Cheap flights from Key West to San Francisco from $162

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 12/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.

Find the cheapest flights from Key West to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:40 pm - 7:49 pmEYW-SFO
10h 09m1 stop
American Airlines Logo
9:00 am - 10:27 pmSFO-EYW
10h 27m1 stop
$309American Airlines
Find Deal
Sat, Nov 8 - Fri, Nov 14
United Airlines Logo
3:48 pm - 11:54 pmEYW-SFO
11h 06m1 stop
United Airlines Logo
11:55 pm - 1:09 pmSFO-EYW
10h 14m1 stop
$409United Airlines
Find Deal
Fri, Mar 6 - Tue, Mar 10
Delta Logo
6:00 pm - 11:51 pmEYW-SFO
8h 51m1 stop
Delta Logo
9:30 pm - 11:03 amSFO-EYW
10h 33m1 stop
$438Delta
Find Deal
Fri, Mar 6 - Tue, Mar 10
Delta Logo
6:17 pm - 7:30 amEYW-SFO
16h 13m2 stops
Delta Logo
6:00 am - 5:23 pmSFO-EYW
8h 23m1 stop
$439Delta
Find Deal
Sat, Nov 8 - Fri, Nov 14
Multiple Airlines Logo
10:06 am - 12:05 pmEYW-SFO
28h 59m1 stop
Multiple Airlines Logo
8:09 pm - 10:19 amSFO-EYW
35h 10m2 stops
$464Multiple Airlines
Find Deal
Mon, Nov 3 - Fri, Nov 7
Delta Logo
6:00 pm - 9:22 amEYW-SFO
18h 22m2 stops
Delta Logo
9:30 pm - 11:03 amSFO-EYW
10h 33m1 stop
$485Delta
Find Deal
Fri, Mar 6 - Tue, Mar 10
United Airlines Logo
3:48 pm - 11:54 pmEYW-SFO
11h 06m1 stop
United Airlines Logo
10:59 pm - 4:08 pmSFO-EYW
14h 09m2 stops
$487United Airlines
Find Deal
Fri, Mar 6 - Tue, Mar 10
United Airlines Logo
3:48 pm - 11:54 pmEYW-SFO
11h 06m1 stop
United Airlines Logo
10:59 pm - 4:08 pmSFO-EYW
14h 09m2 stops
$517United Airlines
Find Deal
Fri, Mar 6 - Tue, Mar 10
American Airlines Logo
1:59 pm - 7:00 pmEYW-SFO
8h 01m1 stop
American Airlines Logo
1:07 am - 12:16 pmSFO-EYW
8h 09m1 stop
$524American Airlines
Find Deal
Fri, Mar 6 - Mon, Mar 9
Delta Logo
12:22 pm - 5:22 pmEYW-SFO
8h 00m1 stop
Delta Logo
5:50 am - 5:21 pmSFO-EYW
8h 31m1 stop
$529Delta
Find Deal
Mon, Nov 3 - Fri, Nov 7

American Airlines flights from Key West to San Francisco

Our best American Airlines deals on Key West to San Francisco flight tickets
American Airlines
Nov 8
EYW12:40 pmKey West
10h 09m
1 stop
SFO7:49 pmSan Francisco
Nov 14
SFO9:00 amSan Francisco
10h 27m
1 stop
EYW10:27 pmKey West
American Airlines
Mar 6
EYW1:59 pmKey West
8h 01m
1 stop
SFO7:00 pmSan Francisco
Mar 9
SFO1:07 amSan Francisco
8h 09m
1 stop
EYW12:16 pmKey West
American Airlines
Mar 6
EYW3:51 pmKey West
11h 08m
2 stops
SFO11:59 pmSan Francisco
Mar 10
SFO8:13 amSan Francisco
12h 46m
2 stops
EYW11:59 pmKey West

