Cheap flights from St. Louis to Jacksonville from $65

If you are unable to visit Jacksonville during the month of September, then departing from St. Louis during the month October is also very affordable. Most momondo users find prices during this month for around $275.

According to our data, Friday is the cheapest day to fly to Jacksonville from St. Louis. The lowest ticket price found for a Friday departure recently was $275. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Tuesday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $357.

Flying to Jacksonville from St. Louis in the evening is the least expensive time of day to depart. momondo users have found prices as low as $275 when looking at flights departing in the evening. Flights to Jacksonville are more costly in the afternoon, with an average ticket price of $357. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Lambert-St Louis to Jacksonville for the best Lambert-St Louis - Jacksonville flight prices

You are more likely to see cheaper flights to Jacksonville from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Jacksonville for around $324 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Jacksonville from St. Louis for as low as $271 on momondo.

There is only 1 cabin class available to choose from on Lambert-St Louis to Jacksonville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 3% on your flight if you consider stops on a St. Louis to Jacksonville flight.

As of April 2026, prices for St. Louis to Jacksonville flights are approximately 41% more expensive when compared to flights at the same time last year.

Frontier, Southwest, and Delta are the most popular carriers operating from Lambert-St Louis to Jacksonville

Southwest, Delta and American Airlines are the top three most popular airlines that fly to Jacksonville from St. Louis according to our data. Southwest is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Jacksonville. Keep in mind that there are 5 different airlines that fly to Jacksonville on a routine basis, so you have a few additional options to choose from.

Atlanta (ATL) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Atlanta (ATL) offer the lowest average round-trip price of $425.

Flights connecting via Charlotte (CLT) have the shortest average one-way travel time: 4h 45m.

Charlotte (CLT) has the shortest average layover time for this route: 1h 08m.

The number of flights available between St. Louis and Jacksonville is 1 per day as of April 2026. The most frequent departure time is 1:00PM, with 80% of daily flights leaving in the afternoon.

7 flights are operational weekly from St. Louis to Jacksonville as of April 2026. The most popular departure day for this route is Sat, with 29% of flights per week taking off on this day.