What airlines fly to Key West?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Key West from Des Moines according to our data. American Airlines is the first choice among our users, with 54% of people opting to fly with this airline when traveling to Key West. Keep in mind that there are 4 different airlines that fly to Key West on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

Prices for flights from Des Moines Airport to Key West Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of January 2026.

How old do you have to be to fly from Des Moines Airport to Key West Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

What documentation or ID do you need to fly to Key West Airport?

The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$289 Cheap Flights from Des Moines to Key West in 2026

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Find the cheapest flights from Des Moines to Key West

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 3:21 pm

DSM

EYW

8h 21m

1 stop

6:54 pm - 11:40 pm

EYW

DSM

5h 46m

1 stop

$289American Airlines

Tue, Feb 17 - Tue, Feb 24

6:00 am - 3:21 pm

DSM

EYW

8h 21m

1 stop

1:55 pm - 11:40 pm

EYW

DSM

10h 45m

2 stops

$294American Airlines

Tue, Feb 17 - Tue, Feb 24

5:00 am - 4:49 pm

DSM

EYW

10h 49m

2 stops

1:55 pm - 11:40 pm

EYW

DSM

10h 45m

2 stops

$300American Airlines

Tue, Feb 17 - Tue, Feb 24

6:14 pm - 2:19 pm

DSM

EYW

19h 05m

1 stop

9:46 am - 7:39 pm

EYW

DSM

34h 53m

2 stops

$303Multiple Airlines

Sat, Feb 21 - Thu, Feb 26

6:14 pm - 2:19 pm

DSM

EYW

19h 05m

1 stop

4:13 pm - 9:37 am

EYW

DSM

18h 24m

1 stop

$307Allegiant Air

Sat, Feb 21 - Thu, Feb 26

7:20 pm - 12:21 pm

DSM

EYW

16h 01m

1 stop

4:13 pm - 7:39 pm

EYW

DSM

28h 26m

2 stops

$308Multiple Airlines

Mon, Feb 23 - Thu, Feb 26

1:52 pm - 10:37 pm

DSM

EYW

7h 45m

1 stop

6:49 pm - 11:40 pm

EYW

DSM

5h 51m

1 stop

$309American Airlines

Mon, Mar 9 - Mon, Mar 16

7:20 pm - 12:21 pm

DSM

EYW

16h 01m

1 stop

4:13 pm - 9:37 am

EYW

DSM

18h 24m

1 stop

$310Multiple Airlines

Mon, Feb 23 - Thu, Feb 26

5:00 am - 3:57 pm

DSM

EYW

9h 57m

2 stops

6:49 pm - 11:40 pm

EYW

DSM

5h 51m

1 stop

$314American Airlines

Mon, Mar 9 - Mon, Mar 16

12:03 pm - 10:57 pm

DSM

EYW

9h 54m

2 stops

2:14 pm - 8:47 pm

EYW

DSM

7h 33m

1 stop

$324American Airlines

Sat, Apr 18 - Thu, Apr 23

Allegiant Air flights from Des Moines to Key West

Our best Allegiant Air deals on Des Moines to Key West flight tickets

Allegiant Air

Feb 21

DSM6:14 pmDes Moines

19h 05m

1 stop

EYW2:19 pmKey West

Feb 26

EYW4:13 pmKey West

18h 24m

1 stop

DSM9:37 amDes Moines

$307

Allegiant Air

Feb 20

DSM7:20 pmDes Moines

14h 43m

1 stop

EYW11:03 amKey West

Feb 26

EYW4:13 pmKey West

18h 24m

1 stop

DSM9:37 amDes Moines

$335

Allegiant Air

Jun 20

DSM7:00 amDes Moines

5h 58m

1 stop

EYW1:58 pmKey West

Jun 27

EYW2:48 pmKey West

9h 04m

1 stop

DSM10:52 pmDes Moines

$384

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets

American Airlines

Feb 17

DSM6:00 amDes Moines

8h 21m

1 stop

EYW3:21 pmKey West

Feb 24

EYW6:54 pmKey West

5h 46m

1 stop

DSM11:40 pmDes Moines

$289

American Airlines

Feb 17

DSM6:00 amDes Moines

8h 21m

1 stop

EYW3:21 pmKey West

Feb 24

EYW1:55 pmKey West

10h 45m

2 stops

DSM11:40 pmDes Moines

$294

American Airlines

Feb 17

DSM5:00 amDes Moines

10h 49m

2 stops

EYW4:49 pmKey West

Feb 24

EYW1:55 pmKey West

10h 45m

2 stops

DSM11:40 pmDes Moines

$300

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

6:00 am-3:21 pm

1 stop8h 21m

Key West

Tue 2/24

6:54 pm-11:40 pm

1 stop5h 46m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

6:00 am-3:21 pm

1 stop8h 21m

Key West

Tue 2/24

1:55 pm-11:40 pm

2 stops10h 45m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

5:00 am-4:49 pm

2 stops10h 49m

Key West

Tue 2/24

1:55 pm-11:40 pm

2 stops10h 45m

$300

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 2/21

6:14 pm-2:19 pm

1 stop19h 05m

Key West

Thu 2/26

9:46 am-7:39 pm

2 stops34h 53m

$303

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 2/21

6:14 pm-2:19 pm

1 stop19h 05m

Key West

Thu 2/26

4:13 pm-9:37 am

1 stop18h 24m

$307

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 2/23

7:20 pm-12:21 pm

1 stop16h 01m

Key West

Thu 2/26

4:13 pm-7:39 pm

2 stops28h 26m

$308

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 3/9

1:52 pm-10:37 pm

1 stop7h 45m

Key West

Mon 3/16

6:49 pm-11:40 pm

1 stop5h 51m

$309

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 2/23

7:20 pm-12:21 pm

1 stop16h 01m

Key West

Thu 2/26

4:13 pm-9:37 am

1 stop18h 24m

$310

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 3/9

5:00 am-3:57 pm

2 stops9h 57m

Key West

Mon 3/16

6:49 pm-11:40 pm

1 stop5h 51m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/18

12:03 pm-10:57 pm

2 stops9h 54m

Key West

Thu 4/23

2:14 pm-8:47 pm

1 stop7h 33m

$324

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month November is also very affordable. Most momondo users find prices during this month for around $348.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $465 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $284 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time	4h 45m
Direct flights	None

The fastest flight from Des Moines to Key West takes 4h 45m

There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.

Search flight deals

How far is Des Moines to Key West by plane?
The distance between Des Moines and Key West is about 1357.4 mi. 4h 45m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Key West Airport?
Prices for flights from Des Moines Airport to Key West Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Key West Airport?
The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of January 2026.
How old do you have to be to fly from Des Moines Airport to Key West Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.
What documentation or ID do you need to fly to Key West Airport?
The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Key West?
Based on momondo bookings for flights between Des Moines and Key West, the leading airline is American Airlines, making up 54% of the total bookings. Other popular airlines include Delta with 25%, United Airlines with 12%, and Allegiant Air with 9%.

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.2 706 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.2 11,206 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,127 reviews	Search Delta flights
United Airlines	PriceFrom $281	Free Cancellation	Rating 7.4 9,215 reviews	Search United Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.