Cheap flights from Des Moines to Philadelphia from $34

The cheapest month to fly to Philadelphia from Des Moines is in August. Flight prices, which tend to average around $118, are often lower during this time because this is during the off-season. The month of September is another great option to travel to Philadelphia, with average flight prices from Des Moines averaging around $131.

The cheapest day to depart from Des Moines to Philadelphia is on a Thursday. Travelers who choose to depart for Philadelphia on a Thursday will often find tickets for as low as $338. On the other hand, Monday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $648.

According to our data, the cheapest time of day to fly to Philadelphia is in the afternoon. momondo users have found flights departing from Des Moines to Philadelphia in the afternoon for as low as $124. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In contrast, the most expensive time of day to depart to Philadelphia is at noon when prices are around $691.

Fly from Des Moines to Philadelphia for the best Des Moines - Philadelphia flight prices

You are more likely to see cheaper flights to Philadelphia from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Philadelphia for around $323 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Philadelphia from Des Moines for as low as $177 on momondo.

There are 4 cabin classes available to choose from on Des Moines to Philadelphia flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Des Moines to Philadelphia.

As of October 2026, prices for Des Moines to Philadelphia flights are approximately 64% cheaper when compared to flights at the same time last year.

Allegiant Air and Southwest are the most popular carriers operating from Des Moines to Philadelphia

Delta, American Airlines and Allegiant Air are the top three most popular airlines that fly to Philadelphia from Des Moines according to our data. Delta is the first choice among our users, with 34% of people opting to fly with this airline when traveling to Philadelphia. Keep in mind that there are 5 different airlines that fly to Philadelphia on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 70% of momondo users choosing 1-stop flights on this route connected there.

Flights via Detroit (DTW) offer the lowest average round-trip price of $319.

Flights connecting via Detroit (DTW) have the shortest average one-way travel time: 4h 34m.

Detroit (DTW) has the shortest average layover time for this route: 0h 59m.

2 flights are operational daily from Des Moines to Philadelphia as of October 2026. The most popular departure time for this route is 1:00PM, with 66% of flights per day taking off in the afternoon.

The number of flights available between Des Moines and Philadelphia is 17 per week as of October 2026. The most frequent departure day is Mon, with 18% of weekly flights leaving on this day.