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Cheap flights from Knoxville to Detroit from $106

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Detroit departing on 6/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Detroit

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:32 pm - 12:46 pm
TYS
-
DTW
16h 14m
1 stop
Frontier Logo
8:00 am - 7:37 pm
DTW
-
TYS
11h 37m
1 stop
$234Frontier
Mon, Jun 8 - Mon, Jun 15
Frontier Logo
8:32 pm - 12:46 pm
TYS
-
DTW
16h 14m
1 stop
Frontier Logo
8:00 am - 7:37 pm
DTW
-
TYS
11h 37m
1 stop
$260Frontier
Fri, Jun 12 - Mon, Jun 15
Frontier Logo
8:32 pm - 12:46 pm
TYS
-
DTW
16h 14m
1 stop
Frontier Logo
8:00 am - 7:36 pm
DTW
-
TYS
11h 36m
1 stop
$275Frontier
Fri, Jul 3 - Mon, Jul 6
Southwest Logo
6:55 pm - 10:25 pm
TYS
-
DTW
3h 30m
1 stop
Southwest Logo
3:50 pm - 9:15 pm
DTW
-
TYS
5h 25m
1 stop
$299Southwest
Tue, Jun 23 - Tue, Jun 30
Multiple Airlines Logo
7:27 pm - 11:47 am
TYS
-
DTW
16h 20m
1 stop
Multiple Airlines Logo
6:10 am - 9:50 pm
DTW
-
TYS
15h 40m
2 stops
$303Multiple Airlines
Mon, Jun 8 - Mon, Jun 15
Southwest Logo
8:15 am - 6:20 pm
TYS
-
DTW
10h 05m
2 stops
Southwest Logo
3:50 pm - 9:15 pm
DTW
-
TYS
5h 25m
1 stop
$304Southwest
Tue, Jun 2 - Tue, Jun 9
Frontier Logo
8:32 pm - 11:59 pm
TYS
-
DTW
27h 27m
1 stop
Frontier Logo
8:00 am - 7:37 pm
DTW
-
TYS
11h 37m
1 stop
$305Frontier
Wed, Jun 10 - Wed, Jun 17
Multiple Airlines Logo
7:15 am - 12:40 am
TYS
-
DTW
17h 25m
2 stops
Multiple Airlines Logo
7:25 pm - 11:33 pm
DTW
-
TYS
28h 08m
1 stop
$306Multiple Airlines
Thu, Jul 23 - Sun, Jul 26
Southwest Logo
12:50 pm - 9:35 pm
TYS
-
DTW
8h 45m
2 stops
Southwest Logo
6:40 am - 5:00 pm
DTW
-
TYS
10h 20m
2 stops
$309Southwest
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
5:50 pm - 9:35 pm
TYS
-
DTW
3h 45m
1 stop
Southwest Logo
3:50 pm - 9:15 pm
DTW
-
TYS
5h 25m
1 stop
$310Southwest
Tue, Jun 2 - Tue, Jun 9

Delta flights from Knoxville to Detroit Metropolitan Wayne County Airport

Our best Delta deals on Knoxville to Detroit Metropolitan Wayne County Airport flight tickets
Delta
Jul 23
TYS5:25 pmKnoxville McGhee Tyson
1h 46m
DTW7:11 pmDetroit Metropolitan Wayne County
Jul 27
DTW1:39 pmDetroit Metropolitan Wayne County
1h 39m
TYS3:18 pmKnoxville McGhee Tyson
$339
Delta
Jul 23
TYS5:40 amKnoxville McGhee Tyson
4h 30m
1 stop
DTW10:10 amDetroit Metropolitan Wayne County
Jul 27
DTW4:13 pmDetroit Metropolitan Wayne County
1h 42m
TYS5:55 pmKnoxville McGhee Tyson
$349
Delta
Jul 23
TYS7:43 pmKnoxville McGhee Tyson
5h 16m
1 stop
DTW12:59 amDetroit Metropolitan Wayne County
Jul 26
DTW7:40 pmDetroit Metropolitan Wayne County
4h 12m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$359

