Cheap flights from Illinois to Panama City from $160

The cheapest month to fly to Panama City, Florida from Illinois is in February. Flight prices, which tend to average around $338, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Illinois averaging around $339.

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $339. On the other hand, Thursday is the most expensive day to depart from Illinois because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $449.

Fly from Chicago O'Hare Intl to Panama City NW Florida Beaches for the best Illinois - Panama City NW Florida Beaches flight prices

You are more likely to see cheaper flights to Panama City, Florida from Illinois when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $372 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Illinois for as low as $331 on momondo.

There are 4 cabin classes available to choose from on Illinois to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 27% on your flight if you consider stops on a Illinois to Panama City, Florida flight.

Delta, Southwest, and American Airlines are the most popular carriers operating from Illinois to Panama City NW Florida Beaches

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Panama City, Florida from Illinois according to our data. American Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 5 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

6 flights are operational weekly from Illinois to Panama City, Florida as of October 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.

Flight times vary depending on what airport in Illinois you fly out of and what airport in Panama City, Florida you fly into. For example, flying from Chicago to Pensacola takes 2h 14m on average. On the other hand, flying from Moline to Pensacola takes 3h 50m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.