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Cheap flights from Manchester, New Hampshire to Florence from $299

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Florence departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Manchester, New Hampshire to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 5:50 pm
MHT
-
FLO
11h 50m
2 stops
American Airlines Logo
5:16 am - 11:51 pm
FLO
-
MHT
18h 35m
2 stops
$467American Airlines
Sat, Mar 14 - Wed, Mar 18
American Airlines Logo
5:02 pm - 11:57 pm
MHT
-
FLO
6h 55m
1 stop
American Airlines Logo
6:20 pm - 11:59 pm
FLO
-
MHT
5h 39m
1 stop
$489American Airlines
Sat, Mar 14 - Wed, Mar 18
American Airlines Logo
5:02 pm - 11:57 pm
MHT
-
FLO
6h 55m
1 stop
American Airlines Logo
5:16 am - 11:35 am
FLO
-
MHT
6h 19m
2 stops
$494American Airlines
Sat, Mar 14 - Wed, Mar 18
American Airlines Logo
4:40 pm - 9:47 pm
MHT
-
FLO
5h 07m
1 stop
American Airlines Logo
5:20 am - 10:51 pm
FLO
-
MHT
17h 31m
2 stops
$652American Airlines
Sat, Apr 25 - Thu, Apr 30
American Airlines Logo
5:07 pm - 3:32 pm
MHT
-
FLO
22h 25m
2 stops
American Airlines Logo
5:20 am - 10:51 pm
FLO
-
MHT
17h 31m
2 stops
$656American Airlines
Mon, Apr 27 - Thu, Apr 30
American Airlines Logo
4:40 pm - 9:47 pm
MHT
-
FLO
5h 07m
1 stop
American Airlines Logo
4:16 pm - 11:29 am
FLO
-
MHT
19h 13m
2 stops
$675American Airlines
Mon, Apr 27 - Sat, May 2
American Airlines Logo
4:40 pm - 9:47 pm
MHT
-
FLO
5h 07m
1 stop
American Airlines Logo
4:16 pm - 11:40 pm
FLO
-
MHT
7h 24m
2 stops
$681American Airlines
Sat, Apr 25 - Mon, May 4
American Airlines Logo
12:06 pm - 9:47 pm
MHT
-
FLO
9h 41m
2 stops
American Airlines Logo
5:20 am - 10:51 pm
FLO
-
MHT
17h 31m
2 stops
$682American Airlines
Sat, Apr 25 - Thu, Apr 30
American Airlines Logo
5:07 pm - 3:32 pm
MHT
-
FLO
22h 25m
2 stops
American Airlines Logo
4:16 pm - 11:40 pm
FLO
-
MHT
7h 24m
2 stops
$685American Airlines
Mon, Apr 27 - Mon, May 4
American Airlines Logo
4:40 pm - 9:47 pm
MHT
-
FLO
5h 07m
1 stop
American Airlines Logo
5:20 am - 11:29 am
FLO
-
MHT
6h 09m
2 stops
$689American Airlines
Fri, Apr 24 - Sun, May 3

American Airlines flights from Manchester, New Hampshire to Florence, South Carolina

Our best American Airlines deals on Manchester, New Hampshire to Florence, South Carolina flight tickets
American Airlines
Apr 25
MHT4:40 pmManchester
5h 07m
1 stop
FLO9:47 pmFlorence
Apr 30
FLO5:20 amFlorence
17h 31m
2 stops
MHT10:51 pmManchester
$652
American Airlines
Apr 27
MHT5:07 pmManchester
22h 25m
2 stops
FLO3:32 pmFlorence
Apr 30
FLO5:20 amFlorence
17h 31m
2 stops
MHT10:51 pmManchester
$656
American Airlines
Apr 27
MHT4:40 pmManchester
5h 07m
1 stop
FLO9:47 pmFlorence
May 2
FLO4:16 pmFlorence
19h 13m
2 stops
MHT11:29 amManchester
$675

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 4, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 3/14

6:00 am-5:50 pm

2 stops11h 50m

Florence

Wed 3/18

5:16 am-11:51 pm

2 stops18h 35m

$467

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 3/14

5:02 pm-11:57 pm

1 stop6h 55m

Florence

Wed 3/18

6:20 pm-11:59 pm

1 stop5h 39m

$489

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 3/14

5:02 pm-11:57 pm

1 stop6h 55m

Florence

Wed 3/18

5:16 am-11:35 am

2 stops6h 19m

$494

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 4/25

4:40 pm-9:47 pm

1 stop5h 07m

Florence

Thu 4/30

5:20 am-10:51 pm

2 stops17h 31m

$652

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Mon 4/27

5:07 pm-3:32 pm

2 stops22h 25m

Florence

Thu 4/30

5:20 am-10:51 pm

2 stops17h 31m

$656

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Mon 4/27

4:40 pm-9:47 pm

1 stop5h 07m

Florence

Sat 5/2

4:16 pm-11:29 am

2 stops19h 13m

$675

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 4/25

4:40 pm-9:47 pm

1 stop5h 07m

Florence

Mon 5/4

4:16 pm-11:40 pm

2 stops7h 24m

$681

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 4/25

12:06 pm-9:47 pm

2 stops9h 41m

Florence

Thu 4/30

5:20 am-10:51 pm

2 stops17h 31m

$682

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Mon 4/27

5:07 pm-3:32 pm

2 stops22h 25m

Florence

Mon 5/4

4:16 pm-11:40 pm

2 stops7h 24m

$685

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Fri 4/24

4:40 pm-9:47 pm

1 stop5h 07m

Florence

Sun 5/3

5:20 am-11:29 am

2 stops6h 09m

$689

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Manchester, New Hampshire to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Manchester to Florence?

American Airlines is the most popular carrier operating from Manchester to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Spirit Airlines and Delta are the top three most popular airlines that fly to Florence, South Carolina from Manchester, New Hampshire according to our data. American Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 9 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Manchester, New Hampshire to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Florence, South Carolina (MHT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Florence, South Carolina

Fastest flight time

5h 07m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Florence, South Carolina takes 5h 07m
There are no direct flights from Manchester, New Hampshire to Florence, South Carolina. There are no popular flight routes from Manchester, New Hampshire to Florence, South Carolina.
Search flight deals

  • How far is Manchester to Florence by plane?

    The distance between Manchester and Florence is about 754.2 mi. In terms of flight time, this usually takes a little over 5h 07m.

  • When did momondo last update prices for flights from Manchester Airport to Florence Airport?

    Prices for flights from Manchester Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Manchester Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Manchester Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Florence?

Finding the right flight to Florence from Manchester is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Manchester to Florence with flexible booking policies on momondo?

Flights from Manchester to Florence with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Manchester to Florence?

Once you have performed a search for Manchester to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Manchester to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Manchester to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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