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Cheap flights from Missouri to Florence from $500

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Florence departing on 7/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:31 am - 11:37 pm
STL
-
FLO
12h 06m
2 stops
American Airlines Logo
5:17 am - 4:29 pm
FLO
-
STL
12h 12m
2 stops
$500American Airlines
Wed, Jul 29 - Mon, Aug 3
American Airlines Logo
6:13 pm - 11:37 pm
STL
-
FLO
4h 24m
1 stop
American Airlines Logo
5:17 am - 8:33 am
FLO
-
STL
4h 16m
1 stop
$518American Airlines
Wed, Jul 29 - Mon, Aug 3
American Airlines Logo
7:32 am - 2:10 pm
STL
-
FLO
5h 38m
1 stop
American Airlines Logo
2:35 pm - 8:03 pm
FLO
-
STL
6h 28m
1 stop
$541American Airlines
Tue, Jul 7 - Tue, Jul 14
American Airlines Logo
9:08 am - 11:37 pm
STL
-
FLO
13h 29m
2 stops
American Airlines Logo
5:17 am - 8:33 am
FLO
-
STL
4h 16m
1 stop
$608American Airlines
Wed, Jul 29 - Mon, Aug 3
American Airlines Logo
9:25 am - 2:10 pm
STL
-
FLO
3h 45m
1 stop
American Airlines Logo
2:35 pm - 5:21 pm
FLO
-
STL
3h 46m
1 stop
$619American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
1:14 pm - 11:37 pm
STL
-
FLO
9h 23m
2 stops
American Airlines Logo
2:35 pm - 5:21 pm
FLO
-
STL
3h 46m
1 stop
$647American Airlines
Tue, Jul 7 - Tue, Jul 14
American Airlines Logo
9:25 am - 2:10 pm
STL
-
FLO
3h 45m
1 stop
American Airlines Logo
2:35 pm - 9:48 pm
FLO
-
STL
8h 13m
2 stops
$667American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
2:32 pm - 11:37 pm
STL
-
FLO
8h 05m
2 stops
American Airlines Logo
2:35 pm - 9:48 pm
FLO
-
STL
8h 13m
2 stops
$695American Airlines
Tue, Jul 7 - Tue, Jul 14
American Airlines Logo
2:31 pm - 11:37 pm
STL
-
FLO
8h 06m
2 stops
American Airlines Logo
2:35 pm - 9:21 pm
FLO
-
STL
7h 46m
2 stops
$795American Airlines
Fri, Jul 10 - Tue, Jul 14

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American Airlines flights from Missouri to Florence, South Carolina

Our best American Airlines deals on Missouri to Florence, South Carolina flight tickets
American Airlines
Jul 29
STL10:31 amLambert-St Louis
12h 06m
2 stops
FLO11:37 pmFlorence
Aug 3
FLO5:17 amFlorence
12h 12m
2 stops
STL4:29 pmLambert-St Louis
$500
American Airlines
Jul 29
STL6:13 pmLambert-St Louis
4h 24m
1 stop
FLO11:37 pmFlorence
Aug 3
FLO5:17 amFlorence
4h 16m
1 stop
STL8:33 amLambert-St Louis
$518
American Airlines
Jul 7
STL7:32 amLambert-St Louis
5h 38m
1 stop
FLO2:10 pmFlorence
Jul 14
FLO2:35 pmFlorence
6h 28m
1 stop
STL8:03 pmLambert-St Louis
$541

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from Missouri to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 7/29

10:31 am-11:37 pm

2 stops12h 06m

Florence

Mon 8/3

5:17 am-4:29 pm

2 stops12h 12m

$500

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 7/29

6:13 pm-11:37 pm

1 stop4h 24m

Florence

Mon 8/3

5:17 am-8:33 am

1 stop4h 16m

$518

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 7/7

7:32 am-2:10 pm

1 stop5h 38m

Florence

Tue 7/14

2:35 pm-8:03 pm

1 stop6h 28m

$541

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 7/29

9:08 am-11:37 pm

2 stops13h 29m

Florence

Mon 8/3

5:17 am-8:33 am

1 stop4h 16m

$608
Quickest round-trip

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Fri 7/10

9:25 am-2:10 pm

1 stop3h 45m

Florence

Tue 7/14

2:35 pm-5:21 pm

1 stop3h 46m

$619

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 7/7

1:14 pm-11:37 pm

2 stops9h 23m

Florence

Tue 7/14

2:35 pm-5:21 pm

1 stop3h 46m

$647

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Fri 7/10

9:25 am-2:10 pm

1 stop3h 45m

Florence

Tue 7/14

2:35 pm-9:48 pm

2 stops8h 13m

$667

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 7/7

2:32 pm-11:37 pm

2 stops8h 05m

Florence

Tue 7/14

2:35 pm-9:48 pm

2 stops8h 13m

$695

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Fri 7/10

2:31 pm-11:37 pm

2 stops8h 06m

Florence

Tue 7/14

2:35 pm-9:21 pm

2 stops7h 46m

$795

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Missouri to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Missouri to Florence, South Carolina flights?

You could potentially save up to 27% on your flight if you consider stops on a Missouri to Florence, South Carolina flight.

Cheap Missouri to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Florence, South Carolina

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from Missouri to Florence, South Carolina takes 3h 45m
There are no direct flights from Missouri to Florence, South Carolina. There are no popular flight routes from Missouri to Florence, South Carolina.
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Frequently asked questions about flying from Missouri to Florence, South Carolina

  • When did momondo last update prices for flights from Missouri to Florence Airport?

    Prices for flights from Missouri to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Missouri to Florence Airport?

  • How old do you have to be to fly from Missouri to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Florence, South Carolina

Compare and see reviews for airlines that fly from Missouri to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $408Free CancellationRating
7.1
11,772 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Missouri to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Missouri to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Missouri with this policy.

How can momondo help me find flights from Missouri to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Missouri.

I’m not ready to book a flight from Missouri to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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