What airlines fly to Key West?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Key West from Des Moines according to our data. American Airlines is the first choice among our users, with 62% of people opting to fly with this airline when traveling to Key West. Keep in mind that there are 4 different airlines that fly to Key West on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Key West?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Des Moines to Key West

When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

Prices for flights from Des Moines Airport to Key West Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of July 2025.

How old do you have to be to fly from Des Moines Airport to Key West Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

What documentation or ID do you need to fly to Key West Airport?

The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$182 Cheap Flights from Des Moines to Key West in 2025

Q: What is the typical price of a round-trip flight between Des Moines and Key West?

Prices are currently low for flights on this route. Typical prices usually range from $299 to $533. The lowest price recently found on this route was $269.

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Find the cheapest flights from Des Moines to Key West

Round-trip

One-way

Last minute

Cheap round-trip flights

6:00 am - 1:51 pmDSM-EYW

6h 51m1 stop

4:49 pm - 11:45 pmEYW-DSM

7h 56m1 stop

$269American Airlines

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Fri, Aug 22 - Thu, Aug 28

8:00 am - 6:59 pmDSM-EYW

9h 59m2 stops

12:00 pm - 4:49 pmEYW-DSM

5h 49m1 stop

$274American Airlines

Find Deal

Fri, Sep 5 - Tue, Sep 9

2:12 pm - 8:12 pmDSM-EYW

5h 00m1 stop

7:00 am - 12:18 pmEYW-DSM

6h 18m1 stop

$279Delta

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Fri, Aug 22 - Sat, Aug 30

5:00 am - 4:46 pmDSM-EYW

10h 46m2 stops

12:50 pm - 5:23 pmEYW-DSM

5h 33m1 stop

$284American Airlines

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Fri, Aug 22 - Thu, Aug 28

6:28 am - 7:07 pmDSM-EYW

11h 39m2 stops

1:29 pm - 11:24 pmEYW-DSM

10h 55m2 stops

$289American Airlines

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Fri, Aug 22 - Thu, Aug 28

11:25 am - 8:07 pmDSM-EYW

7h 42m1 stop

7:00 am - 1:28 pmEYW-DSM

7h 28m1 stop

$304Delta

Find Deal

Sat, Oct 4 - Tue, Oct 7

10:20 am - 8:07 pmDSM-EYW

8h 47m2 stops

11:45 am - 5:39 pmEYW-DSM

6h 54m1 stop

$309Delta

Find Deal

Fri, Oct 3 - Wed, Oct 8

6:00 am - 6:59 pmDSM-EYW

11h 59m2 stops

4:37 pm - 11:08 pmEYW-DSM

7h 31m1 stop

$311American Airlines

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Sat, Oct 4 - Tue, Oct 7

6:20 am - 7:44 pmDSM-EYW

12h 24m2 stops

2:35 pm - 9:24 pmEYW-DSM

7h 49m2 stops

$314Delta

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Sat, Oct 18 - Wed, Oct 22

8:00 am - 3:09 pmDSM-EYW

6h 09m1 stop

4:05 pm - 10:20 amEYW-DSM

19h 15m1 stop

$452United Airlines

Find Deal

Tue, Dec 16 - Sun, Dec 21

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets

American Airlines

Aug 22

DSM6:00 amDes Moines

6h 51m

1 stop

EYW1:51 pmKey West

Aug 28

EYW4:49 pmKey West

7h 56m

1 stop

DSM11:45 pmDes Moines

$269

Find similar

American Airlines

Sep 5

DSM8:00 amDes Moines

9h 59m

2 stops

EYW6:59 pmKey West

Sep 9

EYW12:00 pmKey West

5h 49m

1 stop

DSM4:49 pmDes Moines

$274

Find similar

American Airlines

Aug 22

DSM5:00 amDes Moines

10h 46m

2 stops

EYW4:46 pmKey West

Aug 28

EYW12:50 pmKey West

5h 33m

1 stop

DSM5:23 pmDes Moines

$284

Find similar

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets

Delta

Aug 22

DSM2:12 pmDes Moines

5h 00m

1 stop

EYW8:12 pmKey West

Aug 30

EYW7:00 amKey West

6h 18m

1 stop

DSM12:18 pmDes Moines

$279

Find similar

Delta

Oct 4

DSM11:25 amDes Moines

7h 42m

1 stop

EYW8:07 pmKey West

Oct 7

EYW7:00 amKey West

7h 28m

1 stop

DSM1:28 pmDes Moines

$304

Find similar

Delta

Oct 3

DSM10:20 amDes Moines

8h 47m

2 stops

EYW8:07 pmKey West

Oct 8

EYW11:45 amKey West

6h 54m

1 stop

DSM5:39 pmDes Moines

$309

Find similar

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the typical price of a round-trip flight between Des Moines and Key West?

What is the cheapest month to fly to Key West?

In general, April is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of April, then departing from Des Moines during the month November is also very affordable. Most momondo users find prices during this month for around $338.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $331. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Key West for around $558.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Des Moines to Key West at noon for as low as $380. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $436 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $331 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Best Price Found	$182
Fastest flight time	4h 50m
Direct flights	None
Airports in Key West	1 airport

The best one-way flight to Key West from Des Moines in the past 72 hours is $182. The best round-trip flight deal from Des Moines to Key West found on momondo in the last 72 hours is $269.

The fastest flight from Des Moines to Key West takes 4h 50m

There are no direct flights from Des Moines to Key West. Popular non-direct route for this connection is Des Moines Airport - Key West Airport.

There is 1 airport near Key West: Key West (EYW)

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How far is Des Moines to Key West by plane?
The distance between Des Moines and Key West is about 1357.4 mi. 5h 00m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Key West Airport?
Prices for flights from Des Moines Airport to Key West Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Key West Airport?
The number of operators available for flights from Des Moines Airport to Key West Airport is 4 as of July 2025.
How old do you have to be to fly from Des Moines Airport to Key West Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.
What documentation or ID do you need to fly to Key West Airport?
The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Key West?
Based on momondo bookings for flights between Des Moines and Key West, the leading airline is American Airlines, making up 62% of the total bookings. Other popular airlines include Delta with 20%, United Airlines with 12%, and Allegiant Air with 5%.

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.2 705 reviews	Search Allegiant Air flights
Delta	PriceFrom $268	Free Cancellation	Rating 8.0 7,957 reviews	Search Delta flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $292	Free Cancellation	Rating 7.4 8,863 reviews	Search United Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.