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Cheap flights from Missouri to Florence from $409

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Florence departing on 4/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:12 pm - 9:47 pm
STL
-
FLO
6h 35m
1 stop
American Airlines Logo
4:02 pm - 7:30 pm
FLO
-
STL
4h 28m
1 stop
$409American Airlines
Fri, Apr 10 - Tue, Apr 14
American Airlines Logo
2:12 pm - 9:47 pm
STL
-
FLO
6h 35m
1 stop
American Airlines Logo
4:02 pm - 10:07 pm
FLO
-
STL
7h 05m
2 stops
$414American Airlines
Fri, Apr 10 - Tue, Apr 14
American Airlines Logo
2:12 pm - 9:47 pm
STL
-
FLO
6h 35m
1 stop
American Airlines Logo
4:16 pm - 7:30 pm
FLO
-
STL
4h 14m
1 stop
$433American Airlines
Thu, Apr 9 - Mon, Apr 13
American Airlines Logo
2:12 pm - 9:47 pm
STL
-
FLO
6h 35m
1 stop
American Airlines Logo
4:16 pm - 11:46 pm
FLO
-
STL
8h 30m
2 stops
$438American Airlines
Thu, Apr 9 - Mon, Apr 13
American Airlines Logo
5:51 am - 3:50 pm
STL
-
FLO
8h 59m
2 stops
American Airlines Logo
4:16 pm - 11:46 pm
FLO
-
STL
8h 30m
2 stops
$443American Airlines
Thu, Apr 9 - Mon, Apr 13
American Airlines Logo
5:53 pm - 10:42 pm
STL
-
FLO
3h 49m
1 stop
American Airlines Logo
4:16 pm - 7:30 pm
FLO
-
STL
4h 14m
1 stop
$587American Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
10:24 am - 3:32 pm
STL
-
FLO
4h 08m
1 stop
American Airlines Logo
4:16 pm - 10:07 pm
FLO
-
STL
6h 51m
2 stops
$592American Airlines
Tue, Apr 7 - Wed, Apr 15
American Airlines Logo
12:59 pm - 10:42 pm
STL
-
FLO
8h 43m
2 stops
American Airlines Logo
4:16 pm - 10:17 pm
FLO
-
STL
7h 01m
2 stops
$597American Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
2:12 pm - 9:47 pm
STL
-
FLO
6h 35m
1 stop
American Airlines Logo
6:15 am - 9:44 am
FLO
-
STL
4h 29m
1 stop
$603American Airlines
Thu, Apr 9 - Tue, Apr 14
American Airlines Logo
6:00 am - 3:50 pm
STL
-
FLO
8h 50m
2 stops
American Airlines Logo
4:02 pm - 7:30 pm
FLO
-
STL
4h 28m
1 stop
$608American Airlines
Thu, Apr 9 - Tue, Apr 14

American Airlines flights from Missouri to Florence, South Carolina

Our best American Airlines deals on Missouri to Florence, South Carolina flight tickets
American Airlines
Apr 3
STL6:57 pmLambert-St Louis
4h 00m
1 stop
FLO11:57 pmFlorence
Apr 7
FLO6:15 amFlorence
4h 29m
1 stop
STL9:44 amLambert-St Louis
$409
American Airlines
Apr 3
STL6:57 pmLambert-St Louis
4h 00m
1 stop
FLO11:57 pmFlorence
Apr 7
FLO4:02 pmFlorence
8h 44m
2 stops
STL11:46 pmLambert-St Louis
$414
American Airlines
Apr 3
STL2:00 pmLambert-St Louis
8h 57m
2 stops
FLO11:57 pmFlorence
Apr 7
FLO4:02 pmFlorence
7h 17m
2 stops
STL10:19 pmLambert-St Louis
$420

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from Missouri to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Fri 4/10

2:12 pm-9:47 pm

1 stop6h 35m

Florence

Tue 4/14

4:02 pm-7:30 pm

1 stop4h 28m

$409

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Fri 4/10

2:12 pm-9:47 pm

1 stop6h 35m

Florence

Tue 4/14

4:02 pm-10:07 pm

2 stops7h 05m

$414

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 4/9

2:12 pm-9:47 pm

1 stop6h 35m

Florence

Mon 4/13

4:16 pm-7:30 pm

1 stop4h 14m

$433

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 4/9

2:12 pm-9:47 pm

1 stop6h 35m

Florence

Mon 4/13

4:16 pm-11:46 pm

2 stops8h 30m

$438

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 4/9

5:51 am-3:50 pm

2 stops8h 59m

Florence

Mon 4/13

4:16 pm-11:46 pm

2 stops8h 30m

$443
Quickest round-trip

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 4/7

5:53 pm-10:42 pm

1 stop3h 49m

Florence

Sat 4/11

4:16 pm-7:30 pm

1 stop4h 14m

$587

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 4/7

10:24 am-3:32 pm

1 stop4h 08m

Florence

Wed 4/15

4:16 pm-10:07 pm

2 stops6h 51m

$592

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 4/7

12:59 pm-10:42 pm

2 stops8h 43m

Florence

Sat 4/11

4:16 pm-10:17 pm

2 stops7h 01m

$597

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 4/9

2:12 pm-9:47 pm

1 stop6h 35m

Florence

Tue 4/14

6:15 am-9:44 am

1 stop4h 29m

$603

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 4/9

6:00 am-3:50 pm

2 stops8h 50m

Florence

Tue 4/14

4:02 pm-7:30 pm

1 stop4h 28m

$608

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Missouri to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Missouri to Florence, South Carolina flights?

You could potentially save up to 27% on your flight if you consider stops on a Missouri to Florence, South Carolina flight.

Cheap Missouri to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Florence, South Carolina

Fastest flight time

4h 39m

Direct flights

None
The fastest flight from Missouri to Florence, South Carolina takes 4h 39m
There are no direct flights from Missouri to Florence, South Carolina. There are no popular flight routes from Missouri to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Florence Airport?

    Prices for flights from Missouri to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Missouri to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Missouri to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Missouri to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Missouri with this policy.

How can momondo help me find flights from Missouri to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Missouri.

I’m not ready to book a flight from Missouri to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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