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Cheap flights from Knoxville to Detroit from $82

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Detroit departing on 4/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Knoxville to Detroit

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:20 pm - 10:58 am
TYS
-
DTW
18h 38m
1 stop
Frontier Logo
11:54 am - 3:28 pm
DTW
-
TYS
27h 34m
1 stop
$171Frontier
Fri, Apr 10 - Sun, Apr 12
Multiple Airlines Logo
5:10 pm - 12:39 am
TYS
-
DTW
7h 29m
1 stop
Multiple Airlines Logo
9:28 pm - 10:33 pm
DTW
-
TYS
25h 05m
1 stop
$248Multiple Airlines
Thu, Apr 9 - Sat, Apr 11
Multiple Airlines Logo
5:10 pm - 12:39 am
TYS
-
DTW
7h 29m
1 stop
Multiple Airlines Logo
9:28 pm - 10:33 pm
DTW
-
TYS
25h 05m
1 stop
$251Multiple Airlines
Thu, Apr 9 - Sat, Apr 11
Multiple Airlines Logo
5:10 pm - 12:39 am
TYS
-
DTW
7h 29m
1 stop
Multiple Airlines Logo
9:02 am - 3:41 pm
DTW
-
TYS
30h 39m
2 stops
$253Multiple Airlines
Thu, Apr 9 - Sat, Apr 11
Multiple Airlines Logo
6:20 pm - 11:38 am
TYS
-
DTW
41h 18m
2 stops
Multiple Airlines Logo
12:57 pm - 10:24 pm
DTW
-
TYS
9h 27m
1 stop
$263Multiple Airlines
Mon, Apr 20 - Mon, Apr 27
Multiple Airlines Logo
5:10 pm - 12:39 am
TYS
-
DTW
7h 29m
1 stop
Multiple Airlines Logo
9:02 am - 3:41 pm
DTW
-
TYS
30h 39m
2 stops
$265Multiple Airlines
Thu, Apr 9 - Sat, Apr 11
Multiple Airlines Logo
9:32 pm - 12:46 am
TYS
-
DTW
27h 14m
1 stop
Multiple Airlines Logo
10:19 am - 9:48 pm
DTW
-
TYS
35h 29m
2 stops
$272Multiple Airlines
Thu, Apr 16 - Thu, Apr 23
Multiple Airlines Logo
3:46 pm - 11:40 am
TYS
-
DTW
19h 54m
1 stop
Multiple Airlines Logo
12:45 pm - 8:29 pm
DTW
-
TYS
7h 44m
1 stop
$276Multiple Airlines
Thu, May 28 - Sun, May 31
Southwest Logo
7:05 am - 12:40 pm
TYS
-
DTW
5h 35m
1 stop
Southwest Logo
6:10 am - 12:00 pm
DTW
-
TYS
5h 50m
1 stop
$279Southwest
Tue, May 12 - Tue, May 19
Southwest Logo
5:50 pm - 9:35 pm
TYS
-
DTW
3h 45m
1 stop
Southwest Logo
12:40 pm - 8:50 pm
DTW
-
TYS
8h 10m
2 stops
$284Southwest
Tue, May 12 - Tue, May 19

Frontier flights from Knoxville to Detroit Metropolitan Wayne County Airport

Our best Frontier deals on Knoxville to Detroit Metropolitan Wayne County Airport flight tickets
Frontier
Apr 10
TYS4:20 pmKnoxville McGhee Tyson
18h 38m
1 stop
DTW10:58 amDetroit Metropolitan Wayne County
Apr 12
DTW11:54 amDetroit Metropolitan Wayne County
27h 34m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
$171
Frontier
Apr 10
TYS4:20 pmKnoxville McGhee Tyson
18h 38m
1 stop
DTW10:58 amDetroit Metropolitan Wayne County
Apr 12
DTW11:54 amDetroit Metropolitan Wayne County
27h 34m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
$291
Frontier
Mar 27
TYS4:20 pmKnoxville McGhee Tyson
18h 39m
1 stop
DTW10:59 amDetroit Metropolitan Wayne County
Mar 29
DTW10:27 pmDetroit Metropolitan Wayne County
16h 58m
1 stop
TYS3:25 pmKnoxville McGhee Tyson
$351

