Cheap flights from Ohio to St. Louis from $55

In general, October is the cheapest month to fly from Ohio to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $291. The month of September is another great option to travel to St. Louis, with average flight prices from Ohio averaging around $311.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $386. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $454. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Ohio in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $361 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $422 per ticket.

Fly from Cleveland Hopkins Intl to Lambert-St Louis for the best Ohio - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Ohio when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $346 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Ohio for as low as $236 on momondo.

There is only 1 cabin class available to choose from on Ohio to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, Delta, and Southwest are the most popular carriers operating from Ohio to Lambert-St Louis

Southwest, United Airlines and American Airlines are the top three most popular airlines that fly to St. Louis from Ohio according to our data. Southwest is the first choice among our users, with 63% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

The number of flights available between Ohio and St. Louis is 16 per day as of August 2026. The most frequent departure time is 7:00AM, with 66% of daily flights leaving at noon.

As of August 2026, 114 flights take off from Ohio and land in St. Louis each week. The most common flight departure day for this route is Wed, with 22% of weekly flights taking off on this day.