Cheap flights from San Diego to Indianapolis from $105

In general, February is the cheapest month to fly from San Diego to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $305. If you are unable to visit Indianapolis during the month of February, then departing from San Diego during the month July is also very affordable. Most momondo users find prices during this month for around $320.

Our data shows that Friday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $431. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Wednesday is $640.

Flying to Indianapolis from San Diego in the morning is the least expensive time of day to depart. momondo users have found prices as low as $489 when looking at flights departing in the morning. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $587 on average. Flights to Indianapolis from San Diego in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from San Diego to Indianapolis for the best San Diego - Indianapolis flight prices

You are more likely to see cheaper flights to Indianapolis from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Indianapolis for around $385 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Indianapolis from San Diego for as low as $293 on momondo.

You could potentially save up to 15% on your flight if you consider stops on a San Diego to Indianapolis flight.

As of May 2026, prices for San Diego to Indianapolis flights are approximately 41% more expensive when compared to flights at the same time last year.

Delta, United Airlines, and Southwest are the most popular carriers operating from San Diego to Indianapolis

American Airlines, Southwest and United Airlines are the top three most popular airlines that fly to Indianapolis from San Diego according to our data. American Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Indianapolis. Keep in mind that there are 8 different airlines that fly to Indianapolis on a routine basis, so you have a few additional options to choose from.

1 flights are operational daily from San Diego to Indianapolis as of May 2026. The most popular departure time for this route is 1:00PM, with 100% of flights per day taking off in the afternoon.

The number of flights available between San Diego and Indianapolis is 7 per week as of May 2026. The most frequent departure day is Mon, with 29% of weekly flights leaving on this day.