Cheap flights from the Cayman Islands to San Francisco from $323

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from the Cayman Islands to San Francisco departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from the Cayman Islands to San Francisco

Recent round-trip flight deals from the Cayman Islands to San Francisco

JetBlue Logo
12:54 pm - 11:42 pmGCM-SFO
13h 48m1 stop
JetBlue Logo
3:20 pm - 11:54 amSFO-GCM
17h 34m1 stop
$458JetBlue
Find Deal
Sat, Nov 8 - Fri, Nov 14
JetBlue Logo
12:54 pm - 11:42 pmGCM-SFO
13h 48m1 stop
JetBlue Logo
9:00 pm - 2:31 pmSFO-GCM
14h 31m1 stop
$462JetBlue
Find Deal
Sat, Nov 8 - Sun, Nov 16
Southwest Logo
1:30 pm - 9:50 pmGCM-SFO
11h 20m2 stops
Southwest Logo
7:55 pm - 12:35 pmSFO-GCM
13h 40m2 stops
$542Southwest
Find Deal
Tue, Nov 11 - Sun, Nov 16
Air Canada Logo
1:30 pm - 10:54 amGCM-SFO
24h 24m1 stop
Air Canada Logo
8:30 am - 12:25 pmSFO-GCM
24h 55m1 stop
$603Air Canada
Find Deal
Thu, Nov 13 - Sat, Nov 15
 Logo
2:50 pm - 9:35 pmGCM-SFO
33h 45m2 stops
 Logo
10:43 pm - 2:00 pmSFO-GCM
12h 17m1 stop
Thu, Nov 13 - Sun, Nov 16
 Logo
7:00 am - 4:55 pmGCM-SFO
12h 55m2 stops
 Logo
1:35 pm - 2:00 pmSFO-GCM
21h 25m1 stop
Mon, Nov 10 - Sat, Nov 15
 Logo
4:45 pm - 4:55 pmGCM-SFO
27h 10m2 stops
 Logo
10:43 pm - 2:00 pmSFO-GCM
12h 17m1 stop
Sun, Nov 9 - Sun, Nov 16
Air Canada Logo
1:30 pm - 10:54 amGCM-SFO
24h 24m1 stop
Air Canada Logo
8:30 am - 12:25 pmSFO-GCM
24h 55m1 stop
$620Air Canada
Find Deal
Fri, Nov 14 - Wed, Nov 19
United Airlines Logo
5:45 pm - 12:12 amGCM-SFO
9h 27m1 stop
United Airlines Logo
12:43 am - 4:30 pmSFO-GCM
12h 47m1 stop
$701United Airlines
Find Deal
Mon, Nov 10 - Sat, Nov 15
United Airlines Logo
5:45 pm - 9:45 amGCM-SFO
19h 00m1 stop
United Airlines Logo
5:15 am - 4:30 pmSFO-GCM
8h 15m1 stop
$721United Airlines
Find Deal
Mon, Nov 10 - Mon, Nov 17

JetBlue flights from Cayman Islands to San Francisco

Our best JetBlue deals on Cayman Islands to San Francisco flight tickets
JetBlue
Nov 8
GCM12:54 pmGeorge Town Owen Roberts Intl
13h 48m
1 stop
SFO11:42 pmSan Francisco
Nov 14
SFO3:20 pmSan Francisco
17h 34m
1 stop
GCM11:54 amGeorge Town Owen Roberts Intl
JetBlue
Nov 8
GCM12:54 pmGeorge Town Owen Roberts Intl
13h 48m
1 stop
SFO11:42 pmSan Francisco
Nov 16
SFO9:00 pmSan Francisco
14h 31m
1 stop
GCM2:31 pmGeorge Town Owen Roberts Intl

