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Cheap flights from Knoxville to Harrisburg from $141

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Harrisburg departing on 2/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Harrisburg

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:41 pm - 11:27 pm
TYS
-
MDT
4h 46m
1 stop
Delta Logo
5:55 pm - 11:52 pm
MDT
-
TYS
5h 57m
1 stop
$249Delta
Fri, Feb 20 - Mon, Feb 23
American Airlines Logo
5:06 pm - 11:50 pm
TYS
-
MDT
6h 44m
1 stop
American Airlines Logo
6:00 am - 10:56 am
MDT
-
TYS
4h 56m
1 stop
$273American Airlines
Thu, Apr 9 - Sat, Apr 11
Delta Logo
7:20 pm - 11:41 pm
TYS
-
MDT
4h 21m
1 stop
Delta Logo
6:25 pm - 11:46 pm
MDT
-
TYS
5h 21m
1 stop
$308Delta
Fri, Jun 19 - Mon, Jun 22
United Airlines Logo
9:40 am - 1:56 pm
TYS
-
MDT
4h 16m
1 stop
United Airlines Logo
6:15 am - 10:49 am
MDT
-
TYS
4h 34m
1 stop
$309United Airlines
Wed, Feb 18 - Tue, Feb 24
Allegiant Air Logo
10:58 am - 9:19 am
TYS
-
MDT
22h 21m
1 stop
Allegiant Air Logo
7:03 pm - 7:47 am
MDT
-
TYS
12h 44m
1 stop
$318Allegiant Air
Wed, Feb 18 - Sun, Feb 22
Delta Logo
6:41 pm - 11:27 pm
TYS
-
MDT
4h 46m
1 stop
Delta Logo
6:34 am - 11:08 am
MDT
-
TYS
4h 34m
1 stop
$324Delta
Fri, Feb 20 - Sun, Feb 22
American Airlines Logo
11:42 am - 5:50 pm
TYS
-
MDT
6h 08m
1 stop
American Airlines Logo
9:48 am - 3:48 pm
MDT
-
TYS
6h 00m
1 stop
$333American Airlines
Thu, Feb 19 - Sun, Feb 22
American Airlines Logo
12:22 pm - 10:59 pm
TYS
-
MDT
10h 37m
2 stops
American Airlines Logo
9:51 am - 4:21 pm
MDT
-
TYS
6h 30m
1 stop
$339American Airlines
Wed, Feb 18 - Tue, Feb 24
Allegiant Air Logo
7:00 am - 3:17 pm
TYS
-
MDT
32h 17m
2 stops
Allegiant Air Logo
7:03 pm - 7:47 am
MDT
-
TYS
12h 44m
1 stop
$343Allegiant Air
Thu, Feb 19 - Sun, Feb 22
Multiple Airlines Logo
3:52 pm - 6:12 pm
TYS
-
MDT
26h 20m
2 stops
Multiple Airlines Logo
7:03 pm - 7:47 am
MDT
-
TYS
12h 44m
1 stop
$346Multiple Airlines
Wed, Feb 18 - Sun, Feb 22

United Airlines flights from Knoxville to Harrisburg

Our best United Airlines deals on Knoxville to Harrisburg flight tickets
United Airlines
Jan 29
TYS1:59 pmKnoxville McGhee Tyson
7h 06m
1 stop
MDT9:05 pmHarrisburg
Feb 15
MDT6:15 amHarrisburg
4h 34m
1 stop
TYS10:49 amKnoxville McGhee Tyson
$284
United Airlines
Feb 18
TYS9:40 amKnoxville McGhee Tyson
4h 16m
1 stop
MDT1:56 pmHarrisburg
Feb 24
MDT6:15 amHarrisburg
4h 34m
1 stop
TYS10:49 amKnoxville McGhee Tyson
$309
United Airlines
Jan 29
TYS6:45 amKnoxville McGhee Tyson
7h 06m
2 stops
MDT1:51 pmHarrisburg
Feb 15
MDT6:15 amHarrisburg
4h 34m
1 stop
TYS10:49 amKnoxville McGhee Tyson
$370

