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Cheap flights from Key West to San Diego from $188

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Diego departing on 5/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:40 pm - 9:20 pm
EYW
-
SAN
9h 40m
1 stop
Delta Logo
10:25 pm - 10:53 am
SAN
-
EYW
9h 28m
1 stop
$375Delta
Fri, May 1 - Fri, May 8
American Airlines Logo
3:58 pm - 11:56 pm
EYW
-
SAN
10h 58m
2 stops
American Airlines Logo
12:53 pm - 10:58 pm
SAN
-
EYW
7h 05m
1 stop
$380American Airlines
Fri, May 1 - Fri, May 8
Delta Logo
7:45 am - 1:08 pm
EYW
-
SAN
8h 23m
1 stop
Delta Logo
6:20 am - 7:45 pm
SAN
-
EYW
10h 25m
1 stop
$435Delta
Thu, Aug 6 - Wed, Aug 12
American Airlines Logo
3:00 pm - 8:13 pm
EYW
-
SAN
8h 13m
1 stop
American Airlines Logo
6:15 am - 6:39 pm
SAN
-
EYW
9h 24m
2 stops
$465American Airlines
Thu, Aug 6 - Wed, Aug 12
American Airlines Logo
11:26 am - 8:13 pm
EYW
-
SAN
11h 47m
2 stops
American Airlines Logo
6:15 am - 6:39 pm
SAN
-
EYW
9h 24m
2 stops
$471American Airlines
Thu, Aug 6 - Wed, Aug 12
United Airlines Logo
4:47 pm - 9:25 pm
EYW
-
SAN
7h 38m
1 stop
United Airlines Logo
10:20 pm - 1:43 pm
SAN
-
EYW
12h 23m
1 stop
$499United Airlines
Fri, May 1 - Mon, May 4
American Airlines Logo
3:58 pm - 10:28 pm
EYW
-
SAN
9h 30m
1 stop
American Airlines Logo
8:15 am - 10:58 pm
SAN
-
EYW
11h 43m
2 stops
$505American Airlines
Thu, Apr 23 - Thu, Apr 30
Delta Logo
6:24 pm - 11:00 pm
EYW
-
SAN
7h 36m
1 stop
Delta Logo
10:30 pm - 11:02 am
SAN
-
EYW
9h 32m
1 stop
$507Delta
Thu, Jun 11 - Mon, Jun 22
American Airlines Logo
3:58 pm - 10:00 pm
EYW
-
SAN
9h 02m
2 stops
American Airlines Logo
8:15 am - 10:58 pm
SAN
-
EYW
11h 43m
2 stops
$511American Airlines
Thu, Apr 23 - Thu, Apr 30
Delta Logo
6:23 pm - 11:25 pm
EYW
-
SAN
8h 02m
1 stop
Delta Logo
10:30 pm - 10:46 am
SAN
-
EYW
9h 16m
1 stop
$517Delta
Thu, Apr 23 - Thu, Apr 30

United Airlines flights from Key West to San Diego

Our best United Airlines deals on Key West to San Diego flight tickets
United Airlines
May 1
EYW4:47 pmKey West
7h 38m
1 stop
SAN9:25 pmSan Diego
May 4
SAN10:20 pmSan Diego
12h 23m
1 stop
EYW1:43 pmKey West
$499
United Airlines
May 1
EYW4:47 pmKey West
7h 38m
1 stop
SAN9:25 pmSan Diego
May 4
SAN6:15 amSan Diego
6h 47m
1 stop
EYW4:02 pmKey West
$529
United Airlines
May 1
EYW4:47 pmKey West
7h 38m
1 stop
SAN9:25 pmSan Diego
May 4
SAN7:00 pmSan Diego
17h 07m
2 stops
EYW3:07 pmKey West
$532

Delta flights from Key West to San Diego

Our best Delta deals on Key West to San Diego flight tickets
Delta
May 1
EYW2:40 pmKey West
9h 40m
1 stop
SAN9:20 pmSan Diego
May 8
SAN10:25 pmSan Diego
9h 28m
1 stop
EYW10:53 amKey West
$375
Delta
Aug 6
EYW7:45 amKey West
8h 23m
1 stop
SAN1:08 pmSan Diego
Aug 12
SAN6:20 amSan Diego
10h 25m
1 stop
EYW7:45 pmKey West
$435
Delta
Jun 11
EYW6:24 pmKey West
7h 36m
1 stop
SAN11:00 pmSan Diego
Jun 22
SAN10:30 pmSan Diego
9h 32m
1 stop
EYW11:02 amKey West
$507

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from Key West to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 5/1

2:40 pm-9:20 pm

1 stop9h 40m

San Diego

Fri 5/8

10:25 pm-10:53 am

1 stop9h 28m

$375

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 5/1

3:58 pm-11:56 pm

2 stops10h 58m

San Diego

Fri 5/8

12:53 pm-10:58 pm

1 stop7h 05m

$380

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 8/6

7:45 am-1:08 pm

1 stop8h 23m

San Diego

Wed 8/12

6:20 am-7:45 pm

1 stop10h 25m

$435

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 8/6

3:00 pm-8:13 pm

1 stop8h 13m

San Diego

Wed 8/12

6:15 am-6:39 pm

2 stops9h 24m

$465

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 8/6

11:26 am-8:13 pm

2 stops11h 47m

San Diego

Wed 8/12

6:15 am-6:39 pm

2 stops9h 24m

$471

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 5/1

4:47 pm-9:25 pm

1 stop7h 38m

San Diego

Mon 5/4

10:20 pm-1:43 pm

1 stop12h 23m

$499

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/23

3:58 pm-10:28 pm

1 stop9h 30m

San Diego

Thu 4/30

8:15 am-10:58 pm

2 stops11h 43m

$505
Quickest round-trip

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 6/11

6:24 pm-11:00 pm

1 stop7h 36m

San Diego

Mon 6/22

10:30 pm-11:02 am

1 stop9h 32m

$507

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/23

3:58 pm-10:00 pm

2 stops9h 02m

San Diego

Thu 4/30

8:15 am-10:58 pm

2 stops11h 43m

$511

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 4/23

6:23 pm-11:25 pm

1 stop8h 02m

San Diego

Thu 4/30

10:30 pm-10:46 am

1 stop9h 16m

$517

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Key West to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Key West to San Diego?

Delta is the most popular carrier operating from Key West to San Diego

When to book flights from Key West to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Diego (EYW to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Diego

Fastest flight time

7h 38m

Direct flights

None
The fastest flight from Key West to San Diego takes 7h 38m
There are no direct flights from Key West to San Diego. There are no popular flight routes from Key West to San Diego.
Search flight deals

  • How far is Key West to San Diego by plane?

    Key West and San Diego are 2204.3 mi apart from one another. Flights usually cover this in 7h 38m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Key West Airport to San Diego Airport?

    Prices for flights from Key West Airport to San Diego Airport were last updated today.

  • How old do you have to be to fly from Key West Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
Imperial Beach
La Mesa
Borrego Springs
Alpine
Santee
Lemon Grove

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Key West.

Can I find flights from Key West to San Diego with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Key West to San Diego flights to just show those with flexible booking policies.

How can momondo help me find flights from Key West to San Diego?

momondo helps you find the best flight between Key West and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Diego right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Key West to San Diego now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Diego and let you know when they change.

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