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Cheap flights from Myrtle Beach to Buffalo from $104

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Buffalo departing on 12/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Myrtle Beach to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
12:30 pm - 5:02 pmMYR-BUF
4h 32m1 stop
Delta Logo
6:00 am - 11:32 amBUF-MYR
5h 32m1 stop
$297Delta
Find Deal
Tue, Dec 2 - Sat, Dec 6
Delta Logo
6:56 pm - 11:59 pmMYR-BUF
5h 03m1 stop
Delta Logo
6:12 am - 2:56 pmBUF-MYR
8h 44m2 stops
$302Delta
Find Deal
Tue, Dec 2 - Sat, Dec 6
Delta Logo
2:40 pm - 10:58 pmMYR-BUF
8h 18m2 stops
Delta Logo
1:16 pm - 11:43 pmBUF-MYR
10h 27m2 stops
$307Delta
Find Deal
Tue, Dec 2 - Sat, Dec 6
Delta Logo
6:54 pm - 11:28 pmMYR-BUF
4h 34m1 stop
Delta Logo
6:00 am - 3:04 pmBUF-MYR
9h 04m2 stops
$312Delta
Find Deal
Thu, Jan 22 - Tue, Feb 10
Delta Logo
2:19 pm - 10:52 pmMYR-BUF
8h 33m2 stops
Delta Logo
6:00 am - 3:04 pmBUF-MYR
9h 04m2 stops
$317Delta
Find Deal
Fri, Jan 23 - Tue, Feb 10
Delta Logo
12:35 pm - 7:52 pmMYR-BUF
7h 17m1 stop
Delta Logo
12:14 pm - 6:00 pmBUF-MYR
5h 46m1 stop
$332Delta
Find Deal
Sat, Jan 24 - Mon, Feb 16
Delta Logo
10:33 am - 4:59 pmMYR-BUF
6h 26m2 stops
Delta Logo
12:14 pm - 6:00 pmBUF-MYR
5h 46m1 stop
$337Delta
Find Deal
Sat, Jan 24 - Mon, Feb 16
Delta Logo
6:00 am - 11:04 amMYR-BUF
5h 04m1 stop
Delta Logo
6:00 am - 11:32 amBUF-MYR
5h 32m1 stop
$342Delta
Find Deal
Mon, Dec 8 - Wed, Dec 10
Delta Logo
6:56 pm - 11:59 pmMYR-BUF
5h 03m1 stop
Delta Logo
6:12 am - 1:55 pmBUF-MYR
7h 43m2 stops
$347Delta
Find Deal
Mon, Dec 8 - Wed, Dec 10
Delta Logo
2:40 pm - 12:16 amMYR-BUF
9h 36m2 stops
Delta Logo
6:12 am - 1:55 pmBUF-MYR
7h 43m2 stops
$352Delta
Find Deal
Mon, Dec 8 - Wed, Dec 10

American Airlines flights from Myrtle Beach to Buffalo

Our best American Airlines deals on Myrtle Beach to Buffalo flight tickets
American Airlines
Jan 24
MYR6:23 amMyrtle Beach Intl
9h 11m
2 stops
BUF3:34 pmBuffalo
Feb 16
BUF3:56 pmBuffalo
8h 00m
2 stops
MYR11:56 pmMyrtle Beach Intl
$362
Find similar
American Airlines
Jan 2
MYR4:01 pmMyrtle Beach Intl
7h 08m
1 stop
BUF11:09 pmBuffalo
Jan 5
BUF5:24 amBuffalo
6h 43m
1 stop
MYR12:07 pmMyrtle Beach Intl
$367
Find similar
American Airlines
Jan 2
MYR6:00 amMyrtle Beach Intl
6h 17m
2 stops
BUF12:17 pmBuffalo
Jan 5
BUF5:22 pmBuffalo
6h 33m
2 stops
MYR11:55 pmMyrtle Beach Intl
$453
Find similar

