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Cheap flights from Missouri to Florence from $333

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Florence departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Missouri to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
9:08 am - 2:10 pmSTL  Lambert-St Louis-FLO Florence
4h 02m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 9:44 amFLO  Florence-STL Lambert-St Louis
4h 20m1 stop Charlotte Douglas
$333American Airlines
Thu, Nov 5 - Tue, Nov 10
American Airlines Logo
10:22 am - 2:56 pmSTL  Lambert-St Louis-FLO Florence
3h 34m1 stop Charlotte Douglas
American Airlines Logo
3:22 pm - 6:59 pmFLO  Florence-STL Lambert-St Louis
4h 37m1 stop Charlotte Douglas
$399American Airlines
Thu, Aug 27 - Mon, Aug 31
American Airlines Logo
9:08 am - 2:10 pmSTL  Lambert-St Louis-FLO Florence
4h 02m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 7:22 pmFLO  Florence-STL Lambert-St Louis
13h 58m2 stops Charlotte Douglas Chicago O'Hare Intl
$443American Airlines
Thu, Nov 5 - Tue, Nov 10
American Airlines Logo
8:34 am - 2:56 pmSTL  Lambert-St Louis-FLO Florence
5h 22m1 stop Charlotte Douglas
American Airlines Logo
6:22 am - 4:20 pmFLO  Florence-STL Lambert-St Louis
10h 58m2 stops Charlotte Douglas Chicago O'Hare Intl
$542American Airlines
Thu, Aug 27 - Mon, Aug 31
American Airlines Logo
10:22 am - 2:56 pmSTL  Lambert-St Louis-FLO Florence
3h 34m1 stop Charlotte Douglas
American Airlines Logo
6:22 am - 11:26 amFLO  Florence-STL Lambert-St Louis
6h 04m1 stop Charlotte Douglas
$569American Airlines
Thu, Aug 27 - Tue, Sep 1
American Airlines Logo
11:32 am - 11:56 pmSTL  Lambert-St Louis-FLO Florence
11h 24m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
6:24 am - 7:22 pmFLO  Florence-STL Lambert-St Louis
13h 58m2 stops Charlotte Douglas Chicago O'Hare Intl
$615American Airlines
Thu, Nov 5 - Tue, Nov 10
American Airlines Logo
11:32 am - 11:56 pmSTL  Lambert-St Louis-FLO Florence
11h 24m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
2:35 pm - 12:03 amFLO  Florence-STL Lambert-St Louis
10h 28m2 stops Charlotte Douglas Chicago O'Hare Intl
$651American Airlines
Sun, Nov 15 - Thu, Nov 19
American Airlines Logo
3:25 pm - 10:59 pmSTL  Lambert-St Louis-FLO Florence
6h 34m1 stop Charlotte Douglas
American Airlines Logo
6:22 am - 5:27 pmFLO  Florence-STL Lambert-St Louis
12h 05m2 stops Charlotte Douglas Washington, D.C. Reagan-National
$677American Airlines
Thu, Aug 27 - Tue, Sep 1
American Airlines Logo
9:32 am - 10:59 pmSTL  Lambert-St Louis-FLO Florence
12h 27m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
6:22 am - 4:20 pmFLO  Florence-STL Lambert-St Louis
10h 58m2 stops Charlotte Douglas Chicago O'Hare Intl
$800American Airlines
Thu, Aug 27 - Mon, Aug 31
American Airlines Logo
12:45 pm - 10:59 pmSTL  Lambert-St Louis-FLO Florence
9h 14m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
3:22 pm - 11:42 pmFLO  Florence-STL Lambert-St Louis
9h 20m2 stops Charlotte Douglas Dallas/Fort Worth
$806American Airlines
Thu, Aug 27 - Tue, Sep 1

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American Airlines flights from Missouri to Florence, South Carolina

Our best American Airlines deals on Missouri to Florence, South Carolina flight tickets
American Airlines
Nov 5
STL9:08 amLambert-St Louis
4h 02m
1 stop
FLO2:10 pmFlorence
Nov 10
FLO6:24 amFlorence
4h 20m
1 stop
STL9:44 amLambert-St Louis
$333
American Airlines
Aug 27
STL10:22 amLambert-St Louis
3h 34m
1 stop
FLO2:56 pmFlorence
Aug 31
FLO3:22 pmFlorence
4h 37m
1 stop
STL6:59 pmLambert-St Louis
$399
American Airlines
Nov 5
STL9:08 amLambert-St Louis
4h 02m
1 stop
FLO2:10 pmFlorence
Nov 10
FLO6:24 amFlorence
13h 58m
2 stops
STL7:22 pmLambert-St Louis
$443

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 16, 2026.
Use the filters below to find and compare flights from Missouri to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 11/5

9:08 am-2:10 pm

1 stop4h 02m

Florence

Tue 11/10

6:24 am-9:44 am

1 stop4h 20m

$333
Quickest round-trip

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 8/27

10:22 am-2:56 pm

1 stop3h 34m

Florence

Mon 8/31

3:22 pm-6:59 pm

1 stop4h 37m

$399

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 11/5

9:08 am-2:10 pm

1 stop4h 02m

Florence

Tue 11/10

6:24 am-7:22 pm

2 stops13h 58m

$443

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 8/27

8:34 am-2:56 pm

1 stop5h 22m

Florence

Mon 8/31

6:22 am-4:20 pm

2 stops10h 58m

$542

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 8/27

10:22 am-2:56 pm

1 stop3h 34m

Florence

Tue 9/1

6:22 am-11:26 am

1 stop6h 04m

$569

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 11/5

11:32 am-11:56 pm

2 stops11h 24m

Florence

Tue 11/10

6:24 am-7:22 pm

2 stops13h 58m

$615

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Sun 11/15

11:32 am-11:56 pm

2 stops11h 24m

Florence

Thu 11/19

2:35 pm-12:03 am

2 stops10h 28m

$651

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 8/27

3:25 pm-10:59 pm

1 stop6h 34m

Florence

Tue 9/1

6:22 am-5:27 pm

2 stops12h 05m

$677

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 8/27

9:32 am-10:59 pm

2 stops12h 27m

Florence

Mon 8/31

6:22 am-4:20 pm

2 stops10h 58m

$800

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Thu 8/27

12:45 pm-10:59 pm

2 stops9h 14m

Florence

Tue 9/1

3:22 pm-11:42 pm

2 stops9h 20m

$806

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Missouri to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Missouri to Florence, South Carolina flights?

You could potentially save up to 27% on your flight if you consider stops on a Missouri to Florence, South Carolina flight.

Cheap Missouri to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Florence, South Carolina

Fastest flight time

3h 34m

Direct flights

None
The fastest flight from Missouri to Florence, South Carolina takes 3h 34m
There are no direct flights from Missouri to Florence, South Carolina. There are no popular flight routes from Missouri to Florence, South Carolina.
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Frequently asked questions about flying from Missouri to Florence, South Carolina

  • When did momondo last update prices for flights from Missouri to Florence Airport?

    Prices for flights from Missouri to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Missouri to Florence Airport?

  • How old do you have to be to fly from Missouri to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Florence, South Carolina

Compare and see reviews for airlines that fly from Missouri to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $408Free CancellationRating
7.1
11,941 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Missouri to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Missouri to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Missouri with this policy.

How can momondo help me find flights from Missouri to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Missouri.

I’m not ready to book a flight from Missouri to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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