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Cheap flights from Panama to San Francisco from $277

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to San Francisco departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama to San Francisco

Recent round-trip flight deals from Panama to San Francisco

Enter your travel dates to find the best prices.
Avianca Logo
10:10 am - 10:35 pm
PTY
-
SFO
14h 25m
2 stops
Avianca Logo
2:15 pm - 10:30 am
SFO
-
PTY
18h 15m
1 stop
$519Avianca
Thu, Apr 23 - Wed, Apr 29
Avianca Logo
10:10 am - 10:35 pm
PTY
-
SFO
14h 25m
2 stops
Avianca Logo
2:15 pm - 10:30 am
SFO
-
PTY
18h 15m
1 stop
$522Avianca
Thu, Apr 16 - Sun, Apr 19
Avianca Logo
5:30 am - 12:50 pm
PTY
-
SFO
9h 20m
1 stop
Avianca Logo
2:30 am - 1:05 am
SFO
-
PTY
20h 35m
2 stops
$530Avianca
Tue, Apr 14 - Tue, Apr 28
Avianca Logo
5:30 am - 12:50 pm
PTY
-
SFO
9h 20m
1 stop
Avianca Logo
11:55 pm - 10:30 am
SFO
-
PTY
8h 35m
1 stop
$532Avianca
Sat, May 16 - Mon, May 25
Avianca Logo
3:05 am - 10:35 pm
PTY
-
SFO
21h 30m
2 stops
Avianca Logo
2:30 am - 1:05 am
SFO
-
PTY
20h 35m
2 stops
$534Avianca
Mon, Apr 13 - Tue, Apr 28
Avianca Logo
3:50 pm - 11:55 pm
PTY
-
SFO
10h 05m
1 stop
Avianca Logo
2:15 pm - 1:55 am
SFO
-
PTY
9h 40m
1 stop
$542Avianca
Thu, Apr 30 - Tue, May 5
Avianca Logo
3:50 pm - 6:25 am
PTY
-
SFO
16h 35m
2 stops
Avianca Logo
2:15 pm - 1:55 am
SFO
-
PTY
9h 40m
1 stop
$543Avianca
Mon, Jun 1 - Wed, Sep 2
Avianca Logo
5:30 am - 12:50 pm
PTY
-
SFO
9h 20m
1 stop
Avianca Logo
2:15 pm - 1:55 am
SFO
-
PTY
9h 40m
1 stop
$544Avianca
Fri, Apr 3 - Fri, Apr 10
Avianca Logo
10:10 am - 10:35 pm
PTY
-
SFO
14h 25m
2 stops
Avianca Logo
2:15 pm - 1:55 am
SFO
-
PTY
9h 40m
1 stop
$550Avianca
Tue, Jun 2 - Mon, Aug 31
Avianca Logo
5:30 am - 12:50 pm
PTY
-
SFO
9h 20m
1 stop
Avianca Logo
2:15 pm - 1:55 am
SFO
-
PTY
9h 40m
1 stop
$553Avianca
Mon, Jun 1 - Thu, Sep 3

Avianca flights from Panama to San Francisco

Our best Avianca deals on Panama to San Francisco flight tickets
Avianca
Apr 23
PTY10:10 amPanama City Tocumen Intl
14h 25m
2 stops
SFO10:35 pmSan Francisco
Apr 29
SFO2:15 pmSan Francisco
18h 15m
1 stop
PTY10:30 amPanama City Tocumen Intl
$519
Avianca
Apr 16
PTY10:10 amPanama City Tocumen Intl
14h 25m
2 stops
SFO10:35 pmSan Francisco
Apr 19
SFO2:15 pmSan Francisco
18h 15m
1 stop
PTY10:30 amPanama City Tocumen Intl
$522
Avianca
Apr 14
PTY5:30 amPanama City Tocumen Intl
9h 20m
1 stop
SFO12:50 pmSan Francisco
Apr 28
SFO2:30 amSan Francisco
20h 35m
2 stops
PTY1:05 amPanama City Tocumen Intl
$530

