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Cheap flights from the Cayman Islands to San Francisco from $252

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from the Cayman Islands to San Francisco departing on 2/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from the Cayman Islands to San Francisco

Recent round-trip flight deals from the Cayman Islands to San Francisco

Enter your travel dates to find the best prices.
Southwest Logo
1:05 pm - 10:45 pm
GCM
-
SFO
11h 40m
2 stops
Southwest Logo
9:15 pm - 12:10 pm
SFO
-
GCM
12h 55m
2 stops
$452Southwest
Wed, Apr 8 - Sun, Apr 12
JetBlue Logo
2:25 pm - 11:16 pm
GCM
-
SFO
10h 51m
1 stop
JetBlue Logo
11:55 pm - 3:53 pm
SFO
-
GCM
13h 58m
1 stop
$541JetBlue
Tue, Mar 24 - Tue, Mar 31
Southwest Logo
12:40 pm - 11:45 pm
GCM
-
SFO
13h 05m
2 stops
Southwest Logo
4:00 pm - 11:25 am
SFO
-
GCM
17h 25m
2 stops
$558Southwest
Tue, Mar 24 - Tue, Mar 31
JetBlue Logo
2:05 pm - 11:09 am
GCM
-
SFO
23h 04m
1 stop
JetBlue Logo
8:00 am - 12:45 pm
SFO
-
GCM
26h 45m
1 stop
$560JetBlue
Thu, May 14 - Mon, May 18
American Airlines Logo
12:00 pm - 8:54 pm
GCM
-
SFO
10h 54m
1 stop
American Airlines Logo
10:28 pm - 11:33 am
SFO
-
GCM
11h 05m
1 stop
$721American Airlines
Wed, Apr 8 - Sun, Apr 12
United Airlines Logo
1:35 pm - 2:53 pm
GCM
-
SFO
27h 18m
1 stop
United Airlines Logo
12:45 am - 12:30 pm
SFO
-
GCM
9h 45m
1 stop
$722United Airlines
Wed, Apr 8 - Sat, Apr 11
Southwest Logo
12:40 pm - 11:45 pm
GCM
-
SFO
13h 05m
2 stops
Southwest Logo
7:05 pm - 11:45 am
SFO
-
GCM
14h 40m
2 stops
$725Southwest
Tue, Mar 24 - Thu, Mar 26
Multiple Airlines Logo
8:00 am - 10:52 pm
GCM
-
SFO
16h 52m
2 stops
Multiple Airlines Logo
1:45 pm - 12:44 pm
SFO
-
GCM
20h 59m
1 stop
$731Multiple Airlines
Wed, Apr 8 - Sun, Apr 12
Delta Logo
1:19 pm - 12:46 am
GCM
-
SFO
13h 27m
1 stop
Delta Logo
4:10 pm - 11:54 am
SFO
-
GCM
17h 44m
2 stops
$732Delta
Thu, May 14 - Mon, May 18
Multiple Airlines Logo
8:00 am - 10:52 pm
GCM
-
SFO
16h 52m
2 stops
Multiple Airlines Logo
1:45 pm - 12:44 pm
SFO
-
GCM
20h 59m
1 stop
$733Multiple Airlines
Wed, Apr 8 - Sun, Apr 12

Air Canada flights from Cayman Islands to San Francisco

Our best Air Canada deals on Cayman Islands to San Francisco flight tickets
Air Canada
Jun 13
GCM12:25 pmGeorge Town Owen Roberts Intl
24h 25m
1 stop
SFO10:50 amSan Francisco
Jun 17
SFO1:40 pmSan Francisco
19h 50m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
$745
Air Canada
Jun 13
GCM12:25 pmGeorge Town Owen Roberts Intl
25h 00m
2 stops
SFO11:25 amSan Francisco
Jun 17
SFO11:50 amSan Francisco
21h 40m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
$749
Air Canada
Jun 13
GCM12:25 pmGeorge Town Owen Roberts Intl
25h 00m
2 stops
SFO11:25 amSan Francisco
Jun 17
SFO11:10 amSan Francisco
22h 20m
2 stops
GCM11:30 amGeorge Town Owen Roberts Intl
$752