American Airlines flights from Knoxville to Detroit Metropolitan Wayne County Airport

Our best American Airlines deals on Knoxville to Detroit Metropolitan Wayne County Airport flight tickets
American Airlines
Apr 30
TYS5:00 amKnoxville McGhee Tyson
6h 17m
1 stop
DTW11:17 amDetroit Metropolitan Wayne County
May 3
DTW6:00 amDetroit Metropolitan Wayne County
6h 45m
1 stop
TYS12:45 pmKnoxville McGhee Tyson
$340
American Airlines
Apr 2
TYS5:00 amKnoxville McGhee Tyson
4h 25m
1 stop
DTW9:25 amDetroit Metropolitan Wayne County
Apr 5
DTW11:33 amDetroit Metropolitan Wayne County
5h 58m
1 stop
TYS5:31 pmKnoxville McGhee Tyson
$489
American Airlines
Apr 2
TYS5:00 amKnoxville McGhee Tyson
4h 25m
1 stop
DTW9:25 amDetroit Metropolitan Wayne County
Apr 5
DTW5:55 amDetroit Metropolitan Wayne County
5h 25m
1 stop
TYS11:20 amKnoxville McGhee Tyson
$519

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Detroit Metropolitan Wayne County Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Knoxville to Detroit Metropolitan Wayne County Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Fri 4/10

4:20 pm-10:58 am

1 stop18h 38m

Detroit Metropolitan Wayne County

Sun 4/12

11:54 am-3:28 pm

1 stop27h 34m

$171

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Thu 4/9

5:10 pm-12:39 am

1 stop7h 29m

Detroit Metropolitan Wayne County

Sat 4/11

9:28 pm-10:33 pm

1 stop25h 05m

$248

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Thu 4/9

5:10 pm-12:39 am

1 stop7h 29m

Detroit Metropolitan Wayne County

Sat 4/11

9:28 pm-10:33 pm

1 stop25h 05m

$251

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Thu 4/9

5:10 pm-12:39 am

1 stop7h 29m

Detroit Metropolitan Wayne County

Sat 4/11

9:02 am-3:41 pm

2 stops30h 39m

$253

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Mon 4/20

6:20 pm-11:38 am

2 stops41h 18m

Detroit Metropolitan Wayne County

Mon 4/27

12:57 pm-10:24 pm

1 stop9h 27m

$263

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Thu 4/9

5:10 pm-12:39 am

1 stop7h 29m

Detroit Metropolitan Wayne County

Sat 4/11

9:02 am-3:41 pm

2 stops30h 39m

$265

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Thu 4/16

9:32 pm-12:46 am

1 stop27h 14m

Detroit Metropolitan Wayne County

Thu 4/23

10:19 am-9:48 pm

2 stops35h 29m

$272

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Thu 5/28

3:46 pm-11:40 am

1 stop19h 54m

Detroit Metropolitan Wayne County

Sun 5/31

12:45 pm-8:29 pm

1 stop7h 44m

$276
Quickest round-trip

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Tue 5/12

7:05 am-12:40 pm

1 stop5h 35m

Detroit Metropolitan Wayne County

Tue 5/19

6:10 am-12:00 pm

1 stop5h 50m

$279

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Tue 5/12

5:50 pm-9:35 pm

1 stop3h 45m

Detroit Metropolitan Wayne County

Tue 5/19

12:40 pm-8:50 pm

2 stops8h 10m

$284

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Detroit from

How to get the cheapest flight ticket from Knoxville to Detroit Metropolitan Wayne County Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Detroit Metropolitan Wayne County Airport?

The cheapest month to fly to Detroit Metropolitan Wayne County Airport from Knoxville is in January. Flight prices, which tend to average around $324, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to Detroit Metropolitan Wayne County Airport from Knoxville during February instead. Flights to Detroit Metropolitan Wayne County Airport in February, while not as cheap as those in January, still average around $364.

