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Cheap flights from Key West to San Francisco from $130

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 2/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Key West to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:37 pm - 11:36 pm
EYW
-
SFO
9h 59m
1 stop
American Airlines Logo
6:00 am - 4:24 pm
SFO
-
EYW
7h 24m
1 stop
$375American Airlines
Wed, Feb 4 - Sun, Feb 8
American Airlines Logo
12:00 pm - 8:25 pm
EYW
-
SFO
11h 25m
2 stops
American Airlines Logo
7:00 am - 6:01 pm
SFO
-
EYW
8h 01m
1 stop
$380American Airlines
Wed, Feb 4 - Sun, Feb 8
American Airlines Logo
1:33 pm - 10:25 pm
EYW
-
SFO
11h 52m
2 stops
American Airlines Logo
12:17 am - 1:03 pm
SFO
-
EYW
9h 46m
2 stops
$386American Airlines
Wed, Feb 4 - Sat, Feb 7
United Airlines Logo
6:35 pm - 1:28 am
EYW
-
SFO
9h 53m
1 stop
United Airlines Logo
11:55 pm - 1:15 pm
SFO
-
EYW
10h 20m
1 stop
$409United Airlines
Thu, Feb 26 - Mon, Mar 2
United Airlines Logo
6:35 pm - 1:28 am
EYW
-
SFO
9h 53m
1 stop
United Airlines Logo
7:06 pm - 5:54 pm
SFO
-
EYW
19h 48m
2 stops
$488United Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
4:01 pm - 10:34 pm
EYW
-
SFO
9h 33m
1 stop
American Airlines Logo
9:00 am - 9:47 pm
SFO
-
EYW
9h 47m
1 stop
$577American Airlines
Mon, Feb 2 - Fri, Feb 6
American Airlines Logo
4:01 pm - 10:34 pm
EYW
-
SFO
9h 33m
1 stop
American Airlines Logo
11:15 am - 11:56 pm
SFO
-
EYW
9h 41m
2 stops
$582American Airlines
Mon, Feb 2 - Fri, Feb 6
United Airlines Logo
6:35 pm - 7:18 am
EYW
-
SFO
15h 43m
2 stops
United Airlines Logo
9:20 pm - 3:00 pm
SFO
-
EYW
14h 40m
2 stops
$594United Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
2:06 pm - 8:56 pm
EYW
-
SFO
9h 50m
1 stop
American Airlines Logo
9:14 am - 10:37 pm
SFO
-
EYW
10h 23m
1 stop
$705American Airlines
Mon, Mar 23 - Sat, Mar 28
American Airlines Logo
2:06 pm - 11:10 pm
EYW
-
SFO
12h 04m
1 stop
American Airlines Logo
11:35 pm - 1:26 pm
SFO
-
EYW
10h 51m
2 stops
$710American Airlines
Mon, Mar 23 - Sat, Mar 28

American Airlines flights from Key West to San Francisco

Our best American Airlines deals on Key West to San Francisco flight tickets
American Airlines
Feb 4
EYW4:37 pmKey West
9h 59m
1 stop
SFO11:36 pmSan Francisco
Feb 8
SFO6:00 amSan Francisco
7h 24m
1 stop
EYW4:24 pmKey West
$375
American Airlines
Feb 4
EYW12:00 pmKey West
11h 25m
2 stops
SFO8:25 pmSan Francisco
Feb 8
SFO7:00 amSan Francisco
8h 01m
1 stop
EYW6:01 pmKey West
$380
American Airlines
Feb 4
EYW1:33 pmKey West
11h 52m
2 stops
SFO10:25 pmSan Francisco
Feb 7
SFO12:17 amSan Francisco
9h 46m
2 stops
EYW1:03 pmKey West
$386

United Airlines flights from Key West to San Francisco

Our best United Airlines deals on Key West to San Francisco flight tickets
United Airlines
Feb 26
EYW6:35 pmKey West
9h 53m
1 stop
SFO1:28 amSan Francisco
Mar 2
SFO11:55 pmSan Francisco
10h 20m
1 stop
EYW1:15 pmKey West
$409
United Airlines
Feb 26
EYW6:35 pmKey West
9h 53m
1 stop
SFO1:28 amSan Francisco
Mar 2
SFO7:06 pmSan Francisco
19h 48m
2 stops
EYW5:54 pmKey West
$488
United Airlines
Feb 26
EYW6:35 pmKey West
15h 43m
2 stops
SFO7:18 amSan Francisco
Mar 2
SFO9:20 pmSan Francisco
14h 40m
2 stops
EYW3:00 pmKey West
$594

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 2/4

4:37 pm-11:36 pm

1 stop9h 59m

San Francisco

Sun 2/8

6:00 am-4:24 pm

1 stop7h 24m

$375

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 2/4

12:00 pm-8:25 pm

2 stops11h 25m

San Francisco

Sun 2/8

7:00 am-6:01 pm

1 stop8h 01m

$380

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 2/4

1:33 pm-10:25 pm

2 stops11h 52m

San Francisco

Sat 2/7

12:17 am-1:03 pm

2 stops9h 46m

$386

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 2/26

6:35 pm-1:28 am

1 stop9h 53m

San Francisco

Mon 3/2

11:55 pm-1:15 pm

1 stop10h 20m

$409

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 2/26

6:35 pm-1:28 am

1 stop9h 53m

San Francisco

Mon 3/2

7:06 pm-5:54 pm

2 stops19h 48m

$488

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 2/2

4:01 pm-10:34 pm

1 stop9h 33m

San Francisco

Fri 2/6

9:00 am-9:47 pm

1 stop9h 47m

$577

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 2/2

4:01 pm-10:34 pm

1 stop9h 33m

San Francisco

Fri 2/6

11:15 am-11:56 pm

2 stops9h 41m

$582

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 2/26

6:35 pm-7:18 am

2 stops15h 43m

San Francisco

Mon 3/2

9:20 pm-3:00 pm

2 stops14h 40m

$594

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 3/23

2:06 pm-8:56 pm

1 stop9h 50m

San Francisco

Sat 3/28

9:14 am-10:37 pm

1 stop10h 23m

$705

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 3/23

2:06 pm-11:10 pm

1 stop12h 04m

San Francisco

Sat 3/28

11:35 pm-1:26 pm

2 stops10h 51m

$710

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Key West to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Key West to San Francisco flight prices changed over time?

As of January 2026, prices for Key West to San Francisco flights are approximately 46% cheaper when compared to flights at the same time last year.

When to book flights from Key West to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Francisco (EYW to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Francisco

Fastest flight time

9h 53m

Direct flights

None
The fastest flight from Key West to San Francisco takes 9h 53m
There are no direct flights from Key West to San Francisco. There are no popular flight routes from Key West to San Francisco.
Search flight deals

  • How far is Key West to San Francisco by plane?

    A flight from Key West to San Francisco will travel around 2543.6 mi. 9h 53m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Key West Airport to San Francisco Airport?

    Prices for flights from Key West Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Key West Airport to San Francisco Airport?

  • How old do you have to be to fly from Key West Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Key West to San Francisco?

Best airlines flying from Key West to San Francisco

Compare and see reviews for airlines that fly from Key West to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $313Free CancellationRating
7.2
11,169 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
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Calistoga
Big Sur
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Berkeley
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Half Moon Bay
Salinas
Vallejo
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Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Francisco?

Finding the right flight to San Francisco from Key West is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Key West to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to San Francisco?

momondo helps you find the best flight between Key West and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Key West are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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