes Moines
$289
American Airlines
Apr 25
DSM12:03 pmDes Moines
9h 33m
2 stops
EYW10:36 pmKey West
Apr 29
EYW6:46 pmKey West
6h 03m
1 stop
DSM11:49 pmDes Moines
$294
American Airlines
Apr 25
DSM11:09 amDes Moines
10h 49m
2 stops
EYW10:58 pmKey West
Apr 29
EYW6:45 amKey West
8h 01m
2 stops
DSM1:46 pmDes Moines
$327

Allegiant Air flights from Des Moines to Key West

Our best Allegiant Air deals on Des Moines to Key West flight tickets
Allegiant Air
Jun 20
DSM4:22 pmDes Moines
21h 50m
1 stop
EYW3:12 pmKey West
Jun 27
EYW2:48 pmKey West
9h 04m
1 stop
DSM10:52 pmDes Moines
$263
Allegiant Air
Jun 20
DSM4:22 pmDes Moines
21h 50m
1 stop
EYW3:12 pmKey West
Jun 27
EYW2:48 pmKey West
9h 04m
1 stop
DSM10:52 pmDes Moines
$297
Allegiant Air
Jun 20
DSM4:22 pmDes Moines
40h 19m
2 stops
EYW9:41 amKey West
Jun 27
EYW2:48 pmKey West
9h 04m
1 stop
DSM10:52 pmDes Moines
$328

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 1, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 6/20

4:22 pm-3:12 pm

1 stop21h 50m

Key West

Sat 6/27

2:48 pm-10:52 pm

1 stop9h 04m

$263

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 4/24

3:00 pm-10:36 pm

1 stop6h 36m

Key West

Tue 4/28

6:49 pm-11:49 pm

1 stop6h 00m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 4/24

11:09 am-10:36 pm

2 stops10h 27m

Key West

Tue 4/28

6:49 pm-11:49 pm

1 stop6h 00m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 6/20

4:22 pm-3:12 pm

1 stop21h 50m

Key West

Sat 6/27

2:48 pm-10:52 pm

1 stop9h 04m

$297

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 5/17

7:45 am-11:11 am

1 stop26h 26m

Key West

Fri 5/22

4:36 pm-1:35 pm

1 stop21h 59m

$311

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 3/28

11:00 am-3:46 pm

1 stop27h 46m

Key West

Wed 4/1

11:51 am-1:46 pm

2 stops26h 55m

$325

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:09 am-10:58 pm

2 stops10h 49m

Key West

Wed 4/29

6:45 am-1:46 pm

2 stops8h 01m

$327

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 6/20

4:22 pm-9:41 am

2 stops40h 19m

Key West

Sat 6/27

2:48 pm-10:52 pm

1 stop9h 04m

$328

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/16

6:06 am-3:24 pm

1 stop8h 18m

Key West

Sat 5/23

7:29 pm-11:59 pm

1 stop5h 30m

$336

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 4/19

8:30 am-1:35 pm

1 stop28h 05m

Key West

Thu 4/23

4:22 pm-1:09 pm

2 stops21h 47m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $289. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month November is also very affordable. Most momondo users find prices during this month for around $308.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $443 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $215 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time

5h 45m

Direct flights

None
The fastest flight from Des Moines to Key West takes 5h 45m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 5h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.3
714 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.1
11,369 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,237 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,375 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

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