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Cheap flights from Panama to San Francisco from $287

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to San Francisco departing on 11/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama to San Francisco

Recent round-trip flight deals from Panama to San Francisco

Avianca Logo
9:55 am - 10:45 pmPTY-SFO
14h 50m2 stops
Avianca Logo
12:05 am - 9:10 pmSFO-PTY
19h 05m2 stops
$493Avianca
Find Deal
Tue, Sep 30 - Tue, Oct 7
Avianca Logo
10:05 pm - 12:35 pmPTY-SFO
16h 30m2 stops
Avianca Logo
12:05 am - 4:15 pmSFO-PTY
14h 10m1 stop
$496Avianca
Find Deal
Sat, Sep 13 - Wed, Sep 17
Avianca Logo
3:40 pm - 10:45 pmPTY-SFO
9h 05m1 stop
Avianca Logo
2:20 pm - 10:25 amSFO-PTY
18h 05m1 stop
$499Avianca
Find Deal
Wed, Oct 1 - Sun, Oct 5
Avianca Logo
3:35 pm - 11:20 pmPTY-SFO
10h 45m1 stop
Avianca Logo
11:10 pm - 4:55 pmSFO-PTY
14h 45m2 stops
$502Avianca
Find Deal
Thu, Feb 12 - Sat, Feb 21
Avianca Logo
3:20 am - 10:45 pmPTY-SFO
21h 25m2 stops
Avianca Logo
12:05 am - 10:25 amSFO-PTY
8h 20m1 stop
$503Avianca
Find Deal
Sun, Aug 31 - Sun, Sep 7
Avianca Logo
3:25 am - 10:45 pmPTY-SFO
21h 20m2 stops
Avianca Logo
12:05 am - 9:10 pmSFO-PTY
19h 05m2 stops
$506Avianca
Find Deal
Fri, Sep 12 - Wed, Sep 17
Avianca Logo
3:40 pm - 12:35 pmPTY-SFO
22h 55m1 stop
Avianca Logo
12:05 am - 10:25 amSFO-PTY
8h 20m1 stop
$509Avianca
Find Deal
Fri, Sep 5 - Mon, Sep 8
Avianca Logo
3:40 pm - 10:45 pmPTY-SFO
9h 05m1 stop
Avianca Logo
12:05 am - 10:25 amSFO-PTY
32h 20m1 stop
$510Avianca
Find Deal
Thu, Sep 18 - Wed, Sep 24
Logo
8:25 pm - 11:55 amPTY-SFO
18h 30m2 stops
Logo
1:35 am - 2:50 pmSFO-PTY
10h 15m1 stop
$585
Find Deal
Mon, Nov 17 - Sat, Nov 29
Logo
8:25 pm - 11:55 amPTY-SFO
18h 30m2 stops
Logo
1:35 am - 2:50 pmSFO-PTY
10h 15m1 stop
$587
Find Deal
Sun, Nov 16 - Sat, Nov 29

Avianca flights from Panama to San Francisco

Our best Avianca deals on Panama to San Francisco flight tickets
Avianca
Sep 30
PTY9:55 amPanama City Tocumen Intl
14h 50m
2 stops
SFO10:45 pmSan Francisco
Oct 7
SFO12:05 amSan Francisco
19h 05m
2 stops
PTY9:10 pmPanama City Tocumen Intl
$493
Find similar
Avianca
Sep 13
PTY10:05 pmPanama City Tocumen Intl
16h 30m
2 stops
SFO12:35 pmSan Francisco
Sep 17
SFO12:05 amSan Francisco
14h 10m
1 stop
PTY4:15 pmPanama City Tocumen Intl
$496
Find similar
Avianca
Oct 1
PTY3:40 pmPanama City Tocumen Intl
9h 05m
1 stop
SFO10:45 pmSan Francisco
Oct 5
SFO2:20 pmSan Francisco
18h 05m
1 stop
PTY10:25 amPanama City Tocumen Intl
$499
Find similar