Air Canada flights from Cayman Islands to San Francisco

Our best Air Canada deals on Cayman Islands to San Francisco flight tickets
Air Canada
Nov 13
GCM1:30 pmGeorge Town Owen Roberts Intl
24h 24m
1 stop
SFO10:54 amSan Francisco
Nov 15
SFO8:30 amSan Francisco
24h 55m
1 stop
GCM12:25 pmGeorge Town Owen Roberts Intl
Air Canada
Nov 14
GCM1:30 pmGeorge Town Owen Roberts Intl
24h 24m
1 stop
SFO10:54 amSan Francisco
Nov 19
SFO8:30 amSan Francisco
24h 55m
1 stop
GCM12:25 pmGeorge Town Owen Roberts Intl
Air Canada
Nov 13
GCM1:30 pmGeorge Town Owen Roberts Intl
27h 00m
1 stop
SFO1:30 pmSan Francisco
Nov 19
SFO8:30 amSan Francisco
24h 55m
1 stop
GCM12:25 pmGeorge Town Owen Roberts Intl

momondo Fare Finder

 
Customize your flight search to find flights from Cayman Islands to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from the Cayman Islands to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 11/8

12:54 pm-11:42 pm

1 stop13h 48m

San Francisco

Fri 11/14

3:20 pm-11:54 am

1 stop17h 34m

$458

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 11/8

12:54 pm-11:42 pm

1 stop13h 48m

San Francisco

Sun 11/16

9:00 pm-2:31 pm

1 stop14h 31m

$462

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 11/11

1:30 pm-9:50 pm

2 stops11h 20m

San Francisco

Sun 11/16

7:55 pm-12:35 pm

2 stops13h 40m

$542

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 11/13

1:30 pm-10:54 am

1 stop24h 24m

San Francisco

Sat 11/15

8:30 am-12:25 pm

1 stop24h 55m

$603

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Thu 11/13

2:50 pm-9:35 pm

2 stops33h 45m

San Francisco

Sun 11/16

10:43 pm-2:00 pm

1 stop12h 17m

$616

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 11/10

7:00 am-4:55 pm

2 stops12h 55m

San Francisco

Sat 11/15

1:35 pm-2:00 pm

1 stop21h 25m

$618

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sun 11/9

4:45 pm-4:55 pm

2 stops27h 10m

San Francisco

Sun 11/16

10:43 pm-2:00 pm

1 stop12h 17m

$619

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 11/14

1:30 pm-10:54 am

1 stop24h 24m

San Francisco

Wed 11/19

8:30 am-12:25 pm

1 stop24h 55m

$620

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 11/10

5:45 pm-12:12 am

1 stop9h 27m

San Francisco

Sat 11/15

12:43 am-4:30 pm

1 stop12h 47m

$701

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 11/10

5:45 pm-9:45 am

1 stop19h 00m

San Francisco

Mon 11/17

5:15 am-4:30 pm

1 stop8h 15m

$721

Flights are sorted by cheapest round-trip flights first.

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See travel insights to San Francisco from

How to get the cheapest flight ticket from Cayman Islands to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $454.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Cayman Islands to San Francisco is on a Monday when prices can be found for as low as $661. The most expensive day to fly to San Francisco is Saturday, with ticket prices averaging around $870.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Cayman Islands to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $678. Flights in the afternoon are often more expensive with an average ticket price of $758.

Can stopping save me money on Cayman Islands to San Francisco flights?

You could potentially save up to 1% on your flight if you consider stops on a Cayman Islands to San Francisco flight.

Cheap Cayman Islands to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cayman Islands to San Francisco

Direct flights

None
There are no direct flights from Cayman Islands to San Francisco. There are no popular flight routes from Cayman Islands to San Francisco.
  • When did momondo last update prices for flights from Cayman Islands to San Francisco Airport?

    Prices for flights from Cayman Islands to San Francisco Airport refresh daily.

  • How old do you have to be to fly from Cayman Islands to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Cayman Islands to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Calistoga
Hayward
Bodega Bay
Roseville
Santa Clara
Big Sur
Daly City
Fremont
Berkeley
Walnut Creek
Half Moon Bay
Vallejo
South San Francisco
Redwood City
Pacific Grove
Pacifica

Why use momondo?

Why should I use momondo to find a flight deal from Cayman Islands to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Cayman Islands.

Can I find flights from Cayman Islands to San Francisco with flexible booking policies on momondo?

Flights from Cayman Islands to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Cayman Islands to San Francisco?

momondo helps you find the best flight between Cayman Islands and San Francisco by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Cayman Islands to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Cayman Islands and alert you when they change.

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1 adult
Tue 9/9
Tue 9/16

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