What is the cheapest day to depart on your flight to Detroit Metropolitan Wayne County Airport?

The cheapest day to depart from Knoxville to Detroit Metropolitan Wayne County Airport is on a Thursday when prices can be found for as low as $411. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Detroit Metropolitan Wayne County Airport on Sunday is $802.

What is the cheapest time of day to depart on your flight to Detroit Metropolitan Wayne County Airport?

Flying to Detroit Metropolitan Wayne County Airport from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $533 when looking at flights departing in the morning. Flights to Detroit Metropolitan Wayne County Airport are more costly at noon, with an average ticket price of $557. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Knoxville McGhee Tyson to Detroit Metropolitan Wayne County flight route?

Fly from Knoxville McGhee Tyson to Detroit Metropolitan Wayne County for the best Knoxville McGhee Tyson - Detroit Metropolitan Wayne County flight prices

What cabin class options are available on Knoxville McGhee Tyson to Detroit Metropolitan Wayne County flights?

There are 4 cabin classes available to choose from on Knoxville McGhee Tyson to Detroit Metropolitan Wayne County flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Detroit Metropolitan Wayne County Airport flights?

You could potentially save up to 46% on your flight if you consider stops on a Knoxville to Detroit Metropolitan Wayne County Airport flight.

How have Knoxville to Detroit Metropolitan Wayne County Airport flight prices changed over time?

As of March 2026, prices for Knoxville to Detroit Metropolitan Wayne County Airport flights are approximately 11% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Detroit Metropolitan Wayne County Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Detroit Metropolitan Wayne County Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Detroit Metropolitan Wayne County Airport (TYS to DTW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Detroit Metropolitan Wayne County Airport

Best Price Found

$183

Fastest flight time

1h 38m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun
The best one-way flight to Detroit Metropolitan Wayne County Airport from Knoxville in the past 72 hours is $183. The best round-trip flight deal from Knoxville to Detroit Metropolitan Wayne County Airport found on momondo in the last 72 hours is $359.
The fastest flight from Knoxville to Detroit Metropolitan Wayne County Airport takes 1h 38m
Direct flights go from Knoxville to Detroit Metropolitan Wayne County Airport on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
Search flight deals

  • How far is Knoxville McGhee Tyson to Detroit Metropolitan Wayne County by plane?

    A flight from Knoxville McGhee Tyson to Detroit Metropolitan Wayne County will travel around 433.4 mi. By plane, this route typically takes 1h 38m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport.

  • What documentation or ID do you need to fly to Detroit Metropolitan Wayne County Airport?

    The necessary travel and health documents for your Detroit Metropolitan Wayne County Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Detroit Metropolitan Wayne County Airport?

  • What is the most popular airline from Knoxville to Detroit Metropolitan Wayne County Airport?

Best airlines flying from Knoxville to Detroit Metropolitan Wayne County Airport

Compare and see reviews for airlines that fly from Knoxville to Detroit Metropolitan Wayne County Airport with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $299Free CancellationRating
7.9
8,320 reviews
Search Delta flights

  • Delta Flights From Knoxville to Detroit Metropolitan Wayne County Airport

    Delta operates around 15 flights from Knoxville to Detroit Metropolitan Wayne County Airport every week. The average price of these flights found in the last 72 hours has been $431, but momondo users have found Delta deals from Knoxville to Detroit Metropolitan Wayne County Airport from as low as $299 round-trip. Delta has been scored 7.9/10 in 8,327 reviews.

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
Put-in-Bay
Auburn Hills
Warren
Dearborn
Romulus
Troy
Monroe
Southfield
Livonia
Novi
Port Clinton
Roseville
Port Huron
Sterling Heights
Dundee
Brighton
Ypsilanti
Pontiac
Farmington Hills
Plymouth

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Detroit?

Finding the right flight to Detroit from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Detroit quick and easy, saving you time and money.

Can I find flights from Knoxville to Detroit with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Detroit flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Detroit?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Detroit.

I’m not ready to book a flight from Knoxville to Detroit right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Detroit from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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