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Cheap flights from Key West to San Francisco from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 9/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Key West to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:10 pm - 12:54 amEYW  Key West-SFO San Francisco
8h 44m1 stop Miami
American Airlines Logo
9:53 pm - 12:17 pmSFO  San Francisco-EYW Key West
11h 24m1 stop Charlotte Douglas
$301American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
7:10 pm - 12:54 amEYW  Key West-SFO San Francisco
8h 44m1 stop Miami
American Airlines Logo
6:12 am - 5:55 pmSFO  San Francisco-EYW Key West
8h 43m1 stop Charlotte Douglas
$301American Airlines
Sat, Sep 5 - Fri, Sep 11
Delta Logo
6:10 pm - 11:56 pmEYW  Key West-SFO San Francisco
8h 46m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:30 pm - 10:47 amSFO  San Francisco-EYW Key West
9h 17m1 stop Atlanta Hartsfield-Jackson
$301Delta
Tue, Oct 6 - Sat, Oct 10
Delta Logo
6:15 pm - 11:58 pmEYW  Key West-SFO San Francisco
8h 43m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:55 pm - 10:46 amSFO  San Francisco-EYW Key West
9h 51m1 stop Atlanta Hartsfield-Jackson
$340Delta
Mon, Aug 31 - Tue, Sep 15
American Airlines Logo
5:28 pm - 11:59 pmEYW  Key West-SFO San Francisco
9h 31m1 stop Miami
American Airlines Logo
6:47 am - 4:54 pmSFO  San Francisco-EYW Key West
7h 07m1 stop Dallas/Fort Worth
$340American Airlines
Sat, Oct 24 - Fri, Oct 30
Delta Logo
4:00 pm - 11:58 pmEYW  Key West-SFO San Francisco
10h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:00 pm - 10:46 amSFO  San Francisco-EYW Key West
9h 46m1 stop Atlanta Hartsfield-Jackson
$369Delta
Sat, Sep 5 - Fri, Sep 11
Delta Logo
6:15 pm - 11:58 pmEYW  Key West-SFO San Francisco
8h 43m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:55 pm - 10:46 amSFO  San Francisco-EYW Key West
9h 51m1 stop Atlanta Hartsfield-Jackson
$370Delta
Mon, Aug 31 - Tue, Sep 15
American Airlines Logo
11:40 am - 8:23 pmEYW  Key West-SFO San Francisco
11h 43m2 stops Miami Dallas/Fort Worth
American Airlines Logo
6:12 am - 5:55 pmSFO  San Francisco-EYW Key West
8h 43m1 stop Charlotte Douglas
$388American Airlines
Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
1:43 pm - 7:33 pmEYW  Key West-SFO San Francisco
8h 50m1 stop Miami
American Airlines Logo
10:03 pm - 1:03 pmSFO  San Francisco-EYW Key West
12h 00m2 stops Charlotte Douglas Miami
$388American Airlines
Tue, Oct 6 - Sat, Oct 10
American Airlines Logo
4:50 pm - 10:40 pmEYW  Key West-SFO San Francisco
8h 50m1 stop Charlotte Douglas
American Airlines Logo
11:03 pm - 1:11 pmSFO  San Francisco-EYW Key West
11h 08m1 stop Charlotte Douglas
$422American Airlines
Mon, Aug 31 - Tue, Sep 15

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American Airlines flights from Key West to San Francisco

Our best American Airlines deals on Key West to San Francisco flight tickets
American Airlines
Sep 5
EYW7:10 pmKey West
8h 44m
1 stop
SFO12:54 amSan Francisco
Sep 11
SFO6:12 amSan Francisco
8h 43m
1 stop
EYW5:55 pmKey West
$301
American Airlines
Sep 5
EYW11:40 amKey West
11h 43m
2 stops
SFO8:23 pmSan Francisco
Sep 11
SFO6:12 amSan Francisco
8h 43m
1 stop
EYW5:55 pmKey West
$388
American Airlines
Aug 31
EYW4:50 pmKey West
8h 50m
1 stop
SFO10:40 pmSan Francisco
Sep 15
SFO11:03 pmSan Francisco
11h 08m
1 stop
EYW1:11 pmKey West
$422

