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Cheap flights from Des Moines to Key West from $207

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

American Airlines Logo
6:57 am - 3:29 pmDSM-EYW
7h 32m1 stop
American Airlines Logo
5:24 pm - 9:52 pmEYW-DSM
5h 28m1 stop
$269American Airlines
Find Deal
Fri, Jan 9 - Wed, Jan 14
American Airlines Logo
9:22 am - 4:03 pmDSM-EYW
5h 41m1 stop
American Airlines Logo
6:31 am - 2:56 pmEYW-DSM
9h 25m2 stops
$274American Airlines
Find Deal
Fri, Jan 9 - Wed, Jan 14
American Airlines Logo
5:55 am - 4:32 pmDSM-EYW
9h 37m2 stops
American Airlines Logo
12:06 pm - 9:52 pmEYW-DSM
10h 46m2 stops
$279American Airlines
Find Deal
Fri, Jan 9 - Wed, Jan 14
Allegiant Air Logo
1:51 pm - 3:06 pmDSM-EYW
24h 15m2 stops
Allegiant Air Logo
3:30 pm - 8:30 amEYW-DSM
18h 00m1 stop
$291Allegiant Air
Find Deal
Sun, Oct 12 - Thu, Oct 16
Delta Logo
11:25 am - 8:07 pmDSM-EYW
7h 42m1 stop
Delta Logo
2:00 pm - 5:45 pmEYW-DSM
4h 45m1 stop
$294Delta
Find Deal
Sat, Sep 27 - Wed, Oct 1
Delta Logo
11:25 am - 8:07 pmDSM-EYW
7h 42m1 stop
Delta Logo
7:00 am - 4:45 pmEYW-DSM
10h 45m2 stops
$299Delta
Find Deal
Sat, Sep 27 - Wed, Oct 1
American Airlines Logo
3:18 pm - 9:48 pmDSM-EYW
5h 30m1 stop
American Airlines Logo
8:00 am - 1:31 pmEYW-DSM
6h 31m1 stop
$306American Airlines
Find Deal
Wed, Nov 12 - Sat, Nov 15
Allegiant Air Logo
1:51 pm - 8:13 pmDSM-EYW
29h 22m2 stops
Allegiant Air Logo
3:23 pm - 8:34 amEYW-DSM
18h 11m1 stop
$326Allegiant Air
Find Deal
Sun, Oct 26 - Sun, Nov 2
Logo
8:55 am - 9:02 amDSM-EYW
23h 07m1 stop
Logo
8:45 pm - 10:51 amEYW-DSM
39h 06m2 stops
$400
Find Deal
Fri, Oct 24 - Fri, Oct 31
United Airlines Logo
8:00 am - 1:02 pmDSM-EYW
28h 02m3 stops
United Airlines Logo
12:15 pm - 9:36 pmEYW-DSM
10h 21m2 stops
$528United Airlines
Find Deal
Sat, Feb 7 - Fri, Feb 13

Allegiant Air flights from Des Moines to Key West

Our best Allegiant Air deals on Des Moines to Key West flight tickets
Allegiant Air
Oct 12
DSM1:51 pmDes Moines
24h 15m
2 stops
EYW3:06 pmKey West
Oct 16
EYW3:30 pmKey West
18h 00m
1 stop
DSM8:30 amDes Moines
$291
Find similar
Allegiant Air
Oct 26
DSM1:51 pmDes Moines
29h 22m
2 stops
EYW8:13 pmKey West
Nov 2
EYW3:23 pmKey West
18h 11m
1 stop
DSM8:34 amDes Moines
$326
Find similar
Allegiant Air
Feb 7
DSM5:58 pmDes Moines
19h 58m
1 stop
EYW2:56 pmKey West
Feb 13
EYW3:47 pmKey West
26h 37m
1 stop
DSM5:24 pmDes Moines
$354
Find similar

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets
Delta
Sep 27
DSM11:25 amDes Moines
7h 42m
1 stop
EYW8:07 pmKey West
Oct 1
EYW2:00 pmKey West
4h 45m
1 stop
DSM5:45 pmDes Moines
$294
Find similar
Delta
Sep 27
DSM11:25 amDes Moines
7h 42m
1 stop
EYW8:07 pmKey West
Oct 1
EYW7:00 amKey West
10h 45m
2 stops
DSM4:45 pmDes Moines
$299
Find similar
Delta
Oct 24
DSM10:00 amDes Moines
9h 06m
2 stops
EYW8:06 pmKey West
Oct 31
EYW4:00 pmKey West
7h 30m
1 stop
DSM10:30 pmDes Moines
$404
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

6:57 am-3:29 pm

1 stop7h 32m

Key West

Wed 1/14

5:24 pm-9:52 pm

1 stop5h 28m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

9:22 am-4:03 pm

1 stop5h 41m

Key West

Wed 1/14

6:31 am-2:56 pm

2 stops9h 25m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

5:55 am-4:32 pm

2 stops9h 37m

Key West

Wed 1/14

12:06 pm-9:52 pm

2 stops10h 46m

$279

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 10/12

1:51 pm-3:06 pm

2 stops24h 15m

Key West

Thu 10/16

3:30 pm-8:30 am

1 stop18h 00m

$291

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 9/27

11:25 am-8:07 pm

1 stop7h 42m

Key West

Wed 10/1

2:00 pm-5:45 pm

1 stop4h 45m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 9/27

11:25 am-8:07 pm

1 stop7h 42m

Key West

Wed 10/1

7:00 am-4:45 pm

2 stops10h 45m

$299

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 11/12

3:18 pm-9:48 pm

1 stop5h 30m

Key West

Sat 11/15

8:00 am-1:31 pm

1 stop6h 31m

$306

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 10/26

1:51 pm-8:13 pm

2 stops29h 22m

Key West

Sun 11/2

3:23 pm-8:34 am

1 stop18h 11m

$326

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 10/24

8:55 am-9:02 am

1 stop23h 07m

Key West

Fri 10/31

8:45 pm-10:51 am

2 stops39h 06m

$400

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 2/7

8:00 am-1:02 pm

3 stops28h 02m

Key West

Fri 2/13

12:15 pm-9:36 pm

2 stops10h 21m

$528

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, April is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of April, then departing from Des Moines during the month November is also very affordable. Most momondo users find prices during this month for around $318.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $331. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Key West for around $558.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Des Moines to Key West at noon for as low as $380. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $435 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $331 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Direct flights

None
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
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  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 4h 40m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $268Free CancellationRating
7.9
7,960 reviews
Search Delta flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $281Free CancellationRating
7.4
8,937 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

An easier way to manage your Key West trip

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