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Cheap flights from Grand Cayman to San Francisco from $275

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Grand Cayman to San Francisco departing on 1/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Grand Cayman to San Francisco

Cheap round-trip flights

Southwest Logo
1:30 pm - 9:50 pmGCM-SFO
11h 20m2 stops
Southwest Logo
8:30 pm - 12:55 pmSFO-GCM
13h 25m2 stops
$506Southwest
Find Deal
Wed, Dec 24 - Sun, Jan 11
JetBlue Logo
3:55 pm - 11:33 pmGCM-SFO
10h 38m1 stop
JetBlue Logo
10:40 pm - 2:55 pmSFO-GCM
13h 15m1 stop
$566JetBlue
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Tue, Mar 3 - Wed, Mar 4
JetBlue Logo
3:55 pm - 11:33 pmGCM-SFO
10h 38m1 stop
JetBlue Logo
10:40 pm - 2:55 pmSFO-GCM
13h 15m1 stop
$590JetBlue
Find Deal
Tue, Mar 3 - Wed, Mar 4
Delta Logo
12:55 pm - 10:30 pmGCM-SFO
11h 35m1 stop
Delta Logo
3:00 pm - 11:35 amSFO-GCM
18h 35m1 stop
$701Delta
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Fri, Oct 24 - Sun, Oct 26
American Airlines Logo
4:26 pm - 3:06 pmGCM-SFO
25h 40m1 stop
American Airlines Logo
12:46 am - 11:41 amSFO-GCM
7h 55m1 stop
$710American Airlines
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Wed, Dec 24 - Sat, Jan 10
American Airlines Logo
12:25 pm - 10:45 pmGCM-SFO
12h 20m2 stops
American Airlines Logo
10:15 pm - 11:10 amSFO-GCM
10h 55m2 stops
$715American Airlines
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Fri, Oct 24 - Sun, Oct 26
American Airlines Logo
1:05 pm - 8:39 amGCM-SFO
22h 34m2 stops
American Airlines Logo
12:27 am - 2:00 pmSFO-GCM
10h 33m2 stops
$755American Airlines
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Wed, Dec 24 - Sat, Jan 10
American Airlines Logo
2:20 pm - 10:40 pmGCM-SFO
11h 20m2 stops
American Airlines Logo
11:45 pm - 1:50 pmSFO-GCM
11h 05m2 stops
$904American Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
Delta Logo
12:52 pm - 10:41 pmGCM-SFO
11h 49m1 stop
Delta Logo
10:50 pm - 11:35 amSFO-GCM
10h 45m1 stop
$966Delta
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Fri, Oct 3 - Sun, Oct 5
American Airlines Logo
12:10 pm - 8:35 amGCM-SFO
22h 25m2 stops
American Airlines Logo
11:59 pm - 1:10 pmSFO-GCM
11h 11m2 stops
$985American Airlines
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Fri, Oct 3 - Sun, Oct 5

Delta flights from Grand Cayman to San Francisco

Our best Delta deals on Grand Cayman to San Francisco flight tickets
Delta
Oct 24
GCM12:55 pmGeorge Town Owen Roberts Intl
11h 35m
1 stop
SFO10:30 pmSan Francisco
Oct 26
SFO3:00 pmSan Francisco
18h 35m
1 stop
GCM11:35 amGeorge Town Owen Roberts Intl
$701
Find similar
Delta
Oct 3
GCM12:52 pmGeorge Town Owen Roberts Intl
11h 49m
1 stop
SFO10:41 pmSan Francisco
Oct 5
SFO10:50 pmSan Francisco
10h 45m
1 stop
GCM11:35 amGeorge Town Owen Roberts Intl
$966
Find similar

American Airlines flights from Grand Cayman to San Francisco

Our best American Airlines deals on Grand Cayman to San Francisco flight tickets
American Airlines
Dec 24
GCM4:26 pmGeorge Town Owen Roberts Intl
25h 40m
1 stop
SFO3:06 pmSan Francisco
Jan 10
SFO12:46 amSan Francisco
7h 55m
1 stop
GCM11:41 amGeorge Town Owen Roberts Intl
$710
Find similar
American Airlines
Oct 24
GCM12:25 pmGeorge Town Owen Roberts Intl
12h 20m
2 stops
SFO10:45 pmSan Francisco
Oct 26
SFO10:15 pmSan Francisco
10h 55m
2 stops
GCM11:10 amGeorge Town Owen Roberts Intl
$715
Find similar
American Airlines
Dec 24
GCM1:05 pmGeorge Town Owen Roberts Intl
22h 34m
2 stops
SFO8:39 amSan Francisco
Jan 10
SFO12:27 amSan Francisco
10h 33m
2 stops
GCM2:00 pmGeorge Town Owen Roberts Intl
$755
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Grand Cayman to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 22, 2025.
Use the filters below to find and compare flights from Grand Cayman to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 12/24

1:30 pm-9:50 pm

2 stops11h 20m

San Francisco

Sun 1/11

8:30 pm-12:55 pm

2 stops13h 25m

$506

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 3/3

3:55 pm-11:33 pm

1 stop10h 38m

San Francisco

Wed 3/4

10:40 pm-2:55 pm

1 stop13h 15m

$566

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 3/3

3:55 pm-11:33 pm

1 stop10h 38m

San Francisco

Wed 3/4

10:40 pm-2:55 pm

1 stop13h 15m

$590

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 10/24

12:55 pm-10:30 pm

1 stop11h 35m

San Francisco

Sun 10/26

3:00 pm-11:35 am

1 stop18h 35m

$701

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 12/24

4:26 pm-3:06 pm

1 stop25h 40m

San Francisco

Sat 1/10

12:46 am-11:41 am

1 stop7h 55m

$710

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 10/24

12:25 pm-10:45 pm

2 stops12h 20m

San Francisco

Sun 10/26

10:15 pm-11:10 am

2 stops10h 55m

$715

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 12/24

1:05 pm-8:39 am

2 stops22h 34m

San Francisco

Sat 1/10

12:27 am-2:00 pm

2 stops10h 33m

$755

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 3/3

2:20 pm-10:40 pm

2 stops11h 20m

San Francisco

Wed 3/4

11:45 pm-1:50 pm

2 stops11h 05m

$904

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 10/3

12:52 pm-10:41 pm

1 stop11h 49m

San Francisco

Sun 10/5

10:50 pm-11:35 am

1 stop10h 45m

$966

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Fri 10/3

12:10 pm-8:35 am

2 stops22h 25m

San Francisco

Sun 10/5

11:59 pm-1:10 pm

2 stops11h 11m

$985

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Grand Cayman to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Grand Cayman to San Francisco is on a Monday when prices can be found for as low as $661. The most expensive day to fly to San Francisco is Saturday, with ticket prices averaging around $870.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Grand Cayman to San Francisco flights are usually those with departure times in the morning. Our users have found flights to San Francisco in the morning for as low as $678. Flights in the afternoon are often more expensive with an average ticket price of $758.

Can stopping save me money on Grand Cayman to San Francisco flights?

No. A direct flight is the cheapest option for a flight between Grand Cayman to San Francisco.

Cheap Grand Cayman to San Francisco flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Grand Cayman to San Francisco

Direct flights

None
There are no direct flights from Grand Cayman to San Francisco. There are no popular flight routes from Grand Cayman to San Francisco.
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  • When did momondo last update prices for flights from Grand Cayman to San Francisco Airport?

    Prices for flights from Grand Cayman to San Francisco Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Grand Cayman to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Grand Cayman to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Grand Cayman to San Francisco?

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Calistoga
Bodega Bay
Roseville
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Half Moon Bay
Walnut Creek
Vallejo
Redwood City
Salinas
South San Francisco
Fairfield

Why use momondo?

Why should I use momondo to find a flight deal from Grand Cayman to San Francisco?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Francisco from Grand Cayman.

Can I find flights from Grand Cayman to San Francisco with flexible booking policies on momondo?

Flights from Grand Cayman to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Grand Cayman to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Grand Cayman. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Grand Cayman to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Grand Cayman and alert you when they change.

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