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Cheap flights from Myrtle Beach to Buffalo from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Buffalo departing on 5/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Myrtle Beach to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:00 am - 10:41 am
MYR
-
BUF
52h 41m
2 stops
Multiple Airlines Logo
8:49 pm - 9:05 am
BUF
-
MYR
12h 16m
1 stop
$238Multiple Airlines
Fri, May 15 - Sun, May 31
Multiple Airlines Logo
10:27 am - 10:07 am
MYR
-
BUF
23h 40m
1 stop
Multiple Airlines Logo
2:49 pm - 9:00 pm
BUF
-
MYR
30h 11m
2 stops
$255Multiple Airlines
Thu, Apr 30 - Wed, May 6
Multiple Airlines Logo
3:53 pm - 6:46 pm
MYR
-
BUF
26h 53m
1 stop
Multiple Airlines Logo
2:49 pm - 8:36 pm
BUF
-
MYR
29h 47m
2 stops
$258Multiple Airlines
Thu, May 7 - Wed, May 13
Multiple Airlines Logo
2:28 pm - 1:52 pm
MYR
-
BUF
23h 24m
1 stop
Multiple Airlines Logo
2:49 pm - 8:36 pm
BUF
-
MYR
29h 47m
2 stops
$261Multiple Airlines
Fri, May 15 - Wed, May 20
Multiple Airlines Logo
3:53 pm - 6:46 pm
MYR
-
BUF
26h 53m
1 stop
Multiple Airlines Logo
11:36 am - 8:36 pm
BUF
-
MYR
33h 00m
2 stops
$266Multiple Airlines
Thu, May 7 - Thu, May 14
Multiple Airlines Logo
10:27 am - 10:07 am
MYR
-
BUF
23h 40m
1 stop
Multiple Airlines Logo
4:07 pm - 10:00 am
BUF
-
MYR
17h 53m
1 stop
$268Multiple Airlines
Thu, Apr 30 - Sun, May 3
Multiple Airlines Logo
10:27 am - 10:07 am
MYR
-
BUF
23h 40m
1 stop
Multiple Airlines Logo
12:32 pm - 11:29 pm
BUF
-
MYR
10h 57m
2 stops
$269Multiple Airlines
Thu, Apr 30 - Sun, May 3
Multiple Airlines Logo
10:24 am - 1:54 pm
MYR
-
BUF
27h 30m
2 stops
Multiple Airlines Logo
8:49 pm - 9:05 am
BUF
-
MYR
12h 16m
1 stop
$273Multiple Airlines
Tue, May 5 - Thu, May 7
Multiple Airlines Logo
3:43 pm - 10:41 am
MYR
-
BUF
18h 58m
2 stops
Multiple Airlines Logo
2:47 pm - 9:50 am
BUF
-
MYR
19h 03m
1 stop
$274Multiple Airlines
Wed, May 6 - Sat, May 9
Delta Logo
1:43 pm - 6:35 pm
MYR
-
BUF
4h 52m
1 stop
Delta Logo
6:15 am - 10:39 am
BUF
-
MYR
4h 24m
1 stop
$277Delta
Wed, May 6 - Mon, May 11

American Airlines flights from Myrtle Beach to Buffalo

Our best American Airlines deals on Myrtle Beach to Buffalo flight tickets
American Airlines
Jun 6
MYR6:12 pmMyrtle Beach Intl
3h 49m
1 stop
BUF10:01 pmBuffalo
Jun 10
BUF5:00 amBuffalo
6h 37m
1 stop
MYR11:37 amMyrtle Beach Intl
$287
American Airlines
May 9
MYR6:00 amMyrtle Beach Intl
4h 18m
1 stop
BUF10:18 amBuffalo
May 12
BUF12:28 pmBuffalo
9h 28m
2 stops
MYR9:56 pmMyrtle Beach Intl
$290
American Airlines
Jun 6
MYR4:17 pmMyrtle Beach Intl
5h 45m
2 stops
BUF10:02 pmBuffalo
Jun 10
BUF5:25 amBuffalo
7h 03m
1 stop
MYR12:28 pmMyrtle Beach Intl
$293

