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Cheap flights from Key West to San Diego from $289

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to San Diego departing on 11/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:10 pm - 11:47 pmEYW-SAN
8h 37m1 stop
Delta Logo
6:25 am - 5:15 pmSAN-EYW
7h 50m1 stop
$309Delta
Find Deal
Wed, Dec 3 - Sat, Dec 6
Delta Logo
6:10 pm - 9:16 amEYW-SAN
18h 06m2 stops
Delta Logo
8:00 am - 8:06 pmSAN-EYW
9h 06m1 stop
$362Delta
Find Deal
Wed, Dec 3 - Sun, Dec 7
American Airlines Logo
8:06 am - 1:49 pmEYW-SAN
8h 43m1 stop
American Airlines Logo
10:47 am - 11:50 pmSAN-EYW
10h 03m2 stops
$379American Airlines
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Thu, Nov 20 - Sun, Nov 23
Delta Logo
12:37 pm - 6:18 pmEYW-SAN
8h 41m1 stop
Delta Logo
9:59 am - 11:42 amSAN-EYW
22h 43m2 stops
$388Delta
Find Deal
Thu, Dec 4 - Sun, Dec 7
Delta Logo
6:10 pm - 6:18 pmEYW-SAN
27h 08m1 stop
Delta Logo
6:25 am - 5:15 pmSAN-EYW
7h 50m1 stop
$407Delta
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Tue, Dec 2 - Sat, Dec 6
American Airlines Logo
7:00 am - 3:50 pmEYW-SAN
11h 50m2 stops
American Airlines Logo
9:54 pm - 11:02 amSAN-EYW
10h 08m2 stops
$421American Airlines
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Thu, Dec 4 - Sun, Dec 7
Multiple Airlines Logo
10:47 am - 10:33 pmEYW-SAN
14h 46m2 stops
Multiple Airlines Logo
1:21 pm - 10:31 amSAN-EYW
18h 10m1 stop
$443Multiple Airlines
Find Deal
Wed, Dec 3 - Thu, Dec 4
Multiple Airlines Logo
8:55 am - 3:27 pmEYW-SAN
33h 32m2 stops
Multiple Airlines Logo
1:21 pm - 10:31 amSAN-EYW
18h 10m1 stop
$481Multiple Airlines
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Sun, Nov 30 - Sun, Dec 7
Breeze Airways Logo
11:11 am - 12:36 pmEYW-SAN
28h 25m1 stop
Breeze Airways Logo
1:21 pm - 10:31 amSAN-EYW
18h 10m1 stop
$665Breeze Airways
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Mon, Dec 1 - Thu, Dec 4
United Airlines Logo
4:53 pm - 11:40 pmEYW-SAN
9h 47m2 stops
United Airlines Logo
7:38 pm - 2:52 pmSAN-EYW
16h 14m2 stops
$740United Airlines
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Tue, Mar 10 - Wed, Mar 11

American Airlines flights from Key West to San Diego

Our best American Airlines deals on Key West to San Diego flight tickets
American Airlines
Nov 20
EYW8:06 amKey West
8h 43m
1 stop
SAN1:49 pmSan Diego
Nov 23
SAN10:47 amSan Diego
10h 03m
2 stops
EYW11:50 pmKey West
$379
Find similar
American Airlines
Dec 4
EYW7:00 amKey West
11h 50m
2 stops
SAN3:50 pmSan Diego
Dec 7
SAN9:54 pmSan Diego
10h 08m
2 stops
EYW11:02 amKey West
$421
Find similar
American Airlines
Nov 20
EYW2:50 pmKey West
10h 02m
2 stops
SAN9:52 pmSan Diego
Nov 23
SAN9:42 amSan Diego
11h 08m
2 stops
EYW11:50 pmKey West
$449
Find similar

Delta flights from Key West to San Diego

Our best Delta deals on Key West to San Diego flight tickets
Delta
Dec 3
EYW6:10 pmKey West
8h 37m
1 stop
SAN11:47 pmSan Diego
Dec 6
SAN6:25 amSan Diego
7h 50m
1 stop
EYW5:15 pmKey West
$309
Find similar
Delta
Dec 3
EYW6:10 pmKey West
18h 06m
2 stops
SAN9:16 amSan Diego
Dec 7
SAN8:00 amSan Diego
9h 06m
1 stop
EYW8:06 pmKey West
$362
Find similar
Delta
Dec 4
EYW12:37 pmKey West
8h 41m
1 stop
SAN6:18 pmSan Diego
Dec 7
SAN9:59 amSan Diego
22h 43m
2 stops
EYW11:42 amKey West
$388
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Key West to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Key West to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 12/3

6:10 pm-11:47 pm

1 stop8h 37m

San Diego

Sat 12/6

6:25 am-5:15 pm

1 stop7h 50m

$309

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 12/3

6:10 pm-9:16 am

2 stops18h 06m

San Diego

Sun 12/7

8:00 am-8:06 pm

1 stop9h 06m

$362

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 11/20

8:06 am-1:49 pm

1 stop8h 43m

San Diego

Sun 11/23

10:47 am-11:50 pm

2 stops10h 03m

$379

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 12/4

12:37 pm-6:18 pm

1 stop8h 41m

San Diego

Sun 12/7

9:59 am-11:42 am

2 stops22h 43m

$388

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 12/2

6:10 pm-6:18 pm

1 stop27h 08m

San Diego

Sat 12/6

6:25 am-5:15 pm

1 stop7h 50m

$407

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 12/4

7:00 am-3:50 pm

2 stops11h 50m

San Diego

Sun 12/7

9:54 pm-11:02 am

2 stops10h 08m

$421

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 12/3

10:47 am-10:33 pm

2 stops14h 46m

San Diego

Thu 12/4

1:21 pm-10:31 am

1 stop18h 10m

$443

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 11/30

8:55 am-3:27 pm

2 stops33h 32m

San Diego

Sun 12/7

1:21 pm-10:31 am

1 stop18h 10m

$481

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Mon 12/1

11:11 am-12:36 pm

1 stop28h 25m

San Diego

Thu 12/4

1:21 pm-10:31 am

1 stop18h 10m

$665

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 3/10

4:53 pm-11:40 pm

2 stops9h 47m

San Diego

Wed 3/11

7:38 pm-2:52 pm

2 stops16h 14m

$740

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Key West to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Key West to San Diego is on a Friday. Travelers who choose to depart for San Diego on a Friday will often find tickets for as low as $333. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $546. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $347. Flights in the morning are often more expensive with an average ticket price of $537.

When to book flights from Key West to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to San Diego (EYW to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to San Diego

Direct flights

None
There are no direct flights from Key West to San Diego. There are no popular flight routes from Key West to San Diego.
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  • How far is Key West to San Diego by plane?

    Key West and San Diego are 2204.3 mi apart from one another. Flights usually cover this in 8h 11m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Key West Airport to San Diego Airport?

    Prices for flights from Key West Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Key West Airport to San Diego Airport?

  • How old do you have to be to fly from Key West Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Key West to San Diego?

Best airlines flying from Key West to San Diego

Compare and see reviews for airlines that fly from Key West to San Diego with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $299Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
La Mesa
Imperial Beach
Poway
San Ysidro
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Key West to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Key West.

Can I find flights from Key West to San Diego with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Key West to San Diego flights to just show those with flexible booking policies.

How can momondo help me find flights from Key West to San Diego?

momondo helps you find the best flight between Key West and San Diego by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to San Diego right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Key West to San Diego now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Diego and let you know when they change.

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