Cheap flights from Denver to Indianapolis from $49

In general, August is the cheapest month to fly from Denver to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $208. If you are unable to visit Indianapolis during the month of August, then departing from Denver during the month October is also very affordable. Most momondo users find prices during this month for around $221.

Our data shows that Friday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $223. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Sunday is $318.

Flying to Indianapolis from Denver in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $233 when looking at flights departing in the afternoon. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $274 on average. Flights to Indianapolis from Denver at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Denver Intl to Indianapolis for the best Denver Intl - Indianapolis flight prices

You are more likely to see cheaper flights to Indianapolis from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Indianapolis for around $265 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Indianapolis from Denver for as low as $210 on momondo.

There are 4 cabin classes available to choose from on Denver Intl to Indianapolis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Delta, and Southwest are the most popular carriers operating from Denver Intl to Indianapolis

Frontier, United Airlines and Southwest are the top three most popular airlines that fly to Indianapolis from Denver according to our data. Frontier is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Indianapolis. Keep in mind that there are 6 different airlines that fly to Indianapolis on a routine basis, so you have a few additional options to choose from.

The number of flights available between Denver and Indianapolis is 7 per day as of March 2026. The most frequent departure time is 10:00AM, with 55% of daily flights leaving in the afternoon.

As of March 2026, 53 flights take off from Denver and land in Indianapolis each week. The most common flight departure day for this route is Tue, with 19% of weekly flights taking off on this day.