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Cheap flights from Knoxville to San Angelo from $499

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Angelo departing on 12/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Knoxville to San Angelo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:30 am - 11:01 amTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
6h 31m1 stop Dallas/Fort Worth
American Airlines Logo
11:00 am - 5:35 pmSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
5h 35m1 stop Dallas/Fort Worth
$499American Airlines
Wed, Dec 9 - Thu, Dec 31
American Airlines Logo
6:50 am - 11:01 amTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
5h 11m1 stop Dallas/Fort Worth
American Airlines Logo
5:00 am - 3:51 pmSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
9h 51m2 stops Dallas/Fort Worth Charlotte Douglas
$505American Airlines
Wed, Dec 9 - Thu, Dec 31
American Airlines Logo
8:13 am - 6:12 pmTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
10h 59m2 stops Charlotte Douglas Dallas/Fort Worth
American Airlines Logo
5:00 am - 3:51 pmSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
9h 51m2 stops Dallas/Fort Worth Charlotte Douglas
$603American Airlines
Wed, Dec 9 - Thu, Dec 31
American Airlines Logo
6:03 am - 9:57 amTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
4h 54m1 stop Dallas/Fort Worth
American Airlines Logo
5:00 am - 11:18 amSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
5h 18m1 stop Dallas/Fort Worth
$622American Airlines
Fri, Aug 28 - Mon, Sep 7
American Airlines Logo
1:46 pm - 6:23 pmTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
5h 37m1 stop Dallas/Fort Worth
American Airlines Logo
5:00 am - 3:57 pmSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
9h 57m2 stops Dallas/Fort Worth Charlotte Douglas
$628American Airlines
Fri, Aug 28 - Mon, Sep 7
American Airlines Logo
1:56 pm - 10:44 pmTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
9h 48m2 stops Charlotte Douglas Dallas/Fort Worth
American Airlines Logo
5:00 am - 3:57 pmSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
9h 57m2 stops Dallas/Fort Worth Charlotte Douglas
$633American Airlines
Fri, Aug 28 - Mon, Sep 7
American Airlines Logo
8:13 am - 6:12 pmTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
10h 59m2 stops Charlotte Douglas Dallas/Fort Worth
American Airlines Logo
5:00 am - 3:51 pmSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
9h 51m2 stops Dallas/Fort Worth Charlotte Douglas
$635American Airlines
Wed, Dec 9 - Thu, Dec 31
American Airlines Logo
8:13 am - 6:12 pmTYS  Knoxville McGhee Tyson-SJT San Angelo Mathis Field
10h 59m2 stops Charlotte Douglas Dallas/Fort Worth
American Airlines Logo
5:00 am - 3:51 pmSJT  San Angelo Mathis Field-TYS Knoxville McGhee Tyson
9h 51m2 stops Dallas/Fort Worth Charlotte Douglas
$677American Airlines
Wed, Dec 9 - Thu, Dec 31

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American Airlines flights from Knoxville to San Angelo

Our best American Airlines deals on Knoxville to San Angelo flight tickets
American Airlines
Dec 9
TYS5:30 amKnoxville McGhee Tyson
6h 31m
1 stop
SJT11:01 amSan Angelo Mathis Field
Dec 31
SJT11:00 amSan Angelo Mathis Field
5h 35m
1 stop
TYS5:35 pmKnoxville McGhee Tyson
$499
American Airlines
Dec 9
TYS6:50 amKnoxville McGhee Tyson
5h 11m
1 stop
SJT11:01 amSan Angelo Mathis Field
Dec 31
SJT5:00 amSan Angelo Mathis Field
9h 51m
2 stops
TYS3:51 pmKnoxville McGhee Tyson
$505
American Airlines
Dec 9
TYS8:13 amKnoxville McGhee Tyson
10h 59m
2 stops
SJT6:12 pmSan Angelo Mathis Field
Dec 31
SJT5:00 amSan Angelo Mathis Field
9h 51m
2 stops
TYS3:51 pmKnoxville McGhee Tyson
$603

