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Cheap flights from Myrtle Beach to Buffalo from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Buffalo departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
8:15 am - 12:30 pm
MYR
-
BUF
4h 15m1 stop
Southwest Logo
3:45 pm - 7:45 pm
BUF
-
MYR
4h 00m1 stop
$297Southwest
Wed, Feb 11 - Wed, Feb 18
Southwest Logo
11:05 am - 9:55 pm
MYR
-
BUF
10h 50m2 stops
Southwest Logo
3:45 pm - 7:45 pm
BUF
-
MYR
4h 00m1 stop
$302Southwest
Wed, Feb 11 - Wed, Feb 18
Multiple Airlines Logo
3:20 pm - 6:21 pm
MYR
-
BUF
27h 01m1 stop
Multiple Airlines Logo
2:01 pm - 11:57 pm
BUF
-
MYR
33h 56m2 stops
$307Multiple Airlines
Mon, Feb 9 - Mon, Feb 16
Delta Logo
4:00 pm - 10:57 pm
MYR
-
BUF
6h 57m2 stops
Delta Logo
2:58 pm - 11:57 pm
BUF
-
MYR
8h 59m2 stops
$308Delta
Wed, Feb 11 - Wed, Feb 18
Delta Logo
12:25 pm - 5:04 pm
MYR
-
BUF
4h 39m1 stop
Delta Logo
6:01 am - 11:35 am
BUF
-
MYR
5h 34m1 stop
$325Delta
Mon, Feb 9 - Mon, Feb 16
American Airlines Logo
3:30 pm - 10:40 pm
MYR
-
BUF
7h 10m2 stops
American Airlines Logo
5:29 am - 2:27 pm
BUF
-
MYR
8h 58m2 stops
$352American Airlines
Mon, Feb 9 - Mon, Feb 16
American Airlines Logo
4:24 pm - 10:31 pm
MYR
-
BUF
6h 07m1 stop
American Airlines Logo
12:51 pm - 5:37 pm
BUF
-
MYR
4h 46m1 stop
$387American Airlines
Fri, Jun 5 - Wed, Jun 10
American Airlines Logo
12:06 pm - 4:17 pm
MYR
-
BUF
4h 11m1 stop
American Airlines Logo
11:03 am - 5:37 pm
BUF
-
MYR
6h 34m2 stops
$392American Airlines
Fri, Jun 5 - Wed, Jun 10
Delta Logo
10:55 am - 3:59 pm
MYR
-
BUF
5h 04m1 stop
Delta Logo
7:00 am - 2:57 pm
BUF
-
MYR
7h 57m2 stops
$396Delta
Sun, May 31 - Thu, Jun 4
American Airlines Logo
6:26 pm - 11:51 pm
MYR
-
BUF
5h 25m1 stop
American Airlines Logo
1:44 pm - 5:17 pm
BUF
-
MYR
3h 33m1 stop
$407American Airlines
Sun, May 31 - Thu, Jun 4

Southwest flights from Myrtle Beach to Buffalo

Our best Southwest deals on Myrtle Beach to Buffalo flight tickets
Southwest
Feb 11
MYR8:15 amMyrtle Beach Intl
4h 15m
1 stop
BUF12:30 pmBuffalo
Feb 18
BUF3:45 pmBuffalo
4h 00m
1 stop
MYR7:45 pmMyrtle Beach Intl
$297
Southwest
Feb 11
MYR11:05 amMyrtle Beach Intl
10h 50m
2 stops
BUF9:55 pmBuffalo
Feb 18
BUF3:45 pmBuffalo
4h 00m
1 stop
MYR7:45 pmMyrtle Beach Intl
$302
Southwest
Jan 29
MYR8:15 amMyrtle Beach Intl
4h 15m
1 stop
BUF12:30 pmBuffalo
Feb 1
BUF5:30 amBuffalo
4h 25m
1 stop
MYR9:55 amMyrtle Beach Intl
$417

