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Cheap flights from Knoxville to Harrisburg from $229

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Harrisburg departing on 12/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Harrisburg

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:42 am - 9:10 amTYS-MDT
3h 28m1 stop
American Airlines Logo
1:52 pm - 8:43 pmMDT-TYS
6h 51m1 stop
$229American Airlines
Find Deal
Thu, Dec 25 - Thu, Jan 1
American Airlines Logo
8:30 am - 5:05 pmTYS-MDT
8h 35m2 stops
American Airlines Logo
9:41 am - 3:47 pmMDT-TYS
6h 06m1 stop
$234American Airlines
Find Deal
Thu, Dec 25 - Thu, Jan 1
Delta Logo
7:11 am - 10:59 amTYS-MDT
3h 48m1 stop
Delta Logo
7:12 pm - 11:41 pmMDT-TYS
4h 29m1 stop
$273Delta
Find Deal
Fri, Nov 7 - Mon, Nov 10
Delta Logo
5:44 am - 10:59 amTYS-MDT
5h 15m1 stop
Delta Logo
6:25 pm - 11:46 pmMDT-TYS
5h 21m1 stop
$274Delta
Find Deal
Fri, Oct 17 - Mon, Oct 20
United Airlines Logo
1:59 pm - 9:15 pmTYS-MDT
7h 16m1 stop
United Airlines Logo
6:15 am - 10:57 amMDT-TYS
4h 42m1 stop
$289United Airlines
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Thu, Jan 8 - Sun, Jan 11
Multiple Airlines Logo
6:51 pm - 8:17 pmTYS-MDT
25h 26m1 stop
Multiple Airlines Logo
5:25 pm - 10:26 pmMDT-TYS
53h 01m2 stops
$300Multiple Airlines
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Thu, Oct 30 - Wed, Nov 5
Multiple Airlines Logo
8:30 am - 8:17 pmTYS-MDT
11h 47m1 stop
Multiple Airlines Logo
11:38 am - 11:14 pmMDT-TYS
11h 36m1 stop
$317Multiple Airlines
Find Deal
Mon, Nov 3 - Mon, Nov 10
Allegiant Air Logo
2:35 pm - 12:32 pmTYS-MDT
21h 57m1 stop
Allegiant Air Logo
8:25 pm - 3:06 pmMDT-TYS
18h 41m1 stop
$324Allegiant Air
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Sat, Oct 18 - Mon, Oct 20
United Airlines Logo
6:45 am - 1:51 pmTYS-MDT
7h 06m2 stops
United Airlines Logo
10:34 am - 9:02 pmMDT-TYS
10h 28m2 stops
$363United Airlines
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Thu, Jan 8 - Sun, Jan 11
Allegiant Air Logo
2:35 pm - 12:32 pmTYS-MDT
21h 57m1 stop
Allegiant Air Logo
8:21 pm - 9:56 amMDT-TYS
13h 35m1 stop
$367Allegiant Air
Find Deal
Sat, Oct 18 - Sun, Oct 19

Delta flights from Knoxville to Harrisburg

Our best Delta deals on Knoxville to Harrisburg flight tickets
Delta
Nov 7
TYS7:11 amKnoxville McGhee Tyson
3h 48m
1 stop
MDT10:59 amHarrisburg
Nov 10
MDT7:12 pmHarrisburg
4h 29m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$273
Find similar
Delta
Oct 17
TYS5:44 amKnoxville McGhee Tyson
5h 15m
1 stop
MDT10:59 amHarrisburg
Oct 20
MDT6:25 pmHarrisburg
5h 21m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
$274
Find similar
Delta
Mar 25
TYS7:20 pmKnoxville McGhee Tyson
4h 20m
1 stop
MDT11:40 pmHarrisburg
Mar 28
MDT5:00 pmHarrisburg
4h 32m
1 stop
TYS9:32 pmKnoxville McGhee Tyson
$319
Find similar

American Airlines flights from Knoxville to Harrisburg

Our best American Airlines deals on Knoxville to Harrisburg flight tickets
American Airlines
Dec 25
TYS5:42 amKnoxville McGhee Tyson
3h 28m
1 stop
MDT9:10 amHarrisburg
Jan 1
MDT1:52 pmHarrisburg
6h 51m
1 stop
TYS8:43 pmKnoxville McGhee Tyson
$229
Find similar
American Airlines
Dec 25
TYS8:30 amKnoxville McGhee Tyson
8h 35m
2 stops
MDT5:05 pmHarrisburg
Jan 1
MDT9:41 amHarrisburg
6h 06m
1 stop
TYS3:47 pmKnoxville McGhee Tyson
$234
Find similar
American Airlines
Nov 24
TYS6:05 amKnoxville McGhee Tyson
4h 24m
1 stop
MDT10:29 amHarrisburg
Nov 28
MDT5:00 amHarrisburg
3h 34m
1 stop
TYS8:34 amKnoxville McGhee Tyson
$283
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 7, 2025.
Use the filters below to find and compare flights from Knoxville to Harrisburg that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 12/25

