What airlines fly to Indiana?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Indiana from Knoxville according to our data. American Airlines is the first choice among our users, with 37% of people opting to fly with this airline when traveling to Indiana. Keep in mind that there are 3 different airlines that fly to Indiana on a routine basis, so you have a few additional options to choose from.

How many flights depart from Knoxville to Indiana on average per week?

As of September 2026, 141 flights take off from Knoxville and land in Indiana each week. The most common flight departure day for this route is Wed, with 23% of weekly flights taking off on this day.

What is the cheapest airline that flies from Knoxville McGhee Tyson to Indiana?

Allegiant Air, Southwest, and Delta are the most popular carriers operating from Knoxville McGhee Tyson to Indiana

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Indiana?

Prices for flights from Knoxville McGhee Tyson Airport to Indiana are updated daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Indiana?

There are 4 operators available for flights from Knoxville McGhee Tyson Airport to Indiana as of September 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Indiana?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Indiana.

What documentation or ID do you need to fly to Indiana?

The travel and health documents required for your trip to Indiana can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Indiana. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$71 Cheap Flights from Knoxville to Indiana in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Indiana

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:50 pm - 7:35 pmTYS Knoxville McGhee Tyson-MDW Chicago Midway

5h 45m1 stop Nashville Intl

8:00 am - 12:20 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

3h 20m1 stop Nashville Intl

$259Southwest

Sat, Nov 7 - Wed, Nov 11

7:25 pm - 11:55 pmTYS Knoxville McGhee Tyson-MDW Chicago Midway

5h 30m1 stop Nashville Intl

7:20 am - 3:00 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

6h 40m1 stop Dallas Love Field

$259Southwest

Mon, Oct 26 - Mon, Nov 2

8:30 am - 3:18 pmTYS Knoxville McGhee Tyson-IND Indianapolis

6h 48m1 stop Orlando Sanford Intl

2:08 pm - 9:55 pmIND Indianapolis-TYS Knoxville McGhee Tyson

7h 47m1 stop Valparaiso Destin-Ft Walton Beach

$260Allegiant Air

Wed, Sep 23 - Sun, Sep 27

8:00 am - 8:39 amTYS Knoxville McGhee Tyson-MDW Chicago Midway

1h 39mnonstop

3:27 pm - 5:54 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

1h 27mnonstop

$270Allegiant Air

Mon, Nov 23 - Sun, Nov 29

6:00 am - 12:42 pmTYS Knoxville McGhee Tyson-IND Indianapolis

6h 42m1 stop Chicago O'Hare Intl

4:55 pm - 8:49 pmIND Indianapolis-TYS Knoxville McGhee Tyson

3h 54m1 stop Chicago O'Hare Intl

$273United Airlines

Mon, Oct 5 - Mon, Oct 12

6:00 am - 10:56 amTYS Knoxville McGhee Tyson-IND Indianapolis

4h 56m1 stop Chicago O'Hare Intl

4:55 pm - 8:49 pmIND Indianapolis-TYS Knoxville McGhee Tyson

3h 54m1 stop Chicago O'Hare Intl

$273United Airlines

Thu, Oct 8 - Mon, Oct 12

5:40 am - 11:44 amTYS Knoxville McGhee Tyson-IND Indianapolis

6h 04m1 stop Atlanta Hartsfield-Jackson

7:00 am - 10:54 amIND Indianapolis-TYS Knoxville McGhee Tyson

3h 54m1 stop Atlanta Hartsfield-Jackson

$273Delta

Thu, Oct 1 - Tue, Oct 6

2:08 pm - 5:33 pmTYS Knoxville McGhee Tyson-IND Indianapolis

3h 25m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:54 amIND Indianapolis-TYS Knoxville McGhee Tyson

4h 54m1 stop Atlanta Hartsfield-Jackson

$273Delta

Thu, Oct 1 - Tue, Oct 6

4:38 pm - 5:40 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 02mnonstop

8:20 am - 11:05 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 45mnonstop

$279American Airlines

Wed, Oct 7 - Tue, Oct 13

7:39 am - 9:00 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 21mnonstop

4:08 pm - 6:52 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 44mnonstop

$279American Airlines

Tue, Nov 24 - Fri, Nov 27

Cheap last minute flights

Enter your travel dates to find the best prices.

