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Cheap flights from Des Moines to Key West from $289

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 7/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:30 am - 5:23 pm
DSM
-
EYW
4h 53m
1 stop
Delta Logo
6:18 pm - 10:29 pm
EYW
-
DSM
5h 11m
1 stop
$289Delta
Tue, Jul 14 - Tue, Jul 21
Allegiant Air Logo
5:30 pm - 12:48 pm
DSM
-
EYW
42h 18m
2 stops
Allegiant Air Logo
4:41 pm - 10:15 pm
EYW
-
DSM
6h 34m
1 stop
$300Allegiant Air
Fri, Jul 3 - Fri, Jul 10
American Airlines Logo
2:08 pm - 9:45 pm
DSM
-
EYW
6h 37m
1 stop
American Airlines Logo
4:10 pm - 11:29 pm
EYW
-
DSM
8h 19m
1 stop
$309American Airlines
Sat, Dec 5 - Wed, Dec 9
American Airlines Logo
2:08 pm - 9:45 pm
DSM
-
EYW
6h 37m
1 stop
American Airlines Logo
8:00 am - 1:19 pm
EYW
-
DSM
6h 19m
1 stop
$314American Airlines
Sat, Dec 5 - Wed, Dec 9
Multiple Airlines Logo
4:40 pm - 12:34 pm
DSM
-
EYW
18h 54m
2 stops
Multiple Airlines Logo
4:41 pm - 10:15 pm
EYW
-
DSM
6h 34m
1 stop
$324Multiple Airlines
Mon, Jul 6 - Fri, Jul 10
Allegiant Air Logo
3:52 pm - 1:54 pm
DSM
-
EYW
21h 02m
1 stop
Allegiant Air Logo
4:41 pm - 10:15 pm
EYW
-
DSM
6h 34m
1 stop
$329Allegiant Air
Fri, Jul 3 - Fri, Jul 10
American Airlines Logo
2:16 pm - 9:47 pm
DSM
-
EYW
6h 31m
1 stop
American Airlines Logo
8:06 am - 1:31 pm
EYW
-
DSM
6h 25m
1 stop
$339American Airlines
Wed, Nov 4 - Sat, Nov 7
Allegiant Air Logo
3:52 pm - 1:54 pm
DSM
-
EYW
21h 02m
1 stop
Allegiant Air Logo
5:10 pm - 10:07 am
EYW
-
DSM
17h 57m
2 stops
$344Allegiant Air
Fri, Jul 3 - Wed, Jul 8
Allegiant Air Logo
3:59 pm - 6:28 pm
DSM
-
EYW
25h 29m
2 stops
Allegiant Air Logo
4:41 pm - 10:15 pm
EYW
-
DSM
6h 34m
1 stop
$354Allegiant Air
Sun, Jul 5 - Fri, Jul 10
United Airlines Logo
6:00 am - 3:19 pm
DSM
-
EYW
8h 19m
1 stop
United Airlines Logo
4:00 pm - 9:22 pm
EYW
-
DSM
6h 22m
1 stop
$358United Airlines
Thu, Jul 9 - Thu, Jul 16

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American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Dec 5
DSM2:08 pmDes Moines
6h 37m
1 stop
EYW9:45 pmKey West
Dec 9
EYW4:10 pmKey West
8h 19m
1 stop
DSM11:29 pmDes Moines
$309
American Airlines
Dec 5
DSM2:08 pmDes Moines
6h 37m
1 stop
EYW9:45 pmKey West
Dec 9
EYW8:00 amKey West
6h 19m
1 stop
DSM1:19 pmDes Moines
$314
American Airlines
Nov 4
DSM2:16 pmDes Moines
6h 31m
1 stop
EYW9:47 pmKey West
Nov 7
EYW8:06 amKey West
6h 25m
1 stop
DSM1:31 pmDes Moines
$339

Allegiant Air flights from Des Moines to Key West

Our best Allegiant Air deals on Des Moines to Key West flight tickets
Allegiant Air
Jul 3
DSM5:30 pmDes Moines
42h 18m
2 stops
EYW12:48 pmKey West
Jul 10
EYW4:41 pmKey West
6h 34m
1 stop
DSM10:15 pmDes Moines
$300
Allegiant Air
Jun 20
DSM4:22 pmDes Moines
21h 50m
1 stop
EYW3:12 pmKey West
Jun 27
EYW2:48 pmKey West
9h 04m
1 stop
DSM10:52 pmDes Moines
$309
Allegiant Air
Jul 3
DSM3:52 pmDes Moines
21h 02m
1 stop
EYW1:54 pmKey West
Jul 10
EYW4:41 pmKey West
6h 34m
1 stop
DSM10:15 pmDes Moines
$329

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/14

11:30 am-5:23 pm

1 stop4h 53m

Key West

Tue 7/21

6:18 pm-10:29 pm

1 stop5h 11m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 7/3

5:30 pm-12:48 pm

2 stops42h 18m

Key West

Fri 7/10

4:41 pm-10:15 pm

1 stop6h 34m

$300

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/5

2:08 pm-9:45 pm

1 stop6h 37m

Key West

Wed 12/9

4:10 pm-11:29 pm

1 stop8h 19m

$309

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/5

2:08 pm-9:45 pm

1 stop6h 37m

Key West

Wed 12/9

8:00 am-1:19 pm

1 stop6h 19m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 7/6

4:40 pm-12:34 pm

2 stops18h 54m

Key West

Fri 7/10

4:41 pm-10:15 pm

1 stop6h 34m

$324

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 7/3

3:52 pm-1:54 pm

1 stop21h 02m

Key West

Fri 7/10

4:41 pm-10:15 pm

1 stop6h 34m

$329

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 11/4

2:16 pm-9:47 pm

1 stop6h 31m

Key West

Sat 11/7

8:06 am-1:31 pm

1 stop6h 25m

$339

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 7/3

3:52 pm-1:54 pm

1 stop21h 02m

Key West

Wed 7/8

5:10 pm-10:07 am

2 stops17h 57m

$344

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 7/5

3:59 pm-6:28 pm

2 stops25h 29m

Key West

Fri 7/10

4:41 pm-10:15 pm

1 stop6h 34m

$354

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 7/9

6:00 am-3:19 pm

1 stop8h 19m

Key West

Thu 7/16

4:00 pm-9:22 pm

1 stop6h 22m

$358

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Key West?

What is the cheapest month to fly to Key West?

In general, July is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $291. If you are unable to visit Key West during the month of July, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $293.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time

6h 23m

Direct flights

None
The fastest flight from Des Moines to Key West takes 6h 23m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

Frequently asked questions about flying from Des Moines to Key West

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 6h 23m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $268Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,399 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,805 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

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Sat 7/11
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