Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Missouri to Florence from $462

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Florence departing on 12/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Missouri to Florence

Cheap round-trip flights

American Airlines Logo
6:36 pm - 12:15 amMCI-FLO
4h 39m1 stop
American Airlines Logo
12:51 pm - 5:46 pmFLO-MCI
5h 55m1 stop
$462American Airlines
Find Deal
Mon, Dec 22 - Mon, Dec 29
American Airlines Logo
10:35 am - 6:05 pmMCI-FLO
6h 30m1 stop
American Airlines Logo
12:51 pm - 10:39 pmFLO-MCI
10h 48m2 stops
$467American Airlines
Find Deal
Mon, Dec 22 - Mon, Dec 29
American Airlines Logo
5:20 pm - 10:53 pmMCI-FLO
4h 33m1 stop
American Airlines Logo
6:31 pm - 12:03 amFLO-MCI
6h 32m1 stop
$491American Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
American Airlines Logo
10:11 am - 10:53 pmMCI-FLO
11h 42m2 stops
American Airlines Logo
5:15 am - 11:12 amFLO-MCI
6h 57m1 stop
$496American Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
American Airlines Logo
12:20 pm - 10:53 pmMCI-FLO
9h 33m2 stops
American Airlines Logo
11:16 am - 7:03 pmFLO-MCI
8h 47m2 stops
$501American Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
American Airlines Logo
9:14 am - 2:04 pmSTL-FLO
3h 50m1 stop
American Airlines Logo
2:29 pm - 7:30 pmFLO-STL
6h 01m1 stop
$519American Airlines
Find Deal
Thu, Oct 9 - Mon, Oct 13
American Airlines Logo
6:00 am - 2:04 pmSTL-FLO
7h 04m2 stops
American Airlines Logo
2:29 pm - 7:30 pmFLO-STL
6h 01m1 stop
$524American Airlines
Find Deal
Thu, Oct 9 - Mon, Oct 13
American Airlines Logo
6:00 am - 2:04 pmSTL-FLO
7h 04m2 stops
American Airlines Logo
2:29 pm - 11:54 pmFLO-STL
10h 25m2 stops
$529American Airlines
Find Deal
Thu, Oct 9 - Mon, Oct 13
American Airlines Logo
2:08 pm - 12:15 amMCI-FLO
9h 07m2 stops
American Airlines Logo
12:51 pm - 10:39 pmFLO-MCI
10h 48m2 stops
$596American Airlines
Find Deal
Mon, Dec 22 - Mon, Dec 29

American Airlines flights from Missouri to Florence, South Carolina

Our best American Airlines deals on Missouri to Florence, South Carolina flight tickets
American Airlines
Dec 22
MCI6:36 pmKansas City
4h 39m
1 stop
FLO12:15 amFlorence
Dec 29
FLO12:51 pmFlorence
5h 55m
1 stop
MCI5:46 pmKansas City
$462
Find similar
American Airlines
Dec 22
MCI10:35 amKansas City
6h 30m
1 stop
FLO6:05 pmFlorence
Dec 29
FLO12:51 pmFlorence
10h 48m
2 stops
MCI10:39 pmKansas City
$467
Find similar
American Airlines
Dec 10
MCI5:20 pmKansas City
4h 33m
1 stop
FLO10:53 pmFlorence
Dec 13
FLO6:31 pmFlorence
6h 32m
1 stop
MCI12:03 amKansas City
$491
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 24, 2025.
Use the filters below to find and compare flights from Missouri to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Mon 12/22

6:36 pm-12:15 am

1 stop4h 39m

Florence

Mon 12/29

12:51 pm-5:46 pm

1 stop5h 55m

$462

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Mon 12/22

10:35 am-6:05 pm

1 stop6h 30m

Florence

Mon 12/29

12:51 pm-10:39 pm

2 stops10h 48m

$467

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Wed 12/10

5:20 pm-10:53 pm

1 stop4h 33m

Florence

Sat 12/13

6:31 pm-12:03 am

1 stop6h 32m

$491

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Wed 12/10

10:11 am-10:53 pm

2 stops11h 42m

Florence

Sat 12/13

5:15 am-11:12 am

1 stop6h 57m

$496

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Wed 12/10

12:20 pm-10:53 pm

2 stops9h 33m

Florence

Sat 12/13

11:16 am-7:03 pm

2 stops8h 47m

$501

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 10/9

9:14 am-2:04 pm

1 stop3h 50m

Florence

Mon 10/13

2:29 pm-7:30 pm

1 stop6h 01m

$519

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 10/9

6:00 am-2:04 pm

2 stops7h 04m

Florence

Mon 10/13

2:29 pm-7:30 pm

1 stop6h 01m

$524

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 10/9

6:00 am-2:04 pm

2 stops7h 04m

Florence

Mon 10/13

2:29 pm-11:54 pm

2 stops10h 25m

$529

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Mon 12/22

2:08 pm-12:15 am

2 stops9h 07m

Florence

Mon 12/29

12:51 pm-10:39 pm

2 stops10h 48m

$596

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Missouri to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Florence, South Carolina from Missouri according to our data. American Airlines is the first choice among our users, with 62% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Missouri to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Florence, South Carolina

Direct flights

None
There are no direct flights from Missouri to Florence, South Carolina. There are no popular flight routes from Missouri to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Florence Airport?

    Prices for flights from Missouri to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Missouri to Florence Airport?

  • How old do you have to be to fly from Missouri to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Florence, South Carolina

Compare and see reviews for airlines that fly from Missouri to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $414Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Missouri to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Missouri to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Missouri with this policy.

How can momondo help me find flights from Missouri to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Missouri.

I’m not ready to book a flight from Missouri to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 10/24
Fri 10/31
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States