8:15 pm - 9:30 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 15mnonstop

1:24 pm - 4:11 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 47mnonstop

$339American Airlines

Mon, Sep 14 - Sat, Sep 19

8:15 pm - 9:30 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 15mnonstop

1:19 pm - 9:06 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

6h 47m1 stop Charlotte Douglas

$349American Airlines

Mon, Sep 14 - Sat, Sep 19

3:21 pm - 9:58 amTYS Knoxville McGhee Tyson-SBN South Bend/Michiana

18h 37m1 stop Tampa St. Petersburg

8:46 pm - 8:26 amSBN South Bend/Michiana-TYS Knoxville McGhee Tyson

11h 40m1 stop Orlando

$349Multiple Airlines

Tue, Sep 15 - Thu, Sep 17

1:10 pm - 7:53 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

19h 43m2 stops Washington, D.C. Dulles Intl Dayton

10:30 am - 1:18 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 48mnonstop

$429United Airlines

Fri, Sep 11 - Sat, Sep 12

6:00 am - 6:55 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

1h 55mnonstop

7:00 am - 9:54 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 54mnonstop

$439United Airlines

Sat, Sep 12 - Sun, Sep 13

5:45 pm - 10:25 pmTYS Knoxville McGhee Tyson-MDW Chicago Midway

5h 40m1 stop Nashville Intl

6:10 am - 2:00 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

6h 50m1 stop Dallas Love Field

$439Southwest

Fri, Sep 11 - Sun, Sep 13

5:45 pm - 8:56 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

4h 11m1 stop Atlanta Hartsfield-Jackson

6:40 am - 11:23 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

3h 43m1 stop Atlanta Hartsfield-Jackson

$459Delta

Sat, Sep 12 - Sun, Sep 13

6:13 pm - 10:44 pmTYS Knoxville McGhee Tyson-MDW Chicago Midway

5h 31m1 stop Atlanta Hartsfield-Jackson

4:30 pm - 10:27 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

4h 57m1 stop Atlanta Hartsfield-Jackson

$484Delta

Mon, Sep 14 - Sat, Sep 19

9:31 am - 7:45 pmTYS Knoxville McGhee Tyson-IND Indianapolis

10h 14m1 stop Orlando Sanford Intl

2:08 pm - 9:56 pmIND Indianapolis-TYS Knoxville McGhee Tyson

7h 48m1 stop Valparaiso Destin-Ft Walton Beach

$524Allegiant Air

Fri, Sep 11 - Sun, Sep 13

8:10 am - 11:18 amTYS Knoxville McGhee Tyson-IND Indianapolis

27h 08m1 stop Sarasota Bradenton Intl

2:57 pm - 2:31 pmIND Indianapolis-TYS Knoxville McGhee Tyson

23h 34m1 stop Orlando Sanford Intl

$551Allegiant Air

Sun, Sep 13 - Mon, Sep 14

Cheap direct flights

Enter your travel dates to find the best prices.

8:00 am - 8:39 amTYS Knoxville McGhee Tyson-MDW Chicago Midway

1h 39mnonstop

3:27 pm - 5:54 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

1h 27mnonstop

$270Allegiant Air

Mon, Nov 23 - Sun, Nov 29

8:52 pm - 9:58 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 06mnonstop

4:00 pm - 6:46 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 46mnonstop

$279American Airlines

Fri, Nov 13 - Mon, Nov 16

6:00 am - 6:56 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

1h 56mnonstop

6:03 pm - 8:49 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 46mnonstop

$279United Airlines

Wed, Oct 7 - Wed, Oct 14

10:42 am - 11:40 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

1h 58mnonstop

6:03 pm - 8:49 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 46mnonstop

$279United Airlines

Sat, Oct 10 - Sat, Oct 17

11:34 am - 12:46 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 12mnonstop