American Airlines flights from Knoxville to Detroit Metropolitan Wayne County Airport

Our best American Airlines deals on Knoxville to Detroit Metropolitan Wayne County Airport flight tickets
American Airlines
Jun 6
TYS8:59 amKnoxville McGhee Tyson
6h 53m
1 stop
DTW3:52 pmDetroit Metropolitan Wayne County
Jun 13
DTW7:58 pmDetroit Metropolitan Wayne County
3h 49m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$389
American Airlines
Jun 3
TYS11:39 amKnoxville McGhee Tyson
9h 53m
1 stop
DTW9:32 pmDetroit Metropolitan Wayne County
Jun 7
DTW6:00 amDetroit Metropolitan Wayne County
4h 36m
1 stop
TYS10:36 amKnoxville McGhee Tyson
$392
American Airlines
May 27
TYS6:53 pmKnoxville McGhee Tyson
5h 00m
1 stop
DTW11:53 pmDetroit Metropolitan Wayne County
Jun 3
DTW1:45 pmDetroit Metropolitan Wayne County
8h 25m
1 stop
TYS10:10 pmKnoxville McGhee Tyson
$417

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Detroit Metropolitan Wayne County Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Knoxville to Detroit Metropolitan Wayne County Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Mon 6/8

8:32 pm-12:46 pm

1 stop16h 14m

Detroit Metropolitan Wayne County

Mon 6/15

8:00 am-7:37 pm

1 stop11h 37m

$234

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Fri 6/12

8:32 pm-12:46 pm

1 stop16h 14m

Detroit Metropolitan Wayne County

Mon 6/15

8:00 am-7:37 pm

1 stop11h 37m

$260

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Fri 7/3

8:32 pm-12:46 pm

1 stop16h 14m

Detroit Metropolitan Wayne County

Mon 7/6

8:00 am-7:36 pm

1 stop11h 36m

$275
Quickest round-trip

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Tue 6/23

6:55 pm-10:25 pm

1 stop3h 30m

Detroit Metropolitan Wayne County

Tue 6/30

3:50 pm-9:15 pm

1 stop5h 25m

$299

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Mon 6/8

7:27 pm-11:47 am

1 stop16h 20m

Detroit Metropolitan Wayne County

Mon 6/15

6:10 am-9:50 pm

2 stops15h 40m

$303

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Tue 6/2

8:15 am-6:20 pm

2 stops10h 05m

Detroit Metropolitan Wayne County

Tue 6/9

3:50 pm-9:15 pm

1 stop5h 25m

$304

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Wed 6/10

8:32 pm-11:59 pm

1 stop27h 27m

Detroit Metropolitan Wayne County

Wed 6/17

8:00 am-7:37 pm

1 stop11h 37m

$305

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Thu 7/23

7:15 am-12:40 am

2 stops17h 25m

Detroit Metropolitan Wayne County

Sun 7/26

7:25 pm-11:33 pm

1 stop28h 08m

$306

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Tue 6/2

12:50 pm-9:35 pm

2 stops8h 45m

Detroit Metropolitan Wayne County

Tue 6/9

6:40 am-5:00 pm

2 stops10h 20m

$309

KnoxvilleDetroit

TYS - DTW

TYSDTW

Knoxville McGhee Tyson

Tue 6/2

5:50 pm-9:35 pm

1 stop3h 45m

Detroit Metropolitan Wayne County

Tue 6/9

3:50 pm-9:15 pm

1 stop5h 25m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Detroit from

How to get the cheapest flight ticket from Knoxville to Detroit Metropolitan Wayne County Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Detroit Metropolitan Wayne County Airport?

What is the cheapest month to fly to Detroit Metropolitan Wayne County Airport?

The cheapest month to fly to Detroit Metropolitan Wayne County Airport from Knoxville is in January. Flight prices, which tend to average around $324, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to Detroit Metropolitan Wayne County Airport from Knoxville during May instead. Flights to Detroit Metropolitan Wayne County Airport in May, while not as cheap as those in January, still average around $339.