United Airlines flights from Panama to San Francisco

Our best United Airlines deals on Panama to San Francisco flight tickets
United Airlines
Sep 3
PTY3:35 pmPanama City Tocumen Intl
7h 35m
SFO9:10 pmSan Francisco
Sep 20
SFO4:15 pmSan Francisco
19h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
$846
Find similar
United Airlines
Sep 4
PTY3:35 pmPanama City Tocumen Intl
7h 35m
SFO9:10 pmSan Francisco
Sep 7
SFO6:58 pmSan Francisco
17h 16m
1 stop
PTY2:14 pmPanama City Tocumen Intl
$953
Find similar
United Airlines
Sep 2
PTY3:35 pmPanama City Tocumen Intl
7h 35m
SFO9:10 pmSan Francisco
Sep 19
SFO12:43 amSan Francisco
11h 31m
1 stop
PTY2:14 pmPanama City Tocumen Intl
$1,038
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 9/30

9:55 am-10:45 pm

2 stops14h 50m

San Francisco

Tue 10/7

12:05 am-9:10 pm

2 stops19h 05m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 9/13

10:05 pm-12:35 pm

2 stops16h 30m

San Francisco

Wed 9/17

12:05 am-4:15 pm

1 stop14h 10m

$496

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 10/1

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

Sun 10/5

2:20 pm-10:25 am

1 stop18h 05m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 2/12

3:35 pm-11:20 pm

1 stop10h 45m

San Francisco

Sat 2/21

11:10 pm-4:55 pm

2 stops14h 45m

$502

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 8/31

3:20 am-10:45 pm

2 stops21h 25m

San Francisco

Sun 9/7

12:05 am-10:25 am

1 stop8h 20m

$503

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 9/12

3:25 am-10:45 pm

2 stops21h 20m

San Francisco

Wed 9/17

12:05 am-9:10 pm

2 stops19h 05m

$506

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 9/5

3:40 pm-12:35 pm

1 stop22h 55m

San Francisco

Mon 9/8

12:05 am-10:25 am

1 stop8h 20m

$509

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 9/18

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

Wed 9/24

12:05 am-10:25 am

1 stop32h 20m

$510

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 11/17

8:25 pm-11:55 am

2 stops18h 30m

San Francisco

Sat 11/29

1:35 am-2:50 pm

1 stop10h 15m

$585

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 11/16

8:25 pm-11:55 am

2 stops18h 30m

San Francisco

Sat 11/29

1:35 am-2:50 pm

1 stop10h 15m

$587

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in June is also cheap. Prices for this month can be found on momondo for an average of $598.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama to San Francisco is on a Monday when prices can be found for as low as $634. The most expensive day to fly to San Francisco is Friday, with ticket prices averaging around $808.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Panama to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $433. Flights in the afternoon are often more expensive with an average ticket price of $745.

What is the cheapest Panama to San Francisco flight route?

Fly from Panama City Tocumen Intl to San Francisco for the best Panama - San Francisco flight prices

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Panama when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $632 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Panama for as low as $496 on momondo.

What cabin class options are available on Panama to San Francisco flights?

There are 4 cabin classes available to choose from on Panama to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama to San Francisco flights?

You could potentially save up to 37% on your flight if you consider stops on a Panama to San Francisco flight.

Cheap Panama to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to San Francisco

Best Price Found

$390

Fastest flight time

7h 35m

Direct flights

Every day

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Panama in the past 72 hours is $390. The best round-trip flight deal from Panama to San Francisco found on momondo in the last 72 hours is $585.
The fastest flight from Panama to San Francisco takes 7h 35m
Direct flights go from Panama to San Francisco every day.
There is 1 airport near San Francisco: San Francisco (SFO)
Search flight deals

  • When did momondo last update prices for flights from Panama to San Francisco Airport?

    Prices for flights from Panama to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama to San Francisco Airport?

  • How old do you have to be to fly from Panama to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Panama to San Francisco?

Best airlines flying from Panama to San Francisco

Compare and see reviews for airlines that fly from Panama to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $474Free CancellationRating
6.7
2,415 reviews
Search Avianca flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $506Free CancellationRating
7.5
1,512 reviews
Search Copa Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Calistoga
Sonoma
Hayward
Bodega Bay
Roseville
Santa Clara
Big Sur
Daly City
Fremont
Berkeley
Walnut Creek
Half Moon Bay
Vallejo
South San Francisco
Redwood City
Pacific Grove
Sunnyvale

Why use momondo?

Why should I use momondo to find a flight deal from Panama to San Francisco?

It is quick and easy to find Panama to San Francisco flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Francisco that suits you.

Can I find flights from Panama to San Francisco with flexible booking policies on momondo?

All flight searches from Panama to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama to San Francisco?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Francisco from Panama.

I’m not ready to book a flight from Panama to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Panama are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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