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Cheap flights from Key West to San Francisco from $181

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 9/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Key West to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:15 pm - 11:58 pm
EYW
-
SFO
8h 43m
1 stop
Delta Logo
6:00 am - 5:20 pm
SFO
-
EYW
8h 20m
1 stop
$394Delta
Fri, Aug 14 - Sun, Aug 23
American Airlines Logo
7:10 pm - 12:54 am
EYW
-
SFO
8h 44m
1 stop
American Airlines Logo
5:05 am - 4:18 pm
SFO
-
EYW
8h 13m
1 stop
$402American Airlines
Sat, Aug 15 - Sat, Aug 22
American Airlines Logo
1:01 pm - 8:06 pm
EYW
-
SFO
10h 05m
1 stop
American Airlines Logo
5:00 am - 6:48 pm
SFO
-
EYW
10h 48m
1 stop
$409American Airlines
Thu, Jul 2 - Sat, Jul 11
American Airlines Logo
1:01 pm - 8:06 pm
EYW
-
SFO
10h 05m
1 stop
American Airlines Logo
5:00 am - 4:11 pm
SFO
-
EYW
8h 11m
1 stop
$449American Airlines
Thu, Jul 2 - Sun, Jul 5
American Airlines Logo
2:21 pm - 9:10 pm
EYW
-
SFO
9h 49m
1 stop
American Airlines Logo
10:05 pm - 10:55 am
SFO
-
EYW
9h 50m
2 stops
$457American Airlines
Thu, Jul 2 - Sat, Jul 11
Multiple Airlines Logo
1:11 pm - 5:09 pm
EYW
-
SFO
30h 58m
2 stops
Multiple Airlines Logo
12:47 pm - 4:13 pm
SFO
-
EYW
24h 26m
1 stop
$486Multiple Airlines
Fri, Aug 14 - Sun, Aug 23
American Airlines Logo
7:10 pm - 12:54 am
EYW
-
SFO
8h 44m
1 stop
American Airlines Logo
11:30 pm - 1:05 pm
SFO
-
EYW
10h 35m
2 stops
$489American Airlines
Sat, Aug 15 - Sat, Aug 22
American Airlines Logo
1:47 pm - 10:28 pm
EYW
-
SFO
11h 41m
2 stops
American Airlines Logo
11:49 pm - 12:14 pm
SFO
-
EYW
9h 25m
1 stop
$562American Airlines
Thu, Jul 2 - Sun, Jul 5
American Airlines Logo
1:01 pm - 9:10 pm
EYW
-
SFO
11h 09m
2 stops
American Airlines Logo
11:29 pm - 1:14 pm
SFO
-
EYW
10h 45m
2 stops
$570American Airlines
Thu, Jul 2 - Sat, Jul 11
American Airlines Logo
10:15 am - 7:05 pm
EYW
-
SFO
11h 50m
2 stops
American Airlines Logo
11:30 pm - 4:11 pm
SFO
-
EYW
13h 41m
2 stops
$577American Airlines
Sat, Aug 15 - Sat, Aug 22

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United Airlines flights from Key West to San Francisco

Our best United Airlines deals on Key West to San Francisco flight tickets
United Airlines
Oct 27
EYW4:05 pmKey West
9h 40m
1 stop
SFO10:45 pmSan Francisco
Oct 31
SFO4:55 pmSan Francisco
20h 11m
1 stop
EYW4:06 pmKey West
$602
United Airlines
Oct 27
EYW4:05 pmKey West
11h 24m
1 stop
SFO12:29 amSan Francisco
Oct 31
SFO4:45 pmSan Francisco
20h 21m
2 stops
EYW4:06 pmKey West
$614
United Airlines
Oct 27
EYW4:05 pmKey West
9h 40m
1 stop
SFO10:45 pmSan Francisco
Oct 31
SFO2:25 pmSan Francisco
22h 41m
3 stops
EYW4:06 pmKey West
$619