JetBlue flights from Cayman Islands to San Francisco

Our best JetBlue deals on Cayman Islands to San Francisco flight tickets
JetBlue
Mar 24
GCM2:25 pmGeorge Town Owen Roberts Intl
10h 51m
1 stop
SFO11:16 pmSan Francisco
Mar 31
SFO11:55 pmSan Francisco
13h 58m
1 stop
GCM3:53 pmGeorge Town Owen Roberts Intl
$541
JetBlue
May 14
GCM2:05 pmGeorge Town Owen Roberts Intl
23h 04m
1 stop
SFO11:09 amSan Francisco
May 18
SFO8:00 amSan Francisco
26h 45m
1 stop
GCM12:45 pmGeorge Town Owen Roberts Intl
$560

momondo Fare Finder

 
Customize your flight search to find flights from Cayman Islands to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from the Cayman Islands to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 4/8

1:05 pm-10:45 pm

2 stops11h 40m

San Francisco

Sun 4/12

9:15 pm-12:10 pm

2 stops12h 55m

$452

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 3/24

2:25 pm-11:16 pm

1 stop10h 51m

San Francisco

Tue 3/31

11:55 pm-3:53 pm

1 stop13h 58m

$541

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 3/24

12:40 pm-11:45 pm

2 stops13h 05m

San Francisco

Tue 3/31

4:00 pm-11:25 am

2 stops17h 25m

$558

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 5/14

2:05 pm-11:09 am

1 stop23h 04m

San Francisco

Mon 5/18

8:00 am-12:45 pm

1 stop26h 45m

$560

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 4/8

12:00 pm-8:54 pm

1 stop10h 54m

San Francisco

Sun 4/12

10:28 pm-11:33 am

1 stop11h 05m

$721

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 4/8

1:35 pm-2:53 pm

1 stop27h 18m

San Francisco

Sat 4/11

12:45 am-12:30 pm

1 stop9h 45m

$722

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 3/24

12:40 pm-11:45 pm

2 stops13h 05m

San Francisco

Thu 3/26

7:05 pm-11:45 am

2 stops14h 40m

$725

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 4/8

8:00 am-10:52 pm

2 stops16h 52m

San Francisco

Sun 4/12

1:45 pm-12:44 pm

1 stop20h 59m

$731

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 5/14

1:19 pm-12:46 am

1 stop13h 27m

San Francisco

Mon 5/18

4:10 pm-11:54 am

2 stops17h 44m

$732

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 4/8

8:00 am-10:52 pm

2 stops16h 52m

San Francisco

Sun 4/12

1:45 pm-12:44 pm

1 stop20h 59m

$733

Flights are sorted by cheapest round-trip flights first.

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See travel insights to San Francisco from

How to get the cheapest flight ticket from Cayman Islands to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Cayman Islands to San Francisco flights?

You could potentially save up to 17% on your flight if you consider stops on a Cayman Islands to San Francisco flight.

Cheap Cayman Islands to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cayman Islands to San Francisco

Fastest flight time

10h 51m

Direct flights

None
The fastest flight from Cayman Islands to San Francisco takes 10h 51m
There are no direct flights from Cayman Islands to San Francisco. There are no popular flight routes from Cayman Islands to San Francisco.
Search flight deals

  • When did momondo last update prices for flights from Cayman Islands to San Francisco Airport?

    Prices for flights from Cayman Islands to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Cayman Islands to San Francisco Airport?

  • How old do you have to be to fly from Cayman Islands to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Cayman Islands to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Cayman Islands to San Francisco

Compare and see reviews for airlines that fly from Cayman Islands to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $709Free CancellationRating
7.2
11,262 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Walnut Creek
Santa Clara
Calistoga
Berkeley
Big Sur
Fremont
Daly City
Half Moon Bay
Salinas
Vallejo
Sunnyvale
Milpitas
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Cayman Islands to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Cayman Islands.

Can I find flights from Cayman Islands to San Francisco with flexible booking policies on momondo?

Flights from Cayman Islands to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Cayman Islands to San Francisco?

momondo helps you find the best flight between Cayman Islands and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Cayman Islands to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Cayman Islands and alert you when they change.

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