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Cheap flights from Des Moines to Orlando from $224

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Orlando departing on 5/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Orlando

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:45 am - 11:28 am
DSM
-
MLB
4h 43m
1 stop
Delta Logo
6:00 am - 11:05 am
MLB
-
DSM
6h 05m
1 stop
$431Delta
Wed, Apr 29 - Wed, May 6
American Airlines Logo
6:00 am - 5:02 pm
DSM
-
MLB
10h 02m
2 stops
American Airlines Logo
7:07 pm - 12:10 am
MLB
-
DSM
6h 03m
1 stop
$447American Airlines
Tue, May 5 - Tue, May 26
American Airlines Logo
1:48 pm - 11:59 pm
DSM
-
MLB
9h 11m
2 stops
American Airlines Logo
7:07 pm - 12:10 am
MLB
-
DSM
6h 03m
1 stop
$452American Airlines
Tue, Jun 16 - Tue, Jun 23
Delta Logo
5:45 am - 11:28 am
DSM
-
MLB
4h 43m
1 stop
Delta Logo
6:00 am - 11:05 am
MLB
-
DSM
6h 05m
1 stop
$457Delta
Tue, Apr 21 - Sat, Apr 25
Delta Logo
6:10 am - 5:58 pm
DSM
-
MLB
10h 48m
2 stops
Delta Logo
6:00 am - 11:05 am
MLB
-
DSM
6h 05m
1 stop
$462Delta
Tue, Apr 21 - Tue, Apr 28
Delta Logo
2:15 pm - 10:46 pm
DSM
-
MLB
7h 31m
1 stop
Delta Logo
5:55 am - 10:14 am
MLB
-
DSM
5h 19m
1 stop
$467Delta
Tue, Jun 16 - Tue, Jun 23
Delta Logo
6:31 pm - 11:50 pm
DSM
-
MLB
4h 19m
1 stop
Delta Logo
6:00 am - 11:05 am
MLB
-
DSM
6h 05m
1 stop
$472Delta
Thu, Apr 23 - Tue, Apr 28
Delta Logo
10:34 am - 11:50 pm
DSM
-
MLB
12h 16m
2 stops
Delta Logo
6:00 am - 11:05 am
MLB
-
DSM
6h 05m
1 stop
$477Delta
Mon, Apr 20 - Sat, Apr 25
Delta Logo
6:31 pm - 11:50 pm
DSM
-
MLB
4h 19m
1 stop
Delta Logo
6:43 pm - 10:34 pm
MLB
-
DSM
4h 51m
1 stop
$487Delta
Fri, Apr 17 - Mon, Apr 20
Delta Logo
10:34 am - 11:50 pm
DSM
-
MLB
12h 16m
2 stops
Delta Logo
6:00 am - 11:05 am
MLB
-
DSM
6h 05m
1 stop
$492Delta
Mon, Apr 20 - Thu, Apr 30

American Airlines flights from Des Moines to Melbourne, Florida

Our best American Airlines deals on Des Moines to Melbourne, Florida flight tickets
American Airlines
May 5
DSM6:00 amDes Moines
10h 02m
2 stops
MLB5:02 pmMelbourne
May 26
MLB7:07 pmMelbourne
6h 03m
1 stop
DSM12:10 amDes Moines
$447
American Airlines
Jun 16
DSM1:48 pmDes Moines
9h 11m
2 stops
MLB11:59 pmMelbourne
Jun 23
MLB7:07 pmMelbourne
6h 03m
1 stop
DSM12:10 amDes Moines
$452
American Airlines
Apr 21
DSM11:09 amDes Moines
11h 13m
2 stops
MLB11:22 pmMelbourne
Apr 29
MLB5:35 pmMelbourne
5h 43m
1 stop
DSM10:18 pmDes Moines
$522

Delta flights from Des Moines to Melbourne, Florida

Our best Delta deals on Des Moines to Melbourne, Florida flight tickets
Delta
Apr 29
DSM5:45 amDes Moines
4h 43m
1 stop
MLB11:28 amMelbourne
May 6
MLB6:00 amMelbourne
6h 05m
1 stop
DSM11:05 amDes Moines
$431
Delta
Apr 21
DSM6:31 pmDes Moines
4h 19m
1 stop
MLB11:50 pmMelbourne
Apr 28
MLB6:00 amMelbourne
6h 05m
1 stop
DSM11:05 amDes Moines
$457
Delta
Apr 21
DSM6:10 amDes Moines
10h 48m
2 stops
MLB5:58 pmMelbourne
Apr 28
MLB6:00 amMelbourne
6h 05m
1 stop
DSM11:05 amDes Moines
$462

