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Cheap flights from Seattle to Florence from $387

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Seattle to Florence departing on 12/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Seattle to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:51 pm - 11:41 pm
SEA
-
FLO
6h 50m1 stop
American Airlines Logo
11:13 am - 7:05 pm
FLO
-
SEA
10h 52m1 stop
$411American Airlines
Thu, Apr 23 - Tue, May 5
American Airlines Logo
1:51 pm - 11:41 pm
SEA
-
FLO
6h 50m1 stop
American Airlines Logo
2:33 pm - 11:05 pm
FLO
-
SEA
11h 32m2 stops
$416American Airlines
Thu, Apr 23 - Tue, May 5
American Airlines Logo
12:41 pm - 10:53 pm
SEA
-
FLO
7h 12m1 stop
American Airlines Logo
12:51 pm - 11:13 pm
FLO
-
SEA
13h 22m2 stops
$487American Airlines
Wed, Dec 17 - Sun, Dec 21
American Airlines Logo
9:00 am - 10:53 pm
SEA
-
FLO
10h 53m2 stops
American Airlines Logo
12:51 pm - 11:13 pm
FLO
-
SEA
13h 22m2 stops
$492American Airlines
Wed, Dec 17 - Sun, Dec 21
American Airlines Logo
8:04 am - 11:11 pm
SEA
-
FLO
12h 07m2 stops
American Airlines Logo
6:15 am - 6:05 pm
FLO
-
SEA
14h 50m2 stops
$497American Airlines
Sat, Jan 10 - Wed, Jan 14
American Airlines Logo
11:51 am - 11:41 pm
SEA
-
FLO
8h 50m2 stops
American Airlines Logo
2:33 pm - 11:05 pm
FLO
-
SEA
11h 32m2 stops
$507American Airlines
Thu, Apr 23 - Tue, May 5
American Airlines Logo
12:41 pm - 10:53 pm
SEA
-
FLO
7h 12m1 stop
American Airlines Logo
12:51 pm - 7:28 pm
FLO
-
SEA
9h 37m1 stop
$551American Airlines
Wed, Dec 17 - Sun, Dec 21
American Airlines Logo
10:07 pm - 9:50 am
SEA
-
FLO
8h 43m1 stop
American Airlines Logo
5:15 am - 2:02 pm
FLO
-
SEA
11h 47m2 stops
$753American Airlines
Tue, Dec 16 - Fri, Dec 19
American Airlines Logo
9:00 am - 10:53 pm
SEA
-
FLO
10h 53m2 stops
American Airlines Logo
5:15 am - 2:02 pm
FLO
-
SEA
11h 47m2 stops
$758American Airlines
Tue, Dec 16 - Fri, Dec 19
American Airlines Logo
10:07 pm - 9:50 am
SEA
-
FLO
8h 43m1 stop
American Airlines Logo
12:51 pm - 7:28 pm
FLO
-
SEA
9h 37m1 stop
$778American Airlines
Tue, Dec 16 - Fri, Dec 19

American Airlines flights from Seattle to Florence, South Carolina

Our best American Airlines deals on Seattle to Florence, South Carolina flight tickets
American Airlines
Apr 23
SEA1:51 pmSeattle/Tacoma Intl
6h 50m
1 stop
FLO11:41 pmFlorence
May 5
FLO11:13 amFlorence
10h 52m
1 stop
SEA7:05 pmSeattle/Tacoma Intl
$411
Find similar
American Airlines
Apr 23
SEA1:51 pmSeattle/Tacoma Intl
6h 50m
1 stop
FLO11:41 pmFlorence
May 5
FLO2:33 pmFlorence
11h 32m
2 stops
SEA11:05 pmSeattle/Tacoma Intl
$416
Find similar
American Airlines
Dec 17
SEA12:41 pmSeattle/Tacoma Intl
7h 12m
1 stop
FLO10:53 pmFlorence
Dec 21
FLO12:51 pmFlorence
13h 22m
2 stops
SEA11:13 pmSeattle/Tacoma Intl
$487
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Seattle to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Seattle to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Thu 4/23

1:51 pm-11:41 pm

1 stop6h 50m

Florence

Tue 5/5

11:13 am-7:05 pm

1 stop10h 52m

$411

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Thu 4/23

1:51 pm-11:41 pm

1 stop6h 50m

Florence

Tue 5/5

2:33 pm-11:05 pm

2 stops11h 32m

$416

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Wed 12/17

12:41 pm-10:53 pm

1 stop7h 12m

Florence

Sun 12/21

12:51 pm-11:13 pm

2 stops13h 22m

$487

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Wed 12/17

9:00 am-10:53 pm

2 stops10h 53m

Florence

Sun 12/21

12:51 pm-11:13 pm

2 stops13h 22m

$492

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Sat 1/10

8:04 am-11:11 pm

2 stops12h 07m

Florence

Wed 1/14

6:15 am-6:05 pm

2 stops14h 50m

$497

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Thu 4/23

11:51 am-11:41 pm

2 stops8h 50m

Florence

Tue 5/5

2:33 pm-11:05 pm

2 stops11h 32m

$507

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Wed 12/17

12:41 pm-10:53 pm

1 stop7h 12m

Florence

Sun 12/21

12:51 pm-7:28 pm

1 stop9h 37m

$551

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Tue 12/16

10:07 pm-9:50 am

1 stop8h 43m

Florence

Fri 12/19

5:15 am-2:02 pm

2 stops11h 47m

$753

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Tue 12/16

9:00 am-10:53 pm

2 stops10h 53m

Florence

Fri 12/19

5:15 am-2:02 pm

2 stops11h 47m

$758

SeattleFlorence

SEA - FLO

SEAFLO

Seattle/Tacoma Intl

Tue 12/16

10:07 pm-9:50 am

1 stop8h 43m

Florence

Fri 12/19

12:51 pm-7:28 pm

1 stop9h 37m

$778

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Seattle to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Seattle is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $760. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Tuesday is the most expensive day to depart from Seattle because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $790.

When to book flights from Seattle to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Seattle to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Seattle to Florence, South Carolina (SEA to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Seattle to Florence, South Carolina

Fastest flight time

6h 50m

Direct flights

None
The fastest flight from Seattle to Florence, South Carolina takes 6h 50m
There are no direct flights from Seattle to Florence, South Carolina. There are no popular flight routes from Seattle to Florence, South Carolina.
Search flight deals

  • How far is Seattle/Tacoma Intl to Florence by plane?

    The distance between Seattle/Tacoma Intl and Florence is about 2371.0 mi. Typically, this will take 6h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Seattle/Tacoma Intl Airport to Florence Airport?

    Prices for flights from Seattle/Tacoma Intl Airport to Florence Airport refresh daily.

  • How many operators does momondo search for flights from Seattle/Tacoma Intl Airport to Florence Airport?

  • How old do you have to be to fly from Seattle/Tacoma Intl Airport to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Seattle/Tacoma Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Seattle to Florence, South Carolina?

Best airlines flying from Seattle to Florence, South Carolina

Compare and see reviews for airlines that fly from Seattle to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $386Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Seattle to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Seattle.

Can I find flights from Seattle to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Seattle on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Seattle to Florence?

Once all potential Seattle to Florence flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Seattle to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Seattle to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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