Cheap flights from the Cayman Islands to San Francisco from $250

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from the Cayman Islands to San Francisco departing on 1/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from the Cayman Islands to San Francisco

Recent round-trip flight deals from the Cayman Islands to San Francisco

Enter your travel dates to find the best prices.
JetBlue Logo
2:55 pm - 11:55 pm
GCM
-
SFO
11h 00m1 stop
JetBlue Logo
9:00 pm - 1:55 pm
SFO
-
GCM
14h 55m1 stop
$411JetBlue
Thu, May 21 - Mon, May 25
JetBlue Logo
2:55 pm - 11:55 pm
GCM
-
SFO
11h 00m1 stop
JetBlue Logo
9:30 pm - 1:55 pm
SFO
-
GCM
14h 25m2 stops
$499JetBlue
Thu, May 21 - Mon, May 25
Southwest Logo
1:05 pm - 11:35 pm
GCM
-
SFO
12h 30m2 stops
Southwest Logo
9:15 pm - 12:10 pm
SFO
-
GCM
12h 55m2 stops
$565Southwest
Wed, May 20 - Mon, May 25
Multiple Airlines Logo
8:00 am - 11:59 pm
GCM
-
SFO
17h 59m1 stop
Multiple Airlines Logo
9:00 pm - 1:55 pm
SFO
-
GCM
14h 55m1 stop
$584Multiple Airlines
Wed, May 20 - Mon, May 25
Multiple Airlines Logo
12:25 pm - 10:20 am
GCM
-
SFO
23h 55m2 stops
Multiple Airlines Logo
9:30 pm - 1:55 pm
SFO
-
GCM
14h 25m2 stops
$630Multiple Airlines
Thu, May 21 - Mon, May 25
Multiple Airlines Logo
8:00 am - 9:00 pm
GCM
-
SFO
15h 00m1 stop
Multiple Airlines Logo
9:30 pm - 1:55 pm
SFO
-
GCM
14h 25m2 stops
$658Multiple Airlines
Wed, May 20 - Mon, May 25
JetBlue Logo
2:55 pm - 11:55 pm
GCM
-
SFO
11h 00m1 stop
JetBlue Logo
9:00 pm - 1:55 pm
SFO
-
GCM
14h 55m1 stop
$710JetBlue
Thu, May 21 - Mon, May 25
United Airlines Logo
1:45 pm - 12:34 am
GCM
-
SFO
12h 49m1 stop
United Airlines Logo
12:45 am - 12:30 pm
SFO
-
GCM
9h 45m1 stop
$775United Airlines
Sat, Jun 13 - Tue, Jun 16
Air Canada Logo
12:25 pm - 11:17 am
GCM
-
SFO
24h 52m2 stops
Air Canada Logo
4:30 pm - 11:30 am
SFO
-
GCM
17h 00m1 stop
$794Air Canada
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
12:25 pm - 11:17 am
GCM
-
SFO
24h 52m2 stops
Air Canada Logo
4:35 pm - 11:30 am
SFO
-
GCM
16h 55m2 stops
$824Air Canada
Sat, Jun 13 - Wed, Jun 17

JetBlue flights from Cayman Islands to San Francisco

Our best JetBlue deals on Cayman Islands to San Francisco flight tickets
JetBlue
May 21
GCM2:55 pmGeorge Town Owen Roberts Intl
11h 00m
1 stop
SFO11:55 pmSan Francisco
May 25
SFO9:00 pmSan Francisco
14h 55m
1 stop
GCM1:55 pmGeorge Town Owen Roberts Intl
JetBlue
May 21
GCM2:55 pmGeorge Town Owen Roberts Intl
11h 00m
1 stop
SFO11:55 pmSan Francisco
May 25
SFO9:30 pmSan Francisco
14h 25m
2 stops
GCM1:55 pmGeorge Town Owen Roberts Intl
JetBlue
May 21
GCM2:55 pmGeorge Town Owen Roberts Intl
11h 00m
1 stop
SFO11:55 pmSan Francisco
May 25
SFO9:00 pmSan Francisco
14h 55m
1 stop
GCM1:55 pmGeorge Town Owen Roberts Intl