Delta flights from Myrtle Beach to Buffalo

Our best Delta deals on Myrtle Beach to Buffalo flight tickets
Delta
Feb 11
MYR4:00 pmMyrtle Beach Intl
6h 57m
2 stops
BUF10:57 pmBuffalo
Feb 18
BUF2:58 pmBuffalo
8h 59m
2 stops
MYR11:57 pmMyrtle Beach Intl
$308
Delta
Feb 9
MYR12:25 pmMyrtle Beach Intl
4h 39m
1 stop
BUF5:04 pmBuffalo
Feb 16
BUF6:01 amBuffalo
5h 34m
1 stop
MYR11:35 amMyrtle Beach Intl
$325
Delta
May 31
MYR10:55 amMyrtle Beach Intl
5h 04m
1 stop
BUF3:59 pmBuffalo
Jun 4
BUF7:00 amBuffalo
7h 57m
2 stops
MYR2:57 pmMyrtle Beach Intl
$396

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 11, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 2/11

8:15 am-12:30 pm

1 stop4h 15m

Buffalo

Wed 2/18

3:45 pm-7:45 pm

1 stop4h 00m

$297

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 2/11

11:05 am-9:55 pm

2 stops10h 50m

Buffalo

Wed 2/18

3:45 pm-7:45 pm

1 stop4h 00m

$302

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 2/9

3:20 pm-6:21 pm

1 stop27h 01m

Buffalo

Mon 2/16

2:01 pm-11:57 pm

2 stops33h 56m

$307

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 2/11

4:00 pm-10:57 pm

2 stops6h 57m

Buffalo

Wed 2/18

2:58 pm-11:57 pm

2 stops8h 59m

$308

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 2/9

12:25 pm-5:04 pm

1 stop4h 39m

Buffalo

Mon 2/16

6:01 am-11:35 am

1 stop5h 34m

$325

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 2/9

3:30 pm-10:40 pm

2 stops7h 10m

Buffalo

Mon 2/16

5:29 am-2:27 pm

2 stops8h 58m

$352

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 6/5

4:24 pm-10:31 pm

1 stop6h 07m

Buffalo

Wed 6/10

12:51 pm-5:37 pm

1 stop4h 46m

$387

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 6/5

12:06 pm-4:17 pm

1 stop4h 11m

Buffalo

Wed 6/10

11:03 am-5:37 pm

2 stops6h 34m

$392

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Sun 5/31

10:55 am-3:59 pm

1 stop5h 04m

Buffalo

Thu 6/4

7:00 am-2:57 pm

2 stops7h 57m

$396

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Sun 5/31

6:26 pm-11:51 pm

1 stop5h 25m

Buffalo

Thu 6/4

1:44 pm-5:17 pm

1 stop3h 33m

$407

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Myrtle Beach to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of September, then book flights to Buffalo from Myrtle Beach during January instead. Flights to Buffalo in January, while not as cheap as those in September, still average around $303.

How have Myrtle Beach to Buffalo flight prices changed over time?

As of January 2026, prices for Myrtle Beach to Buffalo flights are approximately 9% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Buffalo (MYR to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Buffalo

Fastest flight time

4h 20m

Direct flights

None
The fastest flight from Myrtle Beach to Buffalo takes 4h 20m
There are no direct flights from Myrtle Beach to Buffalo. There are no popular flight routes from Myrtle Beach to Buffalo.
Search flight deals

  • How far is Myrtle Beach Intl to Buffalo by plane?

    The distance between Myrtle Beach Intl and Buffalo is about 635.0 mi. Typically, this will take 4h 20m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Buffalo Airport?

    Prices for flights from Myrtle Beach Intl Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Buffalo Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Myrtle Beach Intl Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Buffalo?

Best airlines flying from Myrtle Beach to Buffalo

Compare and see reviews for airlines that fly from Myrtle Beach to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $195Free CancellationRating
7.2
11,101 reviews
Search American Airlines flights
SouthwestPriceFrom $276Free CancellationRating
8.0
4,252 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Buffalo?

It is quick and easy to find Myrtle Beach to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Myrtle Beach to Buffalo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Myrtle Beach to Buffalo flights to just show those with flexible booking policies.

How can momondo help me find flights from Myrtle Beach to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Myrtle Beach. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Myrtle Beach to Buffalo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Buffalo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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