What is the cheapest airline that flies from South Carolina to Indiana?

Delta, American Airlines, and United Airlines are the most popular carriers operating from South Carolina to Indiana

How long is the flight from South Carolina to Indiana?

Flight times vary depending on what airport in South Carolina you fly out of and what airport in Indiana you fly into. For example, flying from Greenville to Indianapolis takes 3h 20m on average. On the other hand, flying from Columbia to Indianapolis takes 3h 53m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

What airlines fly to Indiana?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Indiana from South Carolina according to our data. American Airlines is the first choice among our users, with 55% of people opting to fly with this airline when traveling to Indiana. Keep in mind that there are 5 different airlines that fly to Indiana on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from South Carolina to Indiana?

Prices for flights from South Carolina to Indiana are updated daily.

How many operators does momondo search for flights from South Carolina to Indiana?

As of September 2026, there are 5 operators available to choose from for flights from South Carolina to Indiana.

How old do you have to be to fly from South Carolina to Indiana?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Indiana.

What documentation or ID do you need to fly to Indiana?

The necessary travel and health documents for your Indiana trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$97 Cheap Flights from South Carolina to Indiana in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Indiana

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 7:04 pmCHS Charleston-IND Indianapolis

13h 04m2 stops Tampa Atlanta Hartsfield-Jackson

9:06 pm - 8:38 amIND Indianapolis-CHS Charleston

11h 32m1 stop Orlando

$204Multiple Airlines

Wed, Oct 21 - Mon, Oct 26

6:12 pm - 1:02 pmMYR Myrtle Beach Intl-IND Indianapolis

18h 50m2 stops Tampa Atlanta Hartsfield-Jackson

1:33 pm - 9:13 amIND Indianapolis-MYR Myrtle Beach Intl

19h 40m1 stop Fort Lauderdale

$227Multiple Airlines

Fri, Nov 6 - Tue, Nov 17

9:22 am - 3:16 pmMYR Myrtle Beach Intl-IND Indianapolis

5h 54m1 stop Charlotte Douglas

6:32 pm - 10:29 pmIND Indianapolis-MYR Myrtle Beach Intl

3h 57m1 stop Charlotte Douglas

$271American Airlines

Wed, Oct 28 - Tue, Nov 3

6:47 am - 12:54 pmMYR Myrtle Beach Intl-IND Indianapolis

6h 07m1 stop Charlotte Douglas

4:16 pm - 10:52 pmIND Indianapolis-MYR Myrtle Beach Intl

6h 36m1 stop Charlotte Douglas

$271American Airlines

Thu, Dec 10 - Mon, Dec 14

4:30 pm - 8:28 pmMYR Myrtle Beach Intl-IND Indianapolis

3h 58m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:07 amIND Indianapolis-MYR Myrtle Beach Intl

4h 07m1 stop Atlanta Hartsfield-Jackson

$271Delta

Tue, Nov 3 - Mon, Nov 9

7:52 pm - 11:59 pmCHS Charleston-IND Indianapolis

4h 07m1 stop Washington, D.C. Dulles Intl

7:10 am - 1:56 pmIND Indianapolis-CHS Charleston

6h 46m1 stop Chicago O'Hare Intl

$304United Airlines

Tue, Oct 27 - Wed, Oct 28

7:45 am - 11:30 amCHS Charleston-IND Indianapolis

3h 45m1 stop Baltimore/Washington

5:30 pm - 10:15 pmIND Indianapolis-CHS Charleston

4h 45m1 stop Baltimore/Washington

$304Southwest

Sat, Oct 31 - Mon, Nov 2

5:31 pm - 10:02 pmGSP Greenville-IND Indianapolis

4h 31m1 stop Chicago O'Hare Intl

11:00 am - 6:50 pmIND Indianapolis-GSP Greenville

7h 50m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$305United Airlines

Fri, Jan 29 - Mon, Feb 1

2:50 pm - 10:45 pmGSP Greenville-IND Indianapolis

7h 55m2 stops Baltimore/Washington Chicago Midway

5:35 am - 10:45 amIND Indianapolis-GSP Greenville

5h 10m1 stop Baltimore/Washington

$305Southwest

Fri, Dec 4 - Mon, Dec 7

7:05 pm - 12:25 amCHS Charleston-IND Indianapolis

5h 20m1 stop Atlanta Hartsfield-Jackson

12:58 pm - 4:35 pmIND Indianapolis-CHS Charleston

3h 37m1 stop Atlanta Hartsfield-Jackson

$309Delta

Mon, Oct 26 - Tue, Oct 27

Cheap last minute flights

Enter your travel dates to find the best prices.

