What airlines fly to Key West?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Key West from Des Moines according to our data. American Airlines is the first choice among our users, with 51% of people opting to fly with this airline when traveling to Key West. Keep in mind that there are 4 different airlines that fly to Key West on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

Prices for flights from Des Moines Airport to Key West Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of December 2025.

How old do you have to be to fly from Des Moines Airport to Key West Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

What documentation or ID do you need to fly to Key West Airport?

The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$204 Cheap Flights from Des Moines to Key West in 2025/26

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Cheap round-trip flights

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5:58 pm - 2:56 pm

DSM

EYW

19h 58m1 stop

12:51 pm - 10:46 pm

EYW

DSM

10h 55m1 stop

$243Multiple Airlines

Th. 7, Thg. 1 24 - Th. 5, Thg. 1 29

5:58 pm - 2:56 pm

DSM

EYW

19h 58m1 stop

12:51 pm - 10:19 am

EYW

DSM

22h 28m2 stops

$263Multiple Airlines

Th. 7, Thg. 1 24 - Th. 5, Thg. 1 29

6:14 pm - 2:19 pm

DSM

EYW

19h 05m1 stop

2:25 pm - 11:06 pm

EYW

DSM

9h 41m1 stop

$266Multiple Airlines

Th. 7, Thg. 2 21 - Th. 5, Thg. 2 26

3:32 pm - 1:30 pm

DSM

EYW

20h 58m1 stop

2:25 pm - 11:06 pm

EYW

DSM

9h 41m1 stop

$269Multiple Airlines

CN, Thg. 2 22 - Th. 5, Thg. 2 26

2:58 pm - 1:30 pm

DSM

EYW

21h 32m1 stop

12:51 pm - 10:46 pm

EYW

DSM

10h 55m1 stop

$274Multiple Airlines

Th. 5, Thg. 1 22 - Th. 5, Thg. 1 29

7:17 pm - 9:06 am

DSM

EYW

36h 49m2 stops

2:25 pm - 11:06 pm

EYW

DSM

9h 41m1 stop

$275Multiple Airlines

Th. 6, Thg. 2 20 - Th. 5, Thg. 2 26

6:14 pm - 9:37 pm

DSM

EYW

26h 23m1 stop

10:49 am - 10:46 pm

EYW

DSM

36h 57m2 stops

$278Multiple Airlines

Th. 4, Thg. 1 21 - Th. 4, Thg. 1 28

11:26 am - 5:11 pm

DSM

EYW

4h 45m1 stop

1:28 pm - 7:34 pm

EYW

DSM

7h 06m1 stop

$279Delta

Th. 3, Thg. 1 20 - Th. 4, Thg. 1 28

11:26 am - 7:40 pm

DSM

EYW

7h 14m1 stop

1:28 pm - 7:34 pm

EYW

DSM

7h 06m1 stop

$289Delta

Th. 2, Thg. 1 19 - Th. 4, Thg. 1 28

2:58 pm - 1:30 pm

DSM

EYW

21h 32m1 stop

12:51 pm - 10:19 am

EYW

DSM

22h 28m2 stops

$293Multiple Airlines

Th. 5, Thg. 1 22 - Th. 5, Thg. 1 29

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets

Delta

Jan 20

DSM11:26 amDes Moines

4h 45m

1 stop

EYW5:11 pmKey West

Jan 28

EYW1:28 pmKey West

7h 06m

1 stop

DSM7:34 pmDes Moines

$279

Find similar

Delta

Jan 19

DSM11:26 amDes Moines

7h 14m

1 stop

EYW7:40 pmKey West

Jan 28

EYW1:28 pmKey West

7h 06m

1 stop

DSM7:34 pmDes Moines

$289

Find similar

Delta

Jan 20

DSM6:24 amDes Moines

9h 47m

2 stops

EYW5:11 pmKey West

Jan 27

EYW6:06 pmKey West

5h 23m

1 stop

DSM10:29 pmDes Moines

$314

Find similar

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets

American Airlines

Mar 25

DSM10:04 amDes Moines

7h 13m

1 stop

EYW6:17 pmKey West

Apr 1

EYW3:56 pmKey West

8h 46m

2 stops

DSM11:42 pmDes Moines

$294

Find similar

American Airlines

Mar 25

DSM6:00 amDes Moines

8h 57m

2 stops

EYW3:57 pmKey West

Apr 1

EYW3:56 pmKey West

8h 46m

2 stops

DSM11:42 pmDes Moines

$299

Find similar

American Airlines

Jan 5

DSM2:07 pmDes Moines

7h 37m

1 stop

EYW10:44 pmKey West

Jan 13

EYW7:08 amKey West

10h 16m

2 stops

DSM4:24 pmDes Moines

$319

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 7 1/24

5:58 pm-2:56 pm

1 stop19h 58m

Key West

Th. 5 1/29

12:51 pm-10:46 pm

1 stop10h 55m

$243

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 7 1/24

5:58 pm-2:56 pm

1 stop19h 58m

Key West

Th. 5 1/29

12:51 pm-10:19 am

2 stops22h 28m

$263

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 7 2/21

6:14 pm-2:19 pm

1 stop19h 05m

Key West

Th. 5 2/26

2:25 pm-11:06 pm

1 stop9h 41m

$266

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

CN 2/22

3:32 pm-1:30 pm

1 stop20h 58m

Key West

Th. 5 2/26

2:25 pm-11:06 pm

1 stop9h 41m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 5 1/22

2:58 pm-1:30 pm

1 stop21h 32m

Key West

Th. 5 1/29

12:51 pm-10:46 pm

1 stop10h 55m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 6 2/20

7:17 pm-9:06 am

2 stops36h 49m

Key West

Th. 5 2/26

2:25 pm-11:06 pm

1 stop9h 41m

$275

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 4 1/21

6:14 pm-9:37 pm

1 stop26h 23m

Key West

Th. 4 1/28

10:49 am-10:46 pm

2 stops36h 57m

$278

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 3 1/20

11:26 am-5:11 pm

1 stop4h 45m

Key West

Th. 4 1/28

1:28 pm-7:34 pm

1 stop7h 06m

$279

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 2 1/19

11:26 am-7:40 pm

1 stop7h 14m

Key West

Th. 4 1/28

1:28 pm-7:34 pm

1 stop7h 06m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Th. 5 1/22

2:58 pm-1:30 pm

1 stop21h 32m

Key West

Th. 5 1/29

12:51 pm-10:19 am

2 stops22h 28m

$293

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Key West?

In general, April is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of April, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $293.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $331. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Key West for around $558.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Des Moines to Key West at noon for as low as $380. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $445 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $350 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time	4h 45m
Direct flights	None

The fastest flight from Des Moines to Key West takes 4h 45m

There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.

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How far is Des Moines to Key West by plane?
The distance between Des Moines and Key West is about 1357.4 mi. 4h 45m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Key West Airport?
Prices for flights from Des Moines Airport to Key West Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Key West Airport?
The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of December 2025.
How old do you have to be to fly from Des Moines Airport to Key West Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.
What documentation or ID do you need to fly to Key West Airport?
The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Key West?
Based on momondo bookings for flights between Des Moines and Key West, the leading airline is American Airlines, making up 51% of the total bookings. Other popular airlines include Delta with 26%, United Airlines with 14%, and Allegiant Air with 8%.

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.2 701 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.2 11,052 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,014 reviews	Search Delta flights
United Airlines	PriceFrom $281	Free Cancellation	Rating 7.4 9,102 reviews	Search United Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.