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Cheap flights from Myrtle Beach to Buffalo from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Buffalo departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:09 am - 12:54 pm
MYR
-
BUF
27h 45m
2 stops
Multiple Airlines Logo
9:25 pm - 11:44 am
BUF
-
MYR
14h 19m
1 stop
$248Multiple Airlines
Wed, Mar 4 - Mon, Mar 9
Multiple Airlines Logo
12:50 pm - 12:13 pm
MYR
-
BUF
23h 23m
2 stops
Multiple Airlines Logo
11:25 am - 11:50 am
BUF
-
MYR
24h 25m
1 stop
$262Multiple Airlines
Thu, May 14 - Mon, May 18
Multiple Airlines Logo
12:50 pm - 7:13 pm
MYR
-
BUF
6h 23m
1 stop
Multiple Airlines Logo
11:25 am - 11:50 am
BUF
-
MYR
24h 25m
1 stop
$275Multiple Airlines
Thu, May 14 - Mon, May 18
Southwest Logo
7:20 pm - 11:20 pm
MYR
-
BUF
4h 00m
1 stop
Southwest Logo
4:00 pm - 8:50 pm
BUF
-
MYR
4h 50m
1 stop
$319Southwest
Fri, May 15 - Mon, May 18
United Airlines Logo
3:14 pm - 9:01 pm
MYR
-
BUF
5h 47m
1 stop
United Airlines Logo
6:00 am - 11:04 am
BUF
-
MYR
5h 04m
1 stop
$327United Airlines
Sat, May 9 - Sun, May 10
United Airlines Logo
5:55 pm - 11:33 pm
MYR
-
BUF
5h 38m
1 stop
United Airlines Logo
6:00 am - 11:04 am
BUF
-
MYR
5h 04m
1 stop
$332United Airlines
Wed, Apr 29 - Sun, May 3
American Airlines Logo
9:14 am - 4:32 pm
MYR
-
BUF
7h 18m
2 stops
American Airlines Logo
5:30 am - 9:58 am
BUF
-
MYR
4h 28m
1 stop
$333American Airlines
Thu, Apr 9 - Mon, Apr 13
United Airlines Logo
5:55 pm - 11:33 pm
MYR
-
BUF
5h 38m
1 stop
United Airlines Logo
6:10 am - 2:18 pm
BUF
-
MYR
8h 08m
2 stops
$337United Airlines
Wed, Apr 29 - Sun, May 3
American Airlines Logo
9:14 am - 4:32 pm
MYR
-
BUF
7h 18m
2 stops
American Airlines Logo
5:32 pm - 11:57 pm
BUF
-
MYR
6h 25m
2 stops
$339American Airlines
Thu, Apr 9 - Mon, Apr 13
Multiple Airlines Logo
2:28 pm - 10:49 am
MYR
-
BUF
20h 21m
1 stop
Multiple Airlines Logo
1:08 pm - 9:41 am
BUF
-
MYR
20h 33m
2 stops
$341Multiple Airlines
Fri, May 15 - Mon, May 18

United Airlines flights from Myrtle Beach to Buffalo

Our best United Airlines deals on Myrtle Beach to Buffalo flight tickets
United Airlines
May 9
MYR3:14 pmMyrtle Beach Intl
5h 47m
1 stop
BUF9:01 pmBuffalo
May 10
BUF6:00 amBuffalo
5h 04m
1 stop
MYR11:04 amMyrtle Beach Intl
$327
United Airlines
Apr 29
MYR5:55 pmMyrtle Beach Intl
5h 38m
1 stop
BUF11:33 pmBuffalo
May 3
BUF6:00 amBuffalo
5h 04m
1 stop
MYR11:04 amMyrtle Beach Intl
$332
United Airlines
Apr 29
MYR5:55 pmMyrtle Beach Intl
5h 38m
1 stop
BUF11:33 pmBuffalo
May 3
BUF6:10 amBuffalo
8h 08m
2 stops
MYR2:18 pmMyrtle Beach Intl
$337