United Airlines flights from Key West to San Francisco

Our best United Airlines deals on Key West to San Francisco flight tickets
United Airlines
Mar 6
EYW3:48 pmKey West
11h 06m
1 stop
SFO11:54 pmSan Francisco
Mar 10
SFO11:55 pmSan Francisco
10h 14m
1 stop
EYW1:09 pmKey West
United Airlines
Mar 6
EYW3:48 pmKey West
11h 06m
1 stop
SFO11:54 pmSan Francisco
Mar 10
SFO10:59 pmSan Francisco
14h 09m
2 stops
EYW4:08 pmKey West
United Airlines
Mar 6
EYW3:48 pmKey West
11h 06m
1 stop
SFO11:54 pmSan Francisco
Mar 10
SFO10:59 pmSan Francisco
14h 09m
2 stops
EYW4:08 pmKey West

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 11/8

12:40 pm-7:49 pm

1 stop10h 09m

San Francisco

Fri 11/14

9:00 am-10:27 pm

1 stop10h 27m

$309

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 3/6

3:48 pm-11:54 pm

1 stop11h 06m

San Francisco

Tue 3/10

11:55 pm-1:09 pm

1 stop10h 14m

$409

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 3/6

6:00 pm-11:51 pm

1 stop8h 51m

San Francisco

Tue 3/10

9:30 pm-11:03 am

1 stop10h 33m

$438

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 11/8

6:17 pm-7:30 am

2 stops16h 13m

San Francisco

Fri 11/14

6:00 am-5:23 pm

1 stop8h 23m

$439

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 11/3

10:06 am-12:05 pm

1 stop28h 59m

San Francisco

Fri 11/7

8:09 pm-10:19 am

2 stops35h 10m

$464

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 3/6

6:00 pm-9:22 am

2 stops18h 22m

San Francisco

Tue 3/10

9:30 pm-11:03 am

1 stop10h 33m

$485

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 3/6

3:48 pm-11:54 pm

1 stop11h 06m

San Francisco

Tue 3/10

10:59 pm-4:08 pm

2 stops14h 09m

$487

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 3/6

3:48 pm-11:54 pm

1 stop11h 06m

San Francisco

Tue 3/10

10:59 pm-4:08 pm

2 stops14h 09m

$517

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 3/6

1:59 pm-7:00 pm

1 stop8h 01m

San Francisco

Mon 3/9

1:07 am-12:16 pm

1 stop8h 09m

$524

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 11/3

12:22 pm-5:22 pm

1 stop8h 00m

San Francisco

Fri 11/7

5:50 am-5:21 pm

1 stop8h 31m

$529

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

See travel insights to San Francisco from

How to get the cheapest flight ticket from Key West to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Key West to San Francisco is on a Saturday when prices can be found for as low as $394. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $617.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Key West to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $430. Flights in the afternoon are often more expensive with an average ticket price of $476.

How have Key West to San Francisco flight prices changed over time?

As of October 2025, prices for Key West to San Francisco flights are approximately 36% cheaper when compared to flights at the same time last year.

When to book flights from Key West to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Francisco (EYW to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Francisco

Direct flights

None
There are no direct flights from Key West to San Francisco. There are no popular flight routes from Key West to San Francisco.
  • How far is Key West to San Francisco by plane?

    A flight from Key West to San Francisco will travel around 2543.6 mi. 8h 00m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Key West Airport to San Francisco Airport?

    Prices for flights from Key West Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Key West Airport to San Francisco Airport?

  • How old do you have to be to fly from Key West Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Key West to San Francisco?

Best airlines flying from Key West to San Francisco

Compare and see reviews for airlines that fly from Key West to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $313Free CancellationRating
7.2
11,026 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Calistoga
Roseville
Hayward
Big Sur
Santa Clara
Fremont
Daly City
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Turlock
South San Francisco
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Francisco?

Finding the right flight to San Francisco from Key West is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Key West to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to San Francisco?

momondo helps you find the best flight between Key West and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Key West are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 11/19
Wed 11/26

Find better results for your trip to the United States