8:55 pm - 11:47 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 52mnonstop

$279American Airlines

Thu, Nov 26 - Mon, Nov 30

8:50 pm - 9:59 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 09mnonstop

8:55 pm - 11:47 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 52mnonstop

$279American Airlines

Fri, Nov 20 - Mon, Nov 30

6:55 pm - 8:03 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 08mnonstop

9:05 pm - 11:59 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 54mnonstop

$279American Airlines

Wed, Oct 21 - Sun, Oct 25

6:55 pm - 8:03 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 08mnonstop

9:05 pm - 11:59 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 54mnonstop

$279American Airlines

Sat, Oct 10 - Sat, Oct 17

1:58 pm - 2:37 pmTYS Knoxville McGhee Tyson-MDW Chicago Midway

1h 39mnonstop

3:27 pm - 5:54 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

1h 27mnonstop

$365Allegiant Air

Wed, Nov 25 - Sun, Nov 29

1:58 pm - 2:37 pmTYS Knoxville McGhee Tyson-MDW Chicago Midway

1h 39mnonstop

3:27 pm - 5:54 pmMDW Chicago Midway-TYS Knoxville McGhee Tyson

1h 27mnonstop

$366Allegiant Air

Wed, Nov 25 - Sun, Nov 29

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American Airlines flights from Knoxville to Indiana

