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Cheap flights from South America to San Francisco from $273

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to San Francisco departing on 8/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South America to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
9:45 am - 6:29 pm
MDE
-
SFO
10h 44m
1 stop
United Airlines Logo
12:45 am - 9:10 pm
SFO
-
MDE
18h 25m
1 stop
$499United Airlines
Wed, Aug 19 - Thu, Aug 27
United Airlines Logo
9:45 am - 6:29 pm
MDE
-
SFO
10h 44m
1 stop
United Airlines Logo
7:05 am - 9:10 pm
SFO
-
MDE
12h 05m
1 stop
$511United Airlines
Tue, Aug 18 - Tue, Aug 25
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
11:55 pm - 11:20 pm
SFO
-
SCL
20h 25m
2 stops
$561Avianca
Thu, Jul 9 - Tue, Jul 14
Copa Airlines Logo
4:14 am - 5:59 pm
SCL
-
SFO
16h 45m
1 stop
Copa Airlines Logo
8:21 pm - 2:20 am
SFO
-
SCL
26h 59m
1 stop
$568Copa Airlines
Wed, Aug 12 - Tue, Aug 18
American Airlines Logo
8:50 pm - 8:18 pm
SCL
-
SFO
26h 28m
1 stop
American Airlines Logo
7:30 am - 6:25 am
SFO
-
SCL
19h 55m
1 stop
$569American Airlines
Wed, Aug 5 - Tue, Aug 11
Avianca Logo
7:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
11:10 pm - 12:30 am
SFO
-
SCL
20h 20m
2 stops
$570Avianca
Sat, Sep 26 - Mon, Nov 30
Copa Airlines Logo
6:02 am - 11:40 pm
UIO
-
SFO
19h 38m
1 stop
Copa Airlines Logo
8:21 pm - 5:30 pm
SFO
-
UIO
19h 09m
1 stop
$576Copa Airlines
Tue, Oct 6 - Wed, Oct 14
American Airlines Logo
6:00 am - 4:57 pm
UIO
-
SFO
12h 57m
1 stop
American Airlines Logo
11:03 pm - 8:51 pm
SFO
-
UIO
19h 48m
2 stops
$579American Airlines
Wed, Sep 23 - Tue, Sep 29
LATAM Airlines Logo
8:15 am - 11:58 pm
LIM
-
SFO
17h 43m
2 stops
LATAM Airlines Logo
10:00 pm - 9:55 pm
SFO
-
LIM
21h 55m
1 stop
$712LATAM Airlines
Tue, Aug 25 - Sat, Aug 29
LATAM Airlines Logo
8:10 pm - 10:20 am
EZE
-
SFO
18h 10m
1 stop
LATAM Airlines Logo
8:59 am - 11:30 am
SFO
-
EZE
22h 31m
2 stops
$840LATAM Airlines
Tue, Jul 7 - Tue, Jul 14

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United Airlines flights from South America to San Francisco

Our best United Airlines deals on South America to San Francisco flight tickets
United Airlines
Aug 19
MDE9:45 amMedellín Jose Maria Cordova Intl
10h 44m
1 stop
SFO6:29 pmSan Francisco
Aug 27
SFO12:45 amSan Francisco
18h 25m
1 stop
MDE9:10 pmMedellín Jose Maria Cordova Intl
$499
United Airlines
Aug 18
MDE9:45 amMedellín Jose Maria Cordova Intl
10h 44m
1 stop
SFO6:29 pmSan Francisco
Aug 25
SFO7:05 amSan Francisco
12h 05m
1 stop
MDE9:10 pmMedellín Jose Maria Cordova Intl
$511
United Airlines
Aug 18
MDE9:45 amMedellín Jose Maria Cordova Intl
10h 44m
1 stop
SFO6:29 pmSan Francisco
Aug 25
SFO7:05 amSan Francisco
12h 05m
1 stop
MDE9:10 pmMedellín Jose Maria Cordova Intl
$527

American Airlines flights from South America to San Francisco

Our best American Airlines deals on South America to San Francisco flight tickets
American Airlines
Aug 5
SCL8:50 pmSantiago Arturo Merino Benitez
26h 28m
1 stop
SFO8:18 pmSan Francisco
Aug 11
SFO7:30 amSan Francisco
19h 55m
1 stop
SCL6:25 amSantiago Arturo Merino Benitez
$569
American Airlines
Aug 5
SCL8:50 pmSantiago Arturo Merino Benitez
26h 28m
1 stop
SFO8:18 pmSan Francisco
Aug 11
SFO7:30 amSan Francisco
19h 55m
1 stop
SCL6:25 amSantiago Arturo Merino Benitez
$576
American Airlines
Sep 23
UIO6:00 amQuito Mariscal Sucr
12h 57m
1 stop
SFO4:57 pmSan Francisco
Sep 29
SFO11:03 pmSan Francisco
19h 48m
2 stops
UIO8:51 pmQuito Mariscal Sucr
$579

momondo Fare Finder

 
Customize your flight search to find flights from South America to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from South America to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedellínSan Francisco