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Melbourne, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from Des Moines to Melbourne, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Wed 4/29

5:45 am-11:28 am

1 stop4h 43m

Melbourne

Wed 5/6

6:00 am-11:05 am

1 stop6h 05m

$431

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Tue 5/5

6:00 am-5:02 pm

2 stops10h 02m

Melbourne

Tue 5/26

7:07 pm-12:10 am

1 stop6h 03m

$447

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Tue 6/16

1:48 pm-11:59 pm

2 stops9h 11m

Melbourne

Tue 6/23

7:07 pm-12:10 am

1 stop6h 03m

$452

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Tue 4/21

5:45 am-11:28 am

1 stop4h 43m

Melbourne

Sat 4/25

6:00 am-11:05 am

1 stop6h 05m

$457

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Tue 4/21

6:10 am-5:58 pm

2 stops10h 48m

Melbourne

Tue 4/28

6:00 am-11:05 am

1 stop6h 05m

$462

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Tue 6/16

2:15 pm-10:46 pm

1 stop7h 31m

Melbourne

Tue 6/23

5:55 am-10:14 am

1 stop5h 19m

$467

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Thu 4/23

6:31 pm-11:50 pm

1 stop4h 19m

Melbourne

Tue 4/28

6:00 am-11:05 am

1 stop6h 05m

$472

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Mon 4/20

10:34 am-11:50 pm

2 stops12h 16m

Melbourne

Sat 4/25

6:00 am-11:05 am

1 stop6h 05m

$477
Quickest round-trip

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Fri 4/17

6:31 pm-11:50 pm

1 stop4h 19m

Melbourne

Mon 4/20

6:43 pm-10:34 pm

1 stop4h 51m

$487

Des MoinesMelbourne

DSM - MLB

DSMMLB

Des Moines

Mon 4/20

10:34 am-11:50 pm

2 stops12h 16m

Melbourne

Thu 4/30

6:00 am-11:05 am

1 stop6h 05m

$492

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Orlando from

How to get the cheapest flight ticket from Des Moines to Melbourne, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Melbourne?

American Airlines and Delta are the most popular carriers operating from Des Moines to Melbourne

What airlines fly to Melbourne, Florida?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Melbourne, Florida from Des Moines according to our data. American Airlines is the first choice among our users, with 38% of people opting to fly with this airline when traveling to Melbourne, Florida. Keep in mind that there are 6 different airlines that fly to Melbourne, Florida on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Melbourne, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Melbourne, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Melbourne, Florida (DSM to MLB) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Melbourne, Florida

Fastest flight time

4h 36m

Direct flights

None
The fastest flight from Des Moines to Melbourne, Florida takes 4h 36m
There are no direct flights from Des Moines to Melbourne, Florida. There are no popular flight routes from Des Moines to Melbourne, Florida.
Search flight deals

  • How far is Des Moines to Melbourne by plane?

    The straight-line distance from Des Moines to Melbourne is 1186.0 mi. Flights usually cover this in 4h 36m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Melbourne Airport?

    Prices for flights from Des Moines Airport to Melbourne Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Melbourne Airport?

  • How old do you have to be to fly from Des Moines Airport to Melbourne Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Melbourne Airport.

  • What documentation or ID do you need to fly to Melbourne Airport?

    The travel and health documents you'll need for your trip to Melbourne Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Melbourne Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Melbourne, Florida?

Best airlines flying from Des Moines to Melbourne, Florida

Compare and see reviews for airlines that fly from Des Moines to Melbourne, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $330Free CancellationRating
7.9
8,286 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Melbourne?

It is quick and easy to find Des Moines to Melbourne flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Melbourne that suits you.

Can I find flights from Des Moines to Melbourne with flexible booking policies on momondo?

Flights from Des Moines to Melbourne with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Melbourne?

momondo helps you find the best flight between Des Moines and Melbourne by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Melbourne right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Melbourne flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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