Cheap flights from San Diego to Indianapolis from $109

In general, February is the cheapest month to fly from San Diego to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $305. If you are unable to visit Indianapolis during the month of February, then departing from San Diego during the month November is also very affordable. Most momondo users find prices during this month for around $340.

Our data shows that Friday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $418. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Sunday is $752.

Flying to Indianapolis from San Diego in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $477 when looking at flights departing in the afternoon. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $540 on average. Flights to Indianapolis from San Diego at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from San Diego to Indianapolis for the best San Diego - Indianapolis flight prices

You are more likely to see cheaper flights to Indianapolis from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Indianapolis for around $401 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Indianapolis from San Diego for as low as $285 on momondo.

There is only 1 cabin class available to choose from on San Diego to Indianapolis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Delta, Frontier, and United Airlines are the most popular carriers operating from San Diego to Indianapolis

American Airlines, Southwest and United Airlines are the top three most popular airlines that fly to Indianapolis from San Diego according to our data. American Airlines is the first choice among our users, with 37% of people opting to fly with this airline when traveling to Indianapolis. Keep in mind that there are 9 different airlines that fly to Indianapolis on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via Chicago (ORD) offer the lowest average round-trip price of $360.

Flights connecting via Phoenix (PHX) have the shortest average one-way travel time: 5h 57m.

Phoenix (PHX) has the shortest average layover time for this route: 0h 51m.

1 flights are operational daily from San Diego to Indianapolis as of October 2026. The most popular departure time for this route is 12:00PM, with 60% of flights per day taking off in the afternoon.

The number of flights available between San Diego and Indianapolis is 7 per week as of October 2026. The most frequent departure day is Fri, with 29% of weekly flights leaving on this day.