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Cheap flights from Key West to San Francisco from $130

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 1/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
1:00 pm - 10:59 pm
EYW
-
SFO
12h 59m1 stop
JetBlue Logo
8:29 pm - 12:05 pm
SFO
-
EYW
12h 36m1 stop
$347JetBlue
jue., ene. 22 - dom., ene. 25
United Airlines Logo
6:05 pm - 1:30 am
EYW
-
SFO
10h 25m1 stop
United Airlines Logo
11:55 pm - 1:03 pm
SFO
-
EYW
10h 08m1 stop
$409United Airlines
jue., ene. 22 - dom., ene. 25
United Airlines Logo
4:15 pm - 11:00 pm
EYW
-
SFO
9h 45m1 stop
United Airlines Logo
10:59 pm - 1:03 pm
SFO
-
EYW
35h 04m2 stops
$501United Airlines
jue., ene. 22 - dom., ene. 25
American Airlines Logo
8:09 pm - 11:02 am
EYW
-
SFO
17h 53m1 stop
American Airlines Logo
1:15 pm - 11:56 pm
SFO
-
EYW
7h 41m1 stop
$642American Airlines
lun., ene. 5 - mié., feb. 4
American Airlines Logo
8:09 pm - 11:02 am
EYW
-
SFO
17h 53m1 stop
American Airlines Logo
10:11 am - 11:56 pm
SFO
-
EYW
10h 45m2 stops
$647American Airlines
lun., ene. 5 - mié., feb. 4
United Airlines Logo
2:25 pm - 11:57 pm
EYW
-
SFO
12h 32m1 stop
United Airlines Logo
9:23 pm - 3:17 pm
SFO
-
EYW
14h 54m2 stops
$653United Airlines
jue., ene. 22 - dom., ene. 25
American Airlines Logo
1:46 pm - 9:39 pm
EYW
-
SFO
10h 53m1 stop
American Airlines Logo
8:00 am - 7:10 pm
SFO
-
EYW
8h 10m1 stop
$707American Airlines
lun., ene. 5 - mié., feb. 4
American Airlines Logo
1:46 pm - 9:39 pm
EYW
-
SFO
10h 53m1 stop
American Airlines Logo
10:11 am - 11:56 pm
SFO
-
EYW
10h 45m2 stops
$712American Airlines
lun., ene. 5 - mié., feb. 4
American Airlines Logo
8:09 pm - 11:02 am
EYW
-
SFO
17h 53m1 stop
American Airlines Logo
8:00 am - 11:56 pm
SFO
-
EYW
12h 56m2 stops
$717American Airlines
lun., ene. 5 - mié., feb. 4
American Airlines Logo
11:47 am - 8:09 pm
EYW
-
SFO
11h 22m2 stops
American Airlines Logo
11:15 am - 11:56 pm
SFO
-
EYW
9h 41m2 stops
$762American Airlines
lun., ene. 5 - mié., feb. 4

American Airlines flights from Key West to San Francisco

Our best American Airlines deals on Key West to San Francisco flight tickets
American Airlines
Jan 5
EYW8:09 pmKey West
17h 53m
1 stop
SFO11:02 amSan Francisco
Feb 4
SFO1:15 pmSan Francisco
7h 41m
1 stop
EYW11:56 pmKey West
$642
Find similar
American Airlines
Jan 5
EYW8:09 pmKey West
17h 53m
1 stop
SFO11:02 amSan Francisco
Feb 4
SFO10:11 amSan Francisco
10h 45m
2 stops
EYW11:56 pmKey West
$647
Find similar
American Airlines
Jan 5
EYW1:46 pmKey West
10h 53m
1 stop
SFO9:39 pmSan Francisco
Feb 4
SFO8:00 amSan Francisco
8h 10m
1 stop
EYW7:10 pmKey West
$707
Find similar

