Cheap flights from Des Moines to Phoenix from $85

In general, October is the cheapest month to fly from Des Moines to Phoenix Sky Harbor Intl Airport. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $268. If you are unable to visit Phoenix Sky Harbor Intl Airport during the month of October, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $295.

On average, the least expensive day to fly to Phoenix Sky Harbor Intl Airport from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $351. However, this price may fluctuate depending on the airline, the season, and holidays. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $446. These prices are subject to change though, so be sure to set up a Price Alert for flights to Phoenix Sky Harbor Intl Airport.

In the evening is the cheapest time of day to fly from Des Moines to Phoenix Sky Harbor Intl Airport when you can find flight prices for as low as $252. Flying to Phoenix Sky Harbor Intl Airport in the evening is an ideal time because this is during off-peak travel hours. Try not to purchase tickets in the morning because they tend to be around $418. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Des Moines to Phoenix Sky Harbor Intl for the best Des Moines - Phoenix Sky Harbor Intl flight prices

You are more likely to see cheaper flights to Phoenix Sky Harbor Intl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Phoenix Sky Harbor Intl Airport for around $336 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Phoenix Sky Harbor Intl Airport from Des Moines for as low as $253 on momondo.

There are 3 cabin classes available to choose from on Des Moines to Phoenix Sky Harbor Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest is the most popular carrier operating from Des Moines to Phoenix Sky Harbor Intl

American Airlines, Southwest and Frontier are the top three most popular airlines that fly to Phoenix Sky Harbor Intl Airport from Des Moines according to our data. American Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to Phoenix Sky Harbor Intl Airport. Keep in mind that there are 7 different airlines that fly to Phoenix Sky Harbor Intl Airport on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 80% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $251.

Flights connecting via Denver (DEN) have the shortest average one-way travel time: 5h 11m.

Las Vegas (LAS) has the shortest average layover time for this route: 0h 58m.

6 flights are operational daily from Des Moines to Phoenix Sky Harbor Intl Airport as of April 2026. The most popular departure time for this route is 5:00AM, with 39% of flights per day taking off in the afternoon.

The number of flights available between Des Moines and Phoenix Sky Harbor Intl Airport is 43 per week as of April 2026. The most frequent departure day is Mon, with 16% of weekly flights leaving on this day.