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Cheap flights from South America to San Francisco from $252

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to San Francisco departing on 2/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
2:10 pm - 10:50 pm
MDE
-
SFO
10h 40m1 stop
Avianca Logo
2:20 pm - 2:05 am
SFO
-
MDE
9h 45m1 stop
$435Avianca
Wed, Mar 25 - Wed, Apr 15
Avianca Logo
3:15 am - 12:35 pm
MDE
-
SFO
11h 20m1 stop
Avianca Logo
2:20 pm - 2:05 am
SFO
-
MDE
9h 45m1 stop
$436Avianca
Wed, Apr 29 - Fri, May 15
Copa Airlines Logo
10:46 am - 11:40 pm
MDE
-
SFO
14h 54m1 stop
Copa Airlines Logo
8:35 pm - 2:45 pm
SFO
-
MDE
16h 10m1 stop
$437Copa Airlines
Wed, Mar 25 - Sun, Apr 5
United Airlines Logo
9:45 am - 11:59 pm
MDE
-
SFO
16h 14m1 stop
United Airlines Logo
12:45 am - 9:10 pm
SFO
-
MDE
18h 25m1 stop
$439United Airlines
Mon, Mar 23 - Sun, Mar 29
Copa Airlines Logo
8:40 am - 11:20 pm
BOG
-
SFO
17h 40m1 stop
Copa Airlines Logo
12:42 am - 10:55 pm
SFO
-
BOG
19h 13m1 stop
$507Copa Airlines
Thu, Feb 5 - Mon, Feb 9
United Airlines Logo
1:30 am - 11:59 pm
BOG
-
SFO
24h 29m1 stop
United Airlines Logo
7:10 pm - 7:20 pm
SFO
-
BOG
22h 10m1 stop
$509United Airlines
Thu, Mar 26 - Sun, Apr 5
American Airlines Logo
10:30 pm - 11:04 am
SCL
-
SFO
17h 34m1 stop
American Airlines Logo
1:15 pm - 9:00 am
SFO
-
SCL
14h 45m1 stop
$534American Airlines
Sat, Jan 24 - Mon, Feb 2
American Airlines Logo
10:30 pm - 9:17 am
SCL
-
SFO
15h 47m1 stop
American Airlines Logo
11:15 am - 9:00 am
SFO
-
SCL
16h 45m2 stops
$539American Airlines
Sat, Jan 24 - Mon, Feb 2
LATAM Airlines Logo
5:30 pm - 8:23 pm
SCL
-
SFO
30h 53m2 stops
LATAM Airlines Logo
11:05 am - 5:35 am
SFO
-
SCL
15h 30m1 stop
$549LATAM Airlines
Wed, Apr 1 - Thu, Apr 23
LATAM Airlines Logo
5:30 pm - 8:23 pm
SCL
-
SFO
30h 53m2 stops
LATAM Airlines Logo
6:00 am - 6:55 am
SFO
-
SCL
21h 55m2 stops
$554LATAM Airlines
Wed, Apr 1 - Thu, Apr 23

Avianca flights from South America to San Francisco

Our best Avianca deals on South America to San Francisco flight tickets
Avianca
Mar 25
MDE2:10 pmMedellín Jose Maria Cordova Intl
10h 40m
1 stop
SFO10:50 pmSan Francisco
Apr 15
SFO2:20 pmSan Francisco
9h 45m
1 stop
MDE2:05 amMedellín Jose Maria Cordova Intl
$435
Find similar
Avianca
Apr 29
MDE3:15 amMedellín Jose Maria Cordova Intl
11h 20m
1 stop
SFO12:35 pmSan Francisco
May 15
SFO2:20 pmSan Francisco
9h 45m
1 stop
MDE2:05 amMedellín Jose Maria Cordova Intl
$436
Find similar
Avianca
Apr 28
MDE3:15 amMedellín Jose Maria Cordova Intl
11h 20m
1 stop
SFO12:35 pmSan Francisco
May 15
SFO2:20 pmSan Francisco
9h 45m
1 stop
MDE2:05 amMedellín Jose Maria Cordova Intl
$438
Find similar

United Airlines flights from South America to San Francisco

Our best United Airlines deals on South America to San Francisco flight tickets
United Airlines
Mar 23
MDE9:45 amMedellín Jose Maria Cordova Intl
28h 57m
1 stop
SFO12:42 pmSan Francisco
Mar 30
SFO11:59 pmSan Francisco
19h 11m
1 stop
MDE9:10 pmMedellín Jose Maria Cordova Intl
$439
Find similar
United Airlines
Dec 18
MDE1:15 amMedellín Jose Maria Cordova Intl
11h 35m
1 stop
SFO9:50 amSan Francisco
Jan 2
SFO5:15 amSan Francisco
21h 27m
1 stop
MDE5:42 amMedellín Jose Maria Cordova Intl
$442
Find similar
United Airlines
Dec 18
BOG8:15 amBogotá El Dorado
17h 34m
1 stop
SFO10:49 pmSan Francisco
Dec 30
SFO7:11 pmSan Francisco
24h 24m
1 stop
BOG10:35 pmBogotá El Dorado
$509
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South America to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from South America to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MedellínSan Francisco