Delta flights from Myrtle Beach to Buffalo

Our best Delta deals on Myrtle Beach to Buffalo flight tickets
Delta
Dec 2
MYR12:30 pmMyrtle Beach Intl
4h 32m
1 stop
BUF5:02 pmBuffalo
Dec 6
BUF6:00 amBuffalo
5h 32m
1 stop
MYR11:32 amMyrtle Beach Intl
$297
Find similar
Delta
Dec 2
MYR6:56 pmMyrtle Beach Intl
5h 03m
1 stop
BUF11:59 pmBuffalo
Dec 6
BUF6:12 amBuffalo
8h 44m
2 stops
MYR2:56 pmMyrtle Beach Intl
$302
Find similar
Delta
Dec 2
MYR2:40 pmMyrtle Beach Intl
8h 18m
2 stops
BUF10:58 pmBuffalo
Dec 6
BUF1:16 pmBuffalo
10h 27m
2 stops
MYR11:43 pmMyrtle Beach Intl
$307
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 18, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 12/2

12:30 pm-5:02 pm

1 stop4h 32m

Buffalo

Sat 12/6

6:00 am-11:32 am

1 stop5h 32m

$297

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 12/2

6:56 pm-11:59 pm

1 stop5h 03m

Buffalo

Sat 12/6

6:12 am-2:56 pm

2 stops8h 44m

$302

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 12/2

2:40 pm-10:58 pm

2 stops8h 18m

Buffalo

Sat 12/6

1:16 pm-11:43 pm

2 stops10h 27m

$307

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 1/22

6:54 pm-11:28 pm

1 stop4h 34m

Buffalo

Tue 2/10

6:00 am-3:04 pm

2 stops9h 04m

$312

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 1/23

2:19 pm-10:52 pm

2 stops8h 33m

Buffalo

Tue 2/10

6:00 am-3:04 pm

2 stops9h 04m

$317

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Sat 1/24

12:35 pm-7:52 pm

1 stop7h 17m

Buffalo

Mon 2/16

12:14 pm-6:00 pm

1 stop5h 46m

$332

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Sat 1/24

10:33 am-4:59 pm

2 stops6h 26m

Buffalo

Mon 2/16

12:14 pm-6:00 pm

1 stop5h 46m

$337

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 12/8

6:00 am-11:04 am

1 stop5h 04m

Buffalo

Wed 12/10

6:00 am-11:32 am

1 stop5h 32m

$342

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 12/8

6:56 pm-11:59 pm

1 stop5h 03m

Buffalo

Wed 12/10

6:12 am-1:55 pm

2 stops7h 43m

$347

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 12/8

2:40 pm-12:16 am

2 stops9h 36m

Buffalo

Wed 12/10

6:12 am-1:55 pm

2 stops7h 43m

$352

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Myrtle Beach to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of September, then book flights to Buffalo from Myrtle Beach during August instead. Flights to Buffalo in August, while not as cheap as those in September, still average around $328.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $316. Flights from Myrtle Beach to Buffalo on a Monday will generally be more expensive and average around $393. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the afternoon is the cheapest time of day to fly from Myrtle Beach to Buffalo when you can find flight prices for as low as $336. Flying to Buffalo in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $376 per ticket.

How have Myrtle Beach to Buffalo flight prices changed over time?

As of November 2025, prices for Myrtle Beach to Buffalo flights are approximately 21% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Buffalo (MYR to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Buffalo

Direct flights

None
There are no direct flights from Myrtle Beach to Buffalo. There are no popular flight routes from Myrtle Beach to Buffalo.
Search flight deals

  • How far is Myrtle Beach Intl to Buffalo by plane?

    The distance between Myrtle Beach Intl and Buffalo is about 635.0 mi. Typically, this will take 3h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Buffalo Airport?

    Prices for flights from Myrtle Beach Intl Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Buffalo Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Myrtle Beach Intl Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Buffalo?

Best airlines flying from Myrtle Beach to Buffalo

Compare and see reviews for airlines that fly from Myrtle Beach to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $195Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
DeltaPriceFrom $256Free CancellationRating
7.9
8,003 reviews
Search Delta flights
SouthwestPriceFrom $286Free CancellationRating
8.0
4,248 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Lockport
Orchard Park
West Seneca
East Aurora
Bowmansville
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Buffalo?

It is quick and easy to find Myrtle Beach to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Myrtle Beach to Buffalo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Myrtle Beach to Buffalo flights to just show those with flexible booking policies.

How can momondo help me find flights from Myrtle Beach to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Myrtle Beach. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Myrtle Beach to Buffalo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Buffalo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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