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Cheap flights from Key West to San Francisco from $174

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 6/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:01 pm - 9:28 pm
EYW
-
SFO
10h 27m
1 stop
American Airlines Logo
12:30 am - 1:21 pm
SFO
-
EYW
9h 51m
1 stop
$349American Airlines
Wed, May 13 - Sat, May 16
American Airlines Logo
3:58 pm - 11:15 pm
EYW
-
SFO
10h 17m
2 stops
American Airlines Logo
12:30 am - 1:21 pm
SFO
-
EYW
9h 51m
1 stop
$354American Airlines
Wed, May 13 - Sat, May 16
United Airlines Logo
4:38 pm - 11:59 pm
EYW
-
SFO
10h 21m
1 stop
United Airlines Logo
5:00 am - 3:57 pm
SFO
-
EYW
7h 57m
1 stop
$447United Airlines
Fri, Apr 3 - Tue, Apr 7
American Airlines Logo
3:58 pm - 11:09 pm
EYW
-
SFO
10h 11m
2 stops
American Airlines Logo
9:08 am - 10:36 pm
SFO
-
EYW
10h 28m
1 stop
$465American Airlines
Thu, Apr 16 - Wed, Apr 22
American Airlines Logo
4:19 pm - 11:47 pm
EYW
-
SFO
10h 28m
1 stop
American Airlines Logo
11:58 pm - 10:56 am
SFO
-
EYW
7h 58m
1 stop
$467American Airlines
Tue, Jun 2 - Tue, Jun 16
American Airlines Logo
4:19 pm - 11:47 pm
EYW
-
SFO
10h 28m
1 stop
American Airlines Logo
5:23 am - 6:49 pm
SFO
-
EYW
10h 26m
2 stops
$472American Airlines
Tue, Jun 2 - Tue, Jun 16
United Airlines Logo
4:47 pm - 11:59 pm
EYW
-
SFO
10h 12m
1 stop
United Airlines Logo
11:05 pm - 1:45 pm
SFO
-
EYW
11h 40m
1 stop
$479United Airlines
Thu, May 7 - Mon, May 11
United Airlines Logo
4:47 pm - 11:59 pm
EYW
-
SFO
10h 12m
1 stop
United Airlines Logo
11:05 pm - 1:45 pm
SFO
-
EYW
11h 40m
1 stop
$499United Airlines
Thu, May 7 - Mon, May 11
American Airlines Logo
3:58 pm - 11:15 pm
EYW
-
SFO
10h 17m
2 stops
American Airlines Logo
10:06 am - 10:58 pm
SFO
-
EYW
9h 52m
2 stops
$502American Airlines
Wed, May 13 - Sun, May 17
American Airlines Logo
3:56 pm - 11:59 pm
EYW
-
SFO
11h 03m
1 stop
American Airlines Logo
8:00 am - 10:58 pm
SFO
-
EYW
11h 58m
2 stops
$551American Airlines
Fri, Apr 3 - Tue, Apr 7

United Airlines flights from Key West to San Francisco

Our best United Airlines deals on Key West to San Francisco flight tickets
United Airlines
Apr 3
EYW4:38 pmKey West
10h 21m
1 stop
SFO11:59 pmSan Francisco
Apr 7
SFO5:00 amSan Francisco
7h 57m
1 stop
EYW3:57 pmKey West
$447
United Airlines
May 7
EYW4:47 pmKey West
10h 12m
1 stop
SFO11:59 pmSan Francisco
May 11
SFO11:05 pmSan Francisco
11h 40m
1 stop
EYW1:45 pmKey West
$479
United Airlines
May 7
EYW4:47 pmKey West
10h 12m
1 stop
SFO11:59 pmSan Francisco
May 11
SFO11:05 pmSan Francisco
11h 40m
1 stop
EYW1:45 pmKey West
$499

American Airlines flights from Key West to San Francisco

Our best American Airlines deals on Key West to San Francisco flight tickets
American Airlines
May 13
EYW2:01 pmKey West
10h 27m
1 stop
SFO9:28 pmSan Francisco
May 16
SFO12:30 amSan Francisco
9h 51m
1 stop
EYW1:21 pmKey West
$349
American Airlines
May 13
EYW3:58 pmKey West
10h 17m
2 stops
SFO11:15 pmSan Francisco
May 16
SFO12:30 amSan Francisco
9h 51m
1 stop
EYW1:21 pmKey West
$354
American Airlines
Apr 16
EYW3:58 pmKey West
10h 11m
2 stops
SFO11:09 pmSan Francisco
Apr 22
SFO9:08 amSan Francisco
10h 28m
1 stop
EYW10:36 pmKey West
$465

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/13

2:01 pm-9:28 pm

1 stop10h 27m

San Francisco

Sat 5/16

12:30 am-1:21 pm

1 stop9h 51m

$349

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/13

3:58 pm-11:15 pm

2 stops10h 17m

San Francisco

Sat 5/16

12:30 am-1:21 pm

1 stop9h 51m

$354
Quickest round-trip

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 4/3

4:38 pm-11:59 pm

1 stop10h 21m

San Francisco

Tue 4/7

5:00 am-3:57 pm

1 stop7h 57m

$447

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 4/16

3:58 pm-11:09 pm

2 stops10h 11m

San Francisco

Wed 4/22

9:08 am-10:36 pm

1 stop10h 28m

$465

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 6/2

4:19 pm-11:47 pm

1 stop10h 28m

San Francisco

Tue 6/16

11:58 pm-10:56 am

1 stop7h 58m

$467

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 6/2

4:19 pm-11:47 pm

1 stop10h 28m

San Francisco

Tue 6/16

5:23 am-6:49 pm

2 stops10h 26m

$472

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 5/7

4:47 pm-11:59 pm

1 stop10h 12m

San Francisco

Mon 5/11

11:05 pm-1:45 pm

1 stop11h 40m

$479

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 5/7

4:47 pm-11:59 pm

1 stop10h 12m

San Francisco

Mon 5/11

11:05 pm-1:45 pm

1 stop11h 40m

$499

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/13

3:58 pm-11:15 pm

2 stops10h 17m

San Francisco

Sun 5/17

10:06 am-10:58 pm

2 stops9h 52m

$502

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 4/3

3:56 pm-11:59 pm

1 stop11h 03m

San Francisco

Tue 4/7

8:00 am-10:58 pm

2 stops11h 58m

$551

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Key West to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Key West to San Francisco flight prices changed over time?

As of March 2026, prices for Key West to San Francisco flights are approximately 67% more expensive when compared to flights at the same time last year.

When to book flights from Key West to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Francisco (EYW to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Francisco

Fastest flight time

8h 05m

Direct flights

None
The fastest flight from Key West to San Francisco takes 8h 05m
There are no direct flights from Key West to San Francisco. There are no popular flight routes from Key West to San Francisco.
Search flight deals

  • How far is Key West to San Francisco by plane?

    A flight from Key West to San Francisco will travel around 2543.6 mi. 8h 05m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Key West Airport to San Francisco Airport?

    Prices for flights from Key West Airport to San Francisco Airport were last updated today.

  • How old do you have to be to fly from Key West Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Big Sur
Fremont
Calistoga
Vallejo
Salinas
Half Moon Bay
Daly City
Milpitas
Pacific Grove
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Francisco?

Finding the right flight to San Francisco from Key West is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Key West to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to San Francisco?

momondo helps you find the best flight between Key West and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Key West are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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