United Airlines flights from Key West to San Francisco

Our best United Airlines deals on Key West to San Francisco flight tickets
United Airlines
Jan 22
EYW6:05 pmKey West
10h 25m
1 stop
SFO1:30 amSan Francisco
Jan 25
SFO11:55 pmSan Francisco
10h 08m
1 stop
EYW1:03 pmKey West
$409
Find similar
United Airlines
Jan 22
EYW4:15 pmKey West
9h 45m
1 stop
SFO11:00 pmSan Francisco
Jan 25
SFO10:59 pmSan Francisco
35h 04m
2 stops
EYW1:03 pmKey West
$501
Find similar
United Airlines
Jan 22
EYW2:25 pmKey West
12h 32m
1 stop
SFO11:57 pmSan Francisco
Jan 25
SFO9:23 pmSan Francisco
14h 54m
2 stops
EYW3:17 pmKey West
$653
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 8, 2025.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

jue. 1/22

1:00 pm-10:59 pm

1 stop12h 59m

San Francisco

dom. 1/25

8:29 pm-12:05 pm

1 stop12h 36m

$347

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

jue. 1/22

6:05 pm-1:30 am

1 stop10h 25m

San Francisco

dom. 1/25

11:55 pm-1:03 pm

1 stop10h 08m

$409

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

jue. 1/22

4:15 pm-11:00 pm

1 stop9h 45m

San Francisco

dom. 1/25

10:59 pm-1:03 pm

2 stops35h 04m

$501

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

lun. 1/5

8:09 pm-11:02 am

1 stop17h 53m

San Francisco

mié. 2/4

1:15 pm-11:56 pm

1 stop7h 41m

$642

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

lun. 1/5

8:09 pm-11:02 am

1 stop17h 53m

San Francisco

mié. 2/4

10:11 am-11:56 pm

2 stops10h 45m

$647

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

jue. 1/22

2:25 pm-11:57 pm

1 stop12h 32m

San Francisco

dom. 1/25

9:23 pm-3:17 pm

2 stops14h 54m

$653

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

lun. 1/5

1:46 pm-9:39 pm

1 stop10h 53m

San Francisco

mié. 2/4

8:00 am-7:10 pm

1 stop8h 10m

$707

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

lun. 1/5

1:46 pm-9:39 pm

1 stop10h 53m

San Francisco

mié. 2/4

10:11 am-11:56 pm

2 stops10h 45m

$712

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

lun. 1/5

8:09 pm-11:02 am

1 stop17h 53m

San Francisco

mié. 2/4

8:00 am-11:56 pm

2 stops12h 56m

$717

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

lun. 1/5

11:47 am-8:09 pm

2 stops11h 22m

San Francisco

mié. 2/4

11:15 am-11:56 pm

2 stops9h 41m

$762

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Key West to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Key West to San Francisco is on a Saturday when prices can be found for as low as $394. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $617.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Key West to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $430. Flights in the afternoon are often more expensive with an average ticket price of $476.

How have Key West to San Francisco flight prices changed over time?

As of December 2025, prices for Key West to San Francisco flights are approximately 68% more expensive when compared to flights at the same time last year.

When to book flights from Key West to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Francisco (EYW to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Francisco

Fastest flight time

9h 15m

Direct flights

None
The fastest flight from Key West to San Francisco takes 9h 15m
There are no direct flights from Key West to San Francisco. There are no popular flight routes from Key West to San Francisco.
Search flight deals

  • How far is Key West to San Francisco by plane?

    A flight from Key West to San Francisco will travel around 2543.6 mi. 9h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Key West Airport to San Francisco Airport?

    Prices for flights from Key West Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Key West Airport to San Francisco Airport?

  • How old do you have to be to fly from Key West Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Key West to San Francisco?

Best airlines flying from Key West to San Francisco

Compare and see reviews for airlines that fly from Key West to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $313Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Big Sur
Calistoga
Santa Clara
Walnut Creek
Berkeley
Daly City
Fremont
Half Moon Bay
Vallejo
Salinas
Livermore
Turlock
Sunnyvale

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Francisco?

Finding the right flight to San Francisco from Key West is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Key West to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to San Francisco?

momondo helps you find the best flight between Key West and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Key West are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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