Air Canada flights from Cayman Islands to San Francisco

Our best Air Canada deals on Cayman Islands to San Francisco flight tickets
Air Canada
Jun 13
GCM12:25 pmGeorge Town Owen Roberts Intl
24h 52m
2 stops
SFO11:17 amSan Francisco
Jun 17
SFO4:30 pmSan Francisco
17h 00m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
Air Canada
Jun 13
GCM12:25 pmGeorge Town Owen Roberts Intl
24h 52m
2 stops
SFO11:17 amSan Francisco
Jun 17
SFO4:35 pmSan Francisco
16h 55m
2 stops
GCM11:30 amGeorge Town Owen Roberts Intl

momondo Fare Finder

 
Customize your flight search to find flights from Cayman Islands to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from the Cayman Islands to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 5/21

2:55 pm-11:55 pm

1 stop11h 00m

San Francisco

Mon 5/25

9:00 pm-1:55 pm

1 stop14h 55m

$411

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 5/21

2:55 pm-11:55 pm

1 stop11h 00m

San Francisco

Mon 5/25

9:30 pm-1:55 pm

2 stops14h 25m

$499

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 5/20

1:05 pm-11:35 pm

2 stops12h 30m

San Francisco

Mon 5/25

9:15 pm-12:10 pm

2 stops12h 55m

$565

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 5/20

8:00 am-11:59 pm

1 stop17h 59m

San Francisco

Mon 5/25

9:00 pm-1:55 pm

1 stop14h 55m

$584

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 5/21

12:25 pm-10:20 am

2 stops23h 55m

San Francisco

Mon 5/25

9:30 pm-1:55 pm

2 stops14h 25m

$630

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 5/20

8:00 am-9:00 pm

1 stop15h 00m

San Francisco

Mon 5/25

9:30 pm-1:55 pm

2 stops14h 25m

$658

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 5/21

2:55 pm-11:55 pm

1 stop11h 00m

San Francisco

Mon 5/25

9:00 pm-1:55 pm

1 stop14h 55m

$710

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 6/13

1:45 pm-12:34 am

1 stop12h 49m

San Francisco

Tue 6/16

12:45 am-12:30 pm

1 stop9h 45m

$775

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 6/13

12:25 pm-11:17 am

2 stops24h 52m

San Francisco

Wed 6/17

4:30 pm-11:30 am

1 stop17h 00m

$794

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 6/13

12:25 pm-11:17 am

2 stops24h 52m

San Francisco

Wed 6/17

4:35 pm-11:30 am

2 stops16h 55m

$824

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Cayman Islands to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Cayman Islands to San Francisco is on a Monday when prices can be found for as low as $661. The most expensive day to fly to San Francisco is Saturday, with ticket prices averaging around $870.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Cayman Islands to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $678. Flights in the afternoon are often more expensive with an average ticket price of $758.

Can stopping save me money on Cayman Islands to San Francisco flights?

You could potentially save up to 1% on your flight if you consider stops on a Cayman Islands to San Francisco flight.

Cheap Cayman Islands to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cayman Islands to San Francisco

Fastest flight time

11h 00m

Direct flights

None
The fastest flight from Cayman Islands to San Francisco takes 11h 00m
There are no direct flights from Cayman Islands to San Francisco. There are no popular flight routes from Cayman Islands to San Francisco.
  • When did momondo last update prices for flights from Cayman Islands to San Francisco Airport?

    Prices for flights from Cayman Islands to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Cayman Islands to San Francisco Airport?

  • How old do you have to be to fly from Cayman Islands to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Cayman Islands to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Cayman Islands to San Francisco

Compare and see reviews for airlines that fly from Cayman Islands to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $709Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Berkeley
Santa Clara
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Salinas
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Cayman Islands to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Cayman Islands.

Can I find flights from Cayman Islands to San Francisco with flexible booking policies on momondo?

Flights from Cayman Islands to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Cayman Islands to San Francisco?

momondo helps you find the best flight between Cayman Islands and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Cayman Islands to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Cayman Islands and alert you when they change.

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1 adult
Thu 1/22
Thu 1/29

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