MDE - SFO

MDESFO

Medellín Jose Maria Cordova Intl

Wed 3/25

2:10 pm-10:50 pm

1 stop10h 40m

San Francisco

Wed 4/15

2:20 pm-2:05 am

1 stop9h 45m

$435

MedellínSan Francisco

MDE - SFO

MDESFO

Medellín Jose Maria Cordova Intl

Wed 4/29

3:15 am-12:35 pm

1 stop11h 20m

San Francisco

Fri 5/15

2:20 pm-2:05 am

1 stop9h 45m

$436

MedellínSan Francisco

MDE - SFO

MDESFO

Medellín Jose Maria Cordova Intl

Wed 3/25

10:46 am-11:40 pm

1 stop14h 54m

San Francisco

Sun 4/5

8:35 pm-2:45 pm

1 stop16h 10m

$437

MedellínSan Francisco

MDE - SFO

MDESFO

Medellín Jose Maria Cordova Intl

Mon 3/23

9:45 am-11:59 pm

1 stop16h 14m

San Francisco

Sun 3/29

12:45 am-9:10 pm

1 stop18h 25m

$439

BogotáSan Francisco

BOG - SFO

BOGSFO

Bogotá El Dorado

Thu 2/5

8:40 am-11:20 pm

1 stop17h 40m

San Francisco

Mon 2/9

12:42 am-10:55 pm

1 stop19h 13m

$507

BogotáSan Francisco

BOG - SFO

BOGSFO

Bogotá El Dorado

Thu 3/26

1:30 am-11:59 pm

1 stop24h 29m

San Francisco

Sun 4/5

7:10 pm-7:20 pm

1 stop22h 10m

$509

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 1/24

10:30 pm-11:04 am

1 stop17h 34m

San Francisco

Mon 2/2

1:15 pm-9:00 am

1 stop14h 45m

$534

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 1/24

10:30 pm-9:17 am

1 stop15h 47m

San Francisco

Mon 2/2

11:15 am-9:00 am

2 stops16h 45m

$539

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/1

5:30 pm-8:23 pm

2 stops30h 53m

San Francisco

Thu 4/23

11:05 am-5:35 am

1 stop15h 30m

$549

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/1

5:30 pm-8:23 pm

2 stops30h 53m

San Francisco

Thu 4/23

6:00 am-6:55 am

2 stops21h 55m

$554

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from South America to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $603.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from South America to San Francisco is on a Tuesday when prices can be found for as low as $648. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $732.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest South America to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $616. Flights in the evening are often more expensive with an average ticket price of $686.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from South America when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $646 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from South America for as low as $620 on momondo.

Can stopping save me money on South America to San Francisco flights?

You could potentially save up to 3% on your flight if you consider stops on a South America to San Francisco flight.

Cheap South America to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to San Francisco

Fastest flight time

0h 00m

Direct flights

None
The fastest flight from South America to San Francisco takes 0h 00m
There are no direct flights from South America to San Francisco. There are no popular flight routes from South America to San Francisco.
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  • When did momondo last update prices for flights from South America to San Francisco Airport?

    Prices for flights from South America to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from South America to San Francisco Airport?

  • How old do you have to be to fly from South America to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South America to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South America to San Francisco

Compare and see reviews for airlines that fly from South America to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $276Free CancellationRating
7.6
1,556 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $288Free CancellationRating
7.5
1,891 reviews
Search LATAM Airlines flights
AviancaPriceFrom $344Free CancellationRating
6.6
2,487 reviews
Search Avianca flights
DeltaPriceFrom $359Free CancellationRating
7.9
8,008 reviews
Search Delta flights
United AirlinesPriceFrom $440Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights
American AirlinesPriceFrom $481Free CancellationRating
7.2
11,049 reviews
Search American Airlines flights
AeromexicoPriceFrom $527Free CancellationRating
7.4
1,629 reviews
Search Aeromexico flights
Air CanadaPriceFrom $569Free CancellationRating
7.1
10,531 reviews
Search Air Canada flights
GOLPriceFrom $832Free CancellationRating
7.3
1,131 reviews
Search GOL flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Berkeley
Santa Clara
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Salinas
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from South America to San Francisco?

It is quick and easy to find South America to San Francisco flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Francisco that suits you.

Can I find flights from South America to San Francisco with flexible booking policies on momondo?

Yes. All flights to San Francisco from South America on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South America to San Francisco?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South America to San Francisco.

I’m not ready to book a flight from South America to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from South America are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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