In general when looking for the cheapest flight to Prague, try to book your flight during the month of March for the best deal.
Most flyers found that booking flight tickets 60 days in advance of their planned departure date is, on average, the best time to get cheap flights to Prague.
In general, booking your departure to Prague for a Tuesday represents the best deal on airfare. Try to avoid a Saturday departure to stay away from the highest prices.
On average you can find the best deals on plane tickets to Prague when looking for flights with morning departure times.