Cheap flights from St. Louis to Jacksonville from $52

If you are unable to visit Jacksonville during the month of October, then departing from St. Louis during the month September is also very affordable. Most momondo users find prices during this month for around $307.

According to our data, Friday is the cheapest day to fly to Jacksonville from St. Louis. The lowest ticket price found for a Friday departure recently was $317. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Sunday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $433.

Flying to Jacksonville from St. Louis in the evening is the least expensive time of day to depart. momondo users have found prices as low as $291 when looking at flights departing in the evening. Flights to Jacksonville are more costly in the afternoon, with an average ticket price of $367. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Lambert-St Louis to Jacksonville for the best Lambert-St Louis - Jacksonville flight prices

You are more likely to see cheaper flights to Jacksonville from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Jacksonville for around $350 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Jacksonville from St. Louis for as low as $264 on momondo.

There is only 1 cabin class available to choose from on St. Louis to Jacksonville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between St. Louis to Jacksonville.

As of August 2026, prices for St. Louis to Jacksonville flights are approximately 32% cheaper when compared to flights at the same time last year.

Frontier and Southwest are the most popular carriers operating from Lambert-St Louis to Jacksonville

Southwest, Delta and American Airlines are the top three most popular airlines that fly to Jacksonville from St. Louis according to our data. Southwest is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Jacksonville. Keep in mind that there are 5 different airlines that fly to Jacksonville on a routine basis, so you have a few additional options to choose from.

Charlotte (CLT) was the most common stop: 60% of momondo users choosing 1-stop flights on this route connected there.

Flights via Atlanta (ATL) offer the lowest average round-trip price of $374.

Flights connecting via Charlotte (CLT) have the shortest average one-way travel time: 4h 22m.

Charlotte (CLT) has the shortest average layover time for this route: 1h 02m.