Cheap flights from Knoxville to Detroit from $125

The cheapest month to fly to Detroit from Knoxville is in May. Flight prices, which tend to average around $349, are often lower during this time because this is during the off-season. If you’re not able to fly to Detroit in May, then February is your next best option. Flight prices from Knoxville to Detroit during February average around $373.

On average, the least expensive day to fly to Detroit from Knoxville is on a Thursday. momondo users have found tickets for Thursday departures for as low as $450. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Detroit for around $928.

In the morning is the cheapest time of day to fly from Knoxville to Detroit when you can find flight prices for as low as $510. Flying to Detroit in the morning is an ideal time because this is during off-peak travel hours. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $826 on average. Flights to Detroit from Knoxville in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Knoxville McGhee Tyson to Detroit Metropolitan Wayne County for the best Knoxville McGhee Tyson - Detroit flight prices

There are 4 cabin classes available to choose from on Knoxville to Detroit flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 8% on your flight if you consider stops on a Knoxville to Detroit flight.

Avelo Airlines is the most popular carrier operating from Knoxville McGhee Tyson to Detroit

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Detroit from Knoxville according to our data. Delta is the first choice among our users, with 77% of people opting to fly with this airline when traveling to Detroit. Keep in mind that there are 3 different airlines that fly to Detroit on a routine basis, so you have a few additional options to choose from.

The number of flights available between Knoxville and Detroit is 2 per day as of November 2026. The most frequent departure time is 11:00AM, with 78% of daily flights leaving at noon.

As of November 2026, there are 20 flights per week flying from Knoxville to Detroit. The most common day of the week flights depart is Fri, with 45% of flights taking off on this day.