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Cheap flights from Des Moines to Key West from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 10/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Key West

Cheap round-trip flights

Delta Logo
2:13 pm - 8:06 pmDSM-EYW
4h 53m1 stop
Delta Logo
1:57 pm - 5:44 pmEYW-DSM
4h 47m1 stop
$269Delta
Find Deal
Tue, Oct 14 - Wed, Oct 22
American Airlines Logo
9:00 am - 9:56 pmDSM-EYW
11h 56m2 stops
American Airlines Logo
7:31 am - 2:31 pmEYW-DSM
8h 00m1 stop
$274American Airlines
Find Deal
Sat, Nov 1 - Tue, Nov 4
American Airlines Logo
9:00 am - 9:56 pmDSM-EYW
11h 56m2 stops
American Airlines Logo
1:33 pm - 10:08 pmEYW-DSM
9h 35m2 stops
$279American Airlines
Find Deal
Sat, Nov 1 - Tue, Nov 4
American Airlines Logo
6:00 am - 6:59 pmDSM-EYW
11h 59m2 stops
American Airlines Logo
6:17 pm - 11:06 pmEYW-DSM
5h 49m1 stop
$299American Airlines
Find Deal
Sat, Sep 13 - Tue, Sep 16
American Airlines Logo
5:10 am - 6:59 pmDSM-EYW
12h 49m2 stops
American Airlines Logo
1:59 pm - 11:13 pmEYW-DSM
10h 14m2 stops
$304American Airlines
Find Deal
Sat, Sep 13 - Tue, Sep 16
Allegiant Air Logo
9:00 am - 9:11 pmDSM-EYW
11h 11m1 stop
Allegiant Air Logo
3:52 pm - 10:17 pmEYW-DSM
7h 25m1 stop
$305Allegiant Air
Find Deal
Mon, Jan 5 - Fri, Jan 9
Delta Logo
2:05 pm - 8:07 pmDSM-EYW
5h 02m1 stop
Delta Logo
11:50 am - 5:45 pmEYW-DSM
6h 55m1 stop
$319Delta
Find Deal
Fri, Sep 12 - Tue, Sep 16
Allegiant Air Logo
3:17 pm - 2:40 pmDSM-EYW
22h 23m1 stop
Allegiant Air Logo
3:30 pm - 8:30 amEYW-DSM
18h 00m1 stop
$453Allegiant Air
Find Deal
Wed, Oct 8 - Sun, Oct 12
United Airlines Logo
8:00 am - 3:17 pmDSM-EYW
6h 17m1 stop
United Airlines Logo
4:15 pm - 9:50 pmEYW-DSM
6h 35m1 stop
$458United Airlines
Find Deal
Wed, Jan 14 - Wed, Jan 21
United Airlines Logo
8:02 am - 3:19 pmDSM-EYW
6h 17m1 stop
United Airlines Logo
3:00 pm - 12:14 pmEYW-DSM
22h 14m2 stops
$548United Airlines
Find Deal
Mon, Nov 17 - Fri, Nov 21

Delta flights from Des Moines to Key West

Our best Delta deals on Des Moines to Key West flight tickets
Delta
Oct 14
DSM2:13 pmDes Moines
4h 53m
1 stop
EYW8:06 pmKey West
Oct 22
EYW1:57 pmKey West
4h 47m
1 stop
DSM5:44 pmDes Moines
$269
Find similar
Delta
Sep 12
DSM2:05 pmDes Moines
5h 02m
1 stop
EYW8:07 pmKey West
Sep 16
EYW11:50 amKey West
6h 55m
1 stop
DSM5:45 pmDes Moines
$319
Find similar
Delta
Nov 25
DSM11:28 amDes Moines
7h 25m
1 stop
EYW7:53 pmKey West
Dec 2
EYW6:00 pmKey West
5h 23m
1 stop
DSM10:23 pmDes Moines
$343
Find similar

American Airlines flights from Des Moines to Key West

Our best American Airlines deals on Des Moines to Key West flight tickets
American Airlines
Nov 1
DSM9:00 amDes Moines
11h 56m
2 stops
EYW9:56 pmKey West
Nov 4
EYW7:31 amKey West
8h 00m
1 stop
DSM2:31 pmDes Moines
$274
Find similar
American Airlines
Nov 1
DSM9:00 amDes Moines
11h 56m
2 stops
EYW9:56 pmKey West
Nov 4
EYW1:33 pmKey West
9h 35m
2 stops
DSM10:08 pmDes Moines
$279
Find similar
American Airlines
Sep 13
DSM6:00 amDes Moines
11h 59m
2 stops
EYW6:59 pmKey West
Sep 16
EYW6:17 pmKey West
5h 49m
1 stop
DSM11:06 pmDes Moines
$299
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 10/14

2:13 pm-8:06 pm

1 stop4h 53m

Key West

Wed 10/22

1:57 pm-5:44 pm

1 stop4h 47m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 11/1

9:00 am-9:56 pm

2 stops11h 56m

Key West

Tue 11/4

7:31 am-2:31 pm

1 stop8h 00m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 11/1

9:00 am-9:56 pm

2 stops11h 56m

Key West

Tue 11/4

1:33 pm-10:08 pm

2 stops9h 35m

$279

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 9/13

6:00 am-6:59 pm

2 stops11h 59m

Key West

Tue 9/16

6:17 pm-11:06 pm

1 stop5h 49m

$299

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 9/13

5:10 am-6:59 pm

2 stops12h 49m

Key West

Tue 9/16

1:59 pm-11:13 pm

2 stops10h 14m

$304

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 1/5

9:00 am-9:11 pm

1 stop11h 11m

Key West

Fri 1/9

3:52 pm-10:17 pm

1 stop7h 25m

$305

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/12

2:05 pm-8:07 pm

1 stop5h 02m

Key West

Tue 9/16

11:50 am-5:45 pm

1 stop6h 55m

$319

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 10/8

3:17 pm-2:40 pm

1 stop22h 23m

Key West

Sun 10/12

3:30 pm-8:30 am

1 stop18h 00m

$453

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 1/14

8:00 am-3:17 pm

1 stop6h 17m

Key West

Wed 1/21

4:15 pm-9:50 pm

1 stop6h 35m

$458

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 11/17

8:02 am-3:19 pm

1 stop6h 17m

Key West

Fri 11/21

3:00 pm-12:14 pm

2 stops22h 14m

$548

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Des Moines to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, April is the cheapest month to fly from Des Moines to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Key West during the month of April, then departing from Des Moines during the month November is also very affordable. Most momondo users find prices during this month for around $318.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $331. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Key West for around $558.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Des Moines to Key West at noon for as low as $380. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $435 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Des Moines for as low as $331 on momondo.

When to book flights from Des Moines to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Key West (DSM to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Key West

Direct flights

None
There are no direct flights from Des Moines to Key West. There are no popular flight routes from Des Moines to Key West.
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  • How far is Des Moines to Key West by plane?

    The distance between Des Moines and Key West is about 1357.4 mi. 4h 53m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Key West Airport?

    Prices for flights from Des Moines Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Key West Airport?

  • How old do you have to be to fly from Des Moines Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Key West?

Best airlines flying from Des Moines to Key West

Compare and see reviews for airlines that fly from Des Moines to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $268Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $292Free CancellationRating
7.4
8,944 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Key West?

It is quick and easy to find Des Moines to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Des Moines to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Des Moines.

I’m not ready to book a flight from Des Moines to Key West right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Key West now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Key West and let you know when they change.

An easier way to manage your Key West trip

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