What is the cheapest day to depart on your flight to Detroit Metropolitan Wayne County Airport?

The cheapest day to depart from Knoxville to Detroit Metropolitan Wayne County Airport is on a Thursday when prices can be found for as low as $450. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Detroit Metropolitan Wayne County Airport on Monday is $808.

What is the cheapest time of day to depart on your flight to Detroit Metropolitan Wayne County Airport?

Flying to Detroit Metropolitan Wayne County Airport from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $550 when looking at flights departing in the morning. Flights to Detroit Metropolitan Wayne County Airport are more costly in the afternoon, with an average ticket price of $652. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Knoxville McGhee Tyson to Detroit Metropolitan Wayne County flight route?

Fly from Knoxville McGhee Tyson to Detroit Metropolitan Wayne County for the best Knoxville McGhee Tyson - Detroit Metropolitan Wayne County flight prices

Can stopping save me money on Knoxville to Detroit Metropolitan Wayne County Airport flights?

You could potentially save up to 33% on your flight if you consider stops on a Knoxville to Detroit Metropolitan Wayne County Airport flight.

How have Knoxville to Detroit Metropolitan Wayne County Airport flight prices changed over time?

As of May 2026, prices for Knoxville to Detroit Metropolitan Wayne County Airport flights are approximately 192% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Detroit Metropolitan Wayne County Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Detroit Metropolitan Wayne County Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Detroit Metropolitan Wayne County Airport (TYS to DTW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Detroit Metropolitan Wayne County Airport

Best Price Found

$217

Fastest flight time

1h 40m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun
The best one-way flight to Detroit Metropolitan Wayne County Airport from Knoxville in the past 72 hours is $217. The best round-trip flight deal from Knoxville to Detroit Metropolitan Wayne County Airport found on momondo in the last 72 hours is $448.
The fastest flight from Knoxville to Detroit Metropolitan Wayne County Airport takes 1h 40m
Direct flights go from Knoxville to Detroit Metropolitan Wayne County Airport on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
Search flight deals

Frequently asked questions about flying from Knoxville to Detroit Metropolitan Wayne County Airport

  • How far is Knoxville McGhee Tyson to Detroit Metropolitan Wayne County by plane?

    A flight from Knoxville McGhee Tyson to Detroit Metropolitan Wayne County will travel around 433.4 mi. By plane, this route typically takes 1h 40m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Detroit Metropolitan Wayne County Airport.

  • What documentation or ID do you need to fly to Detroit Metropolitan Wayne County Airport?

    The necessary travel and health documents for your Detroit Metropolitan Wayne County Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Detroit Metropolitan Wayne County Airport?

  • What is the most popular airline from Knoxville to Detroit Metropolitan Wayne County Airport?

Best airlines flying from Knoxville to Detroit Metropolitan Wayne County Airport

Compare and see reviews for airlines that fly from Knoxville to Detroit Metropolitan Wayne County Airport with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $299Free CancellationRating
7.9
8,454 reviews
Search Delta flights

  • Delta Flights From Knoxville to Detroit Metropolitan Wayne County Airport

    Delta operates around 16 flights from Knoxville to Detroit Metropolitan Wayne County Airport every week. The average price of these flights found in the last 72 hours has been $447, but momondo users have found Delta deals from Knoxville to Detroit Metropolitan Wayne County Airport from as low as $299 round-trip. Delta has been scored 7.9/10 in 8,454 reviews.

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
Put-in-Bay
Auburn Hills
Romulus
Warren
Dearborn
Troy
Monroe
Southfield
Livonia
Novi
Port Clinton
Roseville
Sterling Heights
Port Huron
Dundee
Brighton
Ypsilanti
Pontiac
Madison Heights
Belleville

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Detroit?

Finding the right flight to Detroit from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Detroit quick and easy, saving you time and money.

Can I find flights from Knoxville to Detroit with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Detroit flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Detroit?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Detroit.

I’m not ready to book a flight from Knoxville to Detroit right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Detroit from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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