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Cheap flights from Manchester, New Hampshire to Florence from $373

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Florence departing on 12/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Manchester, New Hampshire to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:30 am - 11:11 pmMHT-FLO
17h 41m2 stops
American Airlines Logo
6:15 am - 11:50 pmFLO-MHT
17h 35m2 stops
$476American Airlines
Find Deal
Sat, Jan 31 - Wed, Feb 4
American Airlines Logo
11:42 am - 11:11 pmMHT-FLO
11h 29m2 stops
American Airlines Logo
5:36 pm - 11:46 pmFLO-MHT
6h 10m1 stop
$488American Airlines
Find Deal
Sat, Jan 31 - Wed, Feb 4
American Airlines Logo
6:00 am - 5:09 pmMHT-FLO
11h 09m2 stops
American Airlines Logo
6:15 am - 4:31 pmFLO-MHT
10h 16m2 stops
$493American Airlines
Find Deal
Sat, Jan 31 - Wed, Feb 4
American Airlines Logo
6:42 am - 5:09 pmMHT-FLO
10h 27m1 stop
American Airlines Logo
5:36 pm - 11:46 pmFLO-MHT
6h 10m1 stop
$784American Airlines
Find Deal
Sat, Jan 31 - Wed, Feb 4

American Airlines flights from Manchester, New Hampshire to Florence, South Carolina

Our best American Airlines deals on Manchester, New Hampshire to Florence, South Carolina flight tickets
American Airlines
Jan 31
MHT5:30 amManchester
17h 41m
2 stops
FLO11:11 pmFlorence
Feb 4
FLO6:15 amFlorence
17h 35m
2 stops
MHT11:50 pmManchester
$476
Find similar
American Airlines
Jan 31
MHT11:42 amManchester
11h 29m
2 stops
FLO11:11 pmFlorence
Feb 4
FLO5:36 pmFlorence
6h 10m
1 stop
MHT11:46 pmManchester
$488
Find similar
American Airlines
Jan 31
MHT6:00 amManchester
11h 09m
2 stops
FLO5:09 pmFlorence
Feb 4
FLO6:15 amFlorence
10h 16m
2 stops
MHT4:31 pmManchester
$493
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 2, 2025.
Use the filters below to find and compare flights from Manchester, New Hampshire to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 1/31

5:30 am-11:11 pm

2 stops17h 41m

Florence

Wed 2/4

6:15 am-11:50 pm

2 stops17h 35m

$476

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 1/31

11:42 am-11:11 pm

2 stops11h 29m

Florence

Wed 2/4

5:36 pm-11:46 pm

1 stop6h 10m

$488

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 1/31

6:00 am-5:09 pm

2 stops11h 09m

Florence

Wed 2/4

6:15 am-4:31 pm

2 stops10h 16m

$493

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 1/31

6:42 am-5:09 pm

1 stop10h 27m

Florence

Wed 2/4

5:36 pm-11:46 pm

1 stop6h 10m

$784

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 12/10

4:07 pm-10:53 pm

1 stop6h 46m

$373

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Tue 12/9

3:52 pm-10:53 pm

2 stops7h 01m

$378

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sun 12/7

4:40 pm-12:03 am

1 stop7h 23m

$403

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sun 12/7

12:16 pm-12:03 am

2 stops11h 47m

$408

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Tue 12/9

4:07 pm-10:53 pm

1 stop6h 46m

$439

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Fri 12/12

3:55 pm-10:53 pm

2 stops6h 58m

$453

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Manchester, New Hampshire to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Manchester, New Hampshire is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $318. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Sunday is the most expensive day to depart from Manchester, New Hampshire because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $558.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the afternoon. momondo users have found flights departing from Manchester, New Hampshire to Florence, South Carolina in the afternoon for as low as $388. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $418 per ticket.

When to book flights from Manchester, New Hampshire to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Florence, South Carolina (MHT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Florence, South Carolina

Fastest flight time

6h 37m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Florence, South Carolina takes 6h 37m
There are no direct flights from Manchester, New Hampshire to Florence, South Carolina. There are no popular flight routes from Manchester, New Hampshire to Florence, South Carolina.
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  • How far is Manchester to Florence by plane?

    The distance between Manchester and Florence is about 754.2 mi. In terms of flight time, this usually takes a little over 10h 27m.

  • When did momondo last update prices for flights from Manchester Airport to Florence Airport?

    Prices for flights from Manchester Airport to Florence Airport refresh daily.

  • How many operators does momondo search for flights from Manchester Airport to Florence Airport?

  • How old do you have to be to fly from Manchester Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Manchester Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Manchester, New Hampshire to Florence, South Carolina?

Best airlines flying from Manchester, New Hampshire to Florence, South Carolina

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $412Free CancellationRating
7.2
11,041 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Florence?

Finding the right flight to Florence from Manchester is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Manchester to Florence with flexible booking policies on momondo?

Flights from Manchester to Florence with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Manchester to Florence?

Once you have performed a search for Manchester to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Manchester to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Manchester to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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