Cheap flights from San Diego to Indianapolis from $99

In general, February is the cheapest month to fly from San Diego to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $305. If you are unable to visit Indianapolis during the month of February, then departing from San Diego during the month July is also very affordable. Most momondo users find prices during this month for around $320.

Our data shows that Friday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $431. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Wednesday is $571.

Flying to Indianapolis from San Diego in the morning is the least expensive time of day to depart. momondo users have found prices as low as $480 when looking at flights departing in the morning. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $540 on average. Flights to Indianapolis from San Diego at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from San Diego to Indianapolis for the best San Diego - Indianapolis flight prices

You are more likely to see cheaper flights to Indianapolis from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Indianapolis for around $383 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Indianapolis from San Diego for as low as $293 on momondo.

There is only 1 cabin class available to choose from on San Diego to Indianapolis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 6% on your flight if you consider stops on a San Diego to Indianapolis flight.

As of April 2026, prices for San Diego to Indianapolis flights are approximately 53% more expensive when compared to flights at the same time last year.

American Airlines and Frontier are the most popular carriers operating from San Diego to Indianapolis

American Airlines, Southwest and United Airlines are the top three most popular airlines that fly to Indianapolis from San Diego according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to Indianapolis. Keep in mind that there are 8 different airlines that fly to Indianapolis on a routine basis, so you have a few additional options to choose from.