Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Key West from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 6/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:04 am - 12:34 pm
DSM
-
EYW
25h 30m
1 stop
Multiple Airlines Logo
11:04 am - 9:14 am
EYW
-
DSM
23h 10m
1 stop
$233Multiple Airlines
Mon, Aug 24 - Thu, Aug 27
Multiple Airlines Logo
4:25 pm - 9:24 am
DSM
-
EYW
15h 59m
1 stop
Multiple Airlines Logo
8:36 pm - 8:35 am
EYW
-
DSM
12h 59m
1 stop
$248Multiple Airlines
Fri, Sep 25 - Thu, Oct 1
Multiple Airlines Logo
10:04 am - 3:02 pm
DSM
-
EYW
27h 58m
1 stop
Multiple Airlines Logo
11:04 am - 9:14 am
EYW
-
DSM
23h 10m
1 stop
$271Multiple Airlines
Fri, Aug 21 - Thu, Aug 27
Multiple Airlines Logo
9:51 pm - 1:24 pm
DSM
-
EYW
38h 33m
2 stops
Multiple Airlines Logo
4:12 pm - 6:28 pm
EYW
-
DSM
27h 16m
1 stop
$278Multiple Airlines
Fri, May 29 - Thu, Jun 4
Multiple Airlines Logo
9:51 pm - 1:24 pm
DSM
-
EYW
38h 33m
2 stops
Multiple Airlines Logo
1:11 pm - 1:30 pm
EYW
-
DSM
25h 19m
1 stop
$283Multiple Airlines
Fri, May 29 - Fri, Jun 5
Delta Logo
5:45 am - 1:09 pm
DSM
-
EYW
6h 24m
1 stop
Delta Logo
7:00 am - 1:22 pm
EYW
-
DSM
7h 22m
1 stop
$289Delta
Tue, Aug 18 - Wed, Aug 26
Multiple Airlines Logo
1:58 pm - 12:34 pm
DSM
-
EYW
45h 36m
2 stops
Multiple Airlines Logo
8:58 am - 3:35 pm
EYW
-
DSM
7h 37m
1 stop
$290Multiple Airlines
Sun, Sep 6 - Fri, Sep 18
Multiple Airlines Logo
9:28 am - 11:27 am
DSM
-
EYW
24h 59m
2 stops
Multiple Airlines Logo
11:04 am - 9:14 am
EYW
-
DSM
23h 10m
1 stop
$292Multiple Airlines
Sun, Aug 23 - Thu, Aug 27
American Airlines Logo
6:33 am - 7:10 pm
DSM
-
EYW
11h 37m
2 stops
American Airlines Logo
7:29 pm - 12:17 am
EYW
-
DSM
5h 48m
1 stop
$294American Airlines
Wed, May 27 - Tue, Jun 2
Allegiant Air Logo
9:43 am - 2:01 pm
DSM
-
EYW
27h 18m
1 stop
Allegiant Air Logo
2:51 pm - 3:35 pm
EYW
-
DSM
25h 44m
1 stop
$295Allegiant Air
Sun, May 24 - Mon, Jun 1

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
May 27
DSM6:02 amDes Moines
11h 47m
2 stops
EYW6:49 pmKey West
Jun 2
EYW7:29 pmKey West
5h 48m
1 stop
DSM12:17 amDes Moines
$294
American Airlines
Sep 23
DSM6:00 amDes Moines
11h 27m
2 stops
EYW6:27 pmKey West
Sep 26
EYW1:59 pmKey West
9h 28m
2 stops
DSM10:27 pmDes Moines
$300
American Airlines
Sep 26
DSM6:00 amDes Moines
11h 27m
2 stops
EYW6:27 pmKey West
Sep 29
EYW3:00 pmKey West
9h 28m
2 stops
DSM11:28 pmDes Moines
$330

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets
Delta
Aug 18
DSM5:45 amDes Moines
6h 24m
1 stop
EYW1:09 pmKey West
Aug 26
EYW7:00 amKey West
7h 22m
1 stop
DSM1:22 pmDes Moines
$289
Delta
Sep 6
DSM5:45 amDes Moines
6h 24m
1 stop
EYW1:09 pmKey West
Sep 15
EYW7:00 amKey West
7h 22m
1 stop
DSM1:22 pmDes Moines
$309
Delta
Aug 21
DSM5:45 amDes Moines
6h 24m
1 stop
EYW1:09 pmKey West
Aug 26
EYW11:45 amKey West
6h 57m
1 stop
DSM5:42 pmDes Moines
$319

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 8/24

10:04 am-12:34 pm

1 stop25h 30m

Key West

Thu 8/27

11:04 am-9:14 am

1 stop23h 10m

$233

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/25

4:25 pm-9:24 am

1 stop15h 59m

Key West

Thu 10/1

8:36 pm-8:35 am

1 stop12h 59m

$248

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 8/21

10:04 am-3:02 pm

1 stop27h 58m

Key West

Thu 8/27

11:04 am-9:14 am

1 stop23h 10m

$271

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 5/29

9:51 pm-1:24 pm

2 stops38h 33m

Key West

Thu 6/4

4:12 pm-6:28 pm

1 stop27h 16m

$278

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 5/29

9:51 pm-1:24 pm

2 stops38h 33m

Key West

Fri 6/5

1:11 pm-1:30 pm

1 stop25h 19m

$283
Quickest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 8/18

5:45 am-1:09 pm

1 stop6h 24m

Key West

Wed 8/26

7:00 am-1:22 pm

1 stop7h 22m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 9/6

1:58 pm-12:34 pm

2 stops45h 36m

Key West

Fri 9/18

8:58 am-3:35 pm

1 stop7h 37m

$290

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 8/23

9:28 am-11:27 am

2 stops24h 59m

Key West

Thu 8/27

11:04 am-9:14 am

1 stop23h 10m

$292

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 5/27

6:33 am-7:10 pm

2 stops11h 37m

Key West

Tue 6/2

7:29 pm-12:17 am

1 stop5h 48m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 5/24

9:43 am-2:01 pm

1 stop27h 18m

Key West

Mon 6/1

2:51 pm-3:35 pm

1 stop25h 44m

$295

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Key West?

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $289. If you are unable to visit Key West during the month of September, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $293.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Fastest flight time

6h 07m

Direct flights

None
The fastest flight from Des Moines to Key West takes 6h 07m
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
Search flight deals

Frequently asked questions about flying from Des Moines to Key West

  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 6h 07m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,463 reviews
Search Delta flights
American AirlinesPriceFrom $274Free CancellationRating
7.1
11,681 reviews
Search American Airlines flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,677 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

An easier way to manage your Key West trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 5/30
Sat 6/6
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States