American Airlines flights from Key West to San Francisco

Our best American Airlines deals on Key West to San Francisco flight tickets
American Airlines
Aug 15
EYW7:10 pmKey West
8h 44m
1 stop
SFO12:54 amSan Francisco
Aug 22
SFO5:05 amSan Francisco
8h 13m
1 stop
EYW4:18 pmKey West
$402
American Airlines
Jul 2
EYW1:01 pmKey West
10h 05m
1 stop
SFO8:06 pmSan Francisco
Jul 11
SFO5:00 amSan Francisco
10h 48m
1 stop
EYW6:48 pmKey West
$409
American Airlines
Jul 2
EYW1:01 pmKey West
10h 05m
1 stop
SFO8:06 pmSan Francisco
Jul 5
SFO5:00 amSan Francisco
8h 11m
1 stop
EYW4:11 pmKey West
$449

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 8/14

6:15 pm-11:58 pm

1 stop8h 43m

San Francisco

Sun 8/23

6:00 am-5:20 pm

1 stop8h 20m

$394
Quickest round-trip

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 8/15

7:10 pm-12:54 am

1 stop8h 44m

San Francisco

Sat 8/22

5:05 am-4:18 pm

1 stop8h 13m

$402

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 7/2

1:01 pm-8:06 pm

1 stop10h 05m

San Francisco

Sat 7/11

5:00 am-6:48 pm

1 stop10h 48m

$409

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 7/2

1:01 pm-8:06 pm

1 stop10h 05m

San Francisco

Sun 7/5

5:00 am-4:11 pm

1 stop8h 11m

$449

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 7/2

2:21 pm-9:10 pm

1 stop9h 49m

San Francisco

Sat 7/11

10:05 pm-10:55 am

2 stops9h 50m

$457

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 8/14

1:11 pm-5:09 pm

2 stops30h 58m

San Francisco

Sun 8/23

12:47 pm-4:13 pm

1 stop24h 26m

$486

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 8/15

7:10 pm-12:54 am

1 stop8h 44m

San Francisco

Sat 8/22

11:30 pm-1:05 pm

2 stops10h 35m

$489

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 7/2

1:47 pm-10:28 pm

2 stops11h 41m

San Francisco

Sun 7/5

11:49 pm-12:14 pm

1 stop9h 25m

$562

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 7/2

1:01 pm-9:10 pm

2 stops11h 09m

San Francisco

Sat 7/11

11:29 pm-1:14 pm

2 stops10h 45m

$570

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 8/15

10:15 am-7:05 pm

2 stops11h 50m

San Francisco

Sat 8/22

11:30 pm-4:11 pm

2 stops13h 41m

$577

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Key West to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Key West to San Francisco flight prices changed over time?

As of June 2026, prices for Key West to San Francisco flights are approximately 2% cheaper when compared to flights at the same time last year.

When to book flights from Key West to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Francisco (EYW to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Francisco

Fastest flight time

8h 16m

Direct flights

None
The fastest flight from Key West to San Francisco takes 8h 16m
There are no direct flights from Key West to San Francisco. There are no popular flight routes from Key West to San Francisco.
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Frequently asked questions about flying from Key West to San Francisco

  • How far is Key West to San Francisco by plane?

    A flight from Key West to San Francisco will travel around 2542.9 mi. 8h 16m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Key West Airport to San Francisco Airport?

    Prices for flights from Key West Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Key West Airport to San Francisco Airport?

  • How old do you have to be to fly from Key West Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Key West to San Francisco?

Best airlines flying from Key West to San Francisco

Compare and see reviews for airlines that fly from Key West to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $348Free CancellationRating
7.1
11,723 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Hayward
Bodega Bay
Roseville
Fremont
Walnut Creek
Santa Clara
South San Francisco
Berkeley
Vallejo
Sunnyvale
Salinas
Big Sur
Pacific Grove
Daly City
Burlingame
Calistoga

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Francisco?

Finding the right flight to San Francisco from Key West is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Key West to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to San Francisco?

momondo helps you find the best flight between Key West and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Key West are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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