Southwest flights from Myrtle Beach to Buffalo

Our best Southwest deals on Myrtle Beach to Buffalo flight tickets
Southwest
May 15
MYR7:20 pmMyrtle Beach Intl
4h 00m
1 stop
BUF11:20 pmBuffalo
May 18
BUF4:00 pmBuffalo
4h 50m
1 stop
MYR8:50 pmMyrtle Beach Intl
$319
Southwest
Apr 29
MYR7:35 amMyrtle Beach Intl
7h 45m
2 stops
BUF3:20 pmBuffalo
May 3
BUF12:25 pmBuffalo
6h 55m
2 stops
MYR7:20 pmMyrtle Beach Intl
$342
Southwest
May 14
MYR3:45 pmMyrtle Beach Intl
7h 35m
2 stops
BUF11:20 pmBuffalo
May 18
BUF6:00 amBuffalo
7h 05m
2 stops
MYR1:05 pmMyrtle Beach Intl
$377

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 3/4

9:09 am-12:54 pm

2 stops27h 45m

Buffalo

Mon 3/9

9:25 pm-11:44 am

1 stop14h 19m

$248

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 5/14

12:50 pm-12:13 pm

2 stops23h 23m

Buffalo

Mon 5/18

11:25 am-11:50 am

1 stop24h 25m

$262

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 5/14

12:50 pm-7:13 pm

1 stop6h 23m

Buffalo

Mon 5/18

11:25 am-11:50 am

1 stop24h 25m

$275

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 5/15

7:20 pm-11:20 pm

1 stop4h 00m

Buffalo

Mon 5/18

4:00 pm-8:50 pm

1 stop4h 50m

$319

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Sat 5/9

3:14 pm-9:01 pm

1 stop5h 47m

Buffalo

Sun 5/10

6:00 am-11:04 am

1 stop5h 04m

$327

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 4/29

5:55 pm-11:33 pm

1 stop5h 38m

Buffalo

Sun 5/3

6:00 am-11:04 am

1 stop5h 04m

$332

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 4/9

9:14 am-4:32 pm

2 stops7h 18m

Buffalo

Mon 4/13

5:30 am-9:58 am

1 stop4h 28m

$333

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 4/29

5:55 pm-11:33 pm

1 stop5h 38m

Buffalo

Sun 5/3

6:10 am-2:18 pm

2 stops8h 08m

$337

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 4/9

9:14 am-4:32 pm

2 stops7h 18m

Buffalo

Mon 4/13

5:32 pm-11:57 pm

2 stops6h 25m

$339

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 5/15

2:28 pm-10:49 am

1 stop20h 21m

Buffalo

Mon 5/18

1:08 pm-9:41 am

2 stops20h 33m

$341

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Myrtle Beach to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of January, then book flights to Buffalo from Myrtle Beach during September instead. Flights to Buffalo in September, while not as cheap as those in January, still average around $292.

How have Myrtle Beach to Buffalo flight prices changed over time?

As of February 2026, prices for Myrtle Beach to Buffalo flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Buffalo (MYR to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Buffalo

Fastest flight time

4h 40m

Direct flights

None
The fastest flight from Myrtle Beach to Buffalo takes 4h 40m
There are no direct flights from Myrtle Beach to Buffalo. There are no popular flight routes from Myrtle Beach to Buffalo.
Search flight deals

  • How far is Myrtle Beach Intl to Buffalo by plane?

    The distance between Myrtle Beach Intl and Buffalo is about 635.0 mi. Typically, this will take 4h 40m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Buffalo Airport?

    Prices for flights from Myrtle Beach Intl Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Buffalo Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Myrtle Beach Intl Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Buffalo?

Best airlines flying from Myrtle Beach to Buffalo

Compare and see reviews for airlines that fly from Myrtle Beach to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $195Free CancellationRating
7.2
11,352 reviews
Search American Airlines flights
SouthwestPriceFrom $276Free CancellationRating
8.0
4,299 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Buffalo?

It is quick and easy to find Myrtle Beach to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Myrtle Beach to Buffalo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Myrtle Beach to Buffalo flights to just show those with flexible booking policies.

How can momondo help me find flights from Myrtle Beach to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Myrtle Beach. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Myrtle Beach to Buffalo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Buffalo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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