United Airlines flights from Myrtle Beach to Buffalo

Our best United Airlines deals on Myrtle Beach to Buffalo flight tickets
United Airlines
May 9
MYR3:14 pmMyrtle Beach Intl
8h 41m
2 stops
BUF11:55 pmBuffalo
May 12
BUF6:04 amBuffalo
8h 14m
2 stops
MYR2:18 pmMyrtle Beach Intl
$318
United Airlines
May 20
MYR3:14 pmMyrtle Beach Intl
5h 47m
1 stop
BUF9:01 pmBuffalo
May 21
BUF6:00 amBuffalo
3h 59m
1 stop
MYR9:59 amMyrtle Beach Intl
$347
United Airlines
Apr 24
MYR3:15 pmMyrtle Beach Intl
5h 28m
1 stop
BUF8:43 pmBuffalo
Apr 28
BUF10:30 amBuffalo
6h 32m
1 stop
MYR5:02 pmMyrtle Beach Intl
$547

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 13, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 5/15

6:00 am-10:41 am

2 stops52h 41m

Buffalo

Sun 5/31

8:49 pm-9:05 am

1 stop12h 16m

$238

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 4/30

10:27 am-10:07 am

1 stop23h 40m

Buffalo

Wed 5/6

2:49 pm-9:00 pm

2 stops30h 11m

$255

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 5/7

3:53 pm-6:46 pm

1 stop26h 53m

Buffalo

Wed 5/13

2:49 pm-8:36 pm

2 stops29h 47m

$258

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 5/15

2:28 pm-1:52 pm

1 stop23h 24m

Buffalo

Wed 5/20

2:49 pm-8:36 pm

2 stops29h 47m

$261

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 5/7

3:53 pm-6:46 pm

1 stop26h 53m

Buffalo

Thu 5/14

11:36 am-8:36 pm

2 stops33h 00m

$266

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 4/30

10:27 am-10:07 am

1 stop23h 40m

Buffalo

Sun 5/3

4:07 pm-10:00 am

1 stop17h 53m

$268

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 4/30

10:27 am-10:07 am

1 stop23h 40m

Buffalo

Sun 5/3

12:32 pm-11:29 pm

2 stops10h 57m

$269

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 5/5

10:24 am-1:54 pm

2 stops27h 30m

Buffalo

Thu 5/7

8:49 pm-9:05 am

1 stop12h 16m

$273

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 5/6

3:43 pm-10:41 am

2 stops18h 58m

Buffalo

Sat 5/9

2:47 pm-9:50 am

1 stop19h 03m

$274
Quickest round-trip

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 5/6

1:43 pm-6:35 pm

1 stop4h 52m

Buffalo

Mon 5/11

6:15 am-10:39 am

1 stop4h 24m

$277

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Myrtle Beach to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and Buffalo?

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of January, then book flights to Buffalo from Myrtle Beach during September instead. Flights to Buffalo in September, while not as cheap as those in January, still average around $292.

How have Myrtle Beach to Buffalo flight prices changed over time?

As of April 2026, prices for Myrtle Beach to Buffalo flights are approximately 18% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Buffalo (MYR to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Buffalo

Fastest flight time

4h 40m

Direct flights

None
The fastest flight from Myrtle Beach to Buffalo takes 4h 40m
There are no direct flights from Myrtle Beach to Buffalo. There are no popular flight routes from Myrtle Beach to Buffalo.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Buffalo

  • How far is Myrtle Beach Intl to Buffalo by plane?

    The distance between Myrtle Beach Intl and Buffalo is about 635.0 mi. Typically, this will take 4h 40m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Buffalo Airport?

    Prices for flights from Myrtle Beach Intl Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Buffalo Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Myrtle Beach Intl Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Buffalo?

Best airlines flying from Myrtle Beach to Buffalo

Compare and see reviews for airlines that fly from Myrtle Beach to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $195Free CancellationRating
7.1
11,567 reviews
Search American Airlines flights
SouthwestPriceFrom $286Free CancellationRating
8.0
4,330 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Orchard Park
Williamsville
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Buffalo?

It is quick and easy to find Myrtle Beach to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Myrtle Beach to Buffalo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Myrtle Beach to Buffalo flights to just show those with flexible booking policies.

How can momondo help me find flights from Myrtle Beach to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Myrtle Beach. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Myrtle Beach to Buffalo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Buffalo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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