MDE - SFO

MDESFO

Medellín Jose Maria Cordova Intl

Wed 8/19

9:45 am-6:29 pm

1 stop10h 44m

San Francisco

Thu 8/27

12:45 am-9:10 pm

1 stop18h 25m

$499
Quickest round-trip

MedellínSan Francisco

MDE - SFO

MDESFO

Medellín Jose Maria Cordova Intl

Tue 8/18

9:45 am-6:29 pm

1 stop10h 44m

San Francisco

Tue 8/25

7:05 am-9:10 pm

1 stop12h 05m

$511

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 7/9

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Tue 7/14

11:55 pm-11:20 pm

2 stops20h 25m

$561

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 8/12

4:14 am-5:59 pm

1 stop16h 45m

San Francisco

Tue 8/18

8:21 pm-2:20 am

1 stop26h 59m

$568

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 8/5

8:50 pm-8:18 pm

1 stop26h 28m

San Francisco

Tue 8/11

7:30 am-6:25 am

1 stop19h 55m

$569

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 9/26

7:40 am-10:35 pm

2 stops18h 55m

San Francisco

Mon 11/30

11:10 pm-12:30 am

2 stops20h 20m

$570

QuitoSan Francisco

UIO - SFO

UIOSFO

Quito Mariscal Sucr

Tue 10/6

6:02 am-11:40 pm

1 stop19h 38m

San Francisco

Wed 10/14

8:21 pm-5:30 pm

1 stop19h 09m

$576

QuitoSan Francisco

UIO - SFO

UIOSFO

Quito Mariscal Sucr

Wed 9/23

6:00 am-4:57 pm

1 stop12h 57m

San Francisco

Tue 9/29

11:03 pm-8:51 pm

2 stops19h 48m

$579

LimaSan Francisco

LIM - SFO

LIMSFO

Lima J Chavez Intl

Tue 8/25

8:15 am-11:58 pm

2 stops17h 43m

San Francisco

Sat 8/29

10:00 pm-9:55 pm

1 stop21h 55m

$712

Buenos AiresSan Francisco

EZE - SFO

EZESFO

Buenos Aires Ministro Pistarini

Tue 7/7

8:10 pm-10:20 am

1 stop18h 10m

San Francisco

Tue 7/14

8:59 am-11:30 am

2 stops22h 31m

$840

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from South America to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $559.

How far in advance should I book a flight from South America to San Francisco?

You are more likely to see cheaper flights to San Francisco from South America when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $650 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from South America for as low as $595 on momondo.

Can stopping save me money on South America to San Francisco flights?

You could potentially save up to 8% on your flight if you consider stops on a South America to San Francisco flight.

Cheap South America to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to San Francisco

Fastest flight time

0h 00m

Direct flights

None
The fastest flight from South America to San Francisco takes 0h 00m
There are no direct flights from South America to San Francisco. There are no popular flight routes from South America to San Francisco.
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Frequently asked questions about flying from South America to San Francisco

  • When did momondo last update prices for flights from South America to San Francisco Airport?

    Prices for flights from South America to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from South America to San Francisco Airport?

  • How old do you have to be to fly from South America to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South America to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South America to San Francisco

Compare and see reviews for airlines that fly from South America to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $212Free CancellationRating
7.9
8,400 reviews
Search Delta flights
AviancaPriceFrom $254Free CancellationRating
6.5
2,535 reviews
Search Avianca flights
Copa AirlinesPriceFrom $274Free CancellationRating
7.5
1,569 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $288Free CancellationRating
7.4
1,928 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $405Free CancellationRating
7.4
9,808 reviews
Search United Airlines flights
American AirlinesPriceFrom $455Free CancellationRating
7.1
11,641 reviews
Search American Airlines flights
GOLPriceFrom $832Free CancellationRating
7.3
1,226 reviews
Search GOL flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Hayward
Bodega Bay
Roseville
Walnut Creek
Santa Clara
Berkeley
Fremont
Vallejo
South San Francisco
Sunnyvale
Big Sur
Pacific Grove
Salinas
Daly City
Calistoga
Burlingame

Why use momondo?

Why should I use momondo to find a flight deal from South America to San Francisco?

It is quick and easy to find South America to San Francisco flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Francisco that suits you.

Can I find flights from South America to San Francisco with flexible booking policies on momondo?

Yes. All flights to San Francisco from South America on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South America to San Francisco?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South America to San Francisco.

I’m not ready to book a flight from South America to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from South America are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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