Cheap flights from the United States to Panama City from $110
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from the United States to Panama City departing on 10/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Fly from
Fly to
Route
Depart
Return
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Mon 11/9
6:25 pm-10:52 pm
1 stop5h 27m
Panama City NW Florida Beaches
Sat 11/21
6:49 pm-12:37 am
1 stop4h 48m
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 10/27
6:10 am-11:38 am
1 stop6h 28m
Panama City NW Florida Beaches
Tue 11/3
5:41 pm-11:28 pm
1 stop4h 47m
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 12/1
6:00 am-9:30 am
1 stop4h 30m
Panama City NW Florida Beaches
Mon 12/7
4:10 pm-9:20 pm
1 stop4h 10m
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Mon 2/15
8:42 am-1:22 pm
1 stop5h 40m
Panama City NW Florida Beaches
Tue 3/2
2:10 pm-10:26 pm
1 stop7h 16m
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Thu 2/25
8:42 am-1:22 pm
1 stop5h 40m
Panama City NW Florida Beaches
Wed 3/3
2:10 pm-10:26 pm
1 stop7h 16m
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 2/9
6:00 am-11:32 am
1 stop6h 32m
Panama City NW Florida Beaches
Wed 2/24
11:09 am-8:06 pm
1 stop7h 57m
ChicagoPanama City
ORD Chicago O'Hare Intl - ECP Panama City NW Florida Beaches
ORDECP
Chicago O'Hare Intl
Sat 10/31
5:27 am-11:34 am
1 stop6h 07m
Panama City NW Florida Beaches
Wed 11/4
5:34 pm-11:57 pm
1 stop6h 23m
ChicagoPanama City
ORD Chicago O'Hare Intl - ECP Panama City NW Florida Beaches
ORDECP
Chicago O'Hare Intl
Thu 10/29
1:23 pm-8:03 pm
1 stop6h 40m
Panama City NW Florida Beaches
Sat 11/7
2:45 pm-8:38 pm
1 stop5h 53m
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 2/9
6:15 am-9:45 am
1 stop4h 30m
Panama City NW Florida Beaches
Wed 2/24
7:55 am-3:55 pm
2 stops7h 00m
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 12/1
6:55 am-3:35 pm
2 stops9h 40m
Panama City NW Florida Beaches
Mon 12/7
4:10 pm-9:20 pm
1 stop4h 10m
See travel insights to Panama City from
How to get the cheapest flight ticket from United States to Panama City, Florida
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest month to fly to Panama City, Florida?
The cheapest month to fly to Panama City, Florida from United States is in January. Flight prices, which tend to average around $384, are often lower during this time because this is during the off-season. The month of February is another great option to travel to Panama City, Florida, with average flight prices from United States averaging around $391.
What is the cheapest day to depart on your flight to Panama City, Florida?
Our data shows that Wednesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $389. On the other hand, Sunday is the most expensive day to depart from United States because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $623.
What is the cheapest United States to Panama City NW Florida Beaches flight route?
Fly from Atlanta Hartsfield-Jackson to Panama City NW Florida Beaches for the best United States - Panama City NW Florida Beaches flight prices
What cabin class options are available on United States to Panama City, Florida flights?
There are 4 cabin classes available to choose from on United States to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.
What is the cheapest airline that flies from United States to Panama City NW Florida Beaches?
Southwest, United Airlines, and Delta are the most popular carriers operating from United States to Panama City NW Florida Beaches
What airlines fly to Panama City, Florida?
American Airlines, Delta and Southwest are the top three most popular airlines that fly to Panama City, Florida from United States according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 10 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.
How many flights depart from United States to Panama City, Florida on average per day?
As of October 2026, there are 9 flights per day flying from United States to Panama City, Florida. The most common time of day flights depart is 11:00PM, with 45% of flights taking off in the evening.
How many flights depart from United States to Panama City, Florida on average per week?
As of October 2026, there are 66 flights per week flying from United States to Panama City, Florida. The most common day of the week flights depart is Wed, with 18% of flights taking off on this day.
Cheap United States to Panama City, Florida flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from United States to Panama City, Florida
Frequently asked questions about flying from the United States to Panama City, Florida
When did momondo last update prices for flights from United States to Panama City NW Florida Beaches Airport?
Prices for flights from United States to Panama City NW Florida Beaches Airport are updated daily.
How many operators does momondo search for flights from United States to Panama City NW Florida Beaches Airport?
The number of operators available for flights from United States to Panama City NW Florida Beaches Airport is 4 as of October 2026.
How old do you have to be to fly from United States to Panama City NW Florida Beaches Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from United States to Panama City NW Florida Beaches Airport.
What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?
The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from United States to Panama City, Florida?
momondo data reveals that the most frequently booked plane model on the route from United States to Panama City, Florida is Embraer 175, representing 17.47% of all bookings. The subsequent popular models are Canadair (Bombardier) Regional Jet 900 at 16.74%, Boeing 737-800 Passenger/BBJ2 (winglets) at 11.01%, and Embraer 175 (Enhanced Winglets) at 10.56%.
Best airlines flying from United States to Panama City, Florida
Compare and see reviews for airlines that fly from United States to Panama City, Florida with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $176 | Free Cancellation | Rating 7.0 12,146 reviews | |||
| PriceFrom $239 | Free Cancellation | Rating 7.8 8,646 reviews | |||
| PriceFrom $266 | Free Cancellation | Rating 7.4 10,322 reviews | |||
| PriceFrom $269 | Free Cancellation | Rating 7.9 4,224 reviews |
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from United States to Panama City?
momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from United States to Panama City. Millions of users trust and use momondo every year so you are in good hands.
Can I find flights from United States to Panama City with flexible booking policies on momondo?
Yes. All flights to Panama City from United States on momondo can be compared and filtered by various policies on offer, including flexible booking.
How can momondo help me find flights from United States to Panama City?
Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from United States.
I’m not ready to book a flight from United States to Panama City right now. Can momondo alert me if prices change?
If you are not ready to book a flight from United States to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.