Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Missouri to Florence from $354

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Florence departing on 2/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Missouri to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:52 pm - 11:08 pm
STL
-
FLO
4h 16m
1 stop
American Airlines Logo
5:16 am - 12:33 pm
FLO
-
STL
8h 17m
2 stops
$354American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
9:37 am - 5:21 pm
STL
-
FLO
6h 44m
2 stops
American Airlines Logo
5:16 am - 12:33 pm
FLO
-
STL
8h 17m
2 stops
$359American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
6:33 pm - 11:57 pm
MCI
-
FLO
4h 24m
1 stop
American Airlines Logo
6:20 pm - 8:42 am
FLO
-
MCI
15h 22m
2 stops
$477American Airlines
Fri, Mar 20 - Mon, Mar 23
American Airlines Logo
10:20 am - 5:21 pm
STL
-
FLO
6h 01m
1 stop
American Airlines Logo
5:16 am - 8:35 am
FLO
-
STL
4h 19m
1 stop
$620American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
1:58 pm - 11:57 pm
MCI
-
FLO
8h 59m
2 stops
American Airlines Logo
6:20 pm - 8:42 am
FLO
-
MCI
15h 22m
2 stops
$626American Airlines
Fri, Mar 20 - Mon, Mar 23
American Airlines Logo
6:30 am - 11:57 pm
MCI
-
FLO
16h 27m
1 stop
American Airlines Logo
6:20 pm - 4:14 pm
FLO
-
MCI
22h 54m
1 stop
$677American Airlines
Fri, Mar 20 - Mon, Mar 23
American Airlines Logo
10:24 am - 5:50 pm
MCI
-
FLO
6h 26m
1 stop
American Airlines Logo
5:16 am - 11:20 am
FLO
-
MCI
7h 04m
1 stop
$739American Airlines
Sat, Mar 14 - Wed, Mar 18
American Airlines Logo
4:08 pm - 11:57 pm
MCI
-
FLO
6h 49m
2 stops
American Airlines Logo
6:20 pm - 11:59 pm
FLO
-
MCI
6h 39m
1 stop
$744American Airlines
Sat, Mar 14 - Wed, Mar 18
American Airlines Logo
4:08 pm - 11:57 pm
MCI
-
FLO
6h 49m
2 stops
American Airlines Logo
5:16 am - 3:52 pm
FLO
-
MCI
11h 36m
2 stops
$783American Airlines
Sat, Mar 14 - Wed, Mar 18

American Airlines flights from Missouri to Florence, South Carolina

Our best American Airlines deals on Missouri to Florence, South Carolina flight tickets
American Airlines
Feb 18
STL5:52 pmLambert-St Louis
4h 16m
1 stop
FLO11:08 pmFlorence
Feb 22
FLO5:16 amFlorence
8h 17m
2 stops
STL12:33 pmLambert-St Louis
$354
American Airlines
Feb 18
STL9:37 amLambert-St Louis
6h 44m
2 stops
FLO5:21 pmFlorence
Feb 22
FLO5:16 amFlorence
8h 17m
2 stops
STL12:33 pmLambert-St Louis
$359
American Airlines
Mar 20
MCI6:33 pmKansas City
4h 24m
1 stop
FLO11:57 pmFlorence
Mar 23
FLO6:20 pmFlorence
15h 22m
2 stops
MCI8:42 amKansas City
$477

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Missouri to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 2/18

5:52 pm-11:08 pm

1 stop4h 16m

Florence

Sun 2/22

5:16 am-12:33 pm

2 stops8h 17m

$354

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 2/18

9:37 am-5:21 pm

2 stops6h 44m

Florence

Sun 2/22

5:16 am-12:33 pm

2 stops8h 17m

$359

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Fri 3/20

6:33 pm-11:57 pm

1 stop4h 24m

Florence

Mon 3/23

6:20 pm-8:42 am

2 stops15h 22m

$477

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 2/18

10:20 am-5:21 pm

1 stop6h 01m

Florence

Sun 2/22

5:16 am-8:35 am

1 stop4h 19m

$620

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Fri 3/20

1:58 pm-11:57 pm

2 stops8h 59m

Florence

Mon 3/23

6:20 pm-8:42 am

2 stops15h 22m

$626

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Fri 3/20

6:30 am-11:57 pm

1 stop16h 27m

Florence

Mon 3/23

6:20 pm-4:14 pm

1 stop22h 54m

$677

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Sat 3/14

10:24 am-5:50 pm

1 stop6h 26m

Florence

Wed 3/18

5:16 am-11:20 am

1 stop7h 04m

$739

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Sat 3/14

4:08 pm-11:57 pm

2 stops6h 49m

Florence

Wed 3/18

6:20 pm-11:59 pm

1 stop6h 39m

$744

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

Sat 3/14

4:08 pm-11:57 pm

2 stops6h 49m

Florence

Wed 3/18

5:16 am-3:52 pm

2 stops11h 36m

$783

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Missouri to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Missouri to Florence, South Carolina flights?

You could potentially save up to 27% on your flight if you consider stops on a Missouri to Florence, South Carolina flight.

Cheap Missouri to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Florence, South Carolina

Fastest flight time

4h 16m

Direct flights

None
The fastest flight from Missouri to Florence, South Carolina takes 4h 16m
There are no direct flights from Missouri to Florence, South Carolina. There are no popular flight routes from Missouri to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Florence Airport?

    Prices for flights from Missouri to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Missouri to Florence Airport?

  • How old do you have to be to fly from Missouri to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Florence, South Carolina

Compare and see reviews for airlines that fly from Missouri to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $414Free CancellationRating
7.2
11,216 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Missouri to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Missouri to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Missouri with this policy.

How can momondo help me find flights from Missouri to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Missouri.

I’m not ready to book a flight from Missouri to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 3/5
Thu 3/12
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States