Cheap flights from Tampa to St. Louis from $40

In general, November is the cheapest month to fly from Tampa to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $287. The month of December is another great option to travel to St. Louis, with average flight prices from Tampa averaging around $328.

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $395. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $489. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Tampa in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $385 when looking at flights departing in the afternoon. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $453 per ticket.

Fly from Tampa to Lambert-St Louis for the best Tampa - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Tampa when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $393 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Tampa for as low as $284 on momondo.

There is only 1 cabin class available to choose from on Tampa to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 66% on your flight if you consider stops on a Tampa to St. Louis flight.

As of August 2026, prices for Tampa to St. Louis flights are approximately 17% cheaper when compared to flights at the same time last year.

Frontier is the most popular carrier operating from Tampa to Lambert-St Louis

Frontier, Southwest and Allegiant Air are the top three most popular airlines that fly to St. Louis from Tampa according to our data. Frontier is the first choice among our users, with 42% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 7 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via Atlanta (ATL) offer the lowest average round-trip price of $141.

Flights connecting via Charlotte (CLT) have the shortest average one-way travel time: 4h 51m.

Charlotte (CLT) has the shortest average layover time for this route: 1h 58m.

1 flights are operational daily from Tampa to St. Louis as of August 2026. The most popular departure time for this route is 6:00AM, with 58% of flights per day taking off at noon.

As of August 2026, there are 10 flights per week flying from Tampa to St. Louis. The most common day of the week flights depart is Mon, with 30% of flights taking off on this day.