Our best American Airlines deals on Knoxville to Indiana flight tickets

American Airlines

Oct 22

TYS4:38 pmKnoxville McGhee Tyson

2h 02m

ORD5:40 pmChicago O'Hare Intl

Oct 29

ORD9:05 pmChicago O'Hare Intl

1h 54m

TYS11:59 pmKnoxville McGhee Tyson

$280

American Airlines

Oct 6

TYS6:55 pmKnoxville McGhee Tyson

5h 51m

1 stop

AZO12:46 amKalamazoo Intl

Oct 13

AZO5:39 pmKalamazoo Intl

6h 20m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

$288

American Airlines

Oct 1

TYS7:18 pmKnoxville McGhee Tyson

4h 13m

1 stop

ORD10:31 pmChicago O'Hare Intl

Oct 4

ORD7:52 pmChicago O'Hare Intl

1h 51m

TYS10:43 pmKnoxville McGhee Tyson

$289

United Airlines flights from Knoxville to Indiana

Our best United Airlines deals on Knoxville to Indiana flight tickets

United Airlines

Oct 1

TYS10:42 amKnoxville McGhee Tyson

1h 58m

ORD11:40 amChicago O'Hare Intl

Oct 6

ORD6:59 amChicago O'Hare Intl

1h 46m

TYS9:45 amKnoxville McGhee Tyson

$279

United Airlines

Oct 20

TYS10:42 amKnoxville McGhee Tyson

5h 52m

1 stop

IND4:34 pmIndianapolis

Oct 22

IND5:40 amIndianapolis

4h 05m

1 stop

TYS9:45 amKnoxville McGhee Tyson

$289

United Airlines

Sep 25

TYS10:42 amKnoxville McGhee Tyson

1h 58m

ORD11:40 amChicago O'Hare Intl

Sep 27

ORD6:03 pmChicago O'Hare Intl

1h 46m

TYS8:49 pmKnoxville McGhee Tyson

$309

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleChicago

TYS Knoxville McGhee Tyson - MDW Chicago Midway

TYSMDW

Knoxville McGhee Tyson

Sat 11/7

2:50 pm-7:35 pm

1 stop5h 45m

Chicago Midway

Wed 11/11

8:00 am-12:20 pm

1 stop3h 20m

$259

KnoxvilleChicago

TYS Knoxville McGhee Tyson - MDW Chicago Midway

TYSMDW

Knoxville McGhee Tyson

Mon 10/26

7:25 pm-11:55 pm

1 stop5h 30m

Chicago Midway

Mon 11/2

7:20 am-3:00 pm

1 stop6h 40m

$259

KnoxvilleIndianapolis

TYS Knoxville McGhee Tyson - IND Indianapolis

TYSIND

Knoxville McGhee Tyson

Wed 9/23

8:30 am-3:18 pm

1 stop6h 48m

Indianapolis

Sun 9/27

2:08 pm-9:55 pm

1 stop7h 47m

$260

Quickest round-trip

KnoxvilleChicago

TYS Knoxville McGhee Tyson - MDW Chicago Midway

TYSMDW

Knoxville McGhee Tyson

Mon 11/23

8:00 am-8:39 am

Nonstop1h 39m

Chicago Midway

Sun 11/29

3:27 pm-5:54 pm

Nonstop1h 27m

$270

KnoxvilleIndianapolis

TYS Knoxville McGhee Tyson - IND Indianapolis

TYSIND

Knoxville McGhee Tyson

Mon 10/5

6:00 am-12:42 pm

1 stop6h 42m

Indianapolis

Mon 10/12

4:55 pm-8:49 pm

1 stop3h 54m

$273

KnoxvilleIndianapolis

TYS Knoxville McGhee Tyson - IND Indianapolis

TYSIND

Knoxville McGhee Tyson

Thu 10/8

6:00 am-10:56 am

1 stop4h 56m

Indianapolis

Mon 10/12

4:55 pm-8:49 pm

1 stop3h 54m

$273

KnoxvilleIndianapolis

TYS Knoxville McGhee Tyson - IND Indianapolis

TYSIND

Knoxville McGhee Tyson

Thu 10/1

5:40 am-11:44 am

1 stop6h 04m

Indianapolis

Tue 10/6

7:00 am-10:54 am

1 stop3h 54m

$273

KnoxvilleIndianapolis

TYS Knoxville McGhee Tyson - IND Indianapolis

TYSIND

Knoxville McGhee Tyson

Thu 10/1

2:08 pm-5:33 pm

1 stop3h 25m

Indianapolis

Tue 10/6

6:00 am-10:54 am

1 stop4h 54m

$273

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Wed 10/7

4:38 pm-5:40 pm

Nonstop2h 02m

Chicago O'Hare Intl

Tue 10/13

8:20 am-11:05 am

Nonstop1h 45m

$279

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Tue 11/24

7:39 am-9:00 am

Nonstop2h 21m

Chicago O'Hare Intl

Fri 11/27

4:08 pm-6:52 pm

Nonstop1h 44m

$279

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Indiana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Indiana?

The cheapest month to fly to Indiana from Knoxville is in July. Flight prices, which tend to average around $0, are often lower during this time because this is during the off-season. The month of October is another great option to travel to Indiana, with average flight prices from Knoxville averaging around $288.

What is the cheapest Knoxville McGhee Tyson to Indiana flight route?

Fly from Knoxville McGhee Tyson to South Bend/Michiana for the best Knoxville McGhee Tyson - Indiana flight prices

What cabin class options are available on Knoxville to Indiana flights?

There is only 1 cabin class available to choose from on Knoxville to Indiana flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Indiana flights?

No. A direct flight is the cheapest option for a flight between Knoxville to Indiana.

Cheap Knoxville to Indiana flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Indiana

Best Price Found	$71
Fastest flight time	1h 32m
Direct flights	Every day
Airports in Indiana	94 airports

The best one-way flight to Indiana from Knoxville in the past 72 hours is $71. The best round-trip flight deal from Knoxville to Indiana found on momondo in the last 72 hours is $259.

The fastest flight from Knoxville to Indiana takes 1h 32m

Direct flights go from Knoxville to Indiana every day.

There are 94 airports in Indiana. From Knoxville there are direct flights to Chicago O'Hare Intl (ORD), Chicago Midway (MDW).

Search flight deals

Frequently asked questions about flying from Knoxville to Indiana

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Indiana?
Prices for flights from Knoxville McGhee Tyson Airport to Indiana are updated daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Indiana?
There are 4 operators available for flights from Knoxville McGhee Tyson Airport to Indiana as of September 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Indiana?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Indiana.
What documentation or ID do you need to fly to Indiana?
The travel and health documents required for your trip to Indiana can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Indiana. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Knoxville to Indiana?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Knoxville to Indiana is Airbus A320-100/200 (100.00% of total bookings).

Best airlines flying from Knoxville to Indiana

Compare and see reviews for airlines that fly from Knoxville to Indiana with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $213	Free Cancellation	Rating 7.4 10,194 reviews		Search United Airlines flights
Delta	PriceFrom $248	Free Cancellation	Rating 7.8 8,554 reviews		Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Indiana?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Indiana from Knoxville.

Can I find flights from Knoxville to Indiana with flexible booking policies on momondo?

All flight searches from Knoxville to Indiana on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Indiana?

momondo helps you find the best flight between Knoxville and Indiana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Indiana right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Indiana, momondo offers a useful price alert feature which will track prices for flights to Indiana from Knoxville and alert you when they change.