Delta flights from Knoxville to Harrisburg

Our best Delta deals on Knoxville to Harrisburg flight tickets
Delta
Feb 20
TYS6:41 pmKnoxville McGhee Tyson
4h 46m
1 stop
MDT11:27 pmHarrisburg
Feb 24
MDT6:00 amHarrisburg
6h 11m
1 stop
TYS12:11 pmKnoxville McGhee Tyson
$249
Delta
Jan 31
TYS5:00 pmKnoxville McGhee Tyson
6h 26m
1 stop
MDT11:26 pmHarrisburg
Feb 7
MDT6:00 amHarrisburg
5h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
$279
Delta
Jun 19
TYS7:20 pmKnoxville McGhee Tyson
4h 21m
1 stop
MDT11:41 pmHarrisburg
Jun 22
MDT6:25 pmHarrisburg
5h 21m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
$308

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 24, 2026.
Use the filters below to find and compare flights from Knoxville to Harrisburg that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 2/20

6:41 pm-11:27 pm

1 stop4h 46m

Harrisburg

Mon 2/23

5:55 pm-11:52 pm

1 stop5h 57m

$249

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 4/9

5:06 pm-11:50 pm

1 stop6h 44m

Harrisburg

Sat 4/11

6:00 am-10:56 am

1 stop4h 56m

$273

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 6/19

7:20 pm-11:41 pm

1 stop4h 21m

Harrisburg

Mon 6/22

6:25 pm-11:46 pm

1 stop5h 21m

$308

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 2/18

9:40 am-1:56 pm

1 stop4h 16m

Harrisburg

Tue 2/24

6:15 am-10:49 am

1 stop4h 34m

$309

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 2/18

10:58 am-9:19 am

1 stop22h 21m

Harrisburg

Sun 2/22

7:03 pm-7:47 am

1 stop12h 44m

$318

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Fri 2/20

6:41 pm-11:27 pm

1 stop4h 46m

Harrisburg

Sun 2/22

6:34 am-11:08 am

1 stop4h 34m

$324

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 2/19

11:42 am-5:50 pm

1 stop6h 08m

Harrisburg

Sun 2/22

9:48 am-3:48 pm

1 stop6h 00m

$333

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 2/18

12:22 pm-10:59 pm

2 stops10h 37m

Harrisburg

Tue 2/24

9:51 am-4:21 pm

1 stop6h 30m

$339

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Thu 2/19

7:00 am-3:17 pm

2 stops32h 17m

Harrisburg

Sun 2/22

7:03 pm-7:47 am

1 stop12h 44m

$343

KnoxvilleHarrisburg

TYS - MDT

TYSMDT

Knoxville McGhee Tyson

Wed 2/18

3:52 pm-6:12 pm

2 stops26h 20m

Harrisburg

Sun 2/22

7:03 pm-7:47 am

1 stop12h 44m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Harrisburg from

How to get the cheapest flight ticket from Knoxville to Harrisburg

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Harrisburg?

What is the cheapest month to fly to Harrisburg?

The month of December is, on average, the cheapest month to fly to Harrisburg from Knoxville, with most prices found around $321. If you aren’t able to travel to Harrisburg during the month of December, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $343.

When to book flights from Knoxville to Harrisburg

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Harrisburg according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Harrisburg (TYS to MDT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Harrisburg

Fastest flight time

4h 21m

Direct flights

None
The fastest flight from Knoxville to Harrisburg takes 4h 21m
There are no direct flights from Knoxville to Harrisburg. There are no popular flight routes from Knoxville to Harrisburg.
Search flight deals

  • How far is Knoxville McGhee Tyson to Harrisburg by plane?

    The straight-line distance from Knoxville McGhee Tyson to Harrisburg is 484.3 mi. 4h 21m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Harrisburg Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Harrisburg Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Harrisburg Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Harrisburg Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Harrisburg Airport.

  • What documentation or ID do you need to fly to Harrisburg Airport?

    The required travel and health documents for your Harrisburg Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Harrisburg Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Harrisburg?

Best airlines flying from Knoxville to Harrisburg

Compare and see reviews for airlines that fly from Knoxville to Harrisburg with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,192 reviews
Search American Airlines flights
DeltaPriceFrom $233Free CancellationRating
7.9
8,110 reviews
Search Delta flights
United AirlinesPriceFrom $321Free CancellationRating
7.4
9,194 reviews
Search United Airlines flights

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Hershey
Carlisle
Mechanicsburg
Camp Hill
Hummelstown

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Harrisburg?

Finding the right flight to Harrisburg from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Harrisburg quick and easy, saving you time and money.

Can I find flights from Knoxville to Harrisburg with flexible booking policies on momondo?

All flight searches from Knoxville to Harrisburg on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Harrisburg?

Once all potential Knoxville to Harrisburg flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Harrisburg right now. Can momondo alert me if prices change?

Price alerts on flights to Harrisburg from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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