Delta flights from Key West to San Francisco

Our best Delta deals on Key West to San Francisco flight tickets
Delta
Aug 31
EYW6:15 pmKey West
8h 43m
1 stop
SFO11:58 pmSan Francisco
Sep 15
SFO9:55 pmSan Francisco
9h 51m
1 stop
EYW10:46 amKey West
$340
Delta
Sep 5
EYW4:00 pmKey West
10h 58m
1 stop
SFO11:58 pmSan Francisco
Sep 11
SFO10:00 pmSan Francisco
9h 46m
1 stop
EYW10:46 amKey West
$369
Delta
Aug 31
EYW6:15 pmKey West
8h 43m
1 stop
SFO11:58 pmSan Francisco
Sep 15
SFO9:55 pmSan Francisco
9h 51m
1 stop
EYW10:46 amKey West
$370

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 9, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Sat 9/5

7:10 pm-12:54 am

1 stop8h 44m

San Francisco

Sat 9/12

9:53 pm-12:17 pm

1 stop11h 24m

$301

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Sat 9/5

7:10 pm-12:54 am

1 stop8h 44m

San Francisco

Fri 9/11

6:12 am-5:55 pm

1 stop8h 43m

$301

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Tue 10/6

6:10 pm-11:56 pm

1 stop8h 46m

San Francisco

Sat 10/10

10:30 pm-10:47 am

1 stop9h 17m

$301

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Mon 8/31

6:15 pm-11:58 pm

1 stop8h 43m

San Francisco

Tue 9/15

9:55 pm-10:46 am

1 stop9h 51m

$340
Quickest round-trip

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Sat 10/24

5:28 pm-11:59 pm

1 stop9h 31m

San Francisco

Fri 10/30

6:47 am-4:54 pm

1 stop7h 07m

$340

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Sat 9/5

4:00 pm-11:58 pm

1 stop10h 58m

San Francisco

Fri 9/11

10:00 pm-10:46 am

1 stop9h 46m

$369

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Mon 8/31

6:15 pm-11:58 pm

1 stop8h 43m

San Francisco

Tue 9/15

9:55 pm-10:46 am

1 stop9h 51m

$370

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Sat 9/5

11:40 am-8:23 pm

2 stops11h 43m

San Francisco

Fri 9/11

6:12 am-5:55 pm

1 stop8h 43m

$388

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Tue 10/6

1:43 pm-7:33 pm

1 stop8h 50m

San Francisco

Sat 10/10

10:03 pm-1:03 pm

2 stops12h 00m

$388

Key WestSan Francisco

EYW Key West - SFO San Francisco

EYWSFO

Key West

Mon 8/31

4:50 pm-10:40 pm

1 stop8h 50m

San Francisco

Tue 9/15

11:03 pm-1:11 pm

1 stop11h 08m

$422

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Key West to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Key West to San Francisco flight prices changed over time?

As of August 2026, prices for Key West to San Francisco flights are approximately 57% cheaper when compared to flights at the same time last year.

When to book flights from Key West to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Francisco (EYW to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Francisco

Fastest flight time

8h 43m

Direct flights

None
The fastest flight from Key West to San Francisco takes 8h 43m
There are no direct flights from Key West to San Francisco. There are no popular flight routes from Key West to San Francisco.
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Frequently asked questions about flying from Key West to San Francisco

  • How far is Key West to San Francisco by plane?

    A flight from Key West to San Francisco will travel around 2542.9 mi. 8h 43m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Key West Airport to San Francisco Airport?

    Prices for flights from Key West Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Key West Airport to San Francisco Airport?

  • How old do you have to be to fly from Key West Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Key West to San Francisco?

Best airlines flying from Key West to San Francisco

Compare and see reviews for airlines that fly from Key West to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $348Free CancellationRating
7.1
11,893 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Berkeley
Bodega Bay
Hayward
Walnut Creek
Santa Clara
Vallejo
Roseville
Sonoma
Salinas
Sunnyvale
Milpitas
Daly City
Burlingame
Marina
Palo Alto

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Francisco?

Finding the right flight to San Francisco from Key West is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Key West to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to San Francisco?

momondo helps you find the best flight between Key West and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Key West are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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