5:42 am-9:10 am

1 stop3h 28m

Harrisburg

Thu 1/1

1:52 pm-8:43 pm

1 stop6h 51m

$229

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 12/25

8:30 am-5:05 pm

2 stops8h 35m

Harrisburg

Thu 1/1

9:41 am-3:47 pm

1 stop6h 06m

$234

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 11/7

7:11 am-10:59 am

1 stop3h 48m

Harrisburg

Mon 11/10

7:12 pm-11:41 pm

1 stop4h 29m

$273

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 10/17

5:44 am-10:59 am

1 stop5h 15m

Harrisburg

Mon 10/20

6:25 pm-11:46 pm

1 stop5h 21m

$274

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 1/8

1:59 pm-9:15 pm

1 stop7h 16m

Harrisburg

Sun 1/11

6:15 am-10:57 am

1 stop4h 42m

$289

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 10/30

6:51 pm-8:17 pm

1 stop25h 26m

Harrisburg

Wed 11/5

5:25 pm-10:26 pm

2 stops53h 01m

$300

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Mon 11/3

8:30 am-8:17 pm

1 stop11h 47m

Harrisburg

Mon 11/10

11:38 am-11:14 pm

1 stop11h 36m

$317

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Sat 10/18

2:35 pm-12:32 pm

1 stop21h 57m

Harrisburg

Mon 10/20

8:25 pm-3:06 pm

1 stop18h 41m

$324

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 1/8

6:45 am-1:51 pm

2 stops7h 06m

Harrisburg

Sun 1/11

10:34 am-9:02 pm

2 stops10h 28m

$363

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Sat 10/18

2:35 pm-12:32 pm

1 stop21h 57m

Harrisburg

Sun 10/19

8:21 pm-9:56 am

1 stop13h 35m

$367

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Harrisburg from

How to get the cheapest flight ticket from Knoxville to Harrisburg

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Harrisburg?

The month of March is, on average, the cheapest month to fly to Harrisburg from Knoxville, with most prices found around $269. If you aren’t able to travel to Harrisburg during the month of March, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $303.

What is the cheapest day to depart on your flight to Harrisburg?

The cheapest day to depart from Knoxville to Harrisburg is on a Tuesday. Travelers who choose to depart for Harrisburg on a Tuesday will often find tickets for as low as $278. On the other hand, Sunday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $531.

What is the cheapest time of day to depart on your flight to Harrisburg?

Our data shows that the cheapest Knoxville to Harrisburg flights are usually those with departure times in the afternoon. Our users have found flights to Harrisburg in the afternoon for as low as $305. Try not to purchase tickets in the evening because they tend to be around $398. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Knoxville to Harrisburg

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Harrisburg according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Harrisburg (TYS to MDT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Harrisburg

Direct flights

None
There are no direct flights from Knoxville to Harrisburg. There are no popular flight routes from Knoxville to Harrisburg.
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  • How far is Knoxville McGhee Tyson to Harrisburg by plane?

    The straight-line distance from Knoxville McGhee Tyson to Harrisburg is 484.3 mi. 3h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Harrisburg Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Harrisburg Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Harrisburg Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Harrisburg Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Harrisburg Airport.

  • What documentation or ID do you need to fly to Harrisburg Airport?

    The required travel and health documents for your Harrisburg Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Harrisburg Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Harrisburg?

Best airlines flying from Knoxville to Harrisburg

Compare and see reviews for airlines that fly from Knoxville to Harrisburg with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,041 reviews
Search American Airlines flights
DeltaPriceFrom $273Free CancellationRating
7.9
7,969 reviews
Search Delta flights
United AirlinesPriceFrom $306Free CancellationRating
7.4
8,957 reviews
Search United Airlines flights

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Hershey
Carlisle
Mechanicsburg
Camp Hill
Hummelstown

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Harrisburg?

Finding the right flight to Harrisburg from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Harrisburg quick and easy, saving you time and money.

Can I find flights from Knoxville to Harrisburg with flexible booking policies on momondo?

All flight searches from Knoxville to Harrisburg on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Harrisburg?

Once all potential Knoxville to Harrisburg flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Harrisburg right now. Can momondo alert me if prices change?

Price alerts on flights to Harrisburg from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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