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Cheap flights from Manchester, New Hampshire to Florence from $281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Florence departing on 7/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Manchester, New Hampshire to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:05 am - 1:18 pm
MHT
-
FLO
6h 13m
1 stop
American Airlines Logo
6:24 am - 10:44 am
FLO
-
MHT
4h 20m
1 stop
$473American Airlines
Sat, Sep 19 - Sat, Oct 3
American Airlines Logo
5:10 pm - 10:00 pm
MHT
-
FLO
4h 50m
1 stop
American Airlines Logo
5:05 am - 11:33 am
FLO
-
MHT
6h 28m
1 stop
$529American Airlines
Tue, Jun 16 - Sat, Jun 20
American Airlines Logo
5:41 am - 10:00 pm
MHT
-
FLO
16h 19m
2 stops
American Airlines Logo
5:05 am - 4:39 pm
FLO
-
MHT
11h 34m
2 stops
$558American Airlines
Tue, Jun 16 - Sat, Jun 20
American Airlines Logo
7:02 am - 10:58 pm
MHT
-
FLO
15h 56m
2 stops
American Airlines Logo
6:24 am - 10:44 am
FLO
-
MHT
4h 20m
1 stop
$561American Airlines
Sat, Sep 19 - Sat, Oct 3
American Airlines Logo
4:44 pm - 10:58 pm
MHT
-
FLO
6h 14m
1 stop
American Airlines Logo
6:24 am - 10:44 am
FLO
-
MHT
4h 20m
1 stop
$563American Airlines
Wed, Sep 16 - Sat, Oct 3
American Airlines Logo
4:44 pm - 10:58 pm
MHT
-
FLO
6h 14m
1 stop
American Airlines Logo
5:22 am - 11:36 am
FLO
-
MHT
6h 14m
1 stop
$581American Airlines
Wed, Sep 16 - Tue, Oct 6
American Airlines Logo
7:02 am - 10:58 pm
MHT
-
FLO
15h 56m
2 stops
American Airlines Logo
6:24 am - 12:15 am
FLO
-
MHT
17h 51m
2 stops
$602American Airlines
Sat, Sep 19 - Sat, Oct 3
American Airlines Logo
7:00 am - 10:00 pm
MHT
-
FLO
15h 00m
2 stops
American Airlines Logo
5:05 am - 11:33 am
FLO
-
MHT
6h 28m
1 stop
$604American Airlines
Tue, Jun 16 - Sat, Jun 20
American Airlines Logo
10:01 am - 2:10 pm
MHT
-
FLO
4h 09m
1 stop
American Airlines Logo
6:24 am - 10:44 am
FLO
-
MHT
4h 20m
1 stop
$606American Airlines
Sun, Sep 20 - Sat, Oct 3
American Airlines Logo
5:10 pm - 11:37 pm
MHT
-
FLO
6h 27m
1 stop
American Airlines Logo
5:17 am - 11:37 am
FLO
-
MHT
6h 20m
1 stop
$614American Airlines
Fri, Jul 10 - Fri, Jul 17

American Airlines flights from Manchester, New Hampshire to Florence, South Carolina

Our best American Airlines deals on Manchester, New Hampshire to Florence, South Carolina flight tickets
American Airlines
Sep 19
MHT7:05 amManchester
6h 13m
1 stop
FLO1:18 pmFlorence
Oct 3
FLO6:24 amFlorence
4h 20m
1 stop
MHT10:44 amManchester
$473
American Airlines
Jun 16
MHT5:10 pmManchester
4h 50m
1 stop
FLO10:00 pmFlorence
Jun 20
FLO5:05 amFlorence
6h 28m
1 stop
MHT11:33 amManchester
$529
American Airlines
Jun 16
MHT5:41 amManchester
16h 19m
2 stops
FLO10:00 pmFlorence
Jun 20
FLO5:05 amFlorence
11h 34m
2 stops
MHT4:39 pmManchester
$558

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 9/19

7:05 am-1:18 pm

1 stop6h 13m

Florence

Sat 10/3

6:24 am-10:44 am

1 stop4h 20m

$473

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Tue 6/16

5:10 pm-10:00 pm

1 stop4h 50m

Florence

Sat 6/20

5:05 am-11:33 am

1 stop6h 28m

$529

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Tue 6/16

5:41 am-10:00 pm

2 stops16h 19m

Florence

Sat 6/20

5:05 am-4:39 pm

2 stops11h 34m

$558

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 9/19

7:02 am-10:58 pm

2 stops15h 56m

Florence

Sat 10/3

6:24 am-10:44 am

1 stop4h 20m

$561

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 9/16

4:44 pm-10:58 pm

1 stop6h 14m

Florence

Sat 10/3

6:24 am-10:44 am

1 stop4h 20m

$563

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 9/16

4:44 pm-10:58 pm

1 stop6h 14m

Florence

Tue 10/6

5:22 am-11:36 am

1 stop6h 14m

$581

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 9/19

7:02 am-10:58 pm

2 stops15h 56m

Florence

Sat 10/3

6:24 am-12:15 am

2 stops17h 51m

$602

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Tue 6/16

7:00 am-10:00 pm

2 stops15h 00m

Florence

Sat 6/20

5:05 am-11:33 am

1 stop6h 28m

$604
Quickest round-trip

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sun 9/20

10:01 am-2:10 pm

1 stop4h 09m

Florence

Sat 10/3

6:24 am-10:44 am

1 stop4h 20m

$606

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Fri 7/10

5:10 pm-11:37 pm

1 stop6h 27m

Florence

Fri 7/17

5:17 am-11:37 am

1 stop6h 20m

$614

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Manchester, New Hampshire to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Manchester to Florence?

American Airlines is the most popular carrier operating from Manchester to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Delta and JetBlue are the top three most popular airlines that fly to Florence, South Carolina from Manchester, New Hampshire according to our data. American Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Manchester, New Hampshire to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Florence, South Carolina (MHT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Florence, South Carolina

Fastest flight time

4h 50m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Florence, South Carolina takes 4h 50m
There are no direct flights from Manchester, New Hampshire to Florence, South Carolina. There are no popular flight routes from Manchester, New Hampshire to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Manchester, New Hampshire to Florence, South Carolina

  • How far is Manchester to Florence by plane?

    The distance between Manchester and Florence is about 754.2 mi. In terms of flight time, this usually takes a little over 4h 50m.

  • When did momondo last update prices for flights from Manchester Airport to Florence Airport?

    Prices for flights from Manchester Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Manchester Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Manchester Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Florence?

Finding the right flight to Florence from Manchester is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Manchester to Florence with flexible booking policies on momondo?

Flights from Manchester to Florence with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Manchester to Florence?

Once you have performed a search for Manchester to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Manchester to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Manchester to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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