Cheap flights from Ohio to St. Louis from $59

In general, October is the cheapest month to fly from Ohio to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $85. The month of April is another great option to travel to St. Louis, with average flight prices from Ohio averaging around $97.

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $370. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $429. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Ohio in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $352 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $398 per ticket.

Fly from Cleveland Hopkins Intl to Lambert-St Louis for the best Ohio - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Ohio when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $332 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Ohio for as low as $251 on momondo.

Southwest, Frontier, and Delta are the most popular carriers operating from Ohio to Lambert-St Louis

Southwest, American Airlines and United Airlines are the top three most popular airlines that fly to St. Louis from Ohio according to our data. Southwest is the first choice among our users, with 59% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

The number of flights available between Ohio and St. Louis is 20 per day as of May 2026. The most frequent departure time is 7:00AM, with 57% of daily flights leaving at noon.

As of May 2026, 141 flights take off from Ohio and land in St. Louis each week. The most common flight departure day for this route is Fri, with 17% of weekly flights taking off on this day.