Copa Airlines flights from Panama to San Francisco

Our best Copa Airlines deals on Panama to San Francisco flight tickets
Copa Airlines
Apr 23
PTY5:53 pmPanama City Tocumen Intl
7h 47m
SFO11:40 pmSan Francisco
Apr 28
SFO1:23 amSan Francisco
7h 04m
PTY10:27 amPanama City Tocumen Intl
$625
Copa Airlines
Mar 5
PTY11:35 amPanama City Tocumen Intl
14h 23m
1 stop
SFO10:58 pmSan Francisco
Mar 26
SFO7:10 pmSan Francisco
18h 57m
1 stop
PTY4:07 pmPanama City Tocumen Intl
$767
Copa Airlines
Mar 13
PTY5:51 pmPanama City Tocumen Intl
7h 49m
SFO11:40 pmSan Francisco
Mar 18
SFO8:42 pmSan Francisco
6h 53m
PTY5:35 amPanama City Tocumen Intl
$794

momondo Fare Finder

 
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 4, 2026.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 4/23

10:10 am-10:35 pm

2 stops14h 25m

San Francisco

Wed 4/29

2:15 pm-10:30 am

1 stop18h 15m

$519

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 4/16

10:10 am-10:35 pm

2 stops14h 25m

San Francisco

Sun 4/19

2:15 pm-10:30 am

1 stop18h 15m

$522

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 4/14

5:30 am-12:50 pm

1 stop9h 20m

San Francisco

Tue 4/28

2:30 am-1:05 am

2 stops20h 35m

$530

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 5/16

5:30 am-12:50 pm

1 stop9h 20m

San Francisco

Mon 5/25

11:55 pm-10:30 am

1 stop8h 35m

$532

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 4/13

3:05 am-10:35 pm

2 stops21h 30m

San Francisco

Tue 4/28

2:30 am-1:05 am

2 stops20h 35m

$534

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 4/30

3:50 pm-11:55 pm

1 stop10h 05m

San Francisco

Tue 5/5

2:15 pm-1:55 am

1 stop9h 40m

$542

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 6/1

3:50 pm-6:25 am

2 stops16h 35m

San Francisco

Wed 9/2

2:15 pm-1:55 am

1 stop9h 40m

$543

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 4/3

5:30 am-12:50 pm

1 stop9h 20m

San Francisco

Fri 4/10

2:15 pm-1:55 am

1 stop9h 40m

$544

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 6/2

10:10 am-10:35 pm

2 stops14h 25m

San Francisco

Mon 8/31

2:15 pm-1:55 am

1 stop9h 40m

$550

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 6/1

5:30 am-12:50 pm

1 stop9h 20m

San Francisco

Thu 9/3

2:15 pm-1:55 am

1 stop9h 40m

$553

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $577.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama to San Francisco is on a Monday when prices can be found for as low as $694. The most expensive day to fly to San Francisco is Thursday, with ticket prices averaging around $805.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Panama to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $562. Flights in the afternoon are often more expensive with an average ticket price of $760.

What is the cheapest Panama to San Francisco flight route?

Fly from Panama City Tocumen Intl to San Francisco for the best Panama - San Francisco flight prices

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Panama when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $644 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama for as low as $376 on momondo.

What cabin class options are available on Panama to San Francisco flights?

There are 4 cabin classes available to choose from on Panama to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama to San Francisco flights?

You could potentially save up to 38% on your flight if you consider stops on a Panama to San Francisco flight.

Cheap Panama to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to San Francisco

Best Price Found

$344

Fastest flight time

7h 21m

Direct flights

Every day

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Panama in the past 72 hours is $344. The best round-trip flight deal from Panama to San Francisco found on momondo in the last 72 hours is $793.
The fastest flight from Panama to San Francisco takes 7h 21m
Direct flights go from Panama to San Francisco every day.
There is 1 airport in San Francisco. From Panama there are direct flights to San Francisco (SFO).
Search flight deals

  • When did momondo last update prices for flights from Panama to San Francisco Airport?

    Prices for flights from Panama to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama to San Francisco Airport?

  • How old do you have to be to fly from Panama to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Panama to San Francisco?

Best airlines flying from Panama to San Francisco

Compare and see reviews for airlines that fly from Panama to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $335Free CancellationRating
7.5
1,557 reviews
Search Copa Airlines flights
AviancaPriceFrom $465Free CancellationRating
6.5
2,495 reviews
Search Avianca flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
9,388 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Walnut Creek
Hayward
Santa Clara
Berkeley
Big Sur
Calistoga
Fremont
Vallejo
Half Moon Bay
Salinas
Daly City
Sunnyvale
Pacific Grove
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Panama to San Francisco?

It is quick and easy to find Panama to San Francisco flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Francisco that suits you.

Can I find flights from Panama to San Francisco with flexible booking policies on momondo?

All flight searches from Panama to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama to San Francisco?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Francisco from Panama.

I’m not ready to book a flight from Panama to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Panama are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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