7:19 pm - 11:22 pmCAE Columbia Metropolitan-IND Indianapolis

4h 03m1 stop Atlanta Hartsfield-Jackson

7:05 am - 1:14 pmIND Indianapolis-CAE Columbia Metropolitan

6h 09m1 stop Atlanta Hartsfield-Jackson

$389Delta

Fri, Oct 2 - Sun, Oct 4

1:53 pm - 6:07 pmCAE Columbia Metropolitan-IND Indianapolis

4h 14m1 stop Charlotte Douglas

9:43 am - 2:03 pmIND Indianapolis-CAE Columbia Metropolitan

4h 20m1 stop Charlotte Douglas

$399American Airlines

Wed, Sep 30 - Sun, Oct 4

5:38 pm - 11:44 pmCAE Columbia Metropolitan-IND Indianapolis

6h 06m1 stop Chicago O'Hare Intl

6:05 am - 2:26 pmIND Indianapolis-CAE Columbia Metropolitan

8h 21m2 stops Newark Washington, D.C. Dulles Intl

$404United Airlines

Wed, Sep 30 - Sun, Oct 4

10:23 am - 5:49 pmCAE Columbia Metropolitan-IND Indianapolis

7h 26m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

7:05 am - 2:26 pmIND Indianapolis-CAE Columbia Metropolitan

7h 21m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$409United Airlines

Wed, Sep 30 - Sun, Oct 4

8:07 pm - 8:18 amGSP Greenville-IND Indianapolis

12h 11m1 stop Sarasota Bradenton Intl

4:12 pm - 7:44 pmIND Indianapolis-GSP Greenville

27h 32m2 stops Denver Intl Tampa

$415Multiple Airlines

Thu, Oct 1 - Tue, Oct 6

2:46 pm - 10:25 amMYR Myrtle Beach Intl-IND Indianapolis

19h 39m1 stop Orlando

7:59 pm - 5:25 pmIND Indianapolis-MYR Myrtle Beach Intl

21h 26m2 stops Atlanta Hartsfield-Jackson Fort Lauderdale

$436Multiple Airlines

Sun, Oct 4 - Wed, Oct 14

7:41 pm - 11:27 pmCHS Charleston-SBN South Bend/Michiana

3h 46m1 stop Charlotte Douglas

7:16 pm - 12:02 amSBN South Bend/Michiana-CHS Charleston

4h 46m1 stop Charlotte Douglas

$469American Airlines

Fri, Oct 2 - Sun, Oct 4

5:10 pm - 9:45 pmCHS Charleston-IND Indianapolis

4h 35m1 stop Baltimore/Washington

7:00 am - 1:15 pmIND Indianapolis-CHS Charleston

6h 15m1 stop Nashville Intl

$537Southwest

Wed, Sep 30 - Tue, Oct 6

2:12 pm - 8:27 pmCHS Charleston-IND Indianapolis

6h 15m1 stop Atlanta Hartsfield-Jackson

3:01 pm - 7:09 pmIND Indianapolis-CHS Charleston

4h 08m1 stop Atlanta Hartsfield-Jackson

$537Delta

Wed, Sep 30 - Tue, Oct 6

8:10 am - 5:00 pmCHS Charleston-IND Indianapolis

8h 50m2 stops Baltimore/Washington Orlando

3:50 pm - 7:35 pmIND Indianapolis-CHS Charleston

3h 45m1 stop Nashville Intl

$542Southwest

Wed, Sep 30 - Tue, Oct 6

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American Airlines flights from South Carolina to Indiana

Our best American Airlines deals on South Carolina to Indiana flight tickets

American Airlines

Nov 4

MYR8:07 amMyrtle Beach Intl

5h 55m

1 stop

IND2:02 pmIndianapolis

Nov 9

IND4:24 pmIndianapolis

6h 05m

1 stop

MYR10:29 pmMyrtle Beach Intl

$271

American Airlines

Nov 5

GSP4:37 pmGreenville

6h 26m

1 stop

IND11:03 pmIndianapolis

Nov 7

IND11:25 amIndianapolis

4h 42m

1 stop

GSP4:07 pmGreenville

$279

American Airlines

Dec 25

MYR9:05 amMyrtle Beach Intl

5h 51m

1 stop

IND2:56 pmIndianapolis

Jan 5

IND7:26 amIndianapolis

4h 48m

1 stop

MYR12:14 pmMyrtle Beach Intl

$284

Southwest flights from South Carolina to Indiana

Our best Southwest deals on South Carolina to Indiana flight tickets

Southwest

Oct 28

MYR7:50 amMyrtle Beach Intl

4h 05m

1 stop

IND11:55 amIndianapolis

Nov 3

IND9:40 amIndianapolis

8h 45m

2 stops

MYR6:25 pmMyrtle Beach Intl

$276

Southwest

Oct 28

MYR1:35 pmMyrtle Beach Intl

8h 25m

2 stops

IND10:00 pmIndianapolis

Nov 3

IND9:40 amIndianapolis

8h 45m

2 stops

MYR6:25 pmMyrtle Beach Intl

$281

Southwest

Oct 30

MYR3:55 pmMyrtle Beach Intl

8h 50m

2 stops

IND12:45 amIndianapolis

Oct 31

IND5:20 amIndianapolis

6h 50m

1 stop

MYR12:10 pmMyrtle Beach Intl

$289

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonIndianapolis

CHS Charleston - IND Indianapolis

CHSIND

Charleston

Wed 10/21

6:00 am-7:04 pm

2 stops13h 04m

Indianapolis

Mon 10/26

9:06 pm-8:38 am

1 stop11h 32m

$204

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Fri 11/6

6:12 pm-1:02 pm

2 stops18h 50m

Indianapolis

Tue 11/17

1:33 pm-9:13 am

1 stop19h 40m

$227

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Wed 10/28

9:22 am-3:16 pm

1 stop5h 54m

Indianapolis

Tue 11/3

6:32 pm-10:29 pm

1 stop3h 57m

$271

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Thu 12/10

6:47 am-12:54 pm

1 stop6h 07m

Indianapolis

Mon 12/14

4:16 pm-10:52 pm

1 stop6h 36m

$271

Quickest round-trip

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Tue 11/3

4:30 pm-8:28 pm

1 stop3h 58m

Indianapolis

Mon 11/9

6:00 am-10:07 am

1 stop4h 07m

$271

CharlestonIndianapolis

CHS Charleston - IND Indianapolis

CHSIND

Charleston

Tue 10/27

7:52 pm-11:59 pm

1 stop4h 07m

Indianapolis

Wed 10/28

7:10 am-1:56 pm

1 stop6h 46m

$304

CharlestonIndianapolis

CHS Charleston - IND Indianapolis

CHSIND

Charleston

Sat 10/31

7:45 am-11:30 am

1 stop3h 45m

Indianapolis

Mon 11/2

5:30 pm-10:15 pm

1 stop4h 45m

$304

GreenvilleIndianapolis

GSP Greenville - IND Indianapolis

GSPIND

Greenville

Fri 1/29

5:31 pm-10:02 pm

1 stop4h 31m

Indianapolis

Mon 2/1

11:00 am-6:50 pm

2 stops7h 50m

$305

GreenvilleIndianapolis

GSP Greenville - IND Indianapolis

GSPIND

Greenville

Fri 12/4

2:50 pm-10:45 pm

2 stops7h 55m

Indianapolis

Mon 12/7

5:35 am-10:45 am

1 stop5h 10m

$305

CharlestonIndianapolis

CHS Charleston - IND Indianapolis

CHSIND

Charleston

Mon 10/26

7:05 pm-12:25 am

1 stop5h 20m

Indianapolis

Tue 10/27

12:58 pm-4:35 pm

1 stop3h 37m

$309

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Indiana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Indiana?

The cheapest month to fly to Indiana from South Carolina is in March. Flight prices, which tend to average around $306, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Indiana, with average flight prices from South Carolina averaging around $334.

What is the cheapest day to depart on your flight to Indiana?

Our data shows that Friday is the least expensive day to fly to Indiana. Tickets to fly out on this day can be as low as $138. On the other hand, Saturday is the most expensive day to depart from South Carolina because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $154.

What is the cheapest South Carolina to Indiana flight route?

Fly from Myrtle Beach Intl to Indianapolis for the best South Carolina - Indiana flight prices

What cabin class options are available on South Carolina to Indiana flights?

There is only 1 cabin class available to choose from on South Carolina to Indiana flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Indiana flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Indiana.

Cheap South Carolina to Indiana flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Indiana

Best Price Found	$97
Fastest flight time	1h 21m
Direct flights	None

The best one-way flight to Indiana from South Carolina in the past 72 hours is $97. The best round-trip flight deal from South Carolina to Indiana found on momondo in the last 72 hours is $204.

The fastest flight from South Carolina to Indiana takes 1h 21m

There are no direct flights from South Carolina to Indiana. There are no popular flight routes from South Carolina to Indiana.

Search flight deals

Frequently asked questions about flying from South Carolina to Indiana

When did momondo last update prices for flights from South Carolina to Indiana?
Prices for flights from South Carolina to Indiana are updated daily.
How many operators does momondo search for flights from South Carolina to Indiana?
As of September 2026, there are 5 operators available to choose from for flights from South Carolina to Indiana.
How old do you have to be to fly from South Carolina to Indiana?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Indiana.
What documentation or ID do you need to fly to Indiana?
The necessary travel and health documents for your Indiana trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from South Carolina to Indiana?
momondo data reveals that the most frequently booked plane model on the route from South Carolina to Indiana is Airbus A320-100/200, representing 90.00% of all bookings. The subsequent popular model is Airbus A220-300 at 10.00%.

Best airlines flying from South Carolina to Indiana

Compare and see reviews for airlines that fly from South Carolina to Indiana with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.3 678 reviews	Search Allegiant Air flights
Delta	PriceFrom $183	Free Cancellation	Rating 7.8 8,611 reviews	Search Delta flights
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.0 12,097 reviews	Search American Airlines flights
Southwest	PriceFrom $228	Free Cancellation	Rating 8.0 4,201 reviews	Search Southwest flights
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 10,251 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Indiana?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Indiana. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Indiana with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Indiana flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Indiana?

Once you have performed a search for South Carolina to Indiana flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Indiana right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Indiana from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.