Cheap flights from South Carolina to Indiana from $81

The cheapest month to fly to Indiana from South Carolina is in July. Flight prices, which tend to average around $45, are often lower during this time because this is during the off-season. The month of June is another great option to travel to Indiana, with average flight prices from South Carolina averaging around $49.

Our data shows that the cheapest South Carolina to Indiana flights are usually those with departure times in the evening. Our users have found flights to Indiana in the evening for as low as $113. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $133 on average. Flights to Indiana from South Carolina in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Charleston to Indianapolis for the best South Carolina - Indiana flight prices

You are more likely to see cheaper flights to Indiana from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Indiana for around $339 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Indiana from South Carolina for as low as $133 on momondo.

No. A direct flight is the cheapest option for a flight between South Carolina to Indiana.

Frontier, Southwest, and American Airlines are the most popular carriers operating from South Carolina to Indiana

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Indiana from South Carolina according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Indiana. Keep in mind that there are 6 different airlines that fly to Indiana on a routine basis, so you have a few additional options to choose from.

As of May 2026, 922 flights take off from South Carolina and land in Indiana each week. The most common flight departure day for this route is Fri, with 16% of weekly flights taking off on this day.

Flight times vary depending on what airport in South Carolina you fly out of and what airport in Indiana you fly into. For example, flying from Myrtle Beach to Indianapolis takes 1h 49m on average. On the other hand, flying from Charleston to Indianapolis takes 1h 54m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.