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Angelo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Knoxville to San Angelo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Wed 12/9

5:30 am-11:01 am

1 stop6h 31m

San Angelo Mathis Field

Thu 12/31

11:00 am-5:35 pm

1 stop5h 35m

$499

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Wed 12/9

6:50 am-11:01 am

1 stop5h 11m

San Angelo Mathis Field

Thu 12/31

5:00 am-3:51 pm

2 stops9h 51m

$505

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Wed 12/9

8:13 am-6:12 pm

2 stops10h 59m

San Angelo Mathis Field

Thu 12/31

5:00 am-3:51 pm

2 stops9h 51m

$603
Quickest round-trip

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Fri 8/28

6:03 am-9:57 am

1 stop4h 54m

San Angelo Mathis Field

Mon 9/7

5:00 am-11:18 am

1 stop5h 18m

$622

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Fri 8/28

1:46 pm-6:23 pm

1 stop5h 37m

San Angelo Mathis Field

Mon 9/7

5:00 am-3:57 pm

2 stops9h 57m

$628

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Fri 8/28

1:56 pm-10:44 pm

2 stops9h 48m

San Angelo Mathis Field

Mon 9/7

5:00 am-3:57 pm

2 stops9h 57m

$633

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Wed 12/9

8:13 am-6:12 pm

2 stops10h 59m

San Angelo Mathis Field

Thu 12/31

5:00 am-3:51 pm

2 stops9h 51m

$635

KnoxvilleSan Angelo

TYS Knoxville McGhee Tyson - SJT San Angelo Mathis Field

TYSSJT

Knoxville McGhee Tyson

Wed 12/9

8:13 am-6:12 pm

2 stops10h 59m

San Angelo Mathis Field

Thu 12/31

5:00 am-3:51 pm

2 stops9h 51m

$677

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Knoxville to San Angelo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Angelo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Angelo (TYS to SJT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Angelo

Fastest flight time

4h 54m

Direct flights

None
The fastest flight from Knoxville to San Angelo takes 4h 54m
There are no direct flights from Knoxville to San Angelo. There are no popular flight routes from Knoxville to San Angelo.
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Frequently asked questions about flying from Knoxville to San Angelo

  • How far is Knoxville McGhee Tyson to San Angelo Mathis Field by plane?

    The distance between Knoxville McGhee Tyson and San Angelo Mathis Field is about 996.6 mi. Typically, this will take 4h 54m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Angelo Mathis Field Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Angelo Mathis Field Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Angelo Mathis Field Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Angelo Mathis Field Airport.

  • What documentation or ID do you need to fly to San Angelo Mathis Field Airport?

    The required travel and health documents for your San Angelo Mathis Field Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Angelo Mathis Field Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Frequently asked questions about flying from Knoxville to San Angelo

  • How do I get Price Alerts for flights from Knoxville to San Angelo?

    Price Alerts will notify you by email when the price for flights to San Angelo from Knoxville decreases. To activate this, select your desired travel dates and search for offers. While browsing through offers you’ll see the Price Alert widget toggle. Click it to turn on notifications.

  • How can I save money on flights from Knoxville to San Angelo with momondo?

    By using tools like our “Price Calendar”, you can see the best day to fly round-trip for your travels. Our “Price Forecast” tool uses AI to predict whether you should purchase or hold off on booking for potentially cheaper prices. Explore shows you all flight options from a city or airport to build your own unique adventure. The Discover blog also provides valuable insights for saving money while booking your experience. After searching you can toggle on “Price Alerts” to track prices for your desired flight and book at the ideal moment.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near San Angelo?

Book flights to San Angelo if you plan to visit one of these locations
Sonora

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Angelo?

Finding the right flight to San Angelo from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Angelo quick and easy, saving you time and money.

Can I find flights from Knoxville to San Angelo with flexible booking policies on momondo?

Yes. All flights to San Angelo from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to San Angelo?

Once all potential Knoxville to San Angelo flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to San Angelo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Angelo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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