Cheap flights from Tampa to St. Louis from $52

In general, December is the cheapest month to fly from Tampa to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $296. The month of November is another great option to travel to St. Louis, with average flight prices from Tampa averaging around $337.

The cheapest day to depart on your flight to St. Louis is on a Friday when prices can be found for as low as $394. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $510. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Tampa in the evening is the least expensive time of day to depart. momondo users have found prices as low as $394 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $489 per ticket.

Fly from Tampa to Lambert-St Louis for the best Tampa - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Tampa when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $397 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Tampa for as low as $285 on momondo.

There is only 1 cabin class available to choose from on Tampa to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 66% on your flight if you consider stops on a Tampa to St. Louis flight.

As of October 2026, prices for Tampa to St. Louis flights are approximately 3% cheaper when compared to flights at the same time last year.

Frontier and Delta are the most popular carriers operating from Tampa to Lambert-St Louis

Frontier, Southwest and Allegiant Air are the top three most popular airlines that fly to St. Louis from Tampa according to our data. Frontier is the first choice among our users, with 40% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 7 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

2 flights are operational daily from Tampa to St. Louis as of October 2026. The most popular departure time for this route is 6:00AM, with 50% of flights per day taking off at noon.

As of October 2026, there are 17 flights per week flying from Tampa to St. Louis. The most common day of the week flights depart is Sun, with 29% of flights taking off on this day.