Cheap flights from Rome to San Francisco from $621

If you aren’t able to travel to San Francisco during the month of February, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $667.

The cheapest day to depart from Rome to San Francisco is on a Friday when prices can be found for as low as $661. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $861.

Our data shows that the cheapest Rome to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $736. Flights in the afternoon are often more expensive with an average ticket price of $818.

Fly from Rome Fiumicino to San Francisco for the best Rome - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Rome when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $772 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Rome for as low as $562 on momondo.

There are 3 cabin classes available to choose from on Rome to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Turkish Airlines, TAP AIR PORTUGAL, and ITA Airways are the most popular carriers operating from Rome to San Francisco

United Airlines, ITA Airways and Lufthansa are the top three most popular airlines that fly to San Francisco from Rome according to our data. United Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 4 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Historically, on average around 27% of flights between Rome and San Francisco have experienced a delay on any given week. The average delay length over the past 12 months has been 139 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Sunday is statistically the day of the week which experiences the fewest number of delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, United Airlines have had the least number of delays on this route over the last 12 months; with about 23% of their flights experiencing any sort of delay.

Frankfurt am Main (FRA) was the most common stop: 25% of momondo users choosing 1-stop flights on this route connected there.

Flights via Lisbon (LIS) offer the lowest average round-trip price of $682.

Flights connecting via Frankfurt am Main (FRA) have the shortest average one-way travel time: 15h 20m.

London (LHR) has the shortest average layover time for this route: 1h 15m.

5 flights are operational daily from Rome to San Francisco as of September 2026. The most popular departure time for this route is 3:00PM, with 60% of flights per day taking off in the afternoon.

35 flights are operational weekly from Rome to San Francisco as of September 2026. The most popular departure day for this route is Mon, with 14% of flights per week taking off on this day.