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Cheap flights from the Cayman Islands to San Francisco from $338

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from the Cayman Islands to San Francisco departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from the Cayman Islands to San Francisco

Recent round-trip flight deals from the Cayman Islands to San Francisco

Enter your travel dates to find the best prices.
Southwest Logo
11:25 am - 10:25 pm
GCM
-
SFO
13h 00m
2 stops
Southwest Logo
5:20 pm - 11:55 am
SFO
-
GCM
16h 35m
2 stops
$683Southwest
Sat, Jul 11 - Wed, Jul 15
Southwest Logo
12:50 pm - 12:50 am
GCM
-
SFO
14h 00m
2 stops
Southwest Logo
9:10 pm - 11:55 am
SFO
-
GCM
12h 45m
2 stops
$703Southwest
Fri, Jun 12 - Mon, Jun 15
Southwest Logo
12:50 pm - 12:30 am
GCM
-
SFO
13h 40m
2 stops
Southwest Logo
9:10 pm - 11:55 am
SFO
-
GCM
12h 45m
2 stops
$733Southwest
Mon, Jul 6 - Sun, Jul 12
American Airlines Logo
5:10 pm - 10:24 am
GCM
-
SFO
19h 14m
1 stop
American Airlines Logo
11:49 pm - 11:00 am
SFO
-
GCM
9h 11m
1 stop
$781American Airlines
Mon, Jul 6 - Sun, Jul 12
American Airlines Logo
5:10 pm - 10:24 am
GCM
-
SFO
19h 14m
1 stop
American Airlines Logo
10:05 pm - 11:00 am
SFO
-
GCM
10h 55m
2 stops
$786American Airlines
Mon, Jul 6 - Sun, Jul 12
American Airlines Logo
4:07 pm - 11:33 pm
GCM
-
SFO
9h 26m
1 stop
American Airlines Logo
6:54 pm - 11:00 am
SFO
-
GCM
14h 06m
2 stops
$791American Airlines
Sat, Jul 11 - Wed, Jul 15
United Airlines Logo
1:35 pm - 6:30 pm
GCM
-
SFO
30h 55m
1 stop
United Airlines Logo
12:45 am - 12:30 pm
SFO
-
GCM
9h 45m
1 stop
$817United Airlines
Fri, Jun 12 - Sun, Jun 14
American Airlines Logo
5:11 pm - 10:53 am
GCM
-
SFO
19h 42m
1 stop
American Airlines Logo
6:56 pm - 11:01 am
SFO
-
GCM
14h 05m
2 stops
$831American Airlines
Fri, Jun 12 - Mon, Jun 15
Multiple Airlines Logo
7:00 am - 10:50 am
GCM
-
SFO
29h 50m
3 stops
Multiple Airlines Logo
12:50 pm - 12:45 pm
SFO
-
GCM
21h 55m
2 stops
$1,122Multiple Airlines
Fri, Jun 12 - Mon, Jun 15
Multiple Airlines Logo
7:00 am - 12:20 pm
GCM
-
SFO
31h 20m
2 stops
Multiple Airlines Logo
6:00 am - 11:25 am
SFO
-
GCM
27h 25m
3 stops
$1,223Multiple Airlines
Mon, Jul 6 - Sun, Jul 12

Southwest flights from Cayman Islands to San Francisco

Our best Southwest deals on Cayman Islands to San Francisco flight tickets
Southwest
Jul 11
GCM11:25 amGeorge Town Owen Roberts Intl
13h 00m
2 stops
SFO10:25 pmSan Francisco
Jul 15
SFO5:20 pmSan Francisco
16h 35m
2 stops
GCM11:55 amGeorge Town Owen Roberts Intl
$683
Southwest
Jun 12
GCM12:50 pmGeorge Town Owen Roberts Intl
14h 00m
2 stops
SFO12:50 amSan Francisco
Jun 15
SFO9:10 pmSan Francisco
12h 45m
2 stops
GCM11:55 amGeorge Town Owen Roberts Intl
$703
Southwest
Jul 6
GCM12:50 pmGeorge Town Owen Roberts Intl
13h 40m
2 stops
SFO12:30 amSan Francisco
Jul 12
SFO9:10 pmSan Francisco
12h 45m
2 stops
GCM11:55 amGeorge Town Owen Roberts Intl
$733

American Airlines flights from Cayman Islands to San Francisco

Our best American Airlines deals on Cayman Islands to San Francisco flight tickets
American Airlines
Jul 6
GCM5:10 pmGeorge Town Owen Roberts Intl
19h 14m
1 stop
SFO10:24 amSan Francisco
Jul 12
SFO11:49 pmSan Francisco
9h 11m
1 stop
GCM11:00 amGeorge Town Owen Roberts Intl
$781
American Airlines
Jul 6
GCM5:10 pmGeorge Town Owen Roberts Intl
19h 14m
1 stop
SFO10:24 amSan Francisco
Jul 12
SFO10:05 pmSan Francisco
10h 55m
2 stops
GCM11:00 amGeorge Town Owen Roberts Intl
$786
American Airlines
Jul 11
GCM4:07 pmGeorge Town Owen Roberts Intl
9h 26m
1 stop
SFO11:33 pmSan Francisco
Jul 15
SFO6:54 pmSan Francisco
14h 06m
2 stops
GCM11:00 amGeorge Town Owen Roberts Intl
$791

momondo Fare Finder

 
Customize your flight search to find flights from Cayman Islands to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from the Cayman Islands to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 7/11

11:25 am-10:25 pm

2 stops13h 00m

San Francisco

Wed 7/15

5:20 pm-11:55 am

2 stops16h 35m

$683

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 6/12

12:50 pm-12:50 am

2 stops14h 00m

San Francisco

Mon 6/15

9:10 pm-11:55 am

2 stops12h 45m

$703

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 7/6

12:50 pm-12:30 am

2 stops13h 40m

San Francisco

Sun 7/12

9:10 pm-11:55 am

2 stops12h 45m

$733

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 7/6

5:10 pm-10:24 am

1 stop19h 14m

San Francisco

Sun 7/12

11:49 pm-11:00 am

1 stop9h 11m

$781

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 7/6

5:10 pm-10:24 am

1 stop19h 14m

San Francisco

Sun 7/12

10:05 pm-11:00 am

2 stops10h 55m

$786
Quickest round-trip

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 7/11

4:07 pm-11:33 pm

1 stop9h 26m

San Francisco

Wed 7/15

6:54 pm-11:00 am

2 stops14h 06m

$791

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 6/12

1:35 pm-6:30 pm

1 stop30h 55m

San Francisco

Sun 6/14

12:45 am-12:30 pm

1 stop9h 45m

$817

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 6/12

5:11 pm-10:53 am

1 stop19h 42m

San Francisco

Mon 6/15

6:56 pm-11:01 am

2 stops14h 05m

$831

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 6/12

7:00 am-10:50 am

3 stops29h 50m

San Francisco

Mon 6/15

12:50 pm-12:45 pm

2 stops21h 55m

$1,122

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 7/6

7:00 am-12:20 pm

2 stops31h 20m

San Francisco

Sun 7/12

6:00 am-11:25 am

3 stops27h 25m

$1,223

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Cayman Islands to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Cayman Islands to San Francisco flights?

You could potentially save up to 56% on your flight if you consider stops on a Cayman Islands to San Francisco flight.

Cheap Cayman Islands to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cayman Islands to San Francisco

Fastest flight time

13h 00m

Direct flights

None
The fastest flight from Cayman Islands to San Francisco takes 13h 00m
There are no direct flights from Cayman Islands to San Francisco. There are no popular flight routes from Cayman Islands to San Francisco.
Search flight deals

Frequently asked questions about flying from the Cayman Islands to San Francisco

  • When did momondo last update prices for flights from Cayman Islands to San Francisco Airport?

    Prices for flights from Cayman Islands to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Cayman Islands to San Francisco Airport?

  • How old do you have to be to fly from Cayman Islands to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Cayman Islands to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Cayman Islands to San Francisco

Compare and see reviews for airlines that fly from Cayman Islands to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $709Free CancellationRating
7.1
11,648 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Walnut Creek
Bodega Bay
Hayward
Roseville
Santa Clara
Berkeley
Fremont
Vallejo
Big Sur
Sunnyvale
Calistoga
South San Francisco
Salinas
Daly City
Milpitas
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Cayman Islands to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Cayman Islands.

Can I find flights from Cayman Islands to San Francisco with flexible booking policies on momondo?

Flights from Cayman Islands to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Cayman Islands to San Francisco?

momondo helps you find the best flight between Cayman Islands and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Cayman Islands to